Gentiopicrin (BioDeep_00000000030)

 

Secondary id: BioDeep_00000398484, BioDeep_00000859833

PANOMIX_OTCML-2023


代谢物信息卡片


(5R,6S)-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-5,6-dihydropyrano[3,4-c]pyran-1(3H)-one

化学式: C16H20O9 (356.1107)
中文名称: 龙胆苦苷, 龙胆苦甙
谱图信息: 最多检出来源 Viridiplantae(plant) 56.09%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

Gentiopicrin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/gentiopicrin (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000000030). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(=C)[C@@H]1C=2C(=CO[C@H]1O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C(=O)OCC2
InChI: InChI=1S/C16H20O9/c1-2-7-8-3-4-22-14(21)9(8)6-23-15(7)25-16-13(20)12(19)11(18)10(5-17)24-16/h2-3,6-7,10-13,15-20H,1,4-5H2/t7-,10-,11-,12+,13-,15+,16+/m1/s1

描述信息

Gentiopicrin is a glycoside.
Gentiopicroside is a natural product found in Aster auriculatus, Exacum affine, and other organisms with data available.
See also: Centaurium erythraea whole (part of).

Gentiopicroside. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=20831-76-9 (retrieved 2024-07-01) (CAS RN: 20831-76-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; Gentiopicroside has anti-inflammatoryand antioxidative effects.
Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6; Gentiopicroside has anti-inflammatoryand antioxidative effects.

同义名列表

20 个代谢物同义名

(5R,6S)-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-5,6-dihydropyrano[3,4-c]pyran-1(3H)-one; (5R,6S)-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-5-vinyl-5,6-dihydropyrano[3,4-c]pyran-1(3H)-one; (3S,4R)-4-ethenyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,6-dihydro-3H-pyrano[3,4-c]pyran-8-one; (5R,6S)-5-ethenyl-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,3H,5H,6H-pyrano[3,4-c]pyran-1-one; 1H,3H-Pyrano(3,4-c)pyran-1-one, 5-ethenyl-6-(beta-D-glucopyranosyloxy)-5,6-dihydro-, (5R-trans)-; (5beta-trans)-6-(beta-D-Glucopyranosyloxy)-5,6-dihydro-5-vinyl-1H,3H-pyrano[3,4-c]pyran-1-one; (5R,6S)-5-ETHENYL-6-(.BETA.-D-GLUCOPYRANOSYLOXY)-5,6-DIHYDRO-1H,3H-PYRANO(3,4-C)PYRAN-1-ONE; (5R-trans)-6-(beta-D-Glucopyranosyloxy)-5,6-dihydro-5-vinyl-1H,3H-pyrano(3,4-c)pyran-1-one; (5R-trans)-6-(b-D-glucopyranosyloxy)-5,6-dihydro-5-vinyl-1H,3H-pyrano[3,4-c]pyran-1-one; (5R-trans)-6-(β-D-glucopyranosyloxy)-5,6-dihydro-5-vinyl-1H,3H-pyrano[3,4-c]pyran-1-one; Gentiopicroside, >=98\\% (HPLC); GENTIOPICRIN [MI]; Gentiopicrin,(S); gentiopicroside; UNII-0WE09Z21RC; MEGxp0_000872; ACon1_001284; Gentiopicrin; 0WE09Z21RC; Gentiopicrin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

50 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 BCL2, CASP1, CASP3, CAT, GRIN2B, IL18, MAPK14, NFE2L2, NLRP3, PIK3CA, PTGS2, SREBF1, VEGFA
Peripheral membrane protein 3 CYP1B1, GORASP1, PTGS2
Endoplasmic reticulum membrane 5 BCL2, CYP1B1, GRIN2B, PTGS2, SREBF1
Nucleus 8 BCL2, CASP3, MAPK14, NFE2L2, NLRP3, PPARA, SREBF1, VEGFA
cytosol 11 BCL2, CASP1, CASP3, CAT, GPT, IL18, MAPK14, NFE2L2, NLRP3, PIK3CA, SREBF1
centrosome 1 NFE2L2
nucleoplasm 5 CASP3, MAPK14, NFE2L2, PPARA, SREBF1
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 3 CASP1, GRIN2B, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 1 PIK3CA
Multi-pass membrane protein 2 GRIN2B, SREBF1
Golgi apparatus membrane 3 GORASP1, NLRP3, SREBF1
cell surface 3 GRIN2B, TNF, VEGFA
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 3 GORASP1, NFE2L2, VEGFA
Golgi membrane 4 GORASP1, INS, NLRP3, SREBF1
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 3 IL18, NFE2L2, NLRP3
Lysosome 1 GRIN2B
plasma membrane 5 CASP1, GRIN2B, NFE2L2, PIK3CA, TNF
Membrane 6 BCL2, CAT, CYP1B1, GRIN2B, NLRP3, VEGFA
caveola 1 PTGS2
extracellular exosome 2 CAT, GPT
endoplasmic reticulum 5 BCL2, NLRP3, PTGS2, SREBF1, VEGFA
extracellular space 5 IL18, IL6, INS, TNF, VEGFA
perinuclear region of cytoplasm 1 PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CAT, CYP1B1, MAPK14, NLRP3
protein-containing complex 5 BCL2, CASP1, CAT, PTGS2, SREBF1
intracellular membrane-bounded organelle 2 CAT, CYP1B1
Microsome membrane 2 CYP1B1, PTGS2
postsynaptic density 2 CASP3, GRIN2B
Secreted 5 IL18, IL6, INS, NLRP3, VEGFA
extracellular region 8 CAT, IL18, IL6, INS, MAPK14, NLRP3, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 CASP1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 GRIN2B
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 GRIN2B
focal adhesion 1 CAT
microtubule 1 CASP1
