Methohexital (BioDeep_00000001492)
Secondary id: BioDeep_00000405898
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
化学式: C14H18N2O3 (262.1317)
中文名称: 美索比妥
谱图信息:
最多检出来源 Homo sapiens(blood) 56.48%
分子结构信息
SMILES: C=CCC1(C(C)C#CCC)C(=O)NC(=O)N(C)C1=O
InChI: InChI=1S/C14H18N2O3/c1-5-7-8-10(3)14(9-6-2)11(17)15-13(19)16(4)12(14)18/h6,10H,2,5,9H2,1,3-4H3,(H,15,17,19)
描述信息
Methohexital is only found in individuals that have used or taken this drug. It is an intravenous anesthetic with a short duration of action that may be used for induction of anesthesia. [PubChem]Methohexital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CA - Barbiturates, plain
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AF - Barbiturates, plain
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C67084 - Barbiturate
同义名列表
34 个代谢物同义名
5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-(hex-3-yn-2-yl)-1-methyl-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione; 5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione; alpha-DL-1-Methyl-5-allyl-5-(1-methylpentyn-2-yl)barbituric acid; alpha-DL-1-Methyl-5-allyl-5-(1-methylpentyn-2-yl)barbitic acid; (+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid; alpha-DL-1-Methyl-5-allyl-5-(1-methylpentyn-2-yl)barbitate; a-DL-1-Methyl-5-allyl-5-(1-methylpentyn-2-yl)barbitic acid; (+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbitic acid; Α-DL-1-methyl-5-allyl-5-(1-methylpentyn-2-yl)barbitic acid; (+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbitate; a-DL-1-Methyl-5-allyl-5-(1-methylpentyn-2-yl)barbitate; Α-DL-1-methyl-5-allyl-5-(1-methylpentyn-2-yl)barbitate; 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid; 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbitic acid; 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbitate; Lilly brand OF methohexital sodium; Jones brand OF methohexital sodium; Methohexital, monosodium salt; Monosodium salt methohexital; Sodium, methohexital; Natrium, brevimytal; methohexital sodium; Brevimytal natrium; Methodrexitone; Methohexitalum; Brietal-sodium; Brietal sodium; Methohexitone; Methohexital; Metohexital; Brevital; Brietal; Methohexital
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:102216
- KEGG: C07844
- KEGGdrug: D04985
- PubChem: 9034
- HMDB: HMDB0014617
- Metlin: METLIN43252
- DrugBank: DB00474
- ChEMBL: CHEMBL7413
- Wikipedia: Methohexital
- MeSH: Methohexital
- chemspider: 8683
- CAS: 18652-93-2
- CAS: 151-83-7
- PMhub: MS000000637
- PubChem: 10046
- NIKKAJI: J10.986J
- RefMet: Methohexital
- KNApSAcK: 102216
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anthony Bonavia, Thomas Verbeek, Sanjib Adhikary, Allen Kunselman, Arne Budde, Jerome Lyn-Sue, Berend Mets. A randomized controlled trial comparing methohexital and propofol for induction in patients receiving angiotensin axis blockade.
Medicine.
2019 Feb; 98(5):e14374. doi:
10.1097/md.0000000000014374. [PMID: 30702630] - Charles William Carspecken, Anna Borisovskaya, Shu-Tsui Lan, Katherine Heller, Jonathan Buchholz, David Ruskin, Irene Rozet. Ketamine Anesthesia Does Not Improve Depression Scores in Electroconvulsive Therapy: A Randomized Clinical Trial.
Journal of neurosurgical anesthesiology.
2018 Oct; 30(4):305-313. doi:
10.1097/ana.0000000000000511. [PMID: 29847468] - Viktoria Stelzhammer, Matthias Rothermundt, Paul C Guest, Nikolaus Michael, Carina Sondermann, Wolfgang Kluge, Daniel Martins-de-Souza, Hassan Rahmoune, Sabine Bahn. Proteomic changes induced by anaesthesia and muscle relaxant treatment prior to electroconvulsive therapy.
Proteomics. Clinical applications.
