2-Amino-5-phosphonopentanoic acid (BioDeep_00000009539)
Secondary id: BioDeep_00001872257
human metabolite blood metabolite
代谢物信息卡片
2-Amino-5-phosphonopentanoic acid
化学式: C5H12NO5P (197.0453)
中文名称: DL-2-氨基-5-膦酰基戊酸
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: C(CC(C(=O)O)N)CP(=O)(O)O
InChI: InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
描述信息
DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina[1][2][3].
同义名列表
15 个代谢物同义名
2-Amino-5-phosphonopentanoic acid; 2-Amino-5-phosphopentanoic acid; 2-Amino-5-phosphonovaleric acid; 2-Amino-5-phosphovaleric acid; 2-Amino-5-phosphonopentanoate; 2-Amino-5-phosphonovalerate; 2-Amino-5-phosphopentanoate; 2-Amino-5-phosphovalerate; 5-Phosphononorvaline; APP acid; APV acid; DL-AP5; 2-APV; DL-2-Amino-5-phosphonovaleric acid; 2-Amino-5-phosphopentanoic acid
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:138644
- KEGG: C13734
- PubChem: 1216
- HMDB: HMDB0247376
- Metlin: METLIN69668
- ChEMBL: CHEMBL28862
- chemspider: 1179
- CAS: 79055-67-7
- CAS: 76326-31-3
- CAS: 76726-92-6
- PMhub: MS000023332
- PubChem: 586323
- NIKKAJI: J228.033G
- medchemexpress: HY-100714
- KNApSAcK: 138644
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Eric G Krause, Dipanwita Pati, Charles J Frazier. Chronic salt-loading reduces basal excitatory input to CRH neurons in the paraventricular nucleus and accelerates recovery from restraint stress in male mice.
Physiology & behavior.
2017 Jul; 176(?):189-194. doi:
10.1016/j.physbeh.2017.03.038. [PMID: 28351560] - Daniel Radzicki, Sarah L Pollema-Mays, Antonio Sanz-Clemente, Marco Martina. Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2017 03; 37(9):2292-2304. doi:
10.1523/jneurosci.1553-16.2017. [PMID: 28137966] - Hong Zheng, Xuefei Liu, Yulong Li, Kaushik P Patel. A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity.
Neural plasticity.
2017; 2017(?):2361675. doi:
10.1155/2017/2361675. [PMID: 28845307] - Marco I González, Heidi L Grabenstatter, Christian A Cea-Del Rio, Yasmin Cruz Del Angel, Jessica Carlsen, Rick P Laoprasert, Andrew M White, Molly M Huntsman, Amy Brooks-Kayal. Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
Neurobiology of disease.
2015 May; 77(?):246-56. doi:
10.1016/j.nbd.2015.03.001. [PMID: 25769812] - Jing Ding, Chen Huang, Zhong Peng, Yuxuan Xie, Shining Deng, Yan-Zhen Nie, Tian-Le Xu, Wei-Hong Ge, Wei-Guang Li, Fei Li. Electrophysiological characterization of methyleugenol: a novel agonist of GABA(A) receptors.
ACS chemical neuroscience.
2014 Sep; 5(9):803-11. doi:
10.1021/cn500022e. [PMID: 24980777] - Hui-Fang Chiu, Jen-Kun Cheng, Pu-Hua Lin, Jung-Chen Chang, I-Ming Chen, Ching-I Lin, Wei-Pin Chang, Chia-Hsien Lin. A mechanistic study on urine retention in d-amphetamine addicts.
The Chinese journal of physiology.
2014 Aug; 57(4):171-81. doi:
10.4077/cjp.2014.bac198. [PMID: 25246058] - V-S Eckle, B Antkowiak. ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn.
Neuroscience.