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 2 CASP1, NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 GRIN2B
Late endosome 1 GRIN2B
neuron projection 2 GRIN2B, PTGS2
chromatin 3 NFE2L2, PPARA, SREBF1
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
cytoskeleton 1 GRIN2B
spindle pole 1 MAPK14
nuclear envelope 1 SREBF1
Endomembrane system 1 NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
Cytoplasmic vesicle membrane 1 SREBF1
Cell projection, dendrite 1 GRIN2B
myelin sheath 1 BCL2
synaptic membrane 1 GRIN2B
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
postsynaptic density membrane 1 GRIN2B
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
ER to Golgi transport vesicle membrane 1 SREBF1
AIM2 inflammasome complex 1 CASP1
protein-DNA complex 1 NFE2L2
NMDA selective glutamate receptor complex 1 GRIN2B
death-inducing signaling complex 1 CASP3
canonical inflammasome complex 1 CASP1
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane 1 SREBF1
[Processed sterol regulatory element-binding protein 1]: Nucleus 1 SREBF1
[Isoform SREBP-1aDelta]: Nucleus 1 SREBF1
[Isoform SREBP-1cDelta]: Nucleus 1 SREBF1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Håvard Hoel, Hugo J de Boer, Anneleen Kool, Helle Wangensteen. Analysis of bitter compounds in traditional preparations of Gentiana purpurea L. Fitoterapia. 2024 Jun; 175(?):105932. doi: 10.1016/j.fitote.2024.105932. [PMID: 38565380]
  • Longfei Li, Qianqian Fan, Yixuan Zhao, Qian Zhang, Gaofeng Qin, Chen Li, Wei Li. Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes. Journal of orthopaedic surgery and research. 2024 Mar; 19(1):198. doi: 10.1186/s13018-024-04676-1. [PMID: 38528538]
  • Chunyu Chen, Xiaoxing Liu, Li Li, Miaomiao Guo, Yifan He, Yinmao Dong, Hong Meng, Fan Yi. Study of the mechanism by gentiopicroside protects against skin fibroblast glycation damage via the RAGE pathway. Scientific reports. 2024 02; 14(1):4685. doi: 10.1038/s41598-024-55525-4. [PMID: 38409584]
  • Bin Liu, Feng Pang, Hongsheng Bi, Dadong Guo. Regulatory mechanisms of Gentiopicroside on human diseases: a brief review. Naunyn-Schmiedeberg's archives of pharmacology. 2024 02; 397(2):725-750. doi: 10.1007/s00210-023-02672-6. [PMID: 37632552]
  • Yangyang Yin, Huanhuan Fu, Fakai Mi, Ye Yang, Yaomin Wang, Zhe Li, Yihan He, Zhenggang Yue. Genomic characterization of WRKY transcription factors related to secoiridoid biosynthesis in Gentiana macrophylla. BMC plant biology. 2024 Jan; 24(1):66. doi: 10.1186/s12870-024-04727-z. [PMID: 38262919]
  • Lemonia Antoniadi, Magdalena Bartnik, Apostolis Angelis, Anna Wawruszak, Maria Halabalaki, Wirginia Kukula-Koch, Leandros A Skaltsounis. Gentiopicroside-An Insight into Its Pharmacological Significance and Future Perspectives. Cells. 2023 12; 13(1):. doi: 10.3390/cells13010070. [PMID: 38201274]
  • Zhiyong Zhang, Nan Hao, Long Wang, Shunan Li, Xinhao Yan, Xuting Guo, Yunlan Lian, Wenlong Li. Rapid quality assessment of Gentianae Macrophyllae Radix based on near infrared spectroscopy and capillary electrophoresis. Electrophoresis. 2023 Apr; ?(?):. doi: 10.1002/elps.202300029. [PMID: 37029336]
  • Xin Xu, Tong Wei, Qianqian Xue, Jiahao Ai, Guixin Li, Zhongguo Liu, Dan Li, Jincai Hou, Hongli Jin, Yanfang Liu, Xinmiao Liang. [Analysis on quality value transmitting of Qinggusan reference sample of classical prescription based on quantitative fingerprint technology]. Se pu = Chinese journal of chromatography. 2023 Feb; 41(2):142-151. doi: 10.3724/sp.j.1123.2022.09024. [PMID: 36725710]
  • Lin Zhang, Emilie Steinbakk Ulriksen, Håvard Hoel, Lene Sandvik, Karl Egil Malterud, Kari Tvete Inngjerdingen, Marit Inngjerdingen, Helle Wangensteen. Phytochemical characterization and anti-inflammatory activity of a water extract of Gentiana purpurea roots. Journal of ethnopharmacology. 2023 Jan; 301(?):115818. doi: 10.1016/j.jep.2022.115818. [PMID: 36220509]
  • Wenqing Li, Zhengming Qian, Qinggui Lei, Yunlan Lian, Yuansheng Zou, Yonghua Wang, Dongming Lan. An ultra-rapid and eco-friendly method for determination of loganic acid and gentiopicroside from Gentianae Macrophyllae Radix by vortex-assisted matrix solid-phase dispersion extraction and LC-MS. Journal of pharmaceutical and biomedical analysis. 2023 Jan; 222(?):115085. doi: 10.1016/j.jpba.2022.115085. [PMID: 36194911]
  • Ping-Xing Qi, Shuang-Shuang Liu, Peng Zhang, Yan-Qing Xie, Zhu-Ya Yang, Afsar Khan, Lu Liu. (±)-Gentiovarisin A and gentiovarisin B, unusual secoiridoid dimer skeletons from gentiopicroside. Fitoterapia. 2023 Jan; 164(?):105392. doi: 10.1016/j.fitote.2022.105392. [PMID: 36526221]