2011 Dec; 5(11-12):644-9. doi:
10.1002/prca.201100040. [PMID: 22006837] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Andreas Meinitzer, Kurt Kalcher, Gabriele Gartner, Gabriele Halwachs-Baumann, Winfried März, Mariana Stettin. Drugs and brain death diagnostics: determination of drugs capable of inducing EEG zero line.
Clinical chemistry and laboratory medicine.
2008; 46(12):1732-8. doi:
10.1515/cclm.2008.335. [PMID: 18973460] - Gregg R Ward, Abdel A Abdel-Rahman. Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats.
BMC pharmacology.
2006 Jan; 6(?):2. doi:
10.1186/1471-2210-6-2. [PMID: 16430770] - Gregg R Ward, Abdel A Abdel-Rahman. Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats.
BMC pharmacology.
2005 Mar; 5(?):9. doi:
10.1186/1471-2210-5-9. [PMID: 15799780] - Jacek Owczarek, Anna Katarzyna Wiktorowska-Owczarek, Daria Orszulak-Michalak. The influence of methohexital on plasma concentration and pharmacokinetic parameters of lidocaine in rabbits.
Acta poloniae pharmaceutica.
2004 Dec; 61 Suppl(?):42-5. doi:
. [PMID: 15909936] - Christoph Greiner, Johannes Wölfer, Hansdetlef Wassmann, Rüdiger Köhling, Erwin-Josef Speckmann. Effects of methohexital on bioelectrical reactions in guinea pig hippocampal slices during hypoxia.
Neuroscience letters.
2002 Aug; 329(2):227-31. doi:
10.1016/s0304-3940(02)00649-3. [PMID: 12165418] - J Bennett, J Gross, F Nichols, N Chidambaram, D Burgess. The chemical and physical stability of a 1:1 mixture of propofol and methohexital.
Anesthesia progress.
2001; 48(2):61-5. doi:
NULL. [PMID: 11515949] - M Auriacombe, J P Rénéric, D Usandizaga, F Gomez, I Combourieu, J Tignol. Post-ECT agitation and plasma lactate concentrations.
The journal of ECT.
2000 Sep; 16(3):263-7. doi:
10.1097/00124509-200009000-00007. [PMID: 11005048] - P Kienbaum, N Scherbaum, N Thürauf, M C Michel, M Gastpar, J Peters. Acute detoxification of opioid-addicted patients with naloxone during propofol or methohexital anesthesia: a comparison of withdrawal symptoms, neuroendocrine, metabolic, and cardiovascular patterns.
Critical care medicine.
2000 Apr; 28(4):969-76. doi:
10.1097/00003246-200004000-00010. [PMID: 10809268] - J H Broadbear, G Winger, J H Woods. Glucocorticoid-reinforced responding in the rhesus monkey.
Psychopharmacology.
1999 Nov; 147(1):46-55. doi:
10.1007/s002130051141. [PMID: 10591868] - O A Farghaly, H M El-Wadood, M A Ghandour. Anodic adsorptive stripping voltammetric determination of the anesthetic drug: methohexital sodium.
Journal of pharmaceutical and biomedical analysis.
1999 Nov; 21(2):233-40. doi:
10.1016/s0731-7085(99)00106-5. [PMID: 10703978] - J Schickendantz, W Funk, K P Ittner, M Gruber, K Taeger, F Kees. Elimination of methohexitone after long-term, high-dose infusion in patients with critically elevated intracranial pressure.
Critical care medicine.
1999 Aug; 27(8):1570-6. doi:
10.1097/00003246-199908000-00028. [PMID: 10470766] - A E Martynyuk, T E Morey, M J Raatikainen, C N Seubert, D M Dennis. Ionic mechanisms mediating the differential effects of methohexital and thiopental on action potential duration in guinea pig and rabbit isolated ventricular myocytes.
Anesthesiology.
1999 Jan; 90(1):156-64. doi:
10.1097/00000542-199901000-00021. [PMID: 9915324] - P Kienbaum, N Thürauf, M C Michel, N Scherbaum, M Gastpar, J Peters. Profound increase in epinephrine concentration in plasma and cardiovascular stimulation after mu-opioid receptor blockade in opioid-addicted patients during barbiturate-induced anesthesia for acute detoxification.