2013 Dec; 253(?):165-71. doi:
10.1016/j.neuroscience.2013.08.042. [PMID: 23994185] - Walid Jalabi, Cornelia Kopp-Scheinpflug, Paul D Allen, Emanuele Schiavon, Rita R DiGiacomo, Ian D Forsythe, Stephen M Maricich. Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Sep; 33(38):15044-9. doi:
10.1523/jneurosci.2604-13.2013. [PMID: 24048834] - Shengyuan Ding, Li Li, Fu-Ming Zhou. Presynaptic serotonergic gating of the subthalamonigral glutamatergic projection.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Mar; 33(11):4875-85. doi:
10.1523/jneurosci.4111-12.2013. [PMID: 23486958] - Richardson N Leão, Sanja Mikulovic, Katarina E Leão, Hermany Munguba, Henrik Gezelius, Anders Enjin, Kalicharan Patra, Anders Eriksson, Leslie M Loew, Adriano B L Tort, Klas Kullander. OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.
Nature neuroscience.
2012 Nov; 15(11):1524-30. doi:
10.1038/nn.3235. [PMID: 23042082] - Yaping Ji, Bin Tang, Dong-Yuan Cao, Gexin Wang, Richard J Traub. Sex differences in spinal processing of transient and inflammatory colorectal stimuli in the rat.
Pain.
2012 Sep; 153(9):1965-1973. doi:
10.1016/j.pain.2012.06.019. [PMID: 22819535] - Chiung-Chun Huang, Jia-Peng Chen, Che-Ming Yeh, Kuei-Sen Hsu. Sex difference in stress-induced enhancement of hippocampal CA1 long-term depression during puberty.
Hippocampus.
2012 Jul; 22(7):1622-34. doi:
10.1002/hipo.21003. [PMID: 22231803] - Liang-Wu Fu, Zhi-Ling Guo, John C Longhurst. Ionotropic glutamate receptors in the external lateral parabrachial nucleus participate in processing cardiac sympathoexcitatory reflexes.
American journal of physiology. Heart and circulatory physiology.
2012 Apr; 302(7):H1444-53. doi:
10.1152/ajpheart.00984.2011. [PMID: 22268111] - Ayelet Orenbuch, Lee Shalev, Vincenzo Marra, Isaac Sinai, Yotam Lavy, Joy Kahn, Jemima J Burden, Kevin Staras, Daniel Gitler. Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Mar; 32(12):3969-80. doi:
10.1523/jneurosci.5058-11.2012. [PMID: 22442064] - Tamra Llewellyn, Hong Zheng, Xuefei Liu, Bo Xu, Kaushik P Patel. Median preoptic nucleus and subfornical organ drive renal sympathetic nerve activity via a glutamatergic mechanism within the paraventricular nucleus.
American journal of physiology. Regulatory, integrative and comparative physiology.
2012 Feb; 302(4):R424-32. doi:
10.1152/ajpregu.00403.2011. [PMID: 22160544] - Yi Dong, Wen Zhang, Bin Lai, Wen-Jie Luan, Yan-Hua Zhu, Bing-Qiao Zhao, Ping Zheng. Two free radical pathways mediate chemical hypoxia-induced glutamate release in synaptosomes from the prefrontal cortex.
Biochimica et biophysica acta.
2012 Feb; 1823(2):493-504. doi:
10.1016/j.bbamcr.2011.10.004. [PMID: 22057390] - Atsushi Takeda, Haruna Tamano, Miki Suzuki, Kazuhiro Sakamoto, Naoto Oku, Hidehiko Yokogoshi. Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response.
Cellular and molecular neurobiology.
2012 Jan; 32(1):41-8. doi:
10.1007/s10571-011-9732-z. [PMID: 21739364] - Eiji Shigetomi, Xiaoping Tong, Kelvin Y Kwan, David P Corey, Baljit S Khakh. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.
Nature neuroscience.
2011 Dec; 15(1):70-80. doi:
10.1038/nn.3000. [PMID: 22158513] - Winfried Neuhaus, Michael Freidl, Phillip Szkokan, Michael Berger, Michael Wirth, Johannes Winkler, Franz Gabor, Christian Pifl, Christian R Noe. Effects of NMDA receptor modulators on a blood-brain barrier in vitro model.
