Benazepril (BioDeep_00000001896)
Secondary id: BioDeep_00000405765
human metabolite blood metabolite
代谢物信息卡片
2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
化学式: C24H28N2O5 (424.1998)
中文名称: 贝那普利游离碱
谱图信息:
最多检出来源 Homo sapiens(blood) 17.88%
分子结构信息
SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O
InChI: InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1
描述信息
Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
16 个代谢物同义名
2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid; Benazepril hydrochloride; Benazepril sandoz; Benazeprilum; Benzazepril; CGS-14824-a; Benazapril; Benazepril; Forteekor; CGS14824A; Lotensin; Cibacène; Cibacen; Labopal; Briem; Benazepril
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:3011
- KEGG: C06843
- KEGGdrug: D07499
- PubChem: 5362124
- PubChem: 2311
- HMDB: HMDB0014682
- Metlin: METLIN1256
- DrugBank: DB00542
- ChEMBL: CHEMBL838
- Wikipedia: Benazepril
- MetaCyc: CPD-15329
- chemspider: 4514935
- CAS: 109010-10-8
- CAS: 86541-75-5
- PMhub: MS000001406
- PubChem: 9061
- NIKKAJI: J22.179A
- RefMet: Benazepril
- KNApSAcK: 3011
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shiqi Wang, Jiahui Wu, Qingcheng Wang, Yunfeng Zhang, Hong Yuan, Jianding Wang, Yonghui Wu, Yaxi Xu, Na Ji, Bin Quan, Haixing Wang, Qing Shen. Evaluation of a miniature mass spectrometer based point-of-care-test method for direct analysis of amlodipine and benazepril in whole blood.
Journal of pharmaceutical and biomedical analysis.
2024 Aug; 245(?):116194. doi:
10.1016/j.jpba.2024.116194. [PMID: 38704878] - Heng Wang, Ran Xia, Bing Gao, Ling-Ji Li, Zhu Wang, Meng Zhu, Jing Wang. Effect of moxibustion combined with intraperitoneal injection of benazepril on endoplasmic reticulum stress-related protein phosphorylation in rats with chronic heart failure.
Zhen ci yan jiu = Acupuncture research.
2024 Mar; 49(3):231-237. doi:
10.13702/j.1000-0607.20221265. [PMID: 38500319] - G Christina Gutierrez, Christopher Dayton, Rebecca L Attridge, Lucas Smedley, Haritha Saikumar, Christopher Everett, Abraham Rodriguez, Shawn Varney. Angiotensin II Use in Treatment of Refractory Shock Due to Benazepril and Amlodipine Toxic Ingestion.
Journal of pharmacy practice.
2022 Oct; ?(?):8971900221137389. doi:
10.1177/08971900221137389. [PMID: 36314764] - Wang Wei, L I Qingling, M A Qiang, Xia Ran, Gao Bing, Wang Yi, Wang Jing. Effects of moxibustion at bilateral Feishu (BL13) and Xinshu (BL15) combined with benazepril on myocardial cells apoptosis index and apoptosis-related proteins cytochrome c and apoptosis-inducing factor in rats with chronic heart failure.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 04; 42(2):227-233. doi:
10.19852/j.cnki.jtcm.20220126.001. [PMID: 35473343] - Wei Wang, Qing-Ling Li, Qiang Ma, Ran Xia, Bing Gao, Yi Wang, Jing Wang. [Effect of moxibustion combined with benazepril on expression of IL-18 and phosphorylated protein kinase B in myocardial tissue of rats with chronic heart failure].
Zhen ci yan jiu = Acupuncture research.
2021 Nov; 46(11):935-41. doi:
10.13702/j.1000-0607.201219. [PMID: 34865330] - Swati D Bhende, Murali Balaram Varanasi, Konde Abbulu. A sensitive and efficient LC-MS/MS method for the bioanalysis of fosinopril diacid from human plasma and its application for a bioequivalence study in humans.
Biomedical chromatography : BMC.
2021 May; 35(5):e5047. doi:
10.1002/bmc.5047. [PMID: 33352616] - Darcy Adin, Clarke Atkins, Gabrielle Wallace, Allison Klein. Effect of spironolactone and benazepril on furosemide-induced diuresis and renin-angiotensin-aldosterone system activation in normal dogs.
Journal of veterinary internal medicine.
2021 May; 35(3):1245-1254. doi:
10.1111/jvim.16097. [PMID: 33713485] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Youbin Liu, Ying Fan, Jinglong Li, Meng Chen, Anyong Chen, Dahao Yang, Xue Guan, Yong Cao. Combination of LCZ696 and ACEI further improves heart failure and myocardial fibrosis after acute myocardial infarction in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jan; 133(?):110824. doi:
10.1016/j.biopha.2020.110824. [PMID: 33378988] - Ekjot Grewal, Bayu Sutarjono, Ibbad Mohammed. Angioedema, ACE inhibitor and COVID-19.
BMJ case reports.