Anesthesiology.
1998 May; 88(5):1154-61. doi:
10.1097/00000542-199805000-00004. [PMID: 9605673] - M D Krasowski, V V Koltchine, C E Rick, Q Ye, S E Finn, N L Harrison. Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.
Molecular pharmacology.
1998 Mar; 53(3):530-8. doi:
10.1124/mol.53.3.530. [PMID: 9495821] - J Heine, M Leuwer, D Scheinichen, L Arseniev, K Jaeger, S Piepenbrock. Flow cytometry evaluation of the in vitro influence of four i.v. anaesthetics on respiratory burst of neutrophils.
British journal of anaesthesia.
1996 Sep; 77(3):387-92. doi:
10.1093/bja/77.3.387. [PMID: 8949817] - W B Gentry, T C Krejcie, T K Henthorn, M J Avram. Induction and maintenance of anesthesia in dogs by intravenous administration of methohexital.
American journal of veterinary research.
1996 Jul; 57(7):1044-9. doi:
NULL. [PMID: 8807019] - S J Gibbons, R Núñez-Hernández, G Mazé, N L Harrison. Inhibition of a fast inwardly rectifying potassium conductance by barbiturates.
Anesthesia and analgesia.
1996 Jun; 82(6):1242-6. doi:
10.1097/00000539-199606000-00024. [PMID: 8638798] - I Girard, S Ferry. Protein binding of methohexital. Study of parameters and modulating factors using the equilibrium dialysis technique.
Journal of pharmaceutical and biomedical analysis.
1996 Mar; 14(5):583-91. doi:
10.1016/0731-7085(95)01636-8. [PMID: 8738188] - M Kasner, J Grosse, M Krebs, G Kaczmarczyk. Methohexital impairs osmoregulation. Studies in conscious and anesthetized volume-expanded dogs.
Anesthesiology.
1995 Jun; 82(6):1396-405. doi:
10.1097/00000542-199506000-00011. [PMID: 7793653] - F Redke, S Björkman. Endotoxin-induced fever increases the clearance of methohexitone in rabbits.
The Journal of pharmacy and pharmacology.
1994 Nov; 46(11):887-91. doi:
10.1111/j.2042-7158.1994.tb05708.x. [PMID: 7897593] - T A Crozier, J E Müller, D Quittkat, M Sydow, W Wuttke, D Kettler. [Total intravenous anesthesia with methohexital-alfentanil or propofol-alfentanil in hypogastric laparotomy. Clinical aspects and the effects of stress reaction].
Der Anaesthesist.
1994 Sep; 43(9):594-604. doi:
10.1007/s001010050098. [PMID: 7978186] - E G Devlin, R S Clarke, R K Mirakhur, T A McNeill. Effect of four i.v. induction agents on T-lymphocyte proliferations to PHA in vitro.
British journal of anaesthesia.
1994 Sep; 73(3):315-7. doi:
10.1093/bja/73.3.315. [PMID: 7946855] - A L Rabinowicz, J D Correale, W T Couldwell, C M DeGiorgio. CSF neuron-specific enolase after methohexital activation during electrocorticography.
Neurology.
1994 Jun; 44(6):1167-9. doi:
10.1212/wnl.44.6.1167. [PMID: 8208418] - Young SS; discussion 495, H J Boermans, A M Sylvestre. Magnetic motor evoked potentials during methohexital anesthesia in the dog.
Neurosurgery.
1994 Mar; 34(3):490-5. doi:
10.1227/00006123-199403000-00015. [PMID: 8190225] - J D'Haese, F Camu. Influence of propofol and methohexitone anesthesia on the cortisol response to surgery.
Acta anaesthesiologica Belgica.
1993; 44(4):135-9. doi:
NULL. [PMID: 8116326] - T A Crozier, C Flamm, C P Speer, W Rath, W Wuttke, W Kuhn, D Kettler. Effects of etomidate on the adrenocortical and metabolic adaptation of the neonate.
