N,N-Dimethylaniline (BioDeep_00000001383)

 

Secondary id: BioDeep_00000405411

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


N,N-DIMETHYLANILINE HYDROCHLORIDE

化学式: C8H11N (121.0891446)
中文名称: N,N-二甲基苯胺
谱图信息: 最多检出来源 Viridiplantae(plant) 1.3%

分子结构信息

SMILES: CN(C)c(c1)cccc1
InChI: InChI=1/C8H11N/c1-9(2)8-6-4-3-5-7-8/h3-7H,1-2H3

描述信息

N,N-Dimethylaniline, also known as dimethylaminobenzene or dimethylphenylamine, belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group. N,N-dimethylaniline is a tertiary amine that is aniline in which the amino hydrogens are replaced by two methyl groups. It is a tertiary amine and a dimethylaniline. N,N-dimethylaniline appears as a yellow to brown colored oily liquid with a fishlike odor. It is less dense than water and insoluble in water. Its flash point is 150 °F, and is toxic by ingestion, inhalation, and skin absorption. N,N-Dimethylaniline was used to make dyes and as a solvent. Outside of the human body, N,N-Dimethylaniline has been detected, but not quantified in several different foods, such as common mushrooms, strawberries, feijoa, limes, and black-eyed pea.
the structural formula shown is also known as N,N-dimethylaniline -- Wikipedia; Dimethylaniline (C8H11N) is an organic chemical compound which is a substituted derivative of aniline. It consists of a benzene ring and a substituted amino group, making it a tertiary aromatic amine. -- Wikipedia; N,N-Dimethylaniline (DMA) is an organic chemical compound, a substituted derivative of aniline. It consists of a tertiary amine, featuring dimethylamino group attached to a phenyl group. This oily liquid is colourless when pure, but commercial samples are often yellow. N,N-Dimethylaniline is found in many foods, some of which are fennel, rose hip, black elderberry, and maitake.
KEIO_ID D032

同义名列表

13 个代谢物同义名

N,N-DIMETHYLANILINE HYDROCHLORIDE; N,N-Dimethylaniline sulfate (1:1); N,N-Dimethylaniline hydroiodide; N,N-(Dimethylamino)benzene; N,N-Dimethyl-N-phenylamine; N,N-Dimethylbenzeneamine; N,N-Dimethyl-benzenamine; N,N-Dimethylphenylamine; N,N-Dimethylbenzenamine; Dimethylaminobenzene; N,N-dimethylaniline; Dimethylphenylamine; dimethylaniline



