5-Methylcytosine (BioDeep_00000001268)
Secondary id: BioDeep_00000400191
natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019
代谢物信息卡片
6-amino-5-methyl-1,2-dihydropyrimidin-2-one
化学式: C5H7N3O (125.0589)
中文名称: 4-氨基-5-甲基-2(1H)-嘧啶酮, 5-甲基胞嘧啶, 5-甲基胞嘧啶 盐酸盐
谱图信息:
最多检出来源 Viridiplantae(plant) 10.82%
分子结构信息
SMILES: CC(=C1)C(N)=NC(=O)N1
InChI: InChI=1S/C5H7N3O/c1-3-2-7-5(9)8-4(3)6/h2H,1H3,(H3,6,7,8,9)
描述信息
5-Methylcytosine is a methylated form of cytosine in which a methyl group is attached to carbon 5, altering its structure without altering its base-pairing properties.; 5-Methylcytosine is a methylated form of cytosine in which a methyl group is attached to carbon 5, altering its structure without altering its base-pairing properties. -- Wikipedia; 5-Methylcytosine is an epigenetic modification formed by the action of DNA methyltransferases. In bacteria, 5-methylcytosine can be found at a variety of sites, and is often used as a marker to protect DNA from being cut by native methylation-sensitive restriction enzymes. In plants, 5-methylcytosine occurs at both CpG and CpNpG sequences. In fungi and animals, 5-methylcytosine predominately occurs at CpG dinucleotides. Although most eukaryotes methylate only a small percentage of these sites, in vertebrates 70-80\\\% of CpG cytosines are methylated. -- Wikipedia; 5-Methylcytosine is an epigenetic modification formed by the action of DNA methyltransferases. Its function varies significantly among species:; A methylated nucleotide base found in eukaryotic DNA. In animals, the DNA methylation of cytosine to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In plants, the methylated sequence is CpNpGp, where N can be any base. -- Pubchem.
5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. In animals, the DNA methylation of cytosine to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In plants, the methylated sequence is CpNpGp, where N can be any base. -- Pubchem; 5-Methylcytosine is a methylated form of cytosine in which a methyl group is attached to carbon 5, altering its structure without altering its base-pairing properties. -- Wikipedia; 5-Methylcytosine is an epigenetic modification formed by the action of DNA methyltransferases. In bacteria, 5-methylcytosine can be found at a variety of sites, and is often used as a marker to protect DNA from being cut by native methylation-sensitive restriction enzymes. In plants, 5-methylcytosine occurs at both CpG and CpNpG sequences. In fungi and animals, 5-methylcytosine predominately occurs at CpG dinucleotides. Although most eukaryotes methylate only a small percentage of these sites, in vertebrates 70-80\\\% of CpG cytosines are methylated. -- Wikipedia.
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID M029
5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. 5-Methylcytosine in mRNA is a new epitranscriptome marker inArabidopsis, and that regulation of this modification is an integral part of gene regulatory networks underlying plant development[1].
同义名列表
16 个代谢物同义名
6-amino-5-methyl-1,2-dihydropyrimidin-2-one; 2-Pyrimidinol, 4-amino-5-methyl- (9CI); 4-Amino-5-methyl-2-(1H)-pyrimidinone; 4-Amino-5-methyl-2(1H)-pyrimidinone; Monohydrochloride, 5-methylcytosine; 5-Methylcytosine monohydrochloride; 5 Methylcytosine monohydrochloride; 4-Amino-5-methyl-2-pyrimidinol; 5-METHYLCYTOSINE HYDROCHLORIDE; 5-Methylcytosine>96; 5-Methyl-cytosine; 5-Methylcytosine; 5 Methylcytosine; 5-Methylcytosine; 5-Methylcytosine; 5-Methylcytosine
数据库引用编号
34 个数据库交叉引用编号
- ChEBI: CHEBI:27551
- KEGG: C02376
- PubChem: 65040
- HMDB: HMDB0002894
- Metlin: METLIN3247
- Wikipedia: 5-Methylcytosine
- MeSH: 5-Methylcytosine
- MetaCyc: CPD0-2018
- foodb: FDB004432
- chemspider: 58551
- CAS: 130170-00-2
- CAS: 130170-01-3
- CAS: 554-01-8
- MoNA: PR100016
- MoNA: PS003502
- MoNA: PS003501
- MoNA: KO003362
- MoNA: PR100017
- MoNA: KO003364
- MoNA: KO003363
- MoNA: KO003366
- MoNA: PS003503
- MoNA: KO003365
- PMhub: MS000000235
- PubChem: 5418
- PDB-CCD: 17E
- 3DMET: B00435
- NIKKAJI: J9.416A
- RefMet: 5-Methylcytosine
- medchemexpress: HY-W008091
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-205
- KNApSAcK: 27551
- LOTUS: LTS0015367
- wikidata: Q238563
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
8 个相关的物种来源信息
- 654 - Aeromonas veronii: 10.3389/FCIMB.2020.00044
- 102211 - Benincasa hispida: 10.1016/S0021-9673(01)88829-4
- 387127 - Coccinia grandis: 10.1016/S0021-9673(01)88829-4
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
- 56866 - Luffa acutangula: 10.1016/S0021-9673(01)88829-4
- 3670 - Luffa aegyptiaca: 10.1016/S0021-9673(01)88829-4
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Navneet Kaur, Swapna Nayakoti, Natasha Brock, Nigel G Halford. Uncovering plant epigenetics: new insights into cytosine methylation in rye genomes.
Journal of experimental botany.
2023 06; 74(12):3395-3398. doi:
10.1093/jxb/erad144. [PMID: 37369102] - Lisha Shen, Jinqi Ma, Ping Li, Yujin Wu, Hao Yu. Recent advances in the plant epitranscriptome.
Genome biology.
2023 03; 24(1):43. doi:
10.1186/s13059-023-02872-6. [PMID: 36882788] - Yu Tian, Haijuan Xiao, Yanhui Yang, Pingping Zhang, Jiahui Yuan, Wei Zhang, Lijie Chen, Yibao Fan, Jinze Zhang, Huan Cheng, Tingwei Deng, Lin Yang, Weiwei Wang, Guoyong Chen, Peiqin Wang, Peng Gong, Xing Niu, Xianbin Zhang. Crosstalk between 5-methylcytosine and N6-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma.
