2-Chlorophenol (BioDeep_00000009769)

 

Secondary id: BioDeep_00001871317

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


2-Chloro-1-hydroxybenzene

化学式: C6H5ClO (128.002891)
中文名称: 邻氯苯酚标准溶液, 2-氯苯酚
谱图信息: 最多检出来源 Homo sapiens(blood) 0.2%

分子结构信息

SMILES: C1=CC=C(C(=C1)O)Cl
InChI: InChI=1S/C6H5ClO/c7-5-3-1-2-4-6(5)8/h1-4,8H

描述信息

同义名列表

9 个代谢物同义名

2-Chloro-1-hydroxybenzene; Ortho-monochlorophenol; Ortho-chlorophenol; O-Monochlorophenol; 2-Monochlorophenol; 2-CHLOROPHENOL; O-Chlorophenol; 2-Chlorophenol; 2-Chlorophenol



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhongfei Zhang, Puyu Yang, Boyan Gao, Guoren Huang, Man Liu, Liangli Lucy Yu. Synthesis of 2-Monochloropanol Fatty Acid Esters and Their Acute Oral Toxicities in Swiss Mice. Journal of agricultural and food chemistry. 2019 Apr; 67(13):3789-3795. doi: 10.1021/acs.jafc.9b01083. [PMID: 30874433]
  • Derya Küçük, Recep Liman. Cytogenetic and genotoxic effects of 2-chlorophenol on Allium cepa L. root meristem cells. Environmental science and pollution research international. 2018 Dec; 25(36):36117-36123. doi: 10.1007/s11356-018-3502-0. [PMID: 30357725]
  • Anping Peng, Juan Gao, Zeyou Chen, Yi Wang, Hui Li, Lena Q Ma, Cheng Gu. Interactions of Gaseous 2-Chlorophenol with Fe3+-Saturated Montmorillonite and Their Toxicity to Human Lung Cells. Environmental science & technology. 2018 05; 52(9):5208-5217. doi: 10.1021/acs.est.7b06664. [PMID: 29613777]
  • Tao Lv, Pedro N Carvalho, Mònica Escolà Casas, Ulla E Bollmann, Carlos A Arias, Hans Brix, Kai Bester. Enantioselective uptake, translocation and degradation of the chiral pesticides tebuconazole and imazalil by Phragmites australis. Environmental pollution (Barking, Essex : 1987). 2017 Oct; 229(?):362-370. doi: 10.1016/j.envpol.2017.06.017. [PMID: 28609737]
  • Satoru Okamoto, Takamasa Suzuki, Masayoshi Kawaguchi, Tetsuya Higashiyama, Yoshikatsu Matsubayashi. A comprehensive strategy for identifying long-distance mobile peptides in xylem sap. The Plant journal : for cell and molecular biology. 2015 Nov; 84(3):611-20. doi: 10.1111/tpj.13015. [PMID: 26333921]
  • Fatemeh Saberi Hosnijeh, Virissa Lenters, Daisy Boers, Lützen Portengen, Ellen Baeten, H Bas Bueno-de-Mesquita, Dick Jj Heederik, Andries C Bloem, Roel Vermeulen. Changes in lymphocyte subsets in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Occupational and environmental medicine. 2012 Nov; 69(11):781-6. doi: 10.1136/oemed-2011-100463. [PMID: 22843439]
  • J Pastor, A J Hernández. Heavy metals, salts and organic residues in old solid urban waste landfills and surface waters in their discharge areas: determinants for restoring their impact. Journal of environmental management. 2012 Mar; 95 Suppl(?):S42-9. doi: 10.1016/j.jenvman.2011.06.048. [PMID: 21764209]
  • Daisy Boers, Lützen Portengen, Wayman E Turner, H Bas Bueno-de-Mesquita, Dick Heederik, Roel Vermeulen. Plasma dioxin levels and cause-specific mortality in an occupational cohort of workers exposed to chlorophenoxy herbicides, chlorophenols and contaminants. Occupational and environmental medicine. 2012 Feb; 69(2):113-8. doi: 10.1136/oem.2010.060426. [PMID: 21810927]
  • Fatemeh Saberi Hosnijeh, Daisy Boers, Lützen Portengen, H Bas Bueno-de-Mesquita, Dick Heederik, Roel Vermeulen. Plasma Cytokine Concentrations in Workers Exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Frontiers in oncology. 2012; 2(?):37. doi: 10.3389/fonc.2012.00037. [PMID: 22655272]
  • Marcella Warner, Paolo Mocarelli, Steven Samuels, Larry Needham, Paolo Brambilla, Brenda Eskenazi. Dioxin exposure and cancer risk in the Seveso Women's Health Study. Environmental health perspectives. 2011 Dec; 119(12):1700-5. doi: 10.1289/ehp.1103720. [PMID: 21810551]