British journal of anaesthesia.
1993 Jan; 70(1):47-53. doi:
10.1093/bja/70.1.47. [PMID: 8431333] - H Lange, H Stephan, C Brand, S Zielmann, H Sonntag. Hepatic disposition of methohexitone in patients undergoing coronary bypass surgery.
British journal of anaesthesia.
1992 Nov; 69(5):478-81. doi:
10.1093/bja/69.5.478. [PMID: 1467080] - P Westrin, C Jonmarker, O Werner. Dissolving methohexital in a lipid emulsion reduces pain associated with intravenous injection.
Anesthesiology.
1992 Jun; 76(6):930-4. doi:
10.1097/00000542-199206000-00009. [PMID: 1599113] - P Westrin. Methohexital dissolved in lipid emulsion for intravenous induction of anesthesia in infants and children.
Anesthesiology.
1992 Jun; 76(6):917-21. doi:
10.1097/00000542-199206000-00007. [PMID: 1599112] - S M Audenaert, R L Lock, G L Johnson, N W Pedigo. Cardiovascular effects of rectal methohexital in children.
Journal of clinical anesthesia.
1992 Mar; 4(2):116-9. doi:
10.1016/0952-8180(92)90026-w. [PMID: 1562334] - B Bally, J F Payen, F Serre-Debeauvais, B Tranchand, M Gavend, P Stieglitz. [Pharmacokinetics of methohexital given by constant rate intravenous infusion].
Annales francaises d'anesthesie et de reanimation.
1992; 11(2):136-40. doi:
10.1016/s0750-7658(05)80003-6. [PMID: 1503284] - P Duvaldestin, M Chauvin, C Lebrault, F Bertrand, F T Karolak, R Farinotti. Effect of upper abdominal surgery and cirrhosis upon the pharmacokinetics of methohexital.
Acta anaesthesiologica Scandinavica.
1991 Feb; 35(2):159-63. doi:
10.1111/j.1399-6576.1991.tb03265.x. [PMID: 2024566] - A Foussadier, R Boulieu, J J Lehot, S Ferry. Pharmacokinetics of methohexital during cardiovascular surgery with cardiopulmonary bypass.
Fundamental & clinical pharmacology.
1991; 5(7):595-600. doi:
10.1111/j.1472-8206.1991.tb00748.x. [PMID: 1778537] - D S Warner, J G Zhou, R Ramani, M M Todd, A McAllister. Nitrous oxide does not alter infarct volume in rats undergoing reversible middle cerebral artery occlusion.
Anesthesiology.
1990 Oct; 73(4):686-93. doi:
10.1097/00000542-199010000-00014. [PMID: 2221437] - S N Khalil, F B Florence, M C Van den Nieuwenhuyzen, A H Wu, T H Stanley. Rectal methohexital: concentration and length of the rectal catheters.
Anesthesia and analgesia.
1990 Jun; 70(6):645-9. doi:
10.1213/00000539-199006000-00011. [PMID: 2344059] - R A Hebden, C L Tang, S Sanderson, J H McNeill. Requirement for solutions with oncotic pressure to release ANF during blood volume expansion in conscious and anesthetized rats.
Journal of pharmacological methods.
1990 May; 23(3):171-8. doi:
10.1016/0160-5402(90)90060-x. [PMID: 2139484] - J C Levron, P Assoune. [Pharmacokinetics of etomidate].
Annales francaises d'anesthesie et de reanimation.
1990; 9(2):123-6. doi:
10.1016/s0750-7658(05)80050-4. [PMID: 2363548] - P J Kulka, P M Lauven, J Schüttler, C Apffelstaedt. Methohexital vs midazolam/flumazenil anaesthesia during laryngoscopy under jet ventilation.
Acta anaesthesiologica Scandinavica. Supplementum.
1990; 92(?):90-5; discussion 107. doi:
10.1111/j.1399-6576.1990.tb03193.x. [PMID: 2109477] - K Korttila, M M Ghoneim, C K Chiang, E Nuotto, L J Fischer. Metabolites of methohexitone do not contribute to its prolonged action on the central nervous system.