2020 Sep; 13(9):. doi:
10.1136/bcr-2020-237888. [PMID: 32912894] - Zhanying Liu, Lin Zhang, Ruijie Zhai, Jiarong Lan. Comparison of Irbesartan and Benazepril Hydrochloride on Urine Protein Reduction in Chronic Glomerulonephritis.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2020 Sep; 30(9):1000-1001. doi:
10.29271/jcpsp.2020.09.1000. [PMID: 33036695] - Wei Guo, Yan Ji, Qi Han, Yao Yang, Fangjie Wang, Yongjian Yang, Youcai Deng, Xiongshan Sun, Xiaohui Li. Postnatal renin-angiotensin system inhibition prevents renal damage from prenatal inflammation in rats.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2020 08; 40(4):646-653. doi:
10.19852/j.cnki.jtcm.2020.04.012. [PMID: 32744032] - Xin Wang, Tao Li, Rui Si, Jinyun Chen, Zhihui Qu, Yanfang Jiang. Increased frequency of PD-1hiCXCR5- T cells and B cells in patients with newly diagnosed IgA nephropathy.
Scientific reports.
2020 01; 10(1):492. doi:
10.1038/s41598-019-57324-8. [PMID: 31949193] - Uta Brandenburg, Gabriele Braun, Peter Klein, Erich Reinhart. The Multicomponent, Multitarget Therapy SUC in Cats with Chronic Kidney Disease: A Multicenter, Prospective, Observational, Nonrandomized Cohort Study.
Complementary medicine research.
2020; 27(3):163-173. doi:
10.1159/000506698. [PMID: 32213769] - Huili Li, Yuanyuan Wang, Zhangqing Zhou, Fang Tian, Huanhuan Yang, Juzhen Yan. Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF-κB, TGF-β and TRPC6.
Renal failure.
2019 Nov; 41(1):899-906. doi:
10.1080/0886022x.2019.1665547. [PMID: 31552773] - Jonathan N King, Mike Martin, Valérie Chetboul, Luca Ferasin, Anne T French, Günther Strehlau, Wolfgang Seewald, Sarah G W Smith, Simon T Swift, Susan L Roberts, Andrea M Harvey, Christopher J L Little, Sarah M A Caney, Kerry E Simpson, Andrew H Sparkes, Eleanor J Mardell, Eric Bomassi, Claude Muller, John P Sauvage, Armelle Diquélou, Matthias A Schneider, Laurence J Brown, David D Clarke, Jean-Francois Rousselot. Evaluation of benazepril in cats with heart disease in a prospective, randomized, blinded, placebo-controlled clinical trial.
Journal of veterinary internal medicine.
2019 Nov; 33(6):2559-2571. doi:
10.1111/jvim.15572. [PMID: 31560137] - Piero Ruggenenti, Matias Trillini, Drazenka P Barlovic, Monica Cortinovis, Antonio Pisani, Aneliya Parvanova, Ilian P Iliev, Barbara Ruggiero, Stefano Rota, Maria C Aparicio, Annalisa Perna, Francesco Peraro, Olimpia Diadei, Flavio Gaspari, Fabiola Carrara, Nadia Stucchi, Davide Martinetti, Andrej Janez, Nadan Gregoric, Eleonora Riccio, Antonio C Bossi, Roberto Trevisan, Paolo Manunta, Giovanni Battaglia, Salvatore David, Filippo Aucella, Antonio Belviso, Andrea Satta, Giuseppe Remuzzi. Effects of valsartan, benazepril and their combination in overt nephropathy of type 2 diabetes: A prospective, randomized, controlled trial.
Diabetes, obesity & metabolism.
2019 05; 21(5):1177-1190. doi:
10.1111/dom.13639. [PMID: 30793466] - Bao-Li Wang, Dong-Qi Pan, Kai-Li Zhou, Yan-Yue Lou, Jie-Hua Shi. Multi-spectroscopic approaches and molecular simulation research of the intermolecular interaction between the angiotensin-converting enzyme inhibitor (ACE inhibitor) benazepril and bovine serum albumin (BSA).
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Apr; 212(?):15-24. doi:
10.1016/j.saa.2018.12.040. [PMID: 30594849] - Jiali Yu, Rong Dong, Jingjing Da, Jiayu Li, Fuxun Yu, Yan Zha. High-Mobility Group Nucleosome-Binding Protein 1 Mediates Renal Fibrosis Correlating with Macrophages Accumulation and Epithelial-to-Mesenchymal Transition in Diabetic Nephropathy Mice Model.
Kidney & blood pressure research.
2019; 44(3):331-343. doi:
10.1159/000499877. [PMID: 31203283] - Marianne A Mahrouse. Simultaneous ultraperformance liquid chromatography/tandem mass spectrometry determination of four antihypertensive drugs in human plasma using hydrophilic-lipophilic balanced reversed-phase sorbents sample preparation protocol.
Biomedical chromatography : BMC.
