Aldosterone (BioDeep_00000001290)

 

Secondary id: BioDeep_00001868204

human metabolite Endogenous blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde

化学式: C21H28O5 (360.1937)
中文名称: 醛甾酮 标准液, 醛固酮
谱图信息: 最多检出来源 Homo sapiens(blood) 18.08%

分子结构信息

SMILES: CC12CCC(=O)C=C1CCC1C2C(O)CC2(C=O)C(C(=O)CO)CCC12
InChI: InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

描述信息

Aldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. Specifically it regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Aldosterone increases the permeability of the apical (luminal) membrane of the kidneys collecting ducts to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. [HMDB]
Aldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. Specifically, it regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Aldosterone increases the permeability of the apical (luminal) membrane of the kidneys collecting ducts to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine.
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AA - Mineralocorticoids
CONFIDENCE Reference Standard (Level 1); NaToxAq - Natural Toxins and Drinking Water Quality - From Source to Tap (https://natoxaq.ku.dk)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
CONFIDENCE standard compound; INTERNAL_ID 2819
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

24 个代谢物同义名

(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11.beta.)-; 18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione; (11beta)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; (11Β)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al; 11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al; 11beta,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-al; (11b)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; 18-Formyl-11β,21-dihydroxy-4-pregnene-3,20-dione; 11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al; 11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al; 11beta,21-Dihydroxypregn-4-ene-3,18,20-trione; 11Β,21-dihydroxy-3,20-diketopregn-4-ene-18-al; 11Β,21-dihydroxy-3,20-diketo-4-pregnen-18-al; 11b,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al; 11Β,21-dihydroxy-3,20-dioxo-4-pregnen-18-al; 11Β,21-dihydroxypregn-4-ene-3,18,20-trione; Aldosterone, (11 beta,17 alpha)-isomer; Aldosterone, (+-)-isomer; 18-Oxocorticosterone; (+)-aldosterone; Aldosterone; ST 21:4;O5; Aldosterone



数据库引用编号

57 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(9)

BioCyc(0)

PlantCyc(0)

代谢反应

72 个相关的代谢反应过程信息。

Reactome(66)

BioCyc(0)