Molecular cancer.
2023 01; 22(1):5. doi:
10.1186/s12943-022-01706-6. [PMID: 36627693] - Xiao-Cong Zhao, Hai-Long Dong, Xiao-Lu Li, Hong-Yu Yang, Xue-Feng Chen, Liang Dai, Wen-Qiang Wu, Zhi-Jie Tan, Xing-Hua Zhang. 5-Methyl-cytosine stabilizes DNA but hinders DNA hybridization revealed by magnetic tweezers and simulations.
Nucleic acids research.
2022 11; 50(21):12344-12354. doi:
10.1093/nar/gkac1122. [PMID: 36477372] - Sreejith Jayasree Varma, Enrica Calvani, Nana-Maria Grüning, Christoph B Messner, Nicholas Grayson, Floriana Capuano, Michael Mülleder, Markus Ralser. Global analysis of cytosine and adenine DNA modifications across the tree of life.
eLife.
2022 07; 11(?):. doi:
10.7554/elife.81002. [PMID: 35900202] - Muthusamy Ramakrishnan, K Shanmugha Rajan, Sileesh Mullasseri, Sarin Palakkal, Krishnan Kalpana, Anket Sharma, Mingbing Zhou, Kunnummal Kurungara Vinod, Subbiah Ramasamy, Qiang Wei. The plant epitranscriptome: revisiting pseudouridine and 2'-O-methyl RNA modifications.
Plant biotechnology journal.
2022 07; 20(7):1241-1256. doi:
10.1111/pbi.13829. [PMID: 35445501] - Yajuan Mu, Lin Zhang, Jingyan Hu, Jiashen Zhou, Hou-Wen Lin, Chuan He, Hong-Zhuan Chen, Liang Zhang. A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA.
Nature chemical biology.
2022 07; 18(7):733-741. doi:
10.1038/s41589-022-01041-3. [PMID: 35654845] - Wen Wang, Hengjun Huang, Hao Jiang, Chi Tian, Yisen Tang, Diwen Gan, Xiaozhen Wen, Zhenyu Song, Yuhao He, Xijun Ou, Liang Fang. A Cross-Tissue Investigation of Molecular Targets and Physiological Functions of Nsun6 Using Knockout Mice.
International journal of molecular sciences.
2022 Jun; 23(12):. doi:
10.3390/ijms23126584. [PMID: 35743028] - Sara Gomez-Cabellos, Peter E Toorop, María Jesús Cañal, Pietro P M Iannetta, Eduardo Fernández-Pascual, Hugh W Pritchard, Anne M Visscher. Global DNA methylation and cellular 5-methylcytosine and H4 acetylated patterns in primary and secondary dormant seeds of Capsella bursa-pastoris (L.) Medik. (shepherd's purse).
Protoplasma.
2022 May; 259(3):595-614. doi:
10.1007/s00709-021-01678-2. [PMID: 34212249] - Michael J Lu, Yabin Lu. 5-Hydroxymethylcytosine (5hmC) at or near cancer mutation hot spots as potential targets for early cancer detection.
BMC research notes.
2022 Apr; 15(1):143. doi:
10.1186/s13104-022-06028-w. [PMID: 35449110] - Sitian He, Songcheng Yu, Yinhua Feng, Leiliang He, Lie Liu, Clement Yaw Effah, Yongjun Wu. A digital immuno-PCR assay for simultaneous determination of 5-methylcytosine and 5-hydroxymethylcytosine in human serum.
Analytica chimica acta.
2022 Feb; 1192(?):339321. doi:
10.1016/j.aca.2021.339321. [PMID: 35057947] - Shuai Wang, Hairong Xie, Fei Mao, Haiyan Wang, Shu Wang, Zhenglin Chen, Yuxia Zhang, Zhihui Xu, Jinming Xing, Zhaokang Cui, Xiquan Gao, Hongmei Jin, Jian Hua, Bo Xiong, Yufeng Wu. N4-acetyldeoxycytosine DNA modification marks euchromatin regions in Arabidopsis thaliana.
Genome biology.
2022 01; 23(1):5. doi:
10.1186/s13059-021-02578-7. [PMID: 34980211] - Zhuoyuan Li, Siyu Wang, Yuxian Chen, Yaozhou Huang, Tianping Li. 5-Methylcytosine-Related Long Noncoding RNAs Are Potential Biomarkers to Predict Overall Survival and Regulate Tumor-Immune Environment in Patients with Bladder Cancer.
Disease markers.
2022; 2022(?):3117359. doi:
10.1155/2022/3117359. [PMID: 35371346] - Lei Chen, Qianqian Shen, Shunliang Xu, Hongzhuan Yu, Shengjie Pei, Yangting Zhang, Xin He, QiuZhen Wang, Duo Li. 5-Hydroxymethylcytosine Signatures in Circulating Cell-Free DNA as Diagnostic Biomarkers for Late-Onset Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2022; 85(2):573-585. doi:
10.3233/jad-215217. [PMID: 34864677] - Aneta Żabka, Natalia Gocek, Konrad Winnicki, Paweł Szczeblewski, Tomasz Laskowski, Justyna Teresa Polit. Changes in Epigenetic Patterns Related to DNA Replication in Vicia faba Root Meristem Cells under Cadmium-Induced Stress Conditions.
Cells.
2021 12; 10(12):. doi:
10.3390/cells10123409. [PMID: 34943918] - Youhua Liu, Yuanling Zhao, Ruifan Wu, Yushi Chen, Wei Chen, Yuxi Liu, Yaojun Luo, Chaoqun Huang, Botao Zeng, Xing Liao, Guanqun Guo, Yizhen Wang, Xinxia Wang. mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation.
RNA biology.
2021 11; 18(sup2):711-721. doi:
10.1080/15476286.2021.1980694. [PMID: 34570675] - Meng Zhou, Ping Hou, Congcong Yan, Lu Chen, Ke Li, Yiran Wang, Jingting Zhao, Jianzhong Su, Jie Sun. Cell-free DNA 5-hydroxymethylcytosine profiles of long non-coding RNA genes enable early detection and progression monitoring of human cancers.