  • Kaixuan Zhao, Siqi Pu, Liyun Sun, Dongmei Zhou. Gentiopicroside-Loaded Chitosan Nanoparticles Inhibit TNF-α-Induced Proliferation and Inflammatory Response in HaCaT Keratinocytes and Ameliorate Imiquimod-Induced Dermatitis Lesions in Mice. International journal of nanomedicine. 2023; 18(?):3781-3800. doi: 10.2147/ijn.s406649. [PMID: 37457802]
  • Guojin Ren, Qili Zhang, Pengfei Xia, Jie Wang, Pengxia Fang, Xiaojie Jin, Xuejing Peng, Yanli Xu, Jian Zhang, Lei Zhao. Synthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity. Drug design, development and therapy. 2023; 17(?):919-935. doi: 10.2147/dddt.s398861. [PMID: 36992901]
  • Miloš S Jovanović, Nemanja Krgović, Katarina Šavikin, Jelena Živković. Ultrasound-Assisted Water Extraction of Gentiopicroside, Isogentisin, and Polyphenols from Willow Gentian "Dust" Supported by Hydroxypropyl-β-Cyclodextrin as Cage Molecules. Molecules (Basel, Switzerland). 2022 Nov; 27(21):. doi: 10.3390/molecules27217606. [PMID: 36364433]
  • Na Jia, Huihui Ma, Tiejun Zhang, Lei Wang, Jia Cui, Yuanyuan Zha, Yi Ding, Jingwen Wang. Gentiopicroside attenuates collagen-induced arthritis in mice via modulating the CD147/p38/NF-κB pathway. International immunopharmacology. 2022 Jul; 108(?):108854. doi: 10.1016/j.intimp.2022.108854. [PMID: 35598398]
  • Jian-Zhi Sun, Xin Lv, Shi-Zhao Xu, Qian Cai. Determination and tissue distribution comparisons of gentiopicroside after oral administration of raw and wine-Processed Gentiana Radix. Pakistan journal of pharmaceutical sciences. 2022 Mar; 35(2):473-477. doi: ". [PMID: 35642402]
  • Syed Mudassir Jeelani, Jasvinder Singh, Arti Sharma, Gulzar A Rather, Sheikh Abid Ali, Ajai Prakash Gupta, Shashank Singh, Surrinder K Lattoo. In-vitro cytotoxicity in relation to chemotypic diversity in diploid and tetraploid populations of Gentiana kurroo Royle. Journal of ethnopharmacology. 2021 Jun; 274(?):113966. doi: 10.1016/j.jep.2021.113966. [PMID: 33647427]
  • Yan Zhang, Xiaomei Yang, Shuang Wang, Shuang Song, Xiudong Yang. Gentiopicroside prevents alcoholic liver damage by improving mitochondrial dysfunction in the rat model. Phytotherapy research : PTR. 2021 Apr; 35(4):2230-2251. doi: 10.1002/ptr.6981. [PMID: 33300653]
  • Zhijie Wan, He Li, Xiaohan Wu, Haiyun Zhao, Ran Wang, Mengmeng Li, Jing Liu, Qingfeng Liu, Rui Wang, Xiaotian Li. Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats. Life sciences. 2021 Jan; 265(?):118689. doi: 10.1016/j.lfs.2020.118689. [PMID: 33130083]
  • Stefana Cvetković, Branislav Nastasijević, Dragana Mitić-Ćulafić, Stefana Đukanović, Dina Tenji, Jelena Knežević-Vukčević, Biljana Nikolić. New insight into the antigenotoxic activity of Gentiana lutea extracts - Protective effect against food borne mutagens. Mutation research. Genetic toxicology and environmental mutagenesis. 2020 Oct; 858-860(?):503251. doi: 10.1016/j.mrgentox.2020.503251. [PMID: 33198932]
  • Yuangui Yang, Yanli Zhao, Zhitian Zuo, Ji Zhang, Yao Shi, Yuanzhong Wang. Investigation of a Medical Plant for Hepatic Diseases with Secoiridoids Using HPLC and FT-IR Spectroscopy for a Case of Gentiana rigescens. Molecules (Basel, Switzerland). 2020 Mar; 25(5):. doi: 10.3390/molecules25051219. [PMID: 32182739]
  • Haiming Xiao, Xiaohong Sun, Renbin Liu, Zhiquan Chen, Zeyuan Lin, Yan Yang, Meng Zhang, Peiqing Liu, Shijian Quan, Heqing Huang. Gentiopicroside activates the bile acid receptor Gpbar1 (TGR5) to repress NF-kappaB pathway and ameliorate diabetic nephropathy. Pharmacological research. 2020 01; 151(?):104559. doi: 10.1016/j.phrs.2019.104559. [PMID: 31759089]
  • Yanxia Huang, Jiatong Lin, Weimin Yi, Qinghua Liu, Linhui Cao, Yongcong Yan, Anqi Fu, Tingxuan Huang, Yingcheng Lyu, Qihui Huang, Jie Wang. Research on the Potential Mechanism of Gentiopicroside Against Gastric Cancer Based on Network Pharmacology. Drug design, development and therapy. 2020; 14(?):5109-5118. doi: 10.2147/dddt.s270757. [PMID: 33262572]
  • Qian Liu, Lihong Cheng, Akira Matsuura, Lan Xiang, Jianhua Qi. Gentiopicroside, a Secoiridoid Glycoside from Gentiana rigescens Franch, Extends the Lifespan of Yeast via Inducing Mitophagy and Antioxidative Stress. Oxidative medicine and cellular longevity. 2020; 2020(?):9125752. doi: 10.1155/2020/9125752. [PMID: 32832008]