WikiPathways(5)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ADM, EGFR, NR3C1, PRKX, PRL, SGK1, WNK4
Golgi apparatus, trans-Golgi network membrane 1 AQP2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, SGK1
Nucleus 6 EGFR, NR3C1, PLCZ1, PRKX, PRL, SGK1
cytosol 6 LEP, NR3C1, PLCZ1, PRKCQ, SGK1, WNK4
centrosome 1 NR3C1
nucleoplasm 5 NR3C1, PLCZ1, PRKX, PRL, SGK1
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 7 AQP2, ATP1A1, ATP2B3, EGFR, KCNJ1, MRAS, SLC5A2
Lipid-anchor 1 MRAS
Cytoplasmic side 1 MRAS
ruffle membrane 1 EGFR
Cell projection, axon 1 ATP1A1
Early endosome membrane 1 EGFR
Multi-pass membrane protein 6 AQP2, ATP1A1, ATP2B3, KCNA3, KCNJ1, SLC5A2
Synapse 1 NR3C1
cell junction 1 EGFR
cell surface 2 EGFR, EPO
glutamatergic synapse 3 ATP2B3, EGFR, KCNA3
Golgi apparatus 2 AQP2, ATP1A1
Golgi membrane 1 EGFR
presynaptic membrane 2 ATP2B3, KCNA3
sarcolemma 1 ATP1A1
endosome 1 EGFR
plasma membrane 12 AQP2, ATP1A1, ATP2B3, EGFR, KCNA3, KCNJ1, KL, KNG1, MRAS, PRKCQ, SGK1, SLC5A2
Membrane 10 AQP2, ATP1A1, ATP2B3, EGFR, KCNA3, KL, MRAS, NR3C1, SLC5A2, WNK4
apical plasma membrane 5 AQP2, ATP1A1, EGFR, KL, SLC5A2
axon 2 ATP1A1, KCNA3
basolateral plasma membrane 3 AQP2, ATP1A1, EGFR
extracellular exosome 6 AQP2, ATP1A1, EPO, KL, KNG1, SLC5A2
endoplasmic reticulum 2 ATP1A1, SGK1
extracellular space 7 ADM, EGFR, EPO, KL, KNG1, LEP, PRL
perinuclear region of cytoplasm 4 AQP2, EGFR, KCNA3, PLCZ1
Cell junction, tight junction 1 WNK4
bicellular tight junction 1 WNK4
mitochondrion 2 NR3C1, SGK1
protein-containing complex 4 ATP1A1, EGFR, NR3C1, WNK4
intracellular membrane-bounded organelle 1 ATP2B3
postsynaptic density 1 ATP1A1
pronucleus 1 PLCZ1
Single-pass type I membrane protein 2 EGFR, KL
Secreted 4 ADM, EPO, LEP, PRL
extracellular region 6 ADM, EPO, KL, KNG1, LEP, PRL
[Isoform 2]: Secreted 1 KL
mitochondrial matrix 1 NR3C1
centriolar satellite 1 PRKCQ
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
nuclear membrane 1 EGFR
Extracellular vesicle 2 ATP1A1, ATP2B3
sodium:potassium-exchanging ATPase complex 1 ATP1A1
T-tubule 1 ATP1A1
nucleolus 1 PLCZ1
recycling endosome 1 AQP2
postsynaptic membrane 1 KCNA3
Apical cell membrane 3 AQP2, KL, SLC5A2
Cell membrane, sarcolemma 1 ATP1A1
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 3 ATP1A1, EGFR, KCNA3
Cytoplasm, cytoskeleton, spindle 1 NR3C1
focal adhesion 1 EGFR
spindle 1 NR3C1
GABA-ergic synapse 1 ATP2B3
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 KNG1
lateral plasma membrane 2 AQP2, ATP1A1
nuclear speck 2 NR3C1, SGK1
receptor complex 1 EGFR
chromatin 2 NR3C1, PRL
Chromosome 1 NR3C1
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
Basolateral cell membrane 2 AQP2, ATP1A1
[Isoform 2]: Cell membrane 1 KCNA3
organelle membrane 1 ATP1A1
sperm flagellum 1 ATP1A1
Endomembrane system 1 MRAS
endosome lumen 1 PRL
monoatomic ion channel complex 1 KCNJ1
Cytoplasmic vesicle membrane 1 AQP2
Nucleus, nucleoplasm 1 NR3C1
Melanosome 1 ATP1A1
Presynaptic cell membrane 1 ATP2B3
cell body 2 EPO, WNK4
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 1 EPO
endoplasmic reticulum lumen 1 KNG1
platelet alpha granule lumen 1 KNG1
Photoreceptor inner segment membrane 1 ATP1A1
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
parallel fiber to Purkinje cell synapse 1 ATP2B3
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Cell membrane 2 KCNA3, KL
[Isoform Alpha]: Cytoplasm 1 NR3C1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transport vesicle membrane 1 AQP2
sperm head 1 PLCZ1
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
lumenal side of membrane 1 AQP2
parallel fiber 1 ATP2B3
[Klotho peptide]: Secreted 1 KL