Clinical epigenetics.
2021 10; 13(1):197. doi:
10.1186/s13148-021-01183-6. [PMID: 34689838] - Ritesh K Aggarwal, Rebecca A Luchtel, Venkata Machha, Alexander Tischer, Yiyu Zou, Kith Pradhan, Nadia Ashai, Nandini Ramachandra, Joseph M Albanese, Jung-In Yang, Xiaoyang Wang, Srinivas Aluri, Shanisha Gordon, Ahmed Aboumohamed, Benjamin A Gartrell, Sassan Hafizi, James Pullman, Niraj Shenoy. Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer.
Proceedings of the National Academy of Sciences of the United States of America.
2021 09; 118(39):. doi:
10.1073/pnas.2106947118. [PMID: 34551979] - Ioannis Konstantinidis, Dafni Anastasiadi, Pål Sætrom, Artem V Nedoluzhko, Robin Mjelle, Tomasz Podgorniak, Francesc Piferrer, Jorge M O Fernandes. Epigenetic mapping of the somatotropic axis in Nile tilapia reveals differential DNA hydroxymethylation marks associated with growth.
Genomics.
2021 09; 113(5):2953-2964. doi:
10.1016/j.ygeno.2021.06.037. [PMID: 34214627] - Bo He, Chao Zhang, Xiaoxue Zhang, Yu Fan, Hu Zeng, Jun'e Liu, Haowei Meng, Dongsheng Bai, Jinying Peng, Qian Zhang, Wei Tao, Chengqi Yi. Tissue-specific 5-hydroxymethylcytosine landscape of the human genome.
Nature communications.
2021 07; 12(1):4249. doi:
10.1038/s41467-021-24425-w. [PMID: 34253716] - Zhenning Yu, Si-Yang Liu, Yanfei Zhang, Yunda Li, Yuzhi Xu, Danping Chen, Zong Dai, Xiaoyong Zou. Pearl Necklacelike Strategy Enables Quantification of Global 5-Hydroxymethylcytosine and 5-Formylcytosine by Inductively Coupled Plasma-Atomic Emission Spectrometry.
Analytical chemistry.
2021 06; 93(22):7787-7791. doi:
10.1021/acs.analchem.1c01548. [PMID: 34037387] - Mareike Möller, Michael Habig, Cécile Lorrain, Alice Feurtey, Janine Haueisen, Wagner C Fagundes, Alireza Alizadeh, Michael Freitag, Eva H Stukenbrock. Recent loss of the Dim2 DNA methyltransferase decreases mutation rate in repeats and changes evolutionary trajectory in a fungal pathogen.
PLoS genetics.
2021 03; 17(3):e1009448. doi:
10.1371/journal.pgen.1009448. [PMID: 33750960] - Hang-Yu Chen, Wei-Long Zhang, Lei Zhang, Ping Yang, Fang Li, Ze-Ruo Yang, Jing Wang, Meng Pang, Yun Hong, Changjian Yan, Wei Li, Jia Liu, Nuo Xu, Long Chen, Xiu-Bing Xiao, Yan Qin, Xiao-Hui He, Hui Liu, Hai-Chuan Zhu, Chuan He, Jian Lin, Hong-Mei Jing. 5-Hydroxymethylcytosine profiles of cfDNA are highly predictive of R-CHOP treatment response in diffuse large B cell lymphoma patients.
Clinical epigenetics.
2021 02; 13(1):33. doi:
10.1186/s13148-020-00973-8. [PMID: 33573703] - Z Cai, J Zhang, Y He, L Xia, X Dong, G Chen, Y Zhou, X Hu, S Zhong, Y Wang, H Chen, D Xie, X Liu, J Liu. Liquid biopsy by combining 5-hydroxymethylcytosine signatures of plasma cell-free DNA and protein biomarkers for diagnosis and prognosis of hepatocellular carcinoma.
ESMO open.
2021 02; 6(1):100021. doi:
10.1016/j.esmoop.2020.100021. [PMID: 33508734] - Chongsheng He, Julianna Bozler, Kevin A Janssen, Jeremy E Wilusz, Benjamin A Garcia, Andrea J Schorn, Roberto Bonasio. TET2 chemically modifies tRNAs and regulates tRNA fragment levels.
Nature structural & molecular biology.
2021 01; 28(1):62-70. doi:
10.1038/s41594-020-00526-w. [PMID: 33230319] - ZeWen Xiao, Wendy Wu, Chunlong Wu, Man Li, Fuming Sun, Lu Zheng, Gaojing Liu, Xiaoling Li, Zhiyuan Yun, Jiebing Tang, Yang Yu, Shengnan Luo, Wenji Sun, Xiaohong Feng, Qian Cheng, Xue Tao, Shuangxiu Wu, Ji Tao. 5-Hydroxymethylcytosine signature in circulating cell-free DNA as a potential diagnostic factor for early-stage colorectal cancer and precancerous adenoma.
Molecular oncology.
2021 01; 15(1):138-150. doi:
10.1002/1878-0261.12833. [PMID: 33107199] - Xinyue Meng, Yingjie Yao, Yongzheng Ma, Nan Zhong, Sowanou Alphonse, Junrui Pei. Effect of fluoride in drinking water on the level of 5-methylcytosine in human and rat blood.
Environmental toxicology and pharmacology.
2021 Jan; 81(?):103511. doi:
10.1016/j.etap.2020.103511. [PMID: 33035703] - Paulo Marcos Amaral-Silva, Wellington Ronildo Clarindo, José Henrique Soler Guilhen, Ana Beatriz Rocha de Jesus Passos, Natália Arruda Sanglard, Adésio Ferreira. Global 5-methylcytosine and physiological changes are triggers of indirect somatic embryogenesis in Coffea canephora.
Protoplasma.
2021 Jan; 258(1):45-57. doi:
10.1007/s00709-020-01551-8. [PMID: 32895735] - Marcos Viejo, Igor Yakovlev, Carl Gunnar Fossdal. Immunochemical Detection of Modified Species of Cytosine in Plant Tissues.
Methods in molecular biology (Clifton, N.J.).