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yoko Hirata, Ruidai Okazaki, Mina Sato, Kentaro Oh-Hashi, Hiroshi Takemori, Kyoji Furuta. Effect of ferroptosis inhibitors oxindole-curcumin hybrid compound and N,N-dimethylaniline derivatives on rotenone-induced oxidative stress. European journal of pharmacology. 2022 Aug; 928(?):175119. doi: 10.1016/j.ejphar.2022.175119. [PMID: 35753403]
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  • Kwang-Su Park, Kyungha Yoo, Mi Kyoung Kim, Woong Jung, Yoon Kyung Choi, Youhoon Chong. A Novel Probe with a Chlorinated α-Cyanoacetophenone Acceptor Moiety Shows Near-Infrared Fluorescence Specific for Tau Fibrils. Chemical & pharmaceutical bulletin. 2017; 65(12):1113-1116. doi: 10.1248/cpb.c17-00559. [PMID: 29199217]
  • M J Galvão, A Santos, M D Ribeiro, A Ferreira, F Nolasco. Optimization of the tartrate-resistant acid phosphatase detection by histochemical method. European journal of histochemistry : EJH. 2011 Feb; 55(1):e1. doi: 10.4081/ejh.2011.e1. [PMID: 21556115]
  • Robert Jordan, Janet M Leeds, Shanthakumar Tyavanagimatt, Dennis E Hruby. Development of ST-246® for Treatment of Poxvirus Infections. Viruses. 2010 Nov; 2(11):2409-35. doi: 10.3390/v2112409. [PMID: 21994624]
  • Sven Sehlmeyer, Linzhu Wang, Dorothee Langel, David G Heckel, Hoda Mohagheghi, Georg Petschenka, Dietrich Ober. Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (lepidoptera). PloS one. 2010 May; 5(5):e10435. doi: 10.1371/journal.pone.0010435. [PMID: 20454663]
  • Anjan Chakraborty, Debabrata Seth, Palash Setua, Nilmoni Sarkar. Photoinduced electron transfer in a protein-surfactant complex: probing the interaction of SDS with BSA. The journal of physical chemistry. B. 2006 Aug; 110(33):16607-17. doi: 10.1021/jp0615860. [PMID: 16913796]
  • Anjan Chakraborty, Debabrata Seth, Palash Setua, Nilmoni Sarkar. Photoinduced electron transfer from N,N-dimethylaniline to 7-amino coumarins in protein-surfactant complex: slowing down of electron transfer dynamics compared to micelles. The Journal of chemical physics. 2006 Feb; 124(7):74512. doi: 10.1063/1.2170081. [PMID: 16497062]
  • David T Moore, Jos Oomens, John R Eyler, Gert von Helden, Gerard Meijer, Robert C Dunbar. Infrared spectroscopy of gas-phase Cr+ coordination complexes: determination of binding sites and electronic states. Journal of the American Chemical Society. 2005 May; 127(19):7243-54. doi: 10.1021/ja042431d. [PMID: 15884966]
  • Haider Raza, Shripad V Bhagwat, Annie John. Flavin-containing monooxygenase activity in camel tissues: comparison with rat and human liver enzymes. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2004 Dec; 139(4):289-93. doi: 10.1016/j.cca.2004.12.004. [PMID: 15683840]
  • N Maeuchihara, S Nakano, T Kawashima. Kinetic flow-injection determination of hydrogen peroxide by use of iron(III)-catalyzed coloration and its application to the determination of biological substances. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2001 Feb; 17(2):255-8. doi: 10.2116/analsci.17.255. [PMID: 11990536]
  • P Hlavica, U Künzel-Mulas. Metabolic N-oxide formation by rabbit-liver microsomal cytochrome P-4502B4: involvement of superoxide in the NADPH-dependent N-oxygenation of N,N-dimethylaniline. Biochimica et biophysica acta. 1993 Aug; 1158(1):83-90. doi: 10.1016/0304-4165(93)90100-m. [PMID: 8394743]
  • M Y Lee, J E Clark, D E Williams. Induction of flavin-containing monooxygenase (FMO B) in rabbit lung and kidney by sex steroids and glucocorticoids. Archives of biochemistry and biophysics. 1993 May; 302(2):332-6. doi: 10.1006/abbi.1993.1219. [PMID: 8489238]
  • S Bhamre, S K Shankar, S V Bhagwat, V Ravindranath. Catalytic activity and immunohistochemical localization of flavin-containing monooxygenase in rat kidney. Life sciences. 1993; 52(20):1601-7. doi: 10.1016/0024-3205(93)90040-a. [PMID: 8483388]
  • D Schlenk, D R Buhler. Role of flavin-containing monooxygenase in the in vitro biotransformation of aldicarb in rainbow trout (Oncorhynchus mykiss). Xenobiotica; the fate of foreign compounds in biological systems. 1991 Dec; 21(12):1583-9. doi: 10.3109/00498259109044407. [PMID: 1785205]
  • W X Guo, D M Ziegler. Estimation of flavin-containing monooxygenase activities in crude tissue preparations by thiourea-dependent oxidation of thiocholine. Analytical biochemistry. 1991 Oct; 198(1):143-8. doi: 10.1016/0003-2697(91)90519-y. [PMID: 1789416]
  • S Cottrell, G C Hartman, D F Lewis, D V Parke. Studies on the cytochrome P-450 of avocado (Persea [corrected] americana) mesocarp microsomal fraction. Xenobiotica; the fate of foreign compounds in biological systems. 1990 Jul; 20(7):711-26. doi: 10.3109/00498259009046887. [PMID: 2238705]
  • K M Abdo, M P Jokinen, R Hiles. Subchronic (13-week) toxicity studies of N,N-dimethylaniline administered to Fischer 344 rats and B6C3F1 mice. Journal of toxicology and environmental health. 1990; 29(1):77-88. doi: 10.1080/15287399009531373. [PMID: 2299689]
  • G D Paulson, V J Feil, J T MacGregor. Formation of a diazonium cation intermediate in the metabolism of sulphamethazine to desaminosulphamethazine in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1987 Jun; 17(6):697-707. doi: 10.3109/00498258709043977. [PMID: 3630205]
  • H Sugimoto, L Spencer, D T Sawyer. Ferric chloride-catalyzed activation of hydrogen peroxide for the demethylation of N,N-dimethylaniline, the epoxidation of olefins, and the oxidative cleavage of vicinal diols in acetonitrile: a reaction mimic for cytochrome P-450. Proceedings of the National Academy of Sciences of the United States of America. 1987 Apr; 84(7):1731-3. doi: 10.1073/pnas.84.7.1731. [PMID: 3470755]
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  • U Olsson, B Beije, C A Wachtmeister, E Arrhenius. Effects of dimethylnitrosamine on metabolism of N,N-dimethylaniline by rat liver microsomes. A comparative study of treatment in vivo, in isolated liver perfusion and in the microsomal system. Chemico-biological interactions. 1983 Jul; 45(2):191-201. doi: 10.1016/0009-2797(83)90068-6. [PMID: 6883572]