  • Meiyu Jin, Haihua Feng, Yue Wang, Siru Yan, Bingyu Shen, Zheng Li, Haiyan Qin, Qi Wang, Jinxia Li, Guowen Liu. Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation. Oxidative medicine and cellular longevity. 2020; 2020(?):2940746. doi: 10.1155/2020/2940746. [PMID: 32655764]
  • Zhenyu Cheng, Haiyan Song, Yuewei Zhang, Dandan Han, Xue Yu, Qihui Shen, Fangli Zhong. Concurrent Extraction and Purification of Gentiopicroside from Gentiana scabra Bunge Using Microwave-Assisted Ethanol-Salt Aqueous Two-Phase Systems. Journal of chromatographic science. 2019 Dec; 58(1):60-74. doi: 10.1093/chromsci/bmz101. [PMID: 31845984]
  • Laura Guedes, Pedro B P S Reis, Miguel Machuqueiro, Asma Ressaissi, Rita Pacheco, Maria Luísa Serralheiro. Bioactivities of Centaurium erythraea (Gentianaceae) Decoctions: Antioxidant Activity, Enzyme Inhibition and Docking Studies. Molecules (Basel, Switzerland). 2019 Oct; 24(20):. doi: 10.3390/molecules24203795. [PMID: 31652501]
  • Nian Zhang, Yi Jiang, Fangxiang Mu, Hong Wu, Qingxia You. Gentiopicrin exerts anti-rheumatic effect in human fibroblast-like synoviocytes via inhibition of p38MAPK/NF-κB pathway. Cellular and molecular biology (Noisy-le-Grand, France). 2019 Aug; 65(6):85-90. doi: . [PMID: 31472052]
  • Ra-Yeong Choi, Sang-Jip Nam, Hae-In Lee, Jihye Lee, Alain S Leutou, Ju Ri Ham, Mi-Kyung Lee. Gentiopicroside isolated from Gentiana scabra Bge. inhibits adipogenesis in 3T3-L1 cells and reduces body weight in diet-induced obese mice. Bioorganic & medicinal chemistry letters. 2019 07; 29(14):1699-1704. doi: 10.1016/j.bmcl.2019.05.038. [PMID: 31130265]
  • Xiaohao Li, Chenglin Yang, Hao Shen. Gentiopicroside exerts convincing antitumor effects in human ovarian carcinoma cells (SKOV3) by inducing cell cycle arrest, mitochondrial mediated apoptosis and inhibition of cell migration. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2019 Jan; 24(1):280-284. doi: . [PMID: 30941981]
  • Wenna Zhou, Jian Ouyang, HongLun Wang, XiaoYan Wang. [Antidermatophyte Activity of the Gentiopicroside-Rich n-Butanol Fraction from Gentiana siphonantha Maxim. Root on a Guinea Pig Model of Dermatophytosis]. Complementary medicine research. 2019; 26(1):31-38. doi: 10.1159/000492384. [PMID: 30562737]
  • Ya-Ting Deng, Xin-Shang Wang, Ming-Gao Zhao, Xuan-Xuan Huang, Xiao-Li Xu. Gentiopicroside protects neurons from astrocyte-mediated inflammatory injuries by inhibition of nuclear factor-κB and mitogen-activated protein kinase signaling pathways. Neuroreport. 2018 09; 29(13):1114-1120. doi: 10.1097/wnr.0000000000001082. [PMID: 29958245]
  • Jie Li, Ji Zhang, Zhitian Zuo, Hengyu Huang, Yuanzhong Wang. Quantification and Discrimination of in Vitro Regeneration Swertia nervosa at Different Growth Periods using the UPLC/UV Coupled with Chemometric Method. Journal of AOAC International. 2018 Sep; 101(5):1473-1481. doi: 10.5740/jaoacint.17-0488. [PMID: 29743131]
  • Shao-Qing Yang, Ye-Dan Chen, Heng Li, Xian Hui, Wen-Yun Gao. Geniposide and Gentiopicroside Suppress Hepatic Gluconeogenesis via Regulation of AKT-FOXO1 Pathway. Archives of medical research. 2018 07; 49(5):314-322. doi: 10.1016/j.arcmed.2018.10.005. [PMID: 30409503]
  • Xia Li, Yu Zhang, Quan Jin, Kai-Li Xia, Min Jiang, Ben-Wen Cui, Yan-Ling Wu, Shun-Zong Song, Li-Hua Lian, Ji-Xing Nan. Liver kinase B1/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis. British journal of pharmacology. 2018 05; 175(9):1451-1470. doi: 10.1111/bph.14145. [PMID: 29338075]
  • Fangqing Chen, Lin Xie, Ran Kang, Rongrong Deng, Zhipeng Xi, Daoxi Sun, Jin Zhu, Liming Wang. Gentiopicroside inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and JNK signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Apr; 100(?):142-146. doi: 10.1016/j.biopha.2018.02.014. [PMID: 29428661]
  • Han Han, Lili Xu, Kai Xiong, Tong Zhang, Zhengtao Wang. Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 49(4):1304-1319. doi: 10.1159/000493409. [PMID: 30223280]
  • Yi Lu, Jiayin Yao, Chulian Gong, Bao Wang, Piao Zhou, Shaoli Zhou, Xinhua Yao. Gentiopicroside Ameliorates Diabetic Peripheral Neuropathy by Modulating PPAR- Γ/AMPK/ACC Signaling Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 50(2):585-596. doi: 10.1159/000494174. [PMID: 30308492]
  • Kai Xiong, Tingting Gao, Tong Zhang, Zhengtao Wang, Han Han. Simultaneous determination of gentiopicroside and its two active metabolites in rat plasma by LC-MS/MS and its application in pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Oct; 1065-1066(?):1-7. doi: 10.1016/j.jchromb.2017.09.017. [PMID: 28934681]