2018 Dec; 32(12):e4362. doi:
10.1002/bmc.4362. [PMID: 30109716] - Qingfei Xiao, Yinghui Guan, Chenhao Li, Li Liu, Dan Zhao, Hongyue Wang. Decreased expression of transforming growth factor-β1 and α-smooth muscle actin contributes to the protection of lotensin against chronic renal failure in rats.
Renal failure.
2018 Nov; 40(1):583-589. doi:
10.1080/0886022x.2018.1496934. [PMID: 30371125] - T Afonso, S Giguère, S A Brown, M H Barton, G Rapoport, M Barba, K A Dembek, R E Toribio, A E Coleman. Preliminary investigation of orally administered benazepril in horses with left-sided valvular regurgitation.
Equine veterinary journal.
2018 Jul; 50(4):446-451. doi:
10.1111/evj.12773. [PMID: 29044678] - J N King, C Christinaz, G Strehlau, J Hornfeld. Effect of benazepril and pimobendan on serum angiotensin-converting enzyme activity in dogs.
Journal of veterinary pharmacology and therapeutics.
2018 Jun; 41(3):485-489. doi:
10.1111/jvp.12475. [PMID: 29392741] - Hua Jin, Zhi-Jun Liu, Chun-Lu Yan, Feng-Lin Liu, Li Chen, Qiu-Ju Zhang, Hou-Qian Xu, Ji-Hong Hu, Rong-Hai Dou, Xin-Yang Wen. [The influence of benazepril and amlodipine on the expression of secretin and somatostatin in spontaneously hypertensive rats].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2018 Feb; 34(2):154-158. doi:
10.12047.j.cjap.5542.2018.038. [PMID: 29926681] - Robert D Brook, Niko Kaciroti, George Bakris, Björn Dahlöf, Bertram Pitt, Eric Velazquez, Michael Weber, Dion H Zappe, Tsushung Hau, Kenneth A Jamerson. Prior Medications and the Cardiovascular Benefits From Combination Angiotensin-Converting Enzyme Inhibition Plus Calcium Channel Blockade Among High-Risk Hypertensive Patients.
Journal of the American Heart Association.
2018 01; 7(1):. doi:
10.1161/jaha.117.006940. [PMID: 29301757] - Jiali Yu, Jingjing Da, Rong Dong, Yi Sun, Yingjie Nie, Fuxun Yu, Li Zuo, Yan Zha. IGF-1R Inhibitor Ameliorates Diabetic Nephropathy with Suppressed HMGN1/TLR4 Pathway.
Endocrine, metabolic & immune disorders drug targets.
2018; 18(3):241-250. doi:
10.2174/1871530318666180131102707. [PMID: 29384065] - Lingyu Xue, Xiaoqing Feng, Chuanhai Wang, Xuebin Zhang, Wenqiang Sun, Kebo Yu. Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL-4 expression.
BMC nephrology.
2017 Oct; 18(1):307. doi:
10.1186/s12882-017-0724-1. [PMID: 28978304] - Juan Manuel Serrano-Rodríguez, Manuel Gómez-Díez, María Esgueva, Cristina Castejón-Riber, Antonio Mena-Bravo, Feliciano Priego-Capote, Nahúm Ayala, Juan Manuel Serrano Caballero, Ana Muñoz. Pharmacokinetic/pharmacodynamic modeling of benazepril and benazeprilat after administration of intravenous and oral doses of benazepril in healthy horses.
Research in veterinary science.
2017 Oct; 114(?):117-122. doi:
10.1016/j.rvsc.2017.03.016. [PMID: 28371693] - J N King, A Font, J-F Rousselot, R A Ash, U Bonfanti, C Brovida, I D Crowe, D Lanore, D Pechereau, W Seewald, G Strehlau. Effects of Benazepril on Survival of Dogs with Chronic Kidney Disease: A Multicenter, Randomized, Blinded, Placebo-Controlled Clinical Trial.
Journal of veterinary internal medicine.
2017 Jul; 31(4):1113-1122. doi:
10.1111/jvim.14726. [PMID: 28669137] - T Afonso, S Giguère, G Rapoport, S A Brown, A E Coleman. Attenuation of the blood pressure response to exogenous angiotensin I after oral administration of benazepril to healthy adult horses.
Equine veterinary journal.
2017 May; 49(3):358-362. doi:
10.1111/evj.12593. [PMID: 27224673] - Jennifer O Lavallee, Gary D Norsworthy, Carla L Huston, Dennis J Chew. Safety of Benazepril in 400 Azotemic and 110 Non-Azotemic Client-Owned Cats (2001-2012).
Journal of the American Animal Hospital Association.
2017 Mar; 53(2):119-127. doi:
10.5326/jaaha-ms-6577. [PMID: 28282231] - A Panteri, A Kukk, C Desevaux, W Seewald, J N King. Effect of benazepril and robenacoxib and their combination on glomerular filtration rate in dogs.
Journal of veterinary pharmacology and therapeutics.
