Crotonosid (BioDeep_00000000311)
Secondary id: BioDeep_00000410517
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C10H13N5O5 (283.0917)
中文名称: 巴豆苷, 巴豆甙, 异鸟苷, 瑞加德松杂质17
谱图信息:
最多检出来源 Viridiplantae(plant) 14.54%
分子结构信息
SMILES: C1=NC2=C(NC(=O)N=C2N1C3C(C(C(O3)CO)O)O)N
InChI: InChI=1S/C10H13N5O5/c11-7-4-8(14-10(19)13-7)15(2-12-4)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)
描述信息
Crotonoside is a purine nucleoside.
Crotonoside is a natural product found in Croton tiglium with data available.
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 26
Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the research of AML[1].
Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the research of AML[1].
Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the research of AML[1].
同义名列表
32 个代谢物同义名
6-amino-9-((2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-3H-purin-2(9H)-one;9-?-D-Ribofuranosylisoguanine; 6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-2H-purin-2-one; 6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,9-dihydro-2H-purin-2-one; 6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-2-one; (2R,3R,4S,5R)-2-(6-Amino-2-hydroxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; 6-azanyl-9-[(2R,3R,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-1H-purin-2-one; 6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-2-one; 9H-PURIN-2-OL, 6-AMINO-9-.BETA.-D-RIBOFURANOSYL-(6C; 9H-Purin-2-ol, 6-amino-9-beta-D-ribofuranosyl-; Isoguanine, 9-.beta.-D-ribofuranosyl-; Isoguanine, 9-beta-D-ribofuranosyl-; Adenosine, 1,2-dihydro-2-oxo-; MIKUYHXYGGJMLM-UUOKFMHZSA-N; 2,3-DIHYDRO-2-OXOADENOSINE; 1,2-Dihydro-2-oxoadenosine; Crotonoside, >=95\\% (HPLC); 2-Oxoado (isoguanosine); 2-Oxo-3-hydroadenosine; Isoguanosine (7CI,8CI); 2-deoxyisoguanosine; Isoguanine riboside; Isoguanosine (VAN); 2-Hydroxyadenosine; UNII-6V7FTE1Z1V; PDSP2_000982; Isoguanosine; PDSP1_000998; Crotonoside; Crotonosid; 6V7FTE1Z1V; H5F; Isoguanosine
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:3927
- KEGG: C08432
- PubChem: 65085
- PubChem: 223996
- Metlin: METLIN66971
- ChEMBL: CHEMBL1688963
- ChEMBL: CHEMBL296017
- MeSH: isoguanosine
- ChemIDplus: 0001818719
- KNApSAcK: C00001496
- chemspider: 58595
- CAS: 1818-71-9
- CAS: 38819-11-3
- MoNA: NA001004
- MoNA: NA001006
- MoNA: NA001007
- MoNA: NA001003
- MoNA: NA001005
- medchemexpress: HY-N0071
- PMhub: MS000014773
- PubChem: 10627
- PDB-CCD: H5F
- NIKKAJI: J14.939J
- KNApSAcK: 3927
- LOTUS: LTS0081028
- wikidata: Q27106249
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 497687 - Croton tiglium: 10.1002/HLCA.193201501106
- 497687 - Croton tiglium L.: -
- 33090 - Plants: -
- 33090 - 巴豆: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chenchen Ma, Peng Liu, Siyuan Cui, Chang Gao, Xing Tan, Zhaopeng Liu, Ruirong Xu. The Identification of APOBEC3G as a Potential Prognostic Biomarker in Acute Myeloid Leukemia and a Possible Drug Target for Crotonoside.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185804. [PMID: 36144542] - Allan Weimann, George McLeod, Trine Henriksen, Vanja Cejvanovic, Henrik E Poulsen. Identification and quantification of isoguanosine in humans and mice.
Scandinavian journal of clinical and laboratory investigation.
2019 Jul; 79(4):225-232. doi:
10.1080/00365513.2019.1585566. [PMID: 30888208] - Bao Zeng, Meng-Qiu Huang, Jun-Ping Tang, Zu-Ping Xiao, Dong-Xu Jiang, Xiao-Ping Lai. [New processing procedure for Croton tiglium with study on comparison of Croton tiglium and processed product].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2012 Mar; 35(3):371-5. doi:
. [PMID: 22876673] - M L Collins, B Irvine, D Tyner, E Fine, C Zayati, C Chang, T Horn, D Ahle, J Detmer, L P Shen, J Kolberg, S Bushnell, M S Urdea, D D Ho. A branched DNA signal amplification assay for quantification of nucleic acid targets below 100 molecules/ml.
Nucleic acids research.
1997 Aug; 25(15):2979-84. doi:
10.1093/nar/25.15.2979. [PMID: 9224596]