文献列表

  • Adalaiti Maitituersun, Mulalibieke Heizhati, Nanfang Li, Lin Gan, Mei Li, Ling Yao, Wenbo Yang, Shasha Liu, Xiayire Aierken, Hui Wang, Miaomiao Liu, Jing Hong, Ting Wu, Delian Zhang, Qing Zhu. Associated lifestyle factors of elevated plasma aldosterone concentration in community population, gender-stratified analysis of a cross-sectional survey. BMC public health. 2024 May; 24(1):1370. doi: 10.1186/s12889-024-18796-0. [PMID: 38773424]
  • Harald Murck, Peter Karailiev, Lucia Karailievova, Agnesa Puhova, Daniela Jezova. Treatment with Glycyrrhiza glabra Extract Induces Anxiolytic Effects Associated with Reduced Salt Preference and Changes in Barrier Protein Gene Expression. Nutrients. 2024 Feb; 16(4):. doi: 10.3390/nu16040515. [PMID: 38398838]
  • Maura Hannon, William D Plant, Caroline Joyce, Noirin E Russell. Rare case of steroid cell tumour presenting as resistant hypertension in early pregnancy. BMJ case reports. 2023 Dec; 16(12):. doi: 10.1136/bcr-2023-255716. [PMID: 38123321]
  • Chenxiao Xu, Tao Chen, Dan Mo, Tingting Zhang, Fangli Zhou, Haoming Tian, Yan Ren. [Metabolic Outcomes of Primary Aldosteronism Patients Receiving Adrenalectomy or Spironolactone Treatments]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2023 Nov; 54(6):1227-1232. doi: 10.12182/20231160501. [PMID: 38162054]
  • Su Liu, Yafeng Liu, Dong Zhang, Huan Li, Xicheng Shao, Pengfei Xie, Jianmei Li. Novel insights into perfluorinated compound-induced hepatotoxicity: Chronic dietary restriction exacerbates the effects of PFBS on hepatic lipid metabolism in mice. Environment international. 2023 Oct; 181(?):108274. doi: 10.1016/j.envint.2023.108274. [PMID: 37879206]
  • Zixuan Li, Bernard Robaire, Barbara F Hales. The Organophosphate Esters Used as Flame Retardants and Plasticizers affect H295R Adrenal Cell Phenotypes and Functions. Endocrinology. 2023 Jul; ?(?):. doi: 10.1210/endocr/bqad119. [PMID: 37522340]
  • Juan Valentín-Goyco, Jiayan Liu, Hwei-Ming Peng, Jerry Oommen, Richard J Auchus. Selectivity of osilodrostat as an inhibitor of human steroidogenic cytochromes P450. The Journal of steroid biochemistry and molecular biology. 2023 07; 231(?):106316. doi: 10.1016/j.jsbmb.2023.106316. [PMID: 37098354]
  • Elizabeth Brammer-Robbins, Mohammad-Zaman Nouri, Emily K Griffin, Juan Aristizabal-Henao, Nancy D Denslow, John A Bowden, Iske V Larkin, Christopher J Martyniuk. Assessment of lipids and adrenal hormones in the Florida manatee (Trichechus manatus latirostris) from different habitats. General and comparative endocrinology. 2023 06; 337(?):114250. doi: 10.1016/j.ygcen.2023.114250. [PMID: 36858274]
  • Yicong Yin, Chaochao Ma, Songlin Yu, Qing Ai, Chuntao Han, Jian Zhong, Wei Luo, Xiaoli Ma, Jialei Yu, Yuanyuan Zhang, Jingwen Cui, Ling Qiu. Reference intervals for LC-MS /MS measurements of plasma renin activity, aldosterone, angiotensin II, and 24-hour urinary aldosterone in Northern Chinese Han population. Clinica chimica acta; international journal of clinical chemistry. 2023 Mar; 543(?):117325. doi: 10.1016/j.cca.2023.117325. [PMID: 37003517]
  • Turgay Saritas, Jürgen Floege. [Retarding progression of chronic kidney disease]. Innere Medizin (Heidelberg, Germany). 2023 Mar; 64(3):240-246. doi: 10.1007/s00108-023-01482-5. [PMID: 36723710]
  • Folarin Owagboriaye, Oladunni Adekunle, Rasheed Oladunjoye, Mistura Adeleke, Sulaimon Aina, Adedamola Adenekan, Pamilerin Bakare, Oyebamiji Fafioye, Gabriel Dedeke, Olusegun Lawal. Implications of atrazine concentrations in drinking water from Ijebu-North, Southwest Nigeria on the hypothalamic-pituitary-adrenal axis. Drug and chemical toxicology. 2023 Feb; ?(?):1-9. doi: 10.1080/01480545.2023.2180025. [PMID: 36847489]
  • Shotaro Miyamoto, Yuichi Yoshida, Yoshinori Ozeki, Mitsuhiro Okamoto, Koro Gotoh, Takayuki Masaki, Haruto Nishida, Hiroyuki Fujinami, Toshitaka Shin, Tsutomu Daa, Yoshiki Asayama, Hirotaka Shibata. Pitfalls in the diagnosis and treatment of a hypertensive patient with unilateral primary aldosteronism and contralateral pheochromocytoma: a case report. BMC endocrine disorders. 2023 Feb; 23(1):44. doi: 10.1186/s12902-023-01297-3. [PMID: 36797699]