2017 Jan; 40(1):44-56. doi:
10.1111/jvp.12325. [PMID: 27302598] - Hong Yao, Li Jiang, Xi Lin, Zhao-Guang Liang. Fluvastatin combined with benazepril may contribute to the favorable prognosis of patients with atrial fibrillation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Oct; 83(?):687-692. doi:
10.1016/j.biopha.2016.07.031. [PMID: 27470569] - Jonathan N King, Alessandro Panteri, Melanie Graille, Wolfgang Seewald, Gabriele Friton, Cyril Desevaux. Effect of benazepril, robenacoxib and their combination on glomerular filtration rate in cats.
BMC veterinary research.
2016 Jun; 12(1):124. doi:
10.1186/s12917-016-0734-4. [PMID: 27338786] - C F Sun, S G Wang, Y G Peng, Y Shi, Y P Du, G X Shi, T Wen, Y K Wang, H Su. [Intervention of systolic pressure and left ventricular hypertrophy in rats under cold stress].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2016 Jun; 34(6):438-43. doi:
10.3760/cma.j.issn.1001-9391.2016.06.010. [PMID: 27514554] - Shanqun Jiang, Mingluo Pan, Suwen Wu, Scott A Venners, Guisheng Zhong, Yi-Hsiang Hsu, Justin Weinstock, Binyan Wang, Genfu Tang, Dahai Liu, Xiping Xu. Elevation in Total Homocysteine Levels in Chinese Patients With Essential Hypertension Treated With Antihypertensive Benazepril.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2016 Mar; 22(2):191-8. doi:
10.1177/1076029614565881. [PMID: 25550183] - M Qian, T Chen, D Zhou, Z Zhang, Q Zhang, S Tang, X Xiao. Development of a new benazepril hydrochloride chewable tablet and evaluation of its bioequivalence for treatment of heart failure in dogs.
Journal of veterinary pharmacology and therapeutics.
2016 Feb; 39(1):98-101. doi:
10.1111/jvp.12252. [PMID: 26228576] - Marisa K Ames, Clarke E Atkins, Seunggon Lee, Andrea C Lantis, James R zumBrunnen. Effects of high doses of enalapril and benazepril on the pharmacologically activated renin-angiotensin-aldosterone system in clinically normal dogs.
American journal of veterinary research.
2015 Dec; 76(12):1041-50. doi:
10.2460/ajvr.76.12.1041. [PMID: 26618728] - U Sent, R Gössl, J Elliott, H M Syme, T Zimmering. Comparison of Efficacy of Long-term Oral Treatment with Telmisartan and Benazepril in Cats with Chronic Kidney Disease.
Journal of veterinary internal medicine.
2015 Nov; 29(6):1479-87. doi:
10.1111/jvim.13639. [PMID: 26474314] - Xiaoyan Xiao, Jie Wang, Xiangdi Chang, Junhui Zhen, Gengyin Zhou, Zhao Hu. Mycophenolate mofetil ameliorates diabetic nephropathy through epithelial mesenchymal transition in rats.
Molecular medicine reports.
2015 Sep; 12(3):4043-4050. doi:
10.3892/mmr.2015.3934. [PMID: 26080907] - Jonathan P Mochel, Martin Fink, Mathieu Peyrou, Antoine Soubret, Jérôme M Giraudel, Meindert Danhof. Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs.
Pharmaceutical research.
2015 Jun; 32(6):1931-46. doi:
10.1007/s11095-014-1587-9. [PMID: 25446774] - D-F Peng, S-Y Tang, Y-J Hu, J Chen, X Peng, Q Huang. Comparison of valsartan and benazepril when combined with atorvastatin in protecting patients with early cardio-renal syndrome (CRS).
European review for medical and pharmacological sciences.
2015 Apr; 19(7):1264-71. doi:
. [PMID: 25912588] - Fei Chen, Jia-Le Wu, Guo-Sheng Fu, Yun Mou, Shen-Jiang Hu. Chronic treatment with qiliqiangxin ameliorates aortic endothelial cell dysfunction in diabetic rats.
Journal of cardiovascular pharmacology and therapeutics.
2015 Mar; 20(2):230-40. doi:
10.1177/1074248414537705. [PMID: 24906540] - A C Lantis, M K Ames, C E Atkins, T C DeFrancesco, B W Keene, S R Werre. Aldosterone breakthrough with benazepril in furosemide-activated renin-angiotensin-aldosterone system in normal dogs.
Journal of veterinary pharmacology and therapeutics.
2015 Feb; 38(1):65-73. doi:
10.1111/jvp.12154. [PMID: 25224804] - I-Te Lee, Wayne Huey-Herng Sheu, Yi-Jen Hung, Jung-Fu Chen, Chih-Yuan Wang, Wen-Jane Lee. Assessment of glomerular filtration rate based on alterations of serum brain-derived neurotrophic factor in type 2 diabetic subjects treated with amlodipine/benazepril or valsartan/hydrochlorothiazide.
Disease markers.