Brain research.
2011 Jun; 1394(?):49-61. doi:
10.1016/j.brainres.2011.04.003. [PMID: 21549356] - Eugene Dimitrov, Ted Björn Usdin. Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons.
The Journal of comparative neurology.
2010 Nov; 518(21):4375-94. doi:
10.1002/cne.22462. [PMID: 20853513] - T Watanabe, Y Tsuboi, B J Sessle, K Iwata, J W Hu. P2X and NMDA receptor involvement in temporomandibular joint-evoked reflex activity in rat jaw muscles.
Brain research.
2010 Jul; 1346(?):83-91. doi:
10.1016/j.brainres.2010.05.055. [PMID: 20501327] - Yelenis Mari, Christopher Katnik, Javier Cuevas. ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis.
Cell calcium.
2010 Jul; 48(1):70-82. doi:
10.1016/j.ceca.2010.07.002. [PMID: 20678793] - Magaly Rincon-Zachary. A possible mechanism and sequence of events that lead to the Al3+-induced [Ca2+]cyt transients and inhibition of root growth.
Plant signaling & behavior.
2010 Jul; 5(7):881-4. doi:
10.4161/psb.5.7.11973. [PMID: 20495379] - Fenglian Xu, Juliane Proft, Sarah Gibbs, Bob Winkfein, Jadah N Johnson, Naweed Syed, Janice E A Braun. Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmission.
PloS one.
2010 Jun; 5(6):e11045. doi:
10.1371/journal.pone.0011045. [PMID: 20548785] - Magaly Rincón-Zachary, Neal D Teaster, J Alan Sparks, Aline H Valster, Christy M Motes, Elison B Blancaflor. Fluorescence resonance energy transfer-sensitized emission of yellow cameleon 3.60 reveals root zone-specific calcium signatures in Arabidopsis in response to aluminum and other trivalent cations.
Plant physiology.
2010 Mar; 152(3):1442-58. doi:
10.1104/pp.109.147256. [PMID: 20053711] - Hwan-Ching Tai, Henrike Besche, Alfred L Goldberg, Erin M Schuman. Characterization of the Brain 26S Proteasome and its Interacting Proteins.
Frontiers in molecular neuroscience.
2010; 3(?):. doi:
10.3389/fnmol.2010.00012. [PMID: 20717473] - Christophe Lachaud, Daniel Da Silva, Valérie Cotelle, Patrice Thuleau, Tou Cheu Xiong, Alain Jauneau, Christian Brière, Annick Graziana, Yannick Bellec, Jean-Denis Faure, Raoul Ranjeva, Christian Mazars. Nuclear calcium controls the apoptotic-like cell death induced by d-erythro-sphinganine in tobacco cells.
Cell calcium.
2010 Jan; 47(1):92-100. doi:
10.1016/j.ceca.2009.11.011. [PMID: 20022633] - A Blot, D Billups, M Bjørkmo, A Z Quazi, N M Uwechue, F A Chaudhry, B Billups. Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons.
Neuroscience.
2009 Dec; 164(3):998-1008. doi:
10.1016/j.neuroscience.2009.09.015. [PMID: 19751803] - Takayuki Ohnishi, Shinji Matsumura, Seiji Ito. Translocation of neuronal nitric oxide synthase to the plasma membrane by ATP is mediated by P2X and P2Y receptors.
Molecular pain.
2009 Jul; 5(?):40. doi:
10.1186/1744-8069-5-40. [PMID: 19619286] - Haijun Zhang, Wenjun Xin, Patrick M Dougherty. Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes.
Molecular pain.
2009 Jul; 5(?):36. doi:
10.1186/1744-8069-5-36. [PMID: 19570219] - Thomas P Jensen, Lucy E Buckby, Ruth M Empson. Reduced expression of the 'fast' calcium transporter PMCA2a during homeostatic plasticity.