2021; 2198(?):209-216. doi:
10.1007/978-1-0716-0876-0_17. [PMID: 32822034] - Jean-Baptiste Alberge, Florence Magrangeas, Mirko Wagner, Soline Denié, Catherine Guérin-Charbonnel, Loïc Campion, Michel Attal, Hervé Avet-Loiseau, Thomas Carell, Philippe Moreau, Stéphane Minvielle, Aurélien A Sérandour. DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma.
Clinical epigenetics.
2020 11; 12(1):163. doi:
10.1186/s13148-020-00953-y. [PMID: 33138842] - Pingxian Zhang, Yifan Wang, Xiaofeng Gu. RNA 5-Methylcytosine Controls Plant Development and Environmental Adaptation.
Trends in plant science.
2020 10; 25(10):954-958. doi:
10.1016/j.tplants.2020.07.004. [PMID: 32736923] - Yu Liang, Jingyuan Zeng, Bo Luo, Wei Li, Yancheng He, Wenjing Zhao, Nan Hu, Nan Jiang, Yujiao Luo, Yujun Xian, Jiajia Liu, Xiaoli Zheng. TET2 promotes IL-1β expression in J774.1 cell through TLR4/MAPK signaling pathway with demethylation of TAB2 promoter.
Molecular immunology.
2020 10; 126(?):136-142. doi:
10.1016/j.molimm.2020.08.003. [PMID: 32823238] - Borbála Szabó, Kinga Németh, Katalin Mészáros, Nikolette Szücs, Sándor Czirják, Lilla Reiniger, Hajnalka Rajnai, Ildikó Krencz, Katalin Karászi, Lilla Krokker, Attila Patócs, Henriett Butz. Demethylation Status of Somatic DNA Extracted From Pituitary Neuroendocrine Tumors Indicates Proliferative Behavior.
The Journal of clinical endocrinology and metabolism.
2020 06; 105(6):. doi:
10.1210/clinem/dgaa156. [PMID: 32232382] - Ting-Ting Wu, Te Liu, Xuan Li, Ya-Jing Chen, Tian-Jiao Chen, Xiao-Ying Zhu, Jiu-Lin Chen, Qing Li, Ye Liu, Ya Feng, Yun-Cheng Wu. TET2-mediated Cdkn2A DNA hydroxymethylation in midbrain dopaminergic neuron injury of Parkinson's disease.
Human molecular genetics.
2020 05; 29(8):1239-1252. doi:
10.1093/hmg/ddaa022. [PMID: 32037456] - Hao Lv, Zi-Mei Zhang, Shi-Hao Li, Jiu-Xin Tan, Wei Chen, Hao Lin. Evaluation of different computational methods on 5-methylcytosine sites identification.
Briefings in bioinformatics.
2020 05; 21(3):982-995. doi:
10.1093/bib/bbz048. [PMID: 31157855] - Eleftheria Saplaoura, Valentina Perrera, Vincent Colot, Friedrich Kragler. Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis.
Journal of visualized experiments : JoVE.
2020 05; ?(159):. doi:
10.3791/61231. [PMID: 32478728] - Yongyan Tang, Chun-Chun Gao, Ying Gao, Ying Yang, Boyang Shi, Jia-Li Yu, Cong Lyu, Bao-Fa Sun, Hai-Lin Wang, Yunyuan Xu, Yun-Gui Yang, Kang Chong. OsNSUN2-Mediated 5-Methylcytosine mRNA Modification Enhances Rice Adaptation to High Temperature.
Developmental cell.
2020 05; 53(3):272-286.e7. doi:
10.1016/j.devcel.2020.03.009. [PMID: 32275888] - Zhaohai Zhu, Heng Zhang. It Takes NSUN2 to Beat the Heat in Rice.
Developmental cell.
2020 05; 53(3):253-254. doi:
10.1016/j.devcel.2020.04.011. [PMID: 32369737] - Abir Mukherjee, Chun-Yi Chiang, Helen A Daifotis, Kristin M Nieman, Johannes F Fahrmann, Ricardo R Lastra, Iris L Romero, Oliver Fiehn, Ernst Lengyel. Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance.
Cancer research.
2020 04; 80(8):1748-1761. doi:
10.1158/0008-5472.can-19-1999. [PMID: 32054768] - Yingzi Hou, Zhenxi Zhang, Yao Wang, Tao Gao, Xiyang Liu, Tao Tang, Quan Du. 5mC profiling characterized TET2 as an anti-adipogenic demethylase.
Gene.
2020 Apr; 733(?):144265. doi:
10.1016/j.gene.2019.144265. [PMID: 31805318] - Veronika Zemanová, Marek Popov, Daniela Pavlíková, Pavel Kotrba, František Hnilička, Jana Česká, Milan Pavlík. Effect of arsenic stress on 5-methylcytosine, photosynthetic parameters and nutrient content in arsenic hyperaccumulator Pteris cretica (L.) var. Albo-lineata.
BMC plant biology.
2020 Mar; 20(1):130. doi:
10.1186/s12870-020-2325-6. [PMID: 32228515] - Iván Devesa-Guerra, Teresa Morales-Ruiz, Juan Pérez-Roldán, Jara Teresa Parrilla-Doblas, Macarena Dorado-León, María Victoria García-Ortiz, Rafael R Ariza, Teresa Roldán-Arjona. DNA Methylation Editing by CRISPR-guided Excision of 5-Methylcytosine.
Journal of molecular biology.
2020 03; 432(7):2204-2216. doi:
10.1016/j.jmb.2020.02.007. [PMID: 32087201] - Mark A Applebaum, Erin K Barr, Jason Karpus, Diana C West-Szymanski, Meritxell Oliva, Elizabeth A Sokol, Sheng Zhang, Zhou Zhang, Wei Zhang, Alexandre Chlenski, Helen R Salwen, Emma Wilkinson, Marija Dobratic, Robert L Grossman, Lucy A Godley, Barbara E Stranger, Chuan He, Susan L Cohn. 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020 03; 26(6):1309-1317. doi:
10.1158/1078-0432.ccr-19-2829. [PMID: 31852832] - Min Yu, Xingfan Zhou, Li Ju, Man Yu, Xiangjing Gao, Meibian Zhang, Shichuan Tang. Characteristics of iron status, oxidation response, and DNA methylation profile in response to occupational iron oxide nanoparticles exposure.