2015; 2015(?):780743. doi:
10.1155/2015/780743. [PMID: 25918454] - Jonathan P Mochel, Meindert Danhof. Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned?.
Reviews of physiology, biochemistry and pharmacology.
2015; 169(?):43-69. doi:
10.1007/112_2015_27. [PMID: 26428686] - Erica Daina, Paolo Cravedi, Mirella Alpa, Dario Roccatello, Sara Gamba, Annalisa Perna, Flavio Gaspari, Giuseppe Remuzzi, Piero Ruggenenti. A multidrug, antiproteinuric approach to alport syndrome: a ten-year cohort study.
Nephron.
2015; 130(1):13-20. doi:
10.1159/000381480. [PMID: 25895746] - S-Y Tang, D-F Peng, Y-J Hu, J Chen. Protective effects of valsartan and benazepril combined with atorvastatin on cardiorenal syndrome in rats.
European review for medical and pharmacological sciences.
2015; 19(5):759-66. doi:
. [PMID: 25807427] - Yu Zhang, Nan Zhou, Ting Li, Hong-ying Wang, Jian-yu He. [Effect of Shenkang Injection on Kidney Function in Hypertensive Renal Damage Rats].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2014 Dec; 37(12):2248-54. doi:
. [PMID: 26080514] - Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.
Scientific reports.
2014 Sep; 4(?):6437. doi:
10.1038/srep06437. [PMID: 25257666] - Mamdouh R Rezk, Kamal A Badr. Development, optimization and validation of a highly sensitive UPLC-ESI-MS/MS method for simultaneous quantification of amlodipine, benazeprile and benazeprilat in human plasma: application to a bioequivalence study.
Journal of pharmaceutical and biomedical analysis.
2014 Sep; 98(?):1-8. doi:
10.1016/j.jpba.2014.05.005. [PMID: 24863555] - S R Liang, J W Bi, Z L Guo, Y Bai, Z Hu. Protective effect of icariin on kidney in 5/6 nephrectomized rats and its mechanism.
Genetics and molecular research : GMR.
2014 Aug; 13(3):6466-71. doi:
10.4238/2014.august.25.10. [PMID: 25158265] - Honglin Niu, Lei Nie, Maodong Liu, Yanqing Chi, Tao Zhang, Ying Li. Benazepril affects integrin-linked kinase and smooth muscle α-actin expression in diabetic rat glomerulus and cultured mesangial cells.
BMC nephrology.
2014 Aug; 15(?):135. doi:
10.1186/1471-2369-15-135. [PMID: 25142208] - A S Hanzlicek, C J Roof, M W Sanderson, G F Grauer. The Effect of Chinese rhubarb, Rheum officinale, with and without benazepril on the progression of naturally occurring chronic kidney disease in cats.
Journal of veterinary internal medicine.
2014 Jul; 28(4):1221-8. doi:
10.1111/jvim.12365. [PMID: 24773179] - Xi-Li Wu, Bing-Yu Ye, Peng An, Cheng-Lin Qiao, Xing-Min Shi, Rong-Guo Fu. [Effect of Qufeng Tongluo Recipe on the expressions of connexin 36 protein and gene in rat mesangial cells].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2014 Mar; 45(2):207-11. doi:
NULL. [PMID: 24749341] - Hua Jin, Shang Guo Piao, Ji Zhe Jin, Ying Shun Jin, Zhen Hua Cui, Hai Feng Jin, Hai Lan Zheng, Jin Ji Li, Yu Ji Jiang, Chul Woo Yang, Can Li. Synergistic effects of leflunomide and benazepril in streptozotocin-induced diabetic nephropathy.
Nephron. Experimental nephrology.
2014; 126(3):148-56. doi:
10.1159/000362556. [PMID: 24855017] - O Cortadellas, J Talavera, M J Fernández del Palacio. Evaluation of the effects of a therapeutic renal diet to control proteinuria in proteinuric non-azotemic dogs treated with benazepril.
Journal of veterinary internal medicine.
2014 Jan; 28(1):30-7. doi:
10.1111/jvim.12246. [PMID: 24372810] - Hua-Ling Pan, Li-Shan Lin, Jue-Fang Ding, Xiao-Yan Chen, Da-Fang Zhong. [Simultaneous determination of amlodipine, benazepril and benazeprilat in human plasma by LC-HESI/MS/MS method].
Yao xue xue bao = Acta pharmaceutica Sinica.
2014 Jan; 49(1):95-100. doi:
NULL. [PMID: 24783513] - J Häggström, P F Lord, K Höglund, I Ljungvall, O Jöns, C Kvart, K Hansson. Short-term hemodynamic and neuroendocrine effects of pimobendan and benazapril in dogs with myxomatous mitral valve disease and congestive heart failure.
Journal of veterinary internal medicine.
2013 Nov; 27(6):1452-62. doi:
10.1111/jvim.12217. [PMID: 24128373] - K Kelers, J L Devi, G A Anderson, P Zahra, J H Vine, T Whittem. Bioequivalence of a new liquid formulation of benazepril compared with the reference tablet product.