Acta anaesthesiologica Scandinavica.
1990 Jan; 34(1):55-8. doi:
10.1111/j.1399-6576.1990.tb03041.x. [PMID: 2309543] - D P Crankshaw, F Karasawa. A method for implementing programmed infusion of thiopentone and methohexitone with a simple infusion pump.
Anaesthesia and intensive care.
1989 Nov; 17(4):496-9. doi:
10.1177/0310057x8901700418. [PMID: 2596683] - G J McCleane, J P Howe. Electroconvulsive therapy and serum potassium.
The Ulster medical journal.
1989 Oct; 58(2):172-4. doi:
NULL. [PMID: 2603269] - R B Forbes, D J Murray, J B Dillman, D L Dull. Pharmacokinetics of two per cent rectal methohexitone in children.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1989 Mar; 36(2):160-4. doi:
10.1007/bf03011440. [PMID: 2650897] - S Widmer, M C Laxenaire, J Manel, J L Gueant. [The amount of histamine released in vivo by hypnotics (thiopental, methohexital, propofol) studied by assays of plasma histamine].
Allergie et immunologie.
1988 Nov; 20(9):346-7. doi:
NULL. [PMID: 2462890] - R B Forbes, G E Vandewalker. Comparison of two and ten per cent rectal methohexitone for induction of anaesthesia in children.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1988 Jul; 35(4):345-9. doi:
10.1007/bf03010853. [PMID: 3402011] - A R Bjorksten, D P Crankshaw, D J Morgan, P R Prideaux. The effects of cardiopulmonary bypass on plasma concentrations and protein binding of methohexital and thiopental.
Journal of cardiothoracic anesthesia.
1988 Jun; 2(3):281-9. doi:
10.1016/0888-6296(88)90306-7. [PMID: 17171861] - K J Kestin, P V Fennessey. Microtechnique for quantitation of plasma methohexital using gas chromatography and mass spectrometry.
Anesthesia and analgesia.
1988 May; 67(5):466-8. doi:
NULL. [PMID: 3364766] - J Kyttä, P H Rosenberg. Comparison of propofol and methohexitone anaesthesia for thermocoagulation therapy of trigeminal neuralgia.
Anaesthesia.
1988 Mar; 43 Suppl(?):50-3. doi:
10.1111/j.1365-2044.1988.tb09070.x. [PMID: 3259098] - Y Le Normand, C De Villepoix, A Athouel, M F Kergueris, M Bourin, C Larousse. Quantitative analysis of serum methohexital by GLC using capillary column and nitrogen-selective detection.
Fundamental & clinical pharmacology.
1988; 2(6):551-8. doi:
10.1111/j.1472-8206.1988.tb00655.x. [PMID: 3240919] - S Björkman, J Gabrielsson, H Quaynor, M Corbey. Pharmacokinetics of i.v. and rectal methohexitone in children.
British journal of anaesthesia.
1987 Dec; 59(12):1541-7. doi:
10.1093/bja/59.12.1541. [PMID: 3426908] - R Dudziak, H Förster, E Hoffmann, H Schmidt, F Asskali. [Behavior of the histamine level in induction of anesthesia with propofol and methohexital].
Der Anaesthesist.
1987 Aug; 36(8):412-9. doi:
NULL. [PMID: 2444132] - D P Crankshaw, M D Boyd, A R Bjorksten. Plasma drug efflux--a new approach to optimization of drug infusion for constant blood concentration of thiopental and methohexital.
Anesthesiology.
1987 Jul; 67(1):32-41. doi:
10.1097/00000542-198707000-00006. [PMID: 3605733] - T A Crozier, D Beck, M Schlaeger, W Wuttke, D Kettler. Endocrinological changes following etomidate, midazolam, or methohexital for minor surgery.
Anesthesiology.
1987 May; 66(5):628-35. doi:
10.1097/00000542-198705000-00006. [PMID: 3034107] - M J Avram, T C Krejcie. Determination of sodium pentobarbital and either sodium methohexital or sodium thiopental in plasma by high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography.