Toxicology and industrial health.
2020 Mar; 36(3):170-180. doi:
10.1177/0748233720918683. [PMID: 32539645] - Yumei Zhang, Enen Gao, Hong Guan, Qianqian Wang, Shuo Zhang, Kexiong Liu, Fengxiang Yan, Hao Tian, Dehai Shan, Huijuan Xu, Jian Hou. Vitamin C treatment of embryos, but not donor cells, improves the cloned embryonic development in sheep.
Reproduction in domestic animals = Zuchthygiene.
2020 Mar; 55(3):255-265. doi:
10.1111/rda.13606. [PMID: 31837175] - Xiguang Xu, Xiaoran Wei, Hehuang Xie. Advances in methods and software for RNA cytosine methylation analysis.
Genomics.
2020 03; 112(2):1840-1846. doi:
10.1016/j.ygeno.2019.10.017. [PMID: 31678155] - Fan Zou, Renjun Tu, Bo Duan, Zhenlin Yang, Zhaohua Ping, Xiaoqing Song, Shiyuan Chen, Andrew Price, Hua Li, Allison Scott, Anoja Perera, Sisi Li, Ting Xie. Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs.
Proceedings of the National Academy of Sciences of the United States of America.
2020 02; 117(7):3603-3609. doi:
10.1073/pnas.1910862117. [PMID: 32015133] - Lulu Liu, Yuan Zhang, Menghao Liu, Wensheng Wei, Chengqi Yi, Jinying Peng. Structural Insights into the Specific Recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL Effectors.
Journal of molecular biology.
2020 02; 432(4):1035-1047. doi:
10.1016/j.jmb.2019.11.023. [PMID: 31863750] - Xiaoteng Fan, Tingting Hou, Shuai Zhang, Yongjing Guan, Jia Jia, Zaizhao Wang. The cellular responses of autophagy, apoptosis, and 5-methylcytosine level in zebrafish cells upon nutrient deprivation stress.
Chemosphere.
2020 Feb; 241(?):124989. doi:
10.1016/j.chemosphere.2019.124989. [PMID: 31590028] - Rebecca A Luchtel, Tushar Bhagat, Kith Pradhan, William R Jacobs, Mark Levine, Amit Verma, Niraj Shenoy. High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.
Proceedings of the National Academy of Sciences of the United States of America.
2020 01; 117(3):1666-1677. doi:
10.1073/pnas.1908158117. [PMID: 31911474] - Fang Yuan, Yue Yu, Ying-Lin Zhou, Xin-Xiang Zhang. 5hmC-MIQuant: Ultrasensitive Quantitative Detection of 5-Hydroxymethylcytosine in Low-Input Cell-Free DNA Samples.
Analytical chemistry.
2020 01; 92(1):1605-1610. doi:
10.1021/acs.analchem.9b04920. [PMID: 31829563] - Xiaoxia Dai, Gwendolyn Gonzalez, Lin Li, Jie Li, Changjun You, Weili Miao, Junchi Hu, Lijuan Fu, Yonghui Zhao, Ruidong Li, Lichao Li, Xuemei Chen, Yanhui Xu, Weifeng Gu, Yinsheng Wang. YTHDF2 Binds to 5-Methylcytosine in RNA and Modulates the Maturation of Ribosomal RNA.
Analytical chemistry.
2020 01; 92(1):1346-1354. doi:
10.1021/acs.analchem.9b04505. [PMID: 31815440] - Zhe Liang, Adeel Riaz, Sadaruddin Chachar, Yike Ding, Hai Du, Xiaofeng Gu. Epigenetic Modifications of mRNA and DNA in Plants.
Molecular plant.
2020 01; 13(1):14-30. doi:
10.1016/j.molp.2019.12.007. [PMID: 31863849] - Anna Kalinka, Magdalena Achrem. The distribution pattern of 5-methylcytosine in rye (Secale L.) chromosomes.
PloS one.
2020; 15(10):e0240869. doi:
10.1371/journal.pone.0240869. [PMID: 33057421] - Igor A Yakovlev, Daniel Gackowski, Abdulkadir Abakir, Marcos Viejo, Alexey Ruzov, Ryszard Olinski, Marta Starczak, Carl Gunnar Fossdal, Konstantin V Krutovsky. Mass spectrometry reveals the presence of specific set of epigenetic DNA modifications in the Norway spruce genome.
Scientific reports.
2019 12; 9(1):19314. doi:
10.1038/s41598-019-55826-z. [PMID: 31848418] - Claudia Figueroa-Romero, Kai Guo, Benjamin J Murdock, Ximena Paez-Colasante, Christine M Bassis, Kristen A Mikhail, Kristen D Raue, Matthew C Evans, Ghislaine F Taubman, Andrew J McDermott, Phillipe D O'Brien, Masha G Savelieff, Junguk Hur, Eva L Feldman. Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice.
Disease models & mechanisms.
2019 11; 13(2):. doi:
10.1242/dmm.041947. [PMID: 31597644] - Danping Chen, Yang Wang, Mingming Mo, Junjie Zhang, Yanfei Zhang, Yuzhi Xu, Si-Yang Liu, Jun Chen, Yingjun Ma, Li Zhang, Zong Dai, Chun Cai, Xiaoyong Zou. Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input.
Nucleic acids research.
2019 11; 47(19):e119. doi:
10.1093/nar/gkz704. [PMID: 31418020] - Brian C-H Chiu, Zhou Zhang, Qiancheng You, Chang Zeng, Elizabeth Stepniak, Paige M Bracci, Kangkang Yu, Girish Venkataraman, Sonali M Smith, Chuan He, Wei Zhang. Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma.
Blood advances.
2019 10; 3(19):2790-2799. doi:
10.1182/bloodadvances.2019000175. [PMID: 31570490] - Chengji Sui, Fei Li, Hanwen Wu, Huanshun Yin, Shenran Zhang, Geoffrey I N Waterhouse, Jun Wang, Lusheng Zhu, Shiyun Ai. Photoelectrochemical biosensor for 5hmC detection based on the photocurrent inhibition effect of ZnO on MoS2/C3N4 heterojunction.