  • Xiaohui Xu, Wendy N Nembhard, Haidong Kan, Greg Kearney, Zhi-Jiang Zhang, Evelyn O Talbott. Urinary trichlorophenol levels and increased risk of attention deficit hyperactivity disorder among US school-aged children. Occupational and environmental medicine. 2011 Aug; 68(8):557-61. doi: 10.1136/oem.2010.063859. [PMID: 21540483]
  • Esther Martí, Jordi Sierra, Joan Cáliz, Genoveva Montserrat, Xavier Vila, María Antonia Garau, Robert Cruañas. Ecotoxicity of chlorophenolic compounds depending on soil characteristics. The Science of the total environment. 2011 Jun; 409(14):2707-16. doi: 10.1016/j.scitotenv.2011.03.005. [PMID: 21531445]
  • Fatemeh Saberi Hosnijeh, Daisy Boers, Lützen Portengen, H Bas Bueno-de-Mesquita, Dick Heederik, Roel Vermeulen. Long-term effects on humoral immunity among workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Occupational and environmental medicine. 2011 Jun; 68(6):419-24. doi: 10.1136/oem.2010.058016. [PMID: 21097950]
  • Darren M Roberts, Andrew H Dawson, Lalith Senarathna, Fahim Mohamed, Ron Cheng, Geoffrey Eaglesham, Nick A Buckley. Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning. Toxicology letters. 2011 Mar; 201(3):270-6. doi: 10.1016/j.toxlet.2011.01.011. [PMID: 21256202]
  • Rung R Chang, Shan L Wang, Yu M Tzou, Yue M Chen, Ming K Wang. Removal of 2-chlorophenol from water using rice-straw derived ash. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2011; 46(2):128-36. doi: 10.1080/03601234.2011.534974. [PMID: 21328121]
  • Abdul Rashid Bhat, Muhammed Afzal Wani, A R Kirmani. Brain cancer and pesticide relationship in orchard farmers of Kashmir. Indian journal of occupational and environmental medicine. 2010 Sep; 14(3):78-86. doi: 10.4103/0019-5278.75694. [PMID: 21461159]
  • Christopher B Lavery, Morgan C Macinnis, M Jason Macdonald, Joanna Bassey Williams, Colin A Spencer, Alicia A Burke, David J G Irwin, Godwin B D'Cunha. Purification of peroxidase from Horseradish (Armoracia rusticana) roots. Journal of agricultural and food chemistry. 2010 Aug; 58(15):8471-6. doi: 10.1021/jf100786h. [PMID: 20681636]
  • Dina M Schreinemachers. Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994. Environmental health : a global access science source. 2010 Feb; 9(?):11. doi: 10.1186/1476-069x-9-11. [PMID: 20187939]
  • David I McBride, Carol J Burns, G Peter Herbison, Noel F Humphry, Kenneth Bodner, James J Collins. Mortality in employees at a New Zealand agrochemical manufacturing site. Occupational medicine (Oxford, England). 2009 Jun; 59(4):255-63. doi: 10.1093/occmed/kqp030. [PMID: 19297337]
  • Shrilatha Balakrishna, Slawo Lomnicki, Kevin M McAvey, Richard B Cole, Barry Dellinger, Stephania A Cormier. Environmentally persistent free radicals amplify ultrafine particle mediated cellular oxidative stress and cytotoxicity. Particle and fibre toxicology. 2009 Apr; 6(?):11. doi: 10.1186/1743-8977-6-11. [PMID: 19374750]
  • Yuhong Su, Yongguan Zhu, Yongchao Liang. Interactions of mixed organic contaminants in uptake by rice seedlings. Chemosphere. 2009 Feb; 74(7):890-5. doi: 10.1016/j.chemosphere.2008.10.057. [PMID: 19095283]
  • Claudia Nunes, Celia Sousa, Helena Ferreira, Marlene Lucio, Jose L F C Lima, Joana Tavares, Anabela Cordeiro-da-Silva, Salette Reis. Substituted phenols as pollutants that affect membrane fluidity. Journal of environmental biology. 2008 Sep; 29(5):733-8. doi: ". [PMID: 19295073]
  • Kentaro Ohyama, Mari Ogawa, Yoshikatsu Matsubayashi. Identification of a biologically active, small, secreted peptide in Arabidopsis by in silico gene screening, followed by LC-MS-based structure analysis. The Plant journal : for cell and molecular biology. 2008 Jul; 55(1):152-60. doi: 10.1111/j.1365-313x.2008.03464.x. [PMID: 18315543]
  • Pentti Lampi, Jouko Tuomisto, Timo Hakulinen, Eero Pukkala. Follow-up study of cancer incidence after chlorophenol exposure in a community in southern Finland. Scandinavian journal of work, environment & health. 2008 Jun; 34(3):230-3. doi: 10.5271/sjweh.1242. [PMID: 18728913]