Australian veterinary journal.
2013 Aug; 91(8):312-9. doi:
10.1111/avj.12080. [PMID: 23889096] - Masato Ohsawa, Kouichi Tamura, Tomohiko Kanaoka, Hiromichi Wakui, Akinobu Maeda, Toru Dejima, Kengo Azushima, Kazushi Uneda, Ryu Kobayashi, Yuko Tsurumi-Ikeya, Yoshiyuki Toya, Tetsuya Fujikawa, Satoshi Umemura. Addition of aliskiren to Angiotensin receptor blocker improves ambulatory blood pressure profile and cardiorenal function better than addition of benazepril in chronic kidney disease.
International journal of molecular sciences.
2013 Jul; 14(8):15361-75. doi:
10.3390/ijms140815361. [PMID: 23887656] - Xiao-Mei Huang, Jing-Ping Yuan, Xing-Ruo Zeng, Cai-Xia Peng, Qi-Hui Mei, Wen-Li Chen. Effects of chronotherapy of benazepril on the diurnal profile of RAAS and clock genes in the kidney of 5/6 nephrectomy rats.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2013 Jun; 33(3):368-374. doi:
10.1007/s11596-013-1126-7. [PMID: 23771662] - Xiaohui Zhang, Rong Wang, Hua Xie, Qiang Yin, Xiaoyun Li, Zhengping Jia, Xiaoyu Wu, Juanhong Zhang, Wenbin Li. [Online enrichment ability of restricted-access column coupled with high performance liquid chromatography by column switching technique for benazepril hydrochloride].
Se pu = Chinese journal of chromatography.
2013 May; 31(5):451-5. doi:
10.3724/sp.j.1123.2012.11021. [PMID: 24010345] - Shi-Hai Yan, Ning-Wei Zhao, Xuan-Xuan Zhu, Qiong Wang, Hai-Dan Wang, Rui Fu, Yuan Sun, Qi-Yi Li. Benazepril inhibited the NF-κB and TGF-β networking on LV hypertrophy in rats.
Immunology letters.
2013 May; 152(2):126-34. doi:
10.1016/j.imlet.2013.05.005. [PMID: 23707880] - J P Mochel, M Peyrou, M Fink, G Strehlau, R Mohamed, J M Giraudel, B Ploeger, M Danhof. Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs.
Journal of veterinary pharmacology and therapeutics.
2013 Apr; 36(2):174-80. doi:
10.1111/j.1365-2885.2012.01406.x. [PMID: 22568394] - Yifei Zhong, Edward Y Chen, Ruijie Liu, Peter Y Chuang, Sandeep K Mallipattu, Christopher M Tan, Neil R Clark, Yueyi Deng, Paul E Klotman, Avi Ma'ayan, John Cijiang He. Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase.
Journal of the American Society of Nephrology : JASN.
2013 Apr; 24(5):801-11. doi:
10.1681/asn.2012060590. [PMID: 23559582] - Michael A Weber, Kenneth Jamerson, George L Bakris, Matthew R Weir, Dion Zappe, Ying Zhang, Bjorn Dahlof, Eric J Velazquez, Bertram Pitt. Effects of body size and hypertension treatments on cardiovascular event rates: subanalysis of the ACCOMPLISH randomised controlled trial.
Lancet (London, England).
2013 Feb; 381(9866):537-45. doi:
10.1016/s0140-6736(12)61343-9. [PMID: 23219284] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Vijaya Kumari Karra, Ramesh Mullangi, Nageswara Rao Pilli, Jaswanth Kumar Inamadugu, Vasu Babu Ravi, J V L N Seshagiri Rao. A rapid and sensitive liquid chromatography-tandem mass spectrometric assay for moexipril, an angiotensin-converting enzyme inhibitor in human plasma.
Biomedical chromatography : BMC.
2012 Dec; 26(12):1552-8. doi:
10.1002/bmc.2731. [PMID: 22419504] - C E Atkins, A C Lantis, M K Ames, S Y Gardner. Utility of urinary aldosterone measurement in quantitating RAAS activation.
Journal of veterinary pharmacology and therapeutics.
2012 Oct; 35(5):512-5; author reply 516. doi:
10.1111/jvp.12011. [PMID: 22966900] - Nicolás R Robles, Roman Hernandez-Gallego. Blood pressure in renal disease: how to accomplish the goal?.
Cardiovascular therapeutics.
2012 Aug; 30(4):193-8. doi:
10.1111/j.1755-5922.2010.00260.x. [PMID: 22759229] - Shin Okui, Hideyuki Yamamoto, Wen Li, Naomi Gamachi, Yukihisa Fujita, Shin-Ichiro Kashiwamura, Daisaku Miura, Shinji Takai, Mizuo Miyazaki, Masahiro Urade, Haruki Okamura, Haruyasu Ueda. Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18.
European journal of pharmacology.