  • Beibei Xiang, Xiaoxue Li, Yan Wang, Xiaoxuan Tian, Zhen Yang, Lin Ma, Xia Liu, Yong Wang. Cloning and Characterization of Two Iridoid Synthase Homologs from Swertia Mussotii. Molecules (Basel, Switzerland). 2017 Aug; 22(8):. doi: 10.3390/molecules22081387. [PMID: 28829394]
  • Zhe Wu, Yanli Zhao, Ji Zhang, Yuanzhong Wang. Quality Assessment of Gentiana rigescens from Different Geographical Origins Using FT-IR Spectroscopy Combined with HPLC. Molecules (Basel, Switzerland). 2017 Jul; 22(7):. doi: 10.3390/molecules22071238. [PMID: 28737713]
  • Mikio Fujii, Hidehiro Ando, Kiju Konno, Motonori Fukumura, Yumiko Hori, Yasuaki Hirai, Yoshiteru Ida. Structural Revision of a Naphthodipyranodione from Gentian Root and its Degradation Pathway from Gentiopicroside. Natural product communications. 2017 Mar; 12(3):395-397. doi: ". [PMID: 30549894]
  • Shaoping Wu, Yaoyao Ning, Yingyong Zhao, Wenji Sun, Serge Thorimbert, Luc Dechoux, Matthieu Sollogoub, Yongmin Zhang. Research Progress of Natural Product Gentiopicroside - a Secoiridoid Compound. Mini reviews in medicinal chemistry. 2017; 17(1):62-77. doi: 10.2174/1389557516666160624124127. [PMID: 27342232]
  • Xiaowen Tang, Qiaoling Yang, Fan Yang, Junting Gong, Han Han, Li Yang, Zhengtao Wang. Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice. Journal of ethnopharmacology. 2016 Dec; 194(?):63-71. doi: 10.1016/j.jep.2016.08.049. [PMID: 27582267]
  • Bo-Wen Chu, Ji Zhang, Zhi-Min Li, Yan-Li Zhao, Zhi-Tian Zuo, Yuan-Zhong Wang, Wan-Yi Li. Evaluation and quantitative analysis of different growth periods of herb-arbor intercropping systems using HPLC and UV-vis methods coupled with chemometrics. Journal of natural medicines. 2016 Oct; 70(4):803-10. doi: 10.1007/s11418-016-1009-x. [PMID: 27193013]
  • Na Jia, Wei Chu, Yuwen Li, Likun Ding, Jialin Duan, Jia Cui, Shanshan Cao, Chao Zhao, Yin Wu, Aidong Wen. Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats. Journal of ethnopharmacology. 2016 Aug; 189(?):1-9. doi: 10.1016/j.jep.2016.05.027. [PMID: 27180880]
  • Yun-xia Shen, Yan-li Zhao, Ji Zhang, Hang Jin, Yuan-zhong Wang. [Study on Gentiana Rigescens with Silvomedicinal and Agriosivomedicinal Systems with FTIR Spectroscopy]. Guang pu xue yu guang pu fen xi = Guang pu. 2016 Aug; 36(8):2468-73. doi: ". [PMID: 30074348]
  • Yaping Wang, Bashir Ahmad, Baozhong Duan, Rui Zeng, Linfang Huang. Chemical and Genetic Comparative Analysis of Gentiana crassicaulis and Gentiana macrophylla. Chemistry & biodiversity. 2016 Jun; 13(6):776-81. doi: 10.1002/cbdv.201500247. [PMID: 27144464]
  • Xian-Ju Huang, Jun Li, Zhi-Yi Mei, Guoxun Chen. Gentiopicroside and sweroside from Veratrilla baillonii Franch. induce phosphorylation of Akt and suppress Pck1 expression in hepatoma cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2016 06; 94(3):270-8. doi: 10.1139/bcb-2015-0173. [PMID: 27248905]
  • Hai-lan Fang, Fei-neng Shang, Xian-ying Yang, Cong-long Xia, Bao-zhong Duan. [HPLC Analyzed the Iridoid Glycosides of Qingyedan Commonly Used in Folk Medicine in Yunnan]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Jun; 39(6):1337-40. doi: ". [PMID: 30156807]
  • Yun-Hao Dai, Man Wang, Ya-Nan Zhu, Lu-Lu Wang, Jian-Ming Ju, Zhen-Hai Zhang. [Effect of D-cellobiose on oral bioavailability of gentiopicroside]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 May; 41(10):1855-1859. doi: 10.4268/cjcmm20161015. [PMID: 28895332]
  • Yun-xia Shen, Yan-li Zhao, Ji Zhang, Yuan-zhong Wang, Qing-zhi Zhang. [Study on the Discrimination of Gentiana Rigescens with Different Processing Methods by Using FTIR Spectroscopy]. Guang pu xue yu guang pu fen xi = Guang pu. 2016 May; 36(5):1369-73. doi: ". [PMID: 30001007]
  • Yun-xia Shen, Yan-li Zhao, Ji Zhang, Zhi-tian Zuo, Yuan-zhong Wang, Qing-zhi Zhang. [Study on Different Parts of Wild and Cultivated Gentiana Rigescens with Fourier Transform Infrared Spectroscopy]. Guang pu xue yu guang pu fen xi = Guang pu. 2016 Mar; 36(3):667-71. doi: ". [PMID: 27400502]
  • Xiaoyan Cao, Xiaorong Guo, Xinbing Yang, Huaiqin Wang, Wenping Hua, Yihan He, Jiefang Kang, Zhezhi Wang. Transcriptional Responses and Gentiopicroside Biosynthesis in Methyl Jasmonate-Treated Gentiana macrophylla Seedlings. PloS one. 2016; 11(11):e0166493. doi: 10.1371/journal.pone.0166493. [PMID: 27851826]