1987 Mar; 414(2):484-91. doi:
10.1016/0378-4347(87)80078-6. [PMID: 3571417] - P E Bickler, R Dueck, R J Prutow. Effects of barbiturate anesthesia on functional residual capacity and ribcage/diaphragm contributions to ventilation.
Anesthesiology.
1987 Feb; 66(2):147-52. doi:
10.1097/00000542-198702000-00007. [PMID: 3813077] - P M Lauven, H Schwilden, H Stoeckel. Threshold hypnotic concentration of methohexitone.
European journal of clinical pharmacology.
1987; 33(3):261-5. doi:
10.1007/bf00637559. [PMID: 3691614] - E P Robinson, R A Sams, W W Muir. Barbiturate anesthesia in greyhound and mixed-breed dogs: comparative cardiopulmonary effects, anesthetic effects, and recovery rates.
American journal of veterinary research.
1986 Oct; 47(10):2105-12. doi:
. [PMID: 3777630] - T J McMurray, F P Robinson, J W Dundee, J G Riddell, E McClean. A method for producing constant plasma concentrations of drugs. Application to methohexitone.
British journal of anaesthesia.
1986 Oct; 58(10):1085-90. doi:
10.1093/bja/58.10.1085. [PMID: 3768221] - J P Jantzen, K Erdmann, P K Witton, A M Klein. [The effect of rectal pH values on the absorption of methohexital].
Der Anaesthesist.
1986 Aug; 35(8):496-9. doi:
NULL. [PMID: 3777412] - W Engelhardt, W Ebert, I Rietbrock, E Richter. [Dose-response relationship and serum concentrations of methohexital and hydroxymethohexital following rectal anesthesia induction with 1\% and 5\% methohexital solutions in children].
Der Anaesthesist.
1986 Aug; 35(8):491-5. doi:
NULL. [PMID: 3777411] - P S Withington, J Morton, R Arnold, P S Sebel, R Moberg. Assessment of power spectral edge for monitoring depth of anaesthesia using low methohexitone infusion.
International journal of clinical monitoring and computing.
1986; 3(2):117-22. doi:
10.1007/bf01880764. [PMID: 3783019] - B Thülig, P Reinhold, C Radig, G Bohn, L Wedy. [Rectal methohexital--anesthesia induction of choice in children?].
Anasthesie, Intensivtherapie, Notfallmedizin.
1985 Dec; 20(6):316-20. doi:
NULL. [PMID: 4091238] - R A Sams, W W Muir, R L Detra, E P Robinson. Comparative pharmacokinetics and anesthetic effects of methohexital, pentobarbital, thiamylal, and thiopental in Greyhound dogs and non-Greyhound, mixed-breed dogs.
American journal of veterinary research.
1985 Aug; 46(8):1677-83. doi:
. [PMID: 4037494] - C Monrigal, M C Bourgeonneau, A Turcant, A Premel-Cabic, P Allain, M Cavellat. [Correlation between plasma concentration of methohexital and the Apgar score of the newborn infant in cesarean sections].
Cahiers d'anesthesiologie.
1985 Aug; 33(5):409-11. doi:
NULL. [PMID: 4075200] - M P Mehta, J B Dillman, B M Sherman, M M Ghoneim, J H Lemke. Etomidate anesthesia inhibits the cortisol response to surgical stress.
Acta anaesthesiologica Scandinavica.
1985 Jul; 29(5):486-9. doi:
10.1111/j.1399-6576.1985.tb02239.x. [PMID: 2994344] - M M Ghoneim, C K Chiang, R D Schoenwald, J K Lilburn, J Dhanaraj. The pharmacokinetics of methohexital in young and elderly subjects.
Acta anaesthesiologica Scandinavica.
1985 Jul; 29(5):480-2. doi:
10.1111/j.1399-6576.1985.tb02237.x. [PMID: 4036532] - M M Todd, J C Drummond, H S U. The hemodynamic consequences of high-dose thiopental anesthesia.
Anesthesia and analgesia.