  • Shinjini C Spaulding, Vivek Choudhary, Wendy B Bollag. Phospholipase D mediates very low-density lipoprotein-induced aldosterone production, in part, via lipin-1. Journal of molecular endocrinology. 2023 Feb; ?(?):. doi: 10.1530/jme-22-0196. [PMID: 36779781]
  • Uei-Lin Chen, Che-Wei Liao, Shuo-Meng Wang, Tai-Shuan Lai, Kuo-How Huang, Chin-Chen Chang, Bo-Ching Lee, Ching-Chu Lu, Yi-Ru Chang, Yi-Yao Chang, Chi-Sheng Hung, Jeff S Chueh, Vin-Cent Wu, Cheng-Hsuan Tsai, Yen-Hung Lin. Diabetes mellitus is associated with more adverse non-hemodynamic left ventricular remodeling and less recovery in patients with primary aldosteronism. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2023 02; 71(2):101-112. doi: 10.1177/10815589221141840. [PMID: 36647318]
  • Shixun Zhong, Biyun Zhang, Li Qin, Qianying Wang, Xiaoli Luo. Aldosterone inhibits Dot1l expression in guinea pig cochlea. European journal of medical research. 2023 Jan; 28(1):26. doi: 10.1186/s40001-023-00994-y. [PMID: 36639782]
  • Felix Atmanspacher, Rolf Schreckenberg, Annemarie Wolf, Ivica Grgic, Klaus-Dieter Schlüter. Effect of Metabolic Adaptation by Voluntary Running Wheel Activity and Aldosterone Inhibition on Renal Function in Female Spontaneously Hypertensive Rats. Cells. 2022 12; 11(24):. doi: 10.3390/cells11243954. [PMID: 36552716]
  • Jing Gao, Abolfazl Akbari, Tao Wang. Green tea could improve elderly hypertension by modulating arterial stiffness, the activity of the renin/angiotensin/aldosterone axis, and the sodium-potassium pumps in old male rats. Journal of food biochemistry. 2022 12; 46(12):e14398. doi: 10.1111/jfbc.14398. [PMID: 36181277]
  • Thomas Weber, Jaques Amar, Tine de Backer, Thilo Burkard, Marcus van der Giet, Philippe Gosse, Andrzej Januszewicz, Thomas Kahan, Giuseppe Mancia, Christopher C Mayer, Maria Lorenza Muiesan, George S Stergiou, Konstantinos Tsioufis, Bernard Vaisse, Reinhold Kreutz. Covid-19 associated reduction in hypertension-related diagnostic and therapeutic procedures in Excellence Centers of the European Society of Hypertension. Blood pressure. 2022 12; 31(1):71-79. doi: 10.1080/08037051.2022.2060182. [PMID: 35465794]
  • Jack L Hulse, Javad Habibi, Aderonke E Igbekele, Bingyue Zhang, Jessie Li, Adam Whaley-Connell, James R Sowers, Guanghong Jia. Mineralocorticoid Receptors Mediate Diet-Induced Lipid Infiltration of Skeletal Muscle and Insulin Resistance. Endocrinology. 2022 10; 163(11):. doi: 10.1210/endocr/bqac145. [PMID: 36039677]
  • Hakan Doneray, Ozlem Ziraatci Akbulut, Ayse Ozden, Abdulkadir Yildirim, Zerrin Orbak. Plasma renin, aldosterone, and urinary prostaglandin E2 levels in children with hypocalcemia due to vitamin D deficiency rickets. Prostaglandins & other lipid mediators. 2022 10; 162(?):106652. doi: 10.1016/j.prostaglandins.2022.106652. [PMID: 35688409]
  • Patrícia Regina Terço Leite, Bethânia Rosa Lorençone, Karyne Garcia Tafarelo Moreno, Katiana Simões Lopes, Aline Aparecida Macedo Marques, Clara Soligo Fortini, Rhanany Alan Calloi Palozi, Mariana Dalmagro, Cândida Aparecida Leite Kassuya, Ariany Carvalho Dos Santos, Marcos José Salvador, Arquimedes Gasparotto Junior. The NO-cGMP-K+ Channel Pathway Participates in Diuretic and Cardioprotective Effects of Blutaparon portulacoides in Spontaneously Hypertensive Rats. Planta medica. 2022 Oct; 88(13):1152-1162. doi: 10.1055/a-1690-3566. [PMID: 35299274]
  • Oyunbileg Bavuu, Daiju Fukuda, Byambasuren Ganbaatar, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata. Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet. European journal of pharmacology. 2022 Sep; 931(?):175190. doi: 10.1016/j.ejphar.2022.175190. [PMID: 35961594]
  • Bidisha Paul, Zachary R Sterner, Ruchika Bhawal, Elizabeth T Anderson, Sheng Zhang, Daniel R Buchholz. Impaired negative feedback and death following acute stress in glucocorticoid receptor knockout Xenopus tropicalis tadpoles. General and comparative endocrinology. 2022 09; 326(?):114072. doi: 10.1016/j.ygcen.2022.114072. [PMID: 35697317]