2012 Jun; 685(1-3):149-55. doi:
10.1016/j.ejphar.2012.04.027. [PMID: 22543082] - Keguang Chen, Jing Zhang, Sha Liu, Dujuan Zhang, Yanni Teng, Chunmin Wei, Benjie Wang, Xiaoyan Liu, Guiyan Yuan, Rui Zhang, Wenjing Zhao, Ruichen Guo. Simultaneous determination of lercanidipine, benazepril and benazeprilat in plasma by LC-MS/MS and its application to a toxicokinetics study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Jun; 899(?):1-7. doi:
10.1016/j.jchromb.2012.04.014. [PMID: 22622066] - Lin-qi Zhang, Wei-ming Li, Wei Sun. Effect of yishen huayu fang on kidney tissue E-cadherin expression in unilateral ureter ligation in rats.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2012 Jun; 32(2):273-7. doi:
10.1016/s0254-6272(13)60024-2. [PMID: 22876456] - Sergej Ramusovic, Gabriele Thielking, Stephanie Läer. Determination of enalapril and enalaprilat in small human serum quantities for pediatric trials by HPLC-tandem mass spectrometry.
Biomedical chromatography : BMC.
2012 Jun; 26(6):697-702. doi:
10.1002/bmc.1716. [PMID: 21953651] - Hui Rong, Mingyue Tan. [Effect of probucol on serum malondialdehyde and superoxide dismutase in patients with primary hypertension].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2012 May; 37(5):458-62. doi:
10.3969/j.issn.1672-7347.2012.05.005. [PMID: 22659656] - Sverre E Kjeldsen, Kenneth A Jamerson, George L Bakris, Bertram Pitt, Björn Dahlöf, Eric J Velazquez, Tsushung A Hua, Roxzana Y Kelly, Dion Zappe, Allen Hester, Jaakko Tuomilehto, Jan Ostergren, Hans Ibsen, Michael Weber. Predictors of systolic BP <140 mmHg and systolic BP level by randomly assigned treatment group (benazepril plus amlodipine or hydrochlorothiazide) in the ACCOMPLISH Study.
Blood pressure.
2012 Apr; 21(2):82-7. doi:
10.3109/08037051.2011.598699. [PMID: 21830844] - Jie Gao, Li Fan, Mao-Jing Liu. [Protective effects and mechanisms of xin'ganbao capsule on STZ induced early kidney injury in diabetic rats].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2012 Apr; 32(4):530-6. doi:
. [PMID: 22803438] - Shreesh Kumar Ojha, Saurabh Bharti, Sujata Joshi, Santosh Kumari, Dharamvir Singh Arya. Protective effect of hydroalcoholic extract of Andrographis paniculata on ischaemia-reperfusion induced myocardial injury in rats.
The Indian journal of medical research.
2012 Mar; 135(?):414-21. doi:
. [PMID: 22561631] - Yi-Qing Fang, Ying Lu, Yong-Jun Wang. [Efficiency of benazepril combined with wind dispelling and dampness removing chinese herbs on stage 3 chronic kidney disease with wind-dampness syndrome: a prospective study].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2012 Mar; 32(3):311-6. doi:
. [PMID: 22686073] - Matthew R Weir, George L Bakris, Michael A Weber, Bjorn Dahlof, Richard B Devereux, Sverre E Kjeldsen, Bertram Pitt, Jackson T Wright, Roxzana Y Kelly, Tsushung A Hua, R Allen Hester, Eric Velazquez, Kenneth A Jamerson. Renal outcomes in hypertensive Black patients at high cardiovascular risk.
Kidney international.
2012 Mar; 81(6):568-76. doi:
10.1038/ki.2011.417. [PMID: 22189843] - Yong-jun Wang, Li-qun He, Wei Sun, Ying Lu, Xiao-qin Wang, Pei-qing Zhang, Lian-bo Wei, Shi-li Cao, Ni-zhi Yang, Hong-zhen Ma, Jing Gao, Ping Li, Xiao-juan Tao, Fa-Huan Yuan, Jing Li, Chen Yao, Xusheng Liu. Optimized project of traditional Chinese medicine in treating chronic kidney disease stage 3: a multicenter double-blinded randomized controlled trial.
Journal of ethnopharmacology.
2012 Feb; 139(3):757-64. doi:
10.1016/j.jep.2011.12.009. [PMID: 22178174] - Na Liu, Song He, Evelyn Tolbert, Rujun Gong, George Bayliss, Shougang Zhuang. Suramin alleviates glomerular injury and inflammation in the remnant kidney.
PloS one.
2012; 7(4):e36194. doi:
10.1371/journal.pone.0036194. [PMID: 22558380] - Martin H de Borst, Ferdau L Nauta, Liffert Vogt, Gozewijn D Laverman, Ron T Gansevoort, Gerjan Navis. Indomethacin reduces glomerular and tubular damage markers but not renal inflammation in chronic kidney disease patients: a post-hoc analysis.
PloS one.