1985 Jul; 64(7):681-7. doi:
NULL. [PMID: 4014729] - H Quaynor, M Corbey, S Björkman. Rectal induction of anaesthesia in children with methohexitone. Patient acceptability and clinical pharmacokinetics.
British journal of anaesthesia.
1985 Jun; 57(6):573-7. doi:
10.1093/bja/57.6.573. [PMID: 4005094] - L M Liu, P Gaudreault, P A Friedman, N G Goudsouzian, P L Liu. Methohexital plasma concentrations in children following rectal administration.
Anesthesiology.
1985 May; 62(5):567-70. doi:
10.1097/00000542-198505000-00004. [PMID: 3994021] - A Kertész, G Falkay, M Boros. Comparative study of intravenous anaesthetic techniques administered during short-term gynecological operations.
Acta medica Hungarica.
1985; 42(1-2):41-9. doi:
NULL. [PMID: 4034336] - M M Todd, J C Drummond, H S U. The hemodynamic consequences of high-dose methohexital anesthesia in humans.
Anesthesiology.
1984 Nov; 61(5):495-501. doi:
10.1097/00000542-198411000-00003. [PMID: 6496988] - G Kraus, S Frank, R Knoll, H Prestele. [Pharmacokinetic studies following intravenous, intramuscular and rectal administration of methohexital in children].
Der Anaesthesist.
1984 Jun; 33(6):266-71. doi:
NULL. [PMID: 6548095] - S Björkman, J Idvall. A high-performance liquid chromatographic method for methohexital and thiopental in plasma or whole blood.
Journal of chromatography.
1984 May; 307(2):481-7. doi:
10.1016/s0378-4347(00)84126-2. [PMID: 6736198] - M Pinaud, M Meignier, M F Kergueris, Y Le Normand, M P Lasserre, R Souron, C Larousse. Pharmacokinetics of intravenous and intramuscular methohexitone in dogs.
European journal of anaesthesiology.
1984 Mar; 1(1):55-62. doi:
. [PMID: 6536507] - S Björkman, J Idvall, P Stenberg. Gas-liquid chromatographic determination of methohexital in plasma or whole blood with electron-capture detection of the pentafluorobenzyl derivative.
Journal of chromatography.
1983 Dec; 278(2):424-8. doi:
10.1016/s0378-4347(00)84803-3. [PMID: 6668323] - M K Steele, R V Gallo, W F Ganong. A possible role for the brain renin-angiotensin system in the regulation of LH secretion.
The American journal of physiology.
1983 Dec; 245(6):R805-10. doi:
10.1152/ajpregu.1983.245.6.r805. [PMID: 6318575] - D Brown, A Grosso, R C DeSousa. Correlation between water flow and intramembrane particle aggregates in toad epidermis.
The American journal of physiology.
1983 Nov; 245(5 Pt 1):C334-42. doi:
10.1152/ajpcell.1983.245.5.c334. [PMID: 6416078] - W S Wilson, E Bárány. Iris delay, a neglected factor in aqueous humour dynamics. A study in the cynomolgus monkey (Macaca fascicularis).
Experimental eye research.
1983 Sep; 37(3):293-301. doi:
10.1016/0014-4835(83)90164-1. [PMID: 6628576] - I W White, A W Gelb, H R Wexler, C R Stiller, P A Keown. The effects of intravenous anaesthetic agents on human neutrophil chemiluminescence.
Canadian Anaesthetists' Society journal.
1983 Sep; 30(5):506-11. doi:
10.1007/bf03007085. [PMID: 6627069] - J Varga, T Machay, F Paulin, M Balázs, L Fedák. [Changes in the serum level of methohexital (Brietal) in mothers and newborn infants during anesthesia and cesarean section].
Zentralblatt fur Gynakologie.
1983; 105(5):297-9. doi:
NULL. [PMID: 6858451] - G Kraus, K Taeger. [Methohexital for rectal anesthetic induction in children].
Anasthesie, Intensivtherapie, Notfallmedizin.
1982 Sep; 17(5):285-9. doi:
NULL. [PMID: 7149211] - H Heusler, J Epping, S Heusler, E Richter, N P Vermeulen, D D Breimer. Simultaneous determination of blood concentrations of methohexital and its hydroxy metabolite by gas chromatography and identification of 4'-hydroxymethohexital by combined gas--liquid chromatography--mass spectrometry.