  • Yi Luo, Yun-xia Sui, Xiao-rong Wang, Yuan Tian. 2-Chlorophenol induced hydroxyl radical production in mitochondria in Carassius auratus and oxidative stress--an electron paramagnetic resonance study. Chemosphere. 2008 Apr; 71(7):1260-8. doi: 10.1016/j.chemosphere.2007.11.066. [PMID: 18262590]
  • R B Ibatullina, V A Myshkin. [Protective and restorative effect of antioxidants in experimental intoxication with chlorophenols]. Meditsina truda i promyshlennaia ekologiia. 2008; ?(5):28-31. doi: . [PMID: 18589727]
  • Li Xu, David C Spink. 1,2-Dimethylimidazole-4-sulfonyl chloride, a novel derivatization reagent for the analysis of phenolic compounds by liquid chromatography electrospray tandem mass spectrometry: application to 1-hydroxypyrene in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Aug; 855(2):159-65. doi: 10.1016/j.jchromb.2007.04.039. [PMID: 17524972]
  • Maëlle Cargouët, Daniel Perdiz, Yves Levi. Evaluation of the estrogenic potential of river and treated waters in the Paris area (France) using in vivo and in vitro assays. Ecotoxicology and environmental safety. 2007 May; 67(1):149-56. doi: 10.1016/j.ecoenv.2006.03.001. [PMID: 16638617]
  • Yu-Hong Su, Yong-Guan Zhu, Ai-Jun Lin, Xu-Hong Zhang. Effects of exposure time and co-existing organic compounds on uptake of atrazine from nutrient solution by rice seedlings (Oryza sativa L.). Journal of hazardous materials. 2007 Mar; 141(1):223-9. doi: 10.1016/j.jhazmat.2006.06.115. [PMID: 16890347]
  • Stephen P Muench, Sean T Prigge, Rima McLeod, John B Rafferty, Michael J Kirisits, Craig W Roberts, Ernest J Mui, David W Rice. Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents. Acta crystallographica. Section D, Biological crystallography. 2007 Mar; 63(Pt 3):328-38. doi: 10.1107/s0907444906053625. [PMID: 17327670]
  • Christelle Briois, Shawn Ryan, Dennis Tabor, Abderrahmane Touati, Brian K Gullett. Formation of polychlorinated dibenzo-p-dioxins and dibenzofurans from a mixture of chlorophenols over fly ash: influence of water vapor. Environmental science & technology. 2007 Feb; 41(3):850-6. doi: 10.1021/es0613761. [PMID: 17328193]
  • D M Roberts, N A Buckley. Urinary alkalinisation for acute chlorophenoxy herbicide poisoning. The Cochrane database of systematic reviews. 2007 Jan; ?(1):CD005488. doi: 10.1002/14651858.cd005488.pub2. [PMID: 17253558]
  • Yi Luo, Yan Su, Ren-Zhang Lin, Hua-Hong Shi, Xiao-Rong Wang. 2-chlorophenol induced ROS generation in fish Carassius auratus based on the EPR method. Chemosphere. 2006 Nov; 65(6):1064-73. doi: 10.1016/j.chemosphere.2006.02.054. [PMID: 16620909]
  • Brancilene Santos de Araujo, Jerzy Dec, Jean Marc Bollag, Marcia Pletsch. Uptake and transformation of phenol and chlorophenols by hairy root cultures of Daucus carota, Ipomoea batatas and Solanum aviculare. Chemosphere. 2006 Apr; 63(4):642-51. doi: 10.1016/j.chemosphere.2005.08.005. [PMID: 16364403]
  • Yu-Hong Su, Yong-Guan Zhu. Bioconcentration of atrazine and chlorophenols into roots and shoots of rice seedlings. Environmental pollution (Barking, Essex : 1987). 2006 Jan; 139(1):32-9. doi: 10.1016/j.envpol.2005.04.035. [PMID: 15993528]
  • Ryuichi Hasegawa, Mutsuko Hirata-Koizumi, Mika Takahashi, Eiichi Kamata, Makoto Ema. Comparative susceptibility of newborn and young rats to six industrial chemicals. Congenital anomalies. 2005 Dec; 45(4):137-45. doi: 10.1111/j.1741-4520.2005.00083.x. [PMID: 16359494]
  • Darren M Roberts, Ruwan Seneviratne, Fahim Mohammed, Renu Patel, Lalith Senarathna, Ariyasena Hittarage, Nick A Buckley, Andrew H Dawson, Michael Eddleston. Intentional self-poisoning with the chlorophenoxy herbicide 4-chloro-2-methylphenoxyacetic acid (MCPA). Annals of emergency medicine. 2005 Sep; 46(3):275-84. doi: 10.1016/j.annemergmed.2005.03.016. [PMID: 16126140]
