1-EBIO (BioDeep_00000009615)
代谢物信息卡片
化学式: C9H10N2O (162.0793)
中文名称: 1-乙基-1,3-二氢-2H-苯并咪唑-2-酮, 1-乙基-2-苯并咪唑啉酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCn1c(O)nc2ccccc21
InChI: InChI=1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)
描述信息
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents > D002120 - Calcium Channel Agonists
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:34076
- KEGG: C13840
- PubChem: 82320
- Metlin: METLIN69727
- ChEMBL: CHEMBL452887
- CAS: 10045-45-1
- PMhub: MS000023417
- PubChem: 854085
- PDB-CCD: 0W8
- NIKKAJI: J241.245D
- RefMet: 1-Ethyl-2-benzimidazolinone
- KNApSAcK: 34076
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhifei Shao, Rohit Gaurav, Devendra K Agrawal. Intermediate-conductance calcium-activated potassium channel KCa3.1 and chloride channel modulate chemokine ligand (CCL19/CCL21)-induced migration of dendritic cells.
Translational research : the journal of laboratory and clinical medicine.
2015 Jul; 166(1):89-102. doi:
10.1016/j.trsl.2014.11.010. [PMID: 25583444] - C Hougaard, M O Fraser, C Chien, A Bookout, M Katofiasc, B S Jensen, F Rode, J Bitsch-Nørhave, L Teuber, K B Thor, D Strøbaek, E C Burgard, L C B Rønn. A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo.
The Journal of pharmacology and experimental therapeutics.
2009 Jan; 328(1):28-39. doi:
10.1124/jpet.108.143123. [PMID: 18820135] - Ralf Köhler, Ines Eichler, Herdis Schönfelder, Ivica Grgic, Philipp Heinau, Han Si, Joachim Hoyer. Impaired EDHF-mediated vasodilation and function of endothelial Ca-activated K channels in uremic rats.
Kidney international.
2005 Jun; 67(6):2280-7. doi:
10.1111/j.1523-1755.2005.00331.x. [PMID: 15882269] - Ayotunde S O Adeagbo, Irving G Joshua, Cameron Falkner, Paul J Matheson. Tempol, an antioxidant, restores endothelium-derived hyperpolarizing factor-mediated vasodilation during hypertension.
European journal of pharmacology.
2003 Nov; 481(1):91-100. doi:
10.1016/j.ejphar.2003.09.005. [PMID: 14637180] - Yasushi Ito, Shinji Sato, Masami Son, Hiroaki Kume, Kenzo Takagi, Kenichi Yamaki. Bioelectric toxicity caused by chlorpromazine in human lung epithelial cells.
Toxicology and applied pharmacology.
2002 Sep; 183(3):198-206. doi:
10.1006/taap.2002.9486. [PMID: 12383711] - J R Broughman, K E Mitchell, R L Sedlacek, T Iwamoto, J M Tomich, B D Schultz. NH(2)-terminal modification of a channel-forming peptide increases capacity for epithelial anion secretion.
American journal of physiology. Cell physiology.
2001 Mar; 280(3):C451-8. doi:
10.1152/ajpcell.2001.280.3.c451. [PMID: 11171563] - K A Pedersen, R L Schrøder, B Skaaning-Jensen, D Strøbaek, S P Olesen, P Christophersen. Activation of the human intermediate-conductance Ca(2+)-activated K(+) channel by 1-ethyl-2-benzimidazolinone is strongly Ca(2+)-dependent.
Biochimica et biophysica acta.
1999 Aug; 1420(1-2):231-40. doi:
10.1016/s0005-2736(99)00110-8. [PMID: 10446306] - A Schwab, B Schuricht, P Seeger, J Reinhardt, P C Dartsch. Migration of transformed renal epithelial cells is regulated by K+ channel modulation of actin cytoskeleton and cell volume.
Pflugers Archiv : European journal of physiology.
1999 Aug; 438(3):330-7. doi:
10.1007/s004240050917. [PMID: 10398863] - B S Jensen, D Strobaek, P Christophersen, T D Jorgensen, C Hansen, A Silahtaroglu, S P Olesen, P K Ahring. Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel.
The American journal of physiology.
1998 09; 275(3):C848-56. doi:
10.1152/ajpcell.1998.275.3.c848. [PMID: 9730970]