Journal of chromatography.
1981 Dec; 226(2):403-12. doi:
10.1016/s0378-4347(00)86074-0. [PMID: 7320169] - P Arhem, H Kristbjarnarson. A barbiturate-induced potassium permeability increase in the myelinated nerve membrane.
Acta physiologica Scandinavica.
1981; 113(3):387-92. doi:
10.1111/j.1748-1716.1981.tb06911.x. [PMID: 6179389] - K L Scholler, G George, J Rudolph, E Gilsbach. [The metabolism of halothane under the influence of thiopental, methohexital, etomidate, enflurane and disulfiram under clinical conditions (author's transl)].
Der Anaesthesist.
1980 Dec; 29(12):650-2. doi:
. [PMID: 7212246] - E Richter, J Epping, M Fuchshofen-Röckel, H Heusler, W Zilly. [Drug metabolism in patients with liver disease (author's transl)].
Leber, Magen, Darm.
1980 Oct; 10(5):234-40. doi:
NULL. [PMID: 7464410] - A Pastuszko. Action of barbiturates on activity of acetylcholinesterase from synaptosomal membranes.
Neurochemical research.
1980 Jul; 5(7):769-76. doi:
10.1007/bf00964714. [PMID: 7422060] - J Scaramella, G D Allen, W M Goebel, D Donaldson. Lidocaine as a supplement to general anesthesia for extraction of third molars: serum levels.
Anesthesia progress.
1979 Sep; 26(5):118-9. doi:
NULL. [PMID: 298457] - R L Wynn, G E Lovelace, J E O'Reilly, A A Gonty. Rapid, sensitive gas-chromatographic quantitation of methohexital in plasma of oral-surgery outpatients.
Anesthesia progress.
1978 May; 25(3):92-5. doi:
NULL. [PMID: 285633] - U Kuhl, G Kaczmarcyk, J Riedel, F Eigenheer, R Eisele, H W Reinhardt. [Water diuresis during methohexitone anaesthesia. Studies in chronically instrumented dogs (author's transl)].
Der Anaesthesist.
1978 Apr; 27(4):193-7. doi:
. [PMID: 655367] - M M Ghoneim, K Korttila. Pharmacokinetics of intravenous anaesthetics: implications for clinical use.
Clinical pharmacokinetics.
1977 Sep; 2(5):344-72. doi:
10.2165/00003088-197702050-00003. [PMID: 21053] - I Pulay. Plasma potassium and inducation agents.
British journal of anaesthesia.
1976 Oct; 48(10):1029. doi:
10.1093/bja/48.10.1029. [PMID: 990143] - D D Breimer. Pharmacokinetics of methohexitone following intravenous infusion in humans.
British journal of anaesthesia.
1976 Jul; 48(7):643-9. doi:
10.1093/bja/48.7.643. [PMID: 797396] - J Verret, C Chaix, P Mugneret, P Rocher, E Gisselmann, G Rifle, B Caillard. [Our experience of anesthesia in the anephric patient].
Anesthesie, analgesie, reanimation.
1976 Jan; 33(1):109-18. doi:
NULL. [PMID: 793448] - D J McCleave, W B Blakemore. Anaesthesia for electroconvulsive therapy.
Anaesthesia and intensive care.
1975 Aug; 3(3):250-6. doi:
10.1177/0310057x7500300313. [PMID: 1166948] - I M Bali. The effect of modified electroconvulsive therapy on plasama potassium concentration.
British journal of anaesthesia.
1975 Mar; 47(3):398-401. doi:
10.1093/bja/47.3.398. [PMID: 1138748] - R S Clarke, I M Bali, M Issac, J W Dundee, B Sheridan. Plasma cortisol and blood sugar following minor surgery under intravenous anaesthetics.
Anaesthesia.
1974 Sep; 29(5):545-50. doi:
10.1111/j.1365-2044.1974.tb00717.x. [PMID: 4433013]