  • V S Baxter-Plant, I P Mikheenko, M Robson, S J Harrad, L E Macaskie. Dehalogenation of chlorinated aromatic compounds using a hybrid bioinorganic catalyst on cells of Desulfovibrio desulfuricans. Biotechnology letters. 2004 Dec; 26(24):1885-90. doi: 10.1007/s10529-004-6039-x. [PMID: 15672233]
  • Christina C Lawson, Teresa M Schnorr, Elizabeth A Whelan, James A Deddens, David A Dankovic, Laurie A Piacitelli, Marie H Sweeney, L Barbara Connally. Paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and birth outcomes of offspring: birth weight, preterm delivery, and birth defects. Environmental health perspectives. 2004 Oct; 112(14):1403-8. doi: 10.1289/ehp.7051. [PMID: 15471733]
  • Antonio Lallai, Giampaolo Mura. Biodegradation of 2-chlorophenol in forest soil: effect of inoculation with aerobic sewage sludge. Environmental toxicology and chemistry. 2004 Feb; 23(2):325-30. doi: 10.1897/02-419. [PMID: 14982378]
  • Sally M Bradberry, Alex T Proudfoot, J Allister Vale. Poisoning due to chlorophenoxy herbicides. Toxicological reviews. 2004; 23(2):65-73. doi: 10.2165/00139709-200423020-00001. [PMID: 15578861]
  • A T Proudfoot, E P Krenzelok, J A Vale. Position Paper on urine alkalinization. Journal of toxicology. Clinical toxicology. 2004; 42(1):1-26. doi: 10.1081/clt-120028740. [PMID: 15083932]
  • Chao-Chien Chang, Szu-Kung Tseng, Chih-Cheng Chang, Chun-Ming Ho. Reductive dechlorination of 2-chlorophenol in a hydrogenotrophic, gas-permeable, silicone membrane bioreactor. Bioresource technology. 2003 Dec; 90(3):323-8. doi: 10.1016/s0960-8524(03)00149-4. [PMID: 14575956]
  • Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chemical research in toxicology. 2003 Oct; 16(10):1338-58. doi: 10.1021/tx030011g. [PMID: 14565775]
  • H J Jones, D I Vernon, S B Brown. Photodynamic therapy effect of m-THPC (Foscan) in vivo: correlation with pharmacokinetics. British journal of cancer. 2003 Jul; 89(2):398-404. doi: 10.1038/sj.bjc.6601101. [PMID: 12865935]
  • B Antizar-Ladislao, N I Galil. Simulation of bioremediation of chlorophenols in a sandy aquifer. Water research. 2003 Jan; 37(1):238-44. doi: 10.1016/s0043-1354(02)00106-9. [PMID: 12465806]
  • N V Zaitseva, T S Ulanova, T V Nurislamova, N A Popova, E A Rudakova. [Gas chromatographic determination of 2-chlorophenol traces in biological fluids]. Gigiena i sanitariia. 2002 May; ?(3):73-4. doi: NULL. [PMID: 12198915]
  • L Bertin, M Majone, D Di Gioia, F Fava. An aerobic fixed-phase biofilm reactor system for the degradation of the low-molecular weight aromatic compounds occurring in the effluents of anaerobic digestors treating olive mill wastewaters. Journal of biotechnology. 2001 May; 87(2):161-77. doi: 10.1016/s0168-1656(01)00236-x. [PMID: 11278039]
  • V F Garry, R E Tarone, I R Kirsch, J M Abdallah, D P Lombardi, L K Long, B L Burroughs, D B Barr, J S Kesner. Biomarker correlations of urinary 2,4-D levels in foresters: genomic instability and endocrine disruption. Environmental health perspectives. 2001 May; 109(5):495-500. doi: 10.1289/ehp.01109495. [PMID: 11401761]
  • P C Kao, J H Tzeng, T L Huang. Removal of chlorophenols from aqueous solution by fly ash. Journal of hazardous materials. 2000 Sep; 76(2-3):237-49. doi: 10.1016/s0304-3894(00)00201-6. [PMID: 10936536]
  • J H Greenberg, A Mellors, J C McGowan. Molar volume relationships and the specific inhibition of a synaptosomal enzyme by psychoactive cannabinoids. Journal of medicinal chemistry. 1978 Dec; 21(12):1208-12. doi: 10.1021/jm00210a007. [PMID: 722729]
  • P Weidmann, C Beretta-Piccoli, W Ziegler, D Hirsch, R D de Châtel, F C Reubi. [Interrelations between blood pressure, blood volume, plasma renin and urinary catecholamines during beta-blockade in essential hypertension (author's transl)]. Klinische Wochenschrift. 1976 Aug; 54(16):765-73. doi: 10.1007/bf01614293. [PMID: 8663]