Biosensors & bioelectronics.
2019 Oct; 142(?):111516. doi:
10.1016/j.bios.2019.111516. [PMID: 31326863] - Jara Teresa Parrilla-Doblas, Teresa Roldán-Arjona, Rafael R Ariza, Dolores Córdoba-Cañero. Active DNA Demethylation in Plants.
International journal of molecular sciences.
2019 Sep; 20(19):. doi:
10.3390/ijms20194683. [PMID: 31546611] - Katia Schoeler, Andreas Aufschnaiter, Simon Messner, Emmanuel Derudder, Sebastian Herzog, Andreas Villunger, Klaus Rajewsky, Verena Labi. TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.
The FEBS journal.
2019 09; 286(18):3566-3581. doi:
10.1111/febs.14934. [PMID: 31120187] - Lei Yang, Valentina Perrera, Eleftheria Saplaoura, Federico Apelt, Mathieu Bahin, Amira Kramdi, Justyna Olas, Bernd Mueller-Roeber, Ewelina Sokolowska, Wenna Zhang, Runsheng Li, Nicolas Pitzalis, Manfred Heinlein, Shoudong Zhang, Auguste Genovesio, Vincent Colot, Friedrich Kragler. m5C Methylation Guides Systemic Transport of Messenger RNA over Graft Junctions in Plants.
Current biology : CB.
2019 08; 29(15):2465-2476.e5. doi:
10.1016/j.cub.2019.06.042. [PMID: 31327714] - Diana M Paredes-Céspedes, José F Herrera-Moreno, Yael Y Bernal-Hernández, Irma M Medina-Díaz, Ana M Salazar, Patricia Ostrosky-Wegman, Briscia S Barrón-Vivanco, Aurora E Rojas-García. Pesticide Exposure Modifies DNA Methylation of Coding Region of WRAP53α, an Antisense Sequence of p53, in a Mexican Population.
Chemical research in toxicology.
2019 07; 32(7):1441-1448. doi:
10.1021/acs.chemrestox.9b00153. [PMID: 31243981] - Ruben Daum, Eva M Brauchle, Daniel Alejandro Carvajal Berrio, Tomasz P Jurkowski, Katja Schenke-Layland. Non-invasive detection of DNA methylation states in carcinoma and pluripotent stem cells using Raman microspectroscopy and imaging.
Scientific reports.
2019 05; 9(1):7014. doi:
10.1038/s41598-019-43520-z. [PMID: 31065074] - Qi Qiu, Hailiang Mei, Xian Deng, Kaixuan He, Baixing Wu, Qingqing Yao, Jixiang Zhang, Falong Lu, Jinbiao Ma, Xiaofeng Cao. DNA methylation repels targeting of Arabidopsis REF6.
Nature communications.
2019 05; 10(1):2063. doi:
10.1038/s41467-019-10026-1. [PMID: 31048693] - Pingting Gao, Shengli Lin, Mingyan Cai, Yan Zhu, Yanqun Song, Yi Sui, Jing Lin, Jiaxiuyu Liu, Xingyu Lu, Yunshi Zhong, Yuehong Cui, Pinghong Zhou. 5-Hydroxymethylcytosine profiling from genomic and cell-free DNA for colorectal cancers patients.
Journal of cellular and molecular medicine.
2019 05; 23(5):3530-3537. doi:
10.1111/jcmm.14252. [PMID: 30912288] - Romana Bacova, Borivoj Klejdus, Pavel Ryant, Natalia Cernei, Vojtech Adam, Dalibor Huska. The effects of 5-azacytidine and cadmium on global 5-methylcytosine content and secondary metabolites in the freshwater microalgae Chlamydomonas reinhardtii and Scenedesmus quadricauda.
Journal of phycology.
2019 04; 55(2):329-342. doi:
10.1111/jpy.12819. [PMID: 30506677] - Niraj Shenoy, Tushar D Bhagat, John Cheville, Christine Lohse, Sanchari Bhattacharyya, Alexander Tischer, Venkata Machha, Shanisha Gordon-Mitchell, Gaurav Choudhary, Li-Fan Wong, LouAnn Gross, Emily Ressigue, Bradley Leibovich, Stephen A Boorjian, Ulrich Steidl, Xiaosheng Wu, Kith Pradhan, Benjamin Gartrell, Beamon Agarwal, Lance Pagliaro, Masako Suzuki, John M Greally, Dinesh Rakheja, R Houston Thompson, Katalin Susztak, Thomas Witzig, Yiyu Zou, Amit Verma. Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma.
The Journal of clinical investigation.
2019 03; 129(4):1612-1625. doi:
10.1172/jci98747. [PMID: 30702441] - James Asenso, Liang Wang, Yan Du, Qing-Hua Liu, Bing-Ju Xu, Meng-Zhe Guo, Dao-Quan Tang. Advances in detection and quantification of methylcytosine and its derivatives.
Journal of separation science.
2019 Mar; 42(5):1105-1116. doi:
10.1002/jssc.201801100. [PMID: 30575277] - Adam J Bewick, Brigitte T Hofmeister, Rob A Powers, Stephen J Mondo, Igor V Grigoriev, Timothy Y James, Jason E Stajich, Robert J Schmitz. Diversity of cytosine methylation across the fungal tree of life.
Nature ecology & evolution.
2019 03; 3(3):479-490. doi:
10.1038/s41559-019-0810-9. [PMID: 30778188] - Eloy Povedano, Víctor Ruiz-Valdepeñas Montiel, Alejandro Valverde, Fernando Navarro-Villoslada, Paloma Yáñez-Sedeño, María Pedrero, Ana Montero-Calle, Rodrigo Barderas, Alberto Peláez-García, Marta Mendiola, David Hardisson, Jaime Feliú, Jordi Camps, Elisabet Rodríguez-Tomàs, Jorge Joven, Meritxell Arenas, Susana Campuzano, José M Pingarrón. Versatile Electroanalytical Bioplatforms for Simultaneous Determination of Cancer-Related DNA 5-Methyl- and 5-Hydroxymethyl-Cytosines at Global and Gene-Specific Levels in Human Serum and Tissues.
ACS sensors.
