Cyclobenzaprine (BioDeep_00000001939)

 

Secondary id: BioDeep_00001868048

human metabolite blood metabolite


代谢物信息卡片


dimethyl(3-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-ylidene}propyl)amine

化学式: C20H21N (275.16739060000003)
中文名称: 环苯扎林
谱图信息: 最多检出来源 Danio rerio(blood) 3.85%

分子结构信息

SMILES: CN(C)CC/C=C\1/c2ccccc2C=Cc2ccccc12
InChI: InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3

描述信息

Cyclobenzaprine is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Cyclobenzaprine acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. It is structurally similar to Amitriptyline, differing by only one double bond.
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
M - Musculo-skeletal system > M03 - Muscle relaxants > M03B - Muscle relaxants, centrally acting agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant

同义名列表

13 个代谢物同义名

dimethyl(3-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-ylidene}propyl)amine; N,N-Dimethyl-5H-dibenzo(a,D)cycloheptene-Delta(5,gamma)-propylamine; N,N-Dimethyl-5H-dibenzo(a,D)cycloheptene-delta(5,g)-propylamine; N,N-Dimethyl-5H-dibenzo(a,D)cycloheptene-δ(5,γ)-propylamine; (3-Dibenzo[a,D]cyclohepten-5-ylidene-propyl)-dimethyl-amine; N,N-Dimethyl-5H-dibenzo(a,D)cycloheptene-δ(5,g)-propylamine; Cyclobenzaprine hydrochloride; Cyclobenzaprine HCL; Cyclobenzaprinum; Ciclobenzaprina; cyclobenzaprine; Flexeril; Lisseril



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cihangir Buyukgoz, Shantaveer Gangu, Faaria Gowani, Dai Kimura. Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange. Journal of clinical apheresis. 2022 Jun; 37(3):313-315. doi: 10.1002/jca.21960. [PMID: 34953071]
  • Mitchelle Katemauswa, Ekram Hossain, Zongyuan Liu, Mahbobeh Lesani, Adwaita R Parab, Danya A Dean, Laura-Isobel McCall. Enabling Quantitative Analysis of Surface Small Molecules for Exposomics and Behavioral Studies. Journal of the American Society for Mass Spectrometry. 2022 Mar; 33(3):412-419. doi: 10.1021/jasms.1c00263. [PMID: 35084848]
  • Haidara Majid, Andreas Puzik, Tanja Maier, Daniel Eberhard, Anke Bartel, Hans-Christian Mueller, Bjoern B Burckhardt. Exploring the transmucosal permeability of cyclobenzaprine: A comparative preformulation by standardized and controlled ex vivo and in vitro permeation studies. International journal of pharmaceutics. 2021 May; 601(?):120574. doi: 10.1016/j.ijpharm.2021.120574. [PMID: 33831487]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Judy Caron, Randall Kaye, Thomas Wessel, Amy Halseth, Gary Kay. An assessment of the centrally acting muscle relaxant tolperisone on driving ability and cognitive effects compared to placebo and cyclobenzaprine. Journal of clinical pharmacy and therapeutics. 2020 Aug; 45(4):774-782. doi: 10.1111/jcpt.13165. [PMID: 32390248]
  • Mehran Haidari, Sravan Mansani, Dezaray Ponds, Lissett Romero, Christine Cobb, Saad Alsaab. Storage of urine specimens in point of care (POC) urine drug testing cups reduces concentrations of many drugs. Clinica chimica acta; international journal of clinical chemistry. 2019 Dec; 499(?):81-86. doi: 10.1016/j.cca.2019.09.001. [PMID: 31491368]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • M I Walash, S A El Abass Mohamed. Green analytical chromatographic assay method for quantitation of cyclobenzaprine in tablets, spiked human urine and in-vitro dissolution test. Annales pharmaceutiques francaises. 2019 Sep; 77(5):418-425. doi: 10.1016/j.pharma.2019.06.004. [PMID: 31296331]
  • Mohammad Hassan Baig, Safikur Rahman, Gulam Rabbani, Mohd Imran, Khurshid Ahmad, Inho Choi. Multi-Spectroscopic Characterization of Human Serum Albumin Binding with Cyclobenzaprine Hydrochloride: Insights from Biophysical and In Silico Approaches. International journal of molecular sciences. 2019 Feb; 20(3):. doi: 10.3390/ijms20030662. [PMID: 30717459]
  • Liat Adar, William Zarycranski, Jill B Conner, Jeffrey Dragone, Lindsay Janka, Laura Rabinovich-Guilatt. Bioequivalence of cyclobenzaprine hydrochloride extended-release capsule taken intact or sprinkled over applesauce
. International journal of clinical pharmacology and therapeutics. 2017 Dec; 55(12):931-938. doi: 10.5414/cp203059. [PMID: 29092731]
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  • Kaylee R Mastrianni, L Andrew Lee, William E Brewer, Nagaraju Dongari, Michael Barna, Stephen L Morgan. Variations in enzymatic hydrolysis efficiencies for amitriptyline and cyclobenzaprine in urine. Journal of analytical toxicology. 2016 Nov; 40(9):732-737. doi: 10.1093/jat/bkw062. [PMID: 27405366]
  • Kelly Ann Scanlon, Robert Stoppacher, Lee M Blum, Samantha J Starkey. Comprehensive Duloxetine Analysis in a Fatal Overdose. Journal of analytical toxicology. 2016 Mar; 40(2):167-70. doi: 10.1093/jat/bkv134. [PMID: 26662354]
  • Michael S Westrol, Nadia I Awad, Patrick J Bridgeman, Erika Page, Jonathan V McCoy, Janos Jeges. Use of an Intravascular Heat Exchange Catheter and Intravenous Lipid Emulsion for Hypothermic Cardiac Arrest After Cyclobenzaprine Overdose. Therapeutic hypothermia and temperature management. 2015 Sep; 5(3):171-6. doi: 10.1089/ther.2015.0006. [PMID: 26154529]
  • Jenny L Chua-Tuan, Dazhe Cao, Janetta L Iwanicki, Christopher O Hoyte. Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report. Clinical toxicology (Philadelphia, Pa.). 2015 Jul; 53(6):565-8. doi: 10.3109/15563650.2015.1040157. [PMID: 25951877]
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  • Yi Xiang, Liping Zhou, Zhenyu Qian, Kelong Peng, Dongyan Li, Xiaomei Chen, Hongliang Jiang, Heng Zheng. Determination of cyclobenzaprine in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study. Biomedical chromatography : BMC. 2012 Sep; 26(9):1083-8. doi: 10.1002/bmc.1751. [PMID: 22120786]
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  • Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller, Hinnerk Boriss. Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals. 2011 Feb; 39(2):312-21. doi: 10.1124/dmd.110.036095. [PMID: 21071520]
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