2012; 7(5):e37957. doi:
10.1371/journal.pone.0037957. [PMID: 22662255] - Sheng-Kui Feng. [Observation on curative effect of glomerular pathological proteinuria treated with heat-producing needling].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2012 Jan; 32(1):8-12. doi:
. [PMID: 22295812] - Rui-Xing Yin, Dong-Feng Wu, Jin-Zhen Wu, Xiao-Li Cao, Lynn Htet Htet Aung, Lin Miao, Xing-Jiang Long, Wan-Ying Liu, Lin Zhang, Meng Li. Interactions of several lipid-related gene polymorphisms and cigarette smoking on blood pressure levels.
International journal of biological sciences.
2012; 8(5):685-96. doi:
10.7150/ijbs.4401. [PMID: 22606049] - Tian Sun, Hao Xu, Fengqin Xu. Astragalus injection for hypertensive renal damage: a systematic review.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):929025. doi:
10.1155/2012/929025. [PMID: 22577466] - J Jiang, L Tian, Y Huang, S Xie, L Xu, H Liu, Y Li. Pharmacokinetic profiles of hydrochlorothiazide alone and in combination with benazepril or valsartan in healthy Chinese volunteers: evaluation of the potential interaction.
International journal of clinical pharmacology and therapeutics.
2011 Dec; 49(12):756-64. doi:
10.5414/cp201583. [PMID: 22122818] - Megumi Kanasaki, Takako Nagai, Munehiro Kitada, Daisuke Koya, Keizo Kanasaki. Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors.
Fibrogenesis & tissue repair.
2011 Nov; 4(?):25. doi:
10.1186/1755-1536-4-25. [PMID: 22126210] - Yi-tian Dou, Hong-tao Yang, Shi-li Cao. [Effects of Shensu II Recipe on the expressions of transforming growth factor-beta1, and plasminogen activator inhibitor-1 in the focal segmental glomerulosclerosis rats].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2011 Nov; 31(11):1531-7. doi:
. [PMID: 22303720] - Lin-lin Guo, Min Li, Ai-hong Wang. [Effects of benazepril and valsartan on erythropoietin levels in patients with essential hypertension].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2011 Oct; 31(10):1761-3. doi:
. [PMID: 22027785] - Hong-yue Wang, Yan-jun Wang, Ming-ji Cui, Chun-mei Gu, Li-zhi Yang, Ying Zhao, Yan Chen, Dan Zhao, Tian-shu Li, Bao-rong Chi. Hepatocyte growth factor-induced amelioration in renal interstitial fibrosis is associated with reduced expression of alpha-smooth muscle actin and transforming growth factor-beta1.
Indian journal of biochemistry & biophysics.
2011 Oct; 48(5):308-15. doi:
NULL. [PMID: 22165288] - Domenic A Sica, Barry Carter, William Cushman, Lee Hamm. Thiazide and loop diuretics.
Journal of clinical hypertension (Greenwich, Conn.).
2011 Sep; 13(9):639-43. doi:
10.1111/j.1751-7176.2011.00512.x. [PMID: 21896142] - Conrad W Liang, Sarah J Diamond, Daniel S Hagg. Lipid rescue of massive verapamil overdose: a case report.
Journal of medical case reports.
2011 Aug; 5(?):399. doi:
10.1186/1752-1947-5-399. [PMID: 21854635] - Fawzi Elsebaei, Yan Zhu. Fast gradient high performance liquid chromatography method with UV detection for simultaneous determination of seven angiotensin converting enzyme inhibitors together with hydrochlorothiazide in pharmaceutical dosage forms and spiked human plasma and urine.
Talanta.
2011 Jul; 85(1):123-9. doi:
10.1016/j.talanta.2011.03.037. [PMID: 21645680] - S V Tomov, P A Flume, A E Stenbit, M E Ullian. Prerenal azotemia from excessive sweating in an adult with a cystic fibrosis gene mutation.
Indian journal of nephrology.
2011 Jul; 21(3):194-7. doi:
10.4103/0971-4065.82637. [PMID: 21886981] - Di Xie, Fan Fan Hou, Bi Ling Fu, Xun Zhang, Min Liang. High level of proteinuria during treatment with renin-angiotensin inhibitors is a strong predictor of renal outcome in nondiabetic kidney disease.
Journal of clinical pharmacology.
2011 Jul; 51(7):1025-34. doi:
10.1177/0091270010377502. [PMID: 20978279] - Xi-ming Li, Hong-liang Cong, Ting-ting Li, Li-jun He, Yu-jie Zhou. Impact of benazepril on contrast-induced acute kidney injury for patients with mild to moderate renal insufficiency undergoing percutaneous coronary intervention.
Chinese medical journal.
2011 Jul; 124(14):2101-6. doi:
. [PMID: 21933609] - Tomasz Stompór, Maria Napora, Artur Olszewski. Renoprotective effects of benazepril: current perspective.
Expert review of cardiovascular therapy.
2011 Jun; 9(6):663-73. doi:
10.1586/erc.11.55. [PMID: 21714597]