2019 01; 4(1):227-234. doi:
10.1021/acssensors.8b01339. [PMID: 30499292] - Xiuxia Song, Maohua Miao, Xiaoyu Zhou, Dekun Li, Youping Tian, Hong Liang, Runsheng Li, Wei Yuan. Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men.
International journal of environmental research and public health.
2019 01; 16(1):. doi:
10.3390/ijerph16010152. [PMID: 30626059] - Maki Ohya, Koh Nakazawa, Hiroyuki Kanno. Lower number of 5-hydroxymethylcytosine-expressing cells in plasma cell myeloma than in reactive plasma cell hyperplasia: a useful immunohistochemical approach for identification of neoplastic plasma cells.
Pathology.
2019 Jan; 51(1):81-85. doi:
10.1016/j.pathol.2018.10.006. [PMID: 30503216] - Xiaofeng Gu, Zhe Liang. Transcriptome-Wide Mapping 5-Methylcytosine by m5C RNA Immunoprecipitation Followed by Deep Sequencing in Plant.
Methods in molecular biology (Clifton, N.J.).
2019; 1933(?):389-394. doi:
10.1007/978-1-4939-9045-0_24. [PMID: 30945199] - Huiping Sun, Huan Wang, Wanqiao Bai, Lin Bao, Jianxun Lin, Yan Li. Sensitive electrogenerated chemiluminescence biosensing method for the determination of DNA hydroxymethylation based on Ru(bpy)32+-doped silica nanoparticles labeling and MoS2-poly(acrylic acid) nanosheets modified electrode.
Talanta.
2019 Jan; 191(?):350-356. doi:
10.1016/j.talanta.2018.08.070. [PMID: 30262070] - Marco Tulio Mendes Ferreira, Laiane Corsini Rocha, Matheus Braga Zanon Vitoriano, Andréa Mittelmann, Vânia Helena Techio. Relationship between epigenetic marks and the behavior of 45S rDNA sites in chromosomes and interphase nuclei of Lolium-Festuca complex.
Molecular biology reports.
2018 Dec; 45(6):1663-1679. doi:
10.1007/s11033-018-4310-9. [PMID: 30121822] - Hu Zeng, Bo He, Bo Xia, Dongsheng Bai, Xingyu Lu, Jiabin Cai, Lei Chen, Ankun Zhou, Chenxu Zhu, Haowei Meng, Yun Gao, Hongshan Guo, Chuan He, Qing Dai, Chengqi Yi. Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution.
Journal of the American Chemical Society.
2018 10; 140(41):13190-13194. doi:
10.1021/jacs.8b08297. [PMID: 30278133] - Lee E Vandivier, Brian D Gregory. New insights into the plant epitranscriptome.
Journal of experimental botany.
2018 09; 69(20):4659-4665. doi:
10.1093/jxb/ery262. [PMID: 30020491] - Ling Shan, Hang-Yuan Guo, Corina N A M van den Heuvel, Joop van Heerikhuize, Judith R Homberg. Impaired fear extinction in serotonin transporter knockout rats is associated with increased 5-hydroxymethylcytosine in the amygdala.
CNS neuroscience & therapeutics.
2018 09; 24(9):810-819. doi:
10.1111/cns.12822. [PMID: 29427306] - Ghada Mkannez, Valérie Gagné-Ouellet, Mohamed Jalloul Nsaibia, Marie-Chloé Boulanger, Mickael Rosa, Deborah Argaud, Fayez Hadji, Nathalie Gaudreault, Gabrielle Rhéaume, Luigi Bouchard, Yohan Bossé, Patrick Mathieu. DNA methylation of a PLPP3 MIR transposon-based enhancer promotes an osteogenic programme in calcific aortic valve disease.
Cardiovascular research.
2018 09; 114(11):1525-1535. doi:
10.1093/cvr/cvy111. [PMID: 29726894] - Youping Tian, Xiaoyu Zhou, Maohua Miao, De-Kun Li, Ziliang Wang, Runsheng Li, Hong Liang, Wei Yuan. Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen.
International journal of environmental research and public health.
2018 08; 15(8):. doi:
10.3390/ijerph15081770. [PMID: 30126118] - Zi-Yue Wang, Meng Wang, Yan Zhang, Chun-Yang Zhang. Sensitive and label-free discrimination of 5-hydroxymethylcytosine and 5-methylcytosine in DNA by ligation-mediated rolling circle amplification.
Chemical communications (Cambridge, England).
2018 Aug; 54(62):8602-8605. doi:
10.1039/c8cc03938k. [PMID: 30015347] - Guangzhe Ge, Ding Peng, Ziying Xu, Bao Guan, Zijuan Xin, Qun He, Yuanyuan Zhou, Xuesong Li, Liqun Zhou, Weimin Ci. Restoration of 5-hydroxymethylcytosine by ascorbate blocks kidney tumour growth.
EMBO reports.
2018 08; 19(8):. doi:
10.15252/embr.201745401. [PMID: 29959161] - Eloy Povedano, Alejandro Valverde, Víctor Ruiz-Valdepeñas Montiel, María Pedrero, Paloma Yáñez-Sedeño, Rodrigo Barderas, Pablo San Segundo-Acosta, Alberto Peláez-García, Marta Mendiola, David Hardisson, Susana Campuzano, José M Pingarrón. Rapid Electrochemical Assessment of Tumor Suppressor Gene Methylations in Raw Human Serum and Tumor Cells and Tissues Using Immunomagnetic Beads and Selective DNA Hybridization.
Angewandte Chemie (International ed. in English).
2018 07; 57(27):8194-8198. doi:
10.1002/anie.201804339. [PMID: 29744991] - Line Heylen, Bernard Thienpont, Maarten Naesens, Pieter Busschaert, Jeroen Depreeuw, Dominiek Smeets, Ina Jochmans, Diethard Monbaliu, Jacques Pirenne, Evelyne Lerut, Bart Ghesquiere, Dirk Kuypers, Diether Lambrechts, Ben Sprangers. Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury.
Journal of the American Society of Nephrology : JASN.