  • Ariadni Spyroglou, Laura Handgriff, Lisa Müller, Paul Schwarzlmüller, Mirko Parasiliti-Caprino, Carmina Teresa Fuss, Hana Remde, Anna Hirsch, Samuel Matthew O'Toole, Moe Thuzar, Luigi Petramala, Claudio Letizia, Elisa Deflorenne, Laurence Amar, Rok Vrckovnik, Tomaz Kocjan, Catherine D Zhang, Dingfeng Li, Sumitabh Singh, Takuyuki Katabami, Takashi Yoneda, Masanori Murakami, Norio Wada, Nobuya Inagaki, Marcus Quinkler, Ezio Ghigo, Mauro Maccario, Michael Stowasser, William M Drake, Martin Fassnacht, Irina Bancos, Martin Reincke, Mitsuhide Naruse, Felix Beuschlein. The metabolic phenotype of patients with primary aldosteronism: impact of subtype and sex - a multicenter-study of 3566 Caucasian and Asian subjects. European journal of endocrinology. 2022 Sep; 187(3):361-372. doi: 10.1530/eje-22-0040. [PMID: 35895721]
  • Taha Sen, Rosalie Scholtes, Peter J Greasley, David Z I Cherney, Claire C J Dekkers, Marc Vervloet, Alexander H J Danser, Sean J Barbour, Cecilia Karlsson, Ann Hammarstedt, Qiang Li, Gozewijn D Laverman, Petter Bjornstad, Daniel H van Raalte, Hiddo J L Heerspink. Effects of dapagliflozin on volume status and systemic haemodynamics in patients with chronic kidney disease without diabetes: Results from DAPASALT and DIAMOND. Diabetes, obesity & metabolism. 2022 Aug; 24(8):1578-1587. doi: 10.1111/dom.14729. [PMID: 35478433]
  • Reham S Ibrahim, Nesrine S El-Mezayen, Alaa A El-Banna. Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study. Scientific reports. 2022 Jul; 12(1):11884. doi: 10.1038/s41598-022-15958-1. [PMID: 35831335]
  • Barbara Schreier, Alexander Zipprich, Henriette Uhlenhaut, Michael Gekle. Mineralocorticoid receptors in non-alcoholic fatty liver disease. British journal of pharmacology. 2022 07; 179(13):3165-3177. doi: 10.1111/bph.15784. [PMID: 34935140]
  • Johann Bauersachs, Natalia López-Andrés. Mineralocorticoid receptor in cardiovascular diseases-Clinical trials and mechanistic insights. British journal of pharmacology. 2022 07; 179(13):3119-3134. doi: 10.1111/bph.15708. [PMID: 34643952]
  • Shinichi Tamaru, Hirotsugu Suwanai, Hironori Abe, Junko Sasaki, Keitaro Ishii, Hajime Iwasaki, Jumpei Shikuma, Rokuro Ito, Takashi Miwa, Toru Sasaki, Tomoko Takamiya, Shigeru Inoue, Kazuhiro Saito, Masato Odawara, Ryo Suzuki. Machine learning approach to predict subtypes of primary aldosteronism is helpful to estimate indication of adrenal vein sampling. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. 2022 Jul; 29(4):375-383. doi: 10.1007/s40292-022-00523-8. [PMID: 35576101]
  • Dorien Clarisse, Lisa Deng, Karolien de Bosscher, Achim Lother. Approaches towards tissue-selective pharmacology of the mineralocorticoid receptor. British journal of pharmacology. 2022 07; 179(13):3235-3249. doi: 10.1111/bph.15719. [PMID: 34698367]
  • Jingru Liang, Hang Dong, Hongsheng Wang, Zhengjun Yi, Guosheng Jiang, Takashi Inagaki, Celso E Gomez-Sanchez, Jinhua Dong, Hiroshi Ueda. Creation of a quick and sensitive fluorescent immunosensor for detecting the mineralocorticoid steroid hormone aldosterone. The Journal of steroid biochemistry and molecular biology. 2022 07; 221(?):106118. doi: 10.1016/j.jsbmb.2022.106118. [PMID: 35487440]
  • Karanjeet Chauhan, Eitan Schachna, Renata Libianto, Jessica Ryan, Holly Hutton, Peter J Fuller, Scott Wilson, Peter G Kerr, Jun Yang. Screening for primary aldosteronism is underutilised in patients with chronic kidney disease. Journal of nephrology. 2022 Jul; 35(6):1667-1677. doi: 10.1007/s40620-022-01267-3. [PMID: 35195879]
  • Yujiro Maeoka, Xiao-Tong Su, Wen-Hui Wang, Xin-Peng Duan, Avika Sharma, Na Li, Olivier Staub, James A McCormick, David H Ellison. Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone. Hypertension (Dallas, Tex. : 1979). 2022 07; 79(7):1423-1434. doi: 10.1161/hypertensionaha.122.19159. [PMID: 35506380]
  • Shogo Harashima, Yuto Yamazaki, Naoki Motomura, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hiroyoshi Suzuki, Go Eun Kwon, Man Ho Choi, Hironobu Sasano. Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism. The Journal of steroid biochemistry and molecular biology. 2022 07; 221(?):106116. doi: 10.1016/j.jsbmb.2022.106116. [PMID: 35533918]
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