  • Yoshiaki Amakura, Morio Yoshimura, Sara Morimoto, Takashi Yoshida, Atsuko Tada, Yusai Ito, Takeshi Yamazaki, Naoki Sugimoto, Hiroshi Akiyama. Chromatographic Evaluation and Characterization of Components of Gentian Root Extract Used as Food Additives. Chemical & pharmaceutical bulletin. 2016; 64(1):78-82. doi: 10.1248/cpb.c15-00776. [PMID: 26726749]
  • Li Zhang, Jun Dang, Li-juan Mei, Yun Shao, Qi-Ian Wang, Xue-juan Liu. [Chemical Constituents from Roots of Gentiana straminea of Tibetan Medicine]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Jan; 39(1):103-6. doi: . [PMID: 30080009]
  • Rui Zeng, Huiling Hu, Guiyou Ren, Haiping Liu, Yan Qu, Wan Hua, Zhanguo Wang. Chemical Profiling Assisted Quality Assessment of Gentianae macrophyllae by High-Performance Liquid Chromatography Using a Fused-Core Column. Journal of chromatographic science. 2015 Sep; 53(8):1274-9. doi: 10.1093/chromsci/bmu227. [PMID: 25650276]
  • Lei Zhao, Juan Ye, Guo-Tai Wu, Xue-Jing Peng, Peng-Fei Xia, Yuan Ren. Gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte. Journal of ethnopharmacology. 2015 Aug; 172(?):100-7. doi: 10.1016/j.jep.2015.06.031. [PMID: 26116164]
  • Ming Ruan, Bin Yu, Li Xu, Liang Zhang, Jun Long, Xiangchun Shen. Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall. Fitoterapia. 2015 Jun; 103(?):265-76. doi: 10.1016/j.fitote.2015.04.015. [PMID: 25936770]
  • Xiaodong Zhang, Andrew C Allan, Caixia Li, Yuanzhong Wang, Qiuyang Yao. De Novo Assembly and Characterization of the Transcriptome of the Chinese Medicinal Herb, Gentiana rigescens. International journal of molecular sciences. 2015 May; 16(5):11550-73. doi: 10.3390/ijms160511550. [PMID: 26006235]
  • Ahmed M Mustafa, Giovanni Caprioli, Massimo Ricciutelli, Filippo Maggi, Rosa Marín, Sauro Vittori, Gianni Sagratini. Comparative HPLC/ESI-MS and HPLC/DAD study of different populations of cultivated, wild and commercial Gentiana lutea L. Food chemistry. 2015 May; 174(?):426-33. doi: 10.1016/j.foodchem.2014.11.089. [PMID: 25529701]
  • Jian Lv, Wei-Liang Gu, Chang-Xun Chen. Effect of gentiopicroside on experimental acute pancreatitis induced by retrograde injection of sodium taurocholate into the biliopancreatic duct in rats. Fitoterapia. 2015 Apr; 102(?):127-33. doi: 10.1016/j.fitote.2015.03.002. [PMID: 25759121]
  • Zhigang Wang, Shuhan Tang, Yan Jin, Yan Zhang, Masao Hattori, Hailong Zhang, Ning Zhang. Two main metabolites of gentiopicroside detected in rat plasma by LC-TOF-MS following 2,4-dinitrophenylhydrazine derivatization. Journal of pharmaceutical and biomedical analysis. 2015 Mar; 107(?):1-6. doi: 10.1016/j.jpba.2014.12.003. [PMID: 25556816]
  • Yu Zeng, Xing-fu Chen, Jie Meng, Jiu-hua Song, Wen-yu Yang, Tao Cheng. [Influences of Base Fertilizer Dosage and Root Size on Quality and Yield of Gentiana crassicaulis Root]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Mar; 38(3):438-42. doi: ". [PMID: 26495639]
  • Zeyun Li, Edward Welbeck, Li Yang, Chunyong He, Haijun Hu, Ming Song, Kaishun Bi, Zhengtao Wang. A quantitative ¹H nuclear magnetic resonance (qHNMR) method for assessing the purity of iridoids and secoiridoids. Fitoterapia. 2015 Jan; 100(?):187-94. doi: 10.1016/j.fitote.2014.12.001. [PMID: 25510321]
  • Chia-Ming Lu, Lie-Chwen Lin, Tung-Hu Tsai. Determination and pharmacokinetic study of gentiopicroside, geniposide, baicalin, and swertiamarin in Chinese herbal formulae after oral administration in rats by LC-MS/MS. Molecules (Basel, Switzerland). 2014 Dec; 19(12):21560-78. doi: 10.3390/molecules191221560. [PMID: 25532849]
  • Bo Feng, Heyun Zhu, Jiao Guan, Longshan Zhao, Jingkai Gu, Lei Yin, J Paul Fawcett, Wenshu Liu. A rapid and sensitive UFLC-MS/MS method for the simultaneous determination of gentiopicroside and swertiamarin in rat plasma and its application in pharmacokinetics. The Journal of pharmacy and pharmacology. 2014 Oct; 66(10):1369-76. doi: 10.1111/jphp.12266. [PMID: 24780079]
  • Gang Fan, Wei-Zao Luo, Shang-Hua Luo, Yan Li, Xian-Li Meng, Xiang-Dong Zhou, Yi Zhang. Metabolic discrimination of Swertia mussotii and Swertia chirayita known as "Zangyinchen" in traditional Tibetan medicine by (1)H NMR-based metabolomics. Journal of pharmaceutical and biomedical analysis. 2014 Sep; 98(?):364-70. doi: 10.1016/j.jpba.2014.06.014. [PMID: 24992216]
  • Vladimir Mihailović, Jelena Katanić, Danijela Mišić, Vesna Stanković, Mirjana Mihailović, Aleksandra Uskoković, Jelena Arambašić, Slavica Solujić, Milan Mladenović, Nevena Stanković. Hepatoprotective effects of secoiridoid-rich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats. Food & function. 2014 Aug; 5(8):1795-803. doi: 10.1039/c4fo00088a. [PMID: 24912992]