2018 05; 29(5):1566-1576. doi:
10.1681/asn.2017091027. [PMID: 29610404] - Beata P Plitta-Michalak, Miroslawa Z Naskret-Barciszewska, Szymon Kotlarski, Dominik Tomaszewski, Tadeusz Tylkowski, Jan Barciszewski, Pawel Chmielarz, Marcin Michalak. Changes in genomic 5-methylcytosine level mirror the response of orthodox (Acer platanoides L.) and recalcitrant (Acer pseudoplatanus L.) seeds to severe desiccation.
Tree physiology.
2018 04; 38(4):617-629. doi:
10.1093/treephys/tpx134. [PMID: 29121348] - Qianyun Deng, Wei Huang, Chunyan Peng, Jiajia Gao, Zuhua Li, Xueping Qiu, Na Yang, Bifeng Yuan, Fang Zheng. Genomic 5-mC contents in peripheral blood leukocytes were independent protective factors for coronary artery disease with a specific profile in different leukocyte subtypes.
Clinical epigenetics.
2018; 10(?):9. doi:
10.1186/s13148-018-0443-x. [PMID: 29410709] - Jie Yu, Chan Cao, Yi-Tao Long. Selective and Sensitive Detection of Methylcytosine by Aerolysin Nanopore under Serum Condition.
Analytical chemistry.
2017 11; 89(21):11685-11689. doi:
10.1021/acs.analchem.7b03133. [PMID: 28988479] - Xuean Cui, Zhe Liang, Lisha Shen, Qian Zhang, Shengjie Bao, Yuke Geng, Bin Zhang, Vonny Leo, Leah A Vardy, Tiegang Lu, Xiaofeng Gu, Hao Yu. 5-Methylcytosine RNA Methylation in Arabidopsis Thaliana.
Molecular plant.
2017 11; 10(11):1387-1399. doi:
10.1016/j.molp.2017.09.013. [PMID: 28965832] - Yuan Zhang, Lulu Liu, Shengjie Guo, Jinghui Song, Chenxu Zhu, Zongwei Yue, Wensheng Wei, Chengqi Yi. Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition.
Nature communications.
2017 10; 8(1):901. doi:
10.1038/s41467-017-00860-6. [PMID: 29026078] - Shanqi Guo, Xingkang Jiang, Yuanyuan Wang, Liwei Chen, Huzi Li, Xiaojiang Li, Yingjie Jia. The protective role of TET2 in erythroid iron homeostasis against oxidative stress and erythropoiesis.
Cellular signalling.
2017 10; 38(?):106-115. doi:
10.1016/j.cellsig.2017.07.002. [PMID: 28697999] - André Ferreira, Teresa Cunha-Oliveira, Rui F Simões, Filipa S Carvalho, Ana Burgeiro, Kendra Nordgren, Kendall B Wallace, Paulo J Oliveira. Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity.
Toxicology.
2017 09; 390(?):63-73. doi:
10.1016/j.tox.2017.08.011. [PMID: 28865727] - A Zinellu, S Sotgia, E Sotgiu, S Assaretti, A Baralla, A A Mangoni, A E Satta, C Carru. Cholesterol lowering treatment restores blood global DNA methylation in chronic kidney disease (CKD) patients.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2017 Sep; 27(9):822-829. doi:
10.1016/j.numecd.2017.06.011. [PMID: 28755807] - Young Geun Mok, Ki Young Choi, Seung Hwan Hong, Jin Hoe Huh. DEMETER plant DNA demethylase induces antiviral response by interferon signalling in animal cells.
Scientific reports.
2017 08; 7(1):9160. doi:
10.1038/s41598-017-08827-9. [PMID: 28831075] - Stephen J Mondo, Richard O Dannebaum, Rita C Kuo, Katherine B Louie, Adam J Bewick, Kurt LaButti, Sajeet Haridas, Alan Kuo, Asaf Salamov, Steven R Ahrendt, Rebecca Lau, Benjamin P Bowen, Anna Lipzen, William Sullivan, Bill B Andreopoulos, Alicia Clum, Erika Lindquist, Christopher Daum, Trent R Northen, Govindarajan Kunde-Ramamoorthy, Robert J Schmitz, Andrii Gryganskyi, David Culley, Jon Magnuson, Timothy Y James, Michelle A O'Malley, Jason E Stajich, Joseph W Spatafora, Axel Visel, Igor V Grigoriev. Widespread adenine N6-methylation of active genes in fungi.
Nature genetics.
2017 Jun; 49(6):964-968. doi:
10.1038/ng.3859. [PMID: 28481340] - Huan Zeng, Chu-Bo Qi, Ting Liu, Hua-Ming Xiao, Qing-Yun Cheng, Han-Peng Jiang, Bi-Feng Yuan, Yu-Qi Feng. Formation and Determination of Endogenous Methylated Nucleotides in Mammals by Chemical Labeling Coupled with Mass Spectrometry Analysis.
Analytical chemistry.
2017 04; 89(7):4153-4160. doi:
10.1021/acs.analchem.7b00052. [PMID: 28271879] - Jara Teresa Parrilla-Doblas, Rafael R Ariza, Teresa Roldán-Arjona. Targeted DNA demethylation in human cells by fusion of a plant 5-methylcytosine DNA glycosylase to a sequence-specific DNA binding domain.
Epigenetics.
2017 04; 12(4):296-303. doi:
10.1080/15592294.2017.1294306. [PMID: 28277978] - Min Yu, Jianlin Lou, Hailing Xia, Min Zhang, Yixiao Zhang, Junqiang Chen, Xing Zhang, Shibo Ying, Lijin Zhu, Lihong Liu, Guang Jia. Global DNA hypomethylation has no impact on lung function or serum inflammatory and fibrosis cytokines in asbestos-exposed population.
International archives of occupational and environmental health.
2017 Apr; 90(3):265-274. doi:
10.1007/s00420-017-1195-1. [PMID: 28105512] - Anne K Ludwig, Peng Zhang, Florian D Hastert, Stephanie Meyer, Cathia Rausch, Henry D Herce, Udo Müller, Anne Lehmkuhl, Ines Hellmann, Carina Trummer, Christian Storm, Heinrich Leonhardt, M Cristina Cardoso. Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise.
Nucleic acids research.
2017 03; 45(5):2438-2457. doi:
10.1093/nar/gkw1197. [PMID: 27923996]