  • Zhigang Wang, Shanshan Wang, Yujia Sun, Huiyu Wang, Guang Chen, Xijun Wang, Masao Hattori, Hailong Zhang. New analytical method for the study of the metabolism of gentiopicroside in rats after oral administration by LC-TOF-MS following picolinoyl derivatization. Journal of separation science. 2014 Feb; 37(3):237-43. doi: 10.1002/jssc.201300898. [PMID: 24376019]
  • Han Han, Ai-Zhen Xiong, Chun-Yong He, Qing Liu, Li Yang, Zheng-Tao Wang. Combination of UHPLC/Q-TOF-MS, NMR spectroscopy, and ECD calculation for screening and identification of reactive metabolites of gentiopicroside in humans. Analytical and bioanalytical chemistry. 2014 Feb; 406(6):1781-93. doi: 10.1007/s00216-013-7572-z. [PMID: 24408300]
  • Huiling Yang, Jianquan Liu, Shilong Chen, Fengzu Hu, Dangwei Zhou. Spatial variation profiling of four phytochemical constituents in Gentiana straminea (Gentianaceae). Journal of natural medicines. 2014 Jan; 68(1):38-45. doi: 10.1007/s11418-013-0763-2. [PMID: 23604973]
  • Wen-Liang Zeng, Wan-Kui Li, Han Han, Yan-Yan Tao, Li Yang, Zheng-Tao Wang, Kai-Xian Chen. Microbial biotransformation of gentiopicroside by the endophytic fungus Penicillium crustosum 2T01Y01. Applied and environmental microbiology. 2014 Jan; 80(1):184-92. doi: 10.1128/aem.02309-13. [PMID: 24141132]
  • Yoshihiro Suyama, Shin-Ichiro Kurimoto, Kazuyoshi Kawazoe, Kotaro Murakami, Han-Dong Sun, Shun-Lin Li, Yoshihisa Takaishi, Yoshiki Kashiwada. Rigenolide A, a new secoiridoid glucoside with a cyclobutane skeleton, and three new acylated secoiridoid glucosides from Gentiana rigescens Franch. Fitoterapia. 2013 Dec; 91(?):166-172. doi: 10.1016/j.fitote.2013.08.006. [PMID: 23994629]
  • Wenliang Zeng, Han Han, Yanyan Tao, Li Yang, Zhengtao Wang, Kaixian Chen. Identification of bio-active metabolites of gentiopicroside by UPLC/Q-TOF MS and NMR. Biomedical chromatography : BMC. 2013 Sep; 27(9):1129-36. doi: 10.1002/bmc.2917. [PMID: 23733682]
  • Bilal A Wani, D Ramamoorthy, Manzoor A Rather, N Arumugam, Asif Khurshid Qazi, Rabiya Majeed, Abid Hamid, Showkat A Ganie, Bashir A Ganai, Rajneesh Anand, Ajai P Gupta. Induction of apoptosis in human pancreatic MiaPaCa-2 cells through the loss of mitochondrial membrane potential (ΔΨm) by Gentiana kurroo root extract and LC-ESI-MS analysis of its principal constituents. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Jun; 20(8-9):723-33. doi: 10.1016/j.phymed.2013.01.011. [PMID: 23453831]
  • Yao-Li Li, Ming-Ying Shang, Chang-An Geng, Xue-Mei Zhang, Ji-Jun Chen, Shao-Qing Cai. [Simultaneous determination of five constituents in eight Qingyedan species derived from Swertia plants by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 May; 38(9):1394-400. doi: . [PMID: 23944076]
  • Bo Feng, He-Yun Zhu, Jiao Guan, Cheng-Yi Hao, Jing-Can Duan, Jing-Kai Gu. [Comparative study on pharmacokinetics of gentiopicroside and gentianae radix extract in rats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 May; 36(5):783-6. doi: ". [PMID: 24218974]
  • Vladimir Mihailović, Mirjana Mihailović, Aleksandra Uskoković, Jelena Arambašić, Danijela Mišić, Vesna Stanković, Jelena Katanić, Milan Mladenović, Slavica Solujić, Sanja Matić. Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Feb; 52(?):83-90. doi: 10.1016/j.fct.2012.10.034. [PMID: 23146698]
  • Kunchi Zhang, Shaowa Lv, Xiuyan Li, Yufei Feng, Xin Li, Lu Liu, Shuang Li, Yongji Li. Preparation, characterization, and in vivo pharmacokinetics of nanostructured lipid carriers loaded with oleanolic acid and gentiopicrin. International journal of nanomedicine. 2013; 8(?):3227-39. doi: 10.2147/ijn.s45031. [PMID: 24009420]
  • Yong Yang, Wei-Zao Luo, Xiang Liu, Chang-Hua Wang, Ji-Feng Zhao, Song-Yun Qin, Guo-Yue Zhong. [Determination and quality assessment of 10 ingredients gentiopicroside and sweroside and so on in Tibetan medicine Jia Di (Swertia chirayita)]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Oct; 37(20):3141-6. doi: . [PMID: 23311169]
  • Li Jiang, Yunfei Cai, Guangmin Xia, Fengning Xiang. Introgression of the heterologous nuclear DNAs and efficacious compositions from Swertia tetraptera Maxim. into Bupleurum scorzonerifolium Willd. via somatic hybridization. Protoplasma. 2012 Jul; 249(3):737-45. doi: 10.1007/s00709-011-0317-y. [PMID: 21956131]
  • Wan-Ling Chang-Liao, Chao-Feng Chien, Lie-Chwen Lin, Tung-Hu Tsai. Isolation of gentiopicroside from Gentianae Radix and its pharmacokinetics on liver ischemia/reperfusion rats. Journal of ethnopharmacology. 2012 Jun; 141(2):668-73. doi: 10.1016/j.jep.2011.08.001. [PMID: 21855624]
  • Qian Hou, Mei Guo, Fan Zhang, Jin-xia Zhou, Li-sha Liu. [Callus cultivation and determination of gentiopicroside from Gentiana macrophylla]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 May; 35(5):675-8. doi: . [PMID: 23213725]
  • Ming Luo, Limei Lin, Chun Li, Zhimin Wang, Wubao Guo. [Chemical constituents of Aconitum tanguticum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 May; 37(9):1245-8. doi: . [PMID: 22803369]
  • Shihu Wei, Guang Chen, Wenfei He, Haidong Chi, Hideki Abe, Koichi Yamashita, Masanori Yokoyama, Hiroyuki Kodama. Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils. Phytotherapy research : PTR. 2012 Feb; 26(2):168-73. doi: 10.1002/ptr.3496. [PMID: 21584870]
  • Zhimin Yan, Hong Hua, Yanying Xu, Lakshman P Samaranayake. Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):106583. doi: 10.1155/2012/106583. [PMID: 22454653]
  • Jing-jing Dou, Jing-hua Yan, Kun Xu, Gui Chen, Xian Hui, Da-hong Ju, Bao-hua Hao. [Transdermal delivery of Gentiana macrophylla complex components system under micro-needle conditions]. Yao xue xue bao = Acta pharmaceutica Sinica. 2011 Sep; 46(9):1137-43. doi: ". [PMID: 22121788]
  • Hong-Liang Li, Xiao-Jin Peng, Jian-Chang He, En-Fu Feng, Gui-Li Xu, Gao-Xiong Rao. Development and validation of a LC-ESI-MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jun; 879(19):1653-8. doi: 10.1016/j.jchromb.2011.04.003. [PMID: 21531636]
  • Junfeng Wang, Cuizhu Zhao, Chang Liu, Guangmin Xia, Fengning Xiang. Introgression of Swertia mussotii gene into Bupleurum scorzonerifolium via somatic hybridization. BMC plant biology. 2011 Apr; 11(?):71. doi: 10.1186/1471-2229-11-71. [PMID: 21513581]
  • Xiangyan Liang, Qiong Tian, Zhangrui Wei, Fang'e Liu, Jiankang Chen, Yufeng Zhao, Ping Qu, Xiaojun Huang, Xingchun Zhou, Nannan Liu, Fei Tian, Ru Tie, Libing Liu, Jun Yu. Effect of Feining on bleomycin-induced pulmonary injuries in rats. Journal of ethnopharmacology. 2011 Apr; 134(3):971-6. doi: 10.1016/j.jep.2011.02.008. [PMID: 21333727]
  • Yu-hong Wu, Wu Di, Zhi-jia Cui, Yue-feng Li, Li-sha Liu. [Study on the quality and genetic diversity of Gentiana macrophylla pall of different habitats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Apr; 34(4):517-9. doi: ". [PMID: 21809537]
  • Li-Hua Lian, Yan-Ling Wu, Ying Wan, Xin Li, Wen-Xue Xie, Ji-Xing Nan. Anti-apoptotic activity of gentiopicroside in D-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure. Chemico-biological interactions. 2010 Oct; 188(1):127-33. doi: 10.1016/j.cbi.2010.06.004. [PMID: 20558151]
  • Branislav Siler, Danijela Misić, Jasmina Nestorović, Tijana Banjanac, Jasmina Glamoclija, Marina Soković, Ana Cirić. Antibacterial and antifungal screening of Centaurium pulchellum crude extracts and main secoiridoid compounds. Natural product communications. 2010 Oct; 5(10):1525-30. doi: ". [PMID: 21121240]
  • Xili He, Xiaofeng Xie, Xiaodong Shao, Zhenghua Song. Sensitive determination of gentiopicroside in medicine and bio-fluids using luminol-myoglobin chemiluminescence combined with flow injection technique. Luminescence : the journal of biological and chemical luminescence. 2010 Sep; 25(5):384-8. doi: 10.1002/bio.1164. [PMID: 19743525]
  • Khuraman Mustafayeva, Carole Di Giorgio, Riad Elias, Yusif Kerimov, Evelyne Ollivier, Michel De Méo. DNA-damaging, mutagenic, and clastogenic activities of gentiopicroside isolated from Cephalaria kotschyi roots. Journal of natural products. 2010 Feb; 73(2):99-103. doi: 10.1021/np900322c. [PMID: 20055434]
  • Li-Yu Chen, Qian-Liang Chen, Dan Xu, Jian-Guo Hao, Michael Schläppi, Zi-Qin Xu. Changes of gentiopicroside synthesis during somatic embryogenesis in Gentiana macrophylla. Planta medica. 2009 Dec; 75(15):1618-24. doi: 10.1055/s-0029-1185808. [PMID: 19548190]
  • Hong Yin, Qiang Zhao, Feng-Ming Sun, Tai An. Gentiopicrin-producing endophytic fungus isolated from Gentiana macrophylla. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2009 Aug; 16(8):793-7. doi: 10.1016/j.phymed.2008.12.009. [PMID: 19200701]
  • Katarina Savikin, Nebojsa Menković, Gordana Zdunić, Tatjana Stević, Dragoja Radanović, Teodora Janković. Antimicrobial activity of Gentiana lutea L. extracts. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2009 May; 64(5-6):339-42. doi: 10.1515/znc-2009-5-606. [PMID: 19678535]