Molecular and cellular neurosciences.
2009 Jul; 41(3):364-72. doi:
10.1016/j.mcn.2009.04.011. [PMID: 19410650] - Mikael Egebjerg Pedersen, Henrik Tang Vestergaard, Gary Ivan Stafford, Johannes van Staden, Anna K Jäger. The effect of extracts of Searsia species on epileptiform activity in slices of the mouse cerebral cortex.
Journal of ethnopharmacology.
2008 Oct; 119(3):538-41. doi:
10.1016/j.jep.2008.08.009. [PMID: 18773951] - Rodrigo C A de Menezes, Dmitry V Zaretsky, Sumit Sarkar, Marco A P Fontes, Joseph A Dimicco. Microinjection of muscimol into the periaqueductal gray suppresses cardiovascular and neuroendocrine response to air jet stress in conscious rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Sep; 295(3):R881-90. doi:
10.1152/ajpregu.00181.2008. [PMID: 18650321] - Shu Yan Yu, Dong Chuan Wu, Lidong Liu, Yuan Ge, Yu Tian Wang. Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdala.
Journal of neurochemistry.
2008 Jul; 106(2):889-99. doi:
10.1111/j.1471-4159.2008.05461.x. [PMID: 18466342] - Lavan Sornarajah, Oana Cristina Vasuta, Lily Zhang, Christine Sutton, Bo Li, Alaa El-Husseini, Lynn A Raymond. NMDA receptor desensitization regulated by direct binding to PDZ1-2 domains of PSD-95.
Journal of neurophysiology.
2008 Jun; 99(6):3052-62. doi:
10.1152/jn.90301.2008. [PMID: 18400955] - Chih-Ching Yang, Chiang-Ting Chien, Ming-Hsiou Wu, Ming-Chieh Ma, Chau-Fong Chen. NMDA receptor blocker ameliorates ischemia-reperfusion-induced renal dysfunction in rat kidneys.
American journal of physiology. Renal physiology.
2008 Jun; 294(6):F1433-40. doi:
10.1152/ajprenal.00481.2007. [PMID: 18272600] - C Thetford Smothers, John J Woodward. Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.
The Journal of pharmacology and experimental therapeutics.
2007 Aug; 322(2):739-48. doi:
10.1124/jpet.107.123836. [PMID: 17502428] - Itziar Igartua, José M Solís, Julián Bustamante. Glycine-induced long-term synaptic potentiation is mediated by the glycine transporter GLYT1.
Neuropharmacology.
2007 Jun; 52(8):1586-95. doi:
10.1016/j.neuropharm.2007.03.003. [PMID: 17462677] - Steven P Braithwaite, Michael Adkisson, John Leung, Adrian Nava, Brett Masterson, Roman Urfer, Donna Oksenberg, Karoly Nikolich. Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP).
The European journal of neuroscience.
2006 Jun; 23(11):2847-56. doi:
10.1111/j.1460-9568.2006.04837.x. [PMID: 16819973] - K Ulrich Bayer, Eric LeBel, Greg L McDonald, Heather O'Leary, Howard Schulman, Paul De Koninck. Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 Jan; 26(4):1164-74. doi:
10.1523/jneurosci.3116-05.2006. [PMID: 16436603] - M Leonetti, C Desvignes, I Bougault, J Souilhac, F Oury-Donat, R Steinberg. 2-Chloro-N-[(S)-phenyl [(2S)-piperidin-2-yl] methyl]-3-trifluoromethyl benzamide, monohydrochloride, an inhibitor of the glycine transporter type 1, increases evoked-dopamine release in the rat nucleus accumbens in vivo via an enhanced glutamatergic neurotransmission.
Neuroscience.
2006; 137(2):555-64. doi:
10.1016/j.neuroscience.2005.09.003. [PMID: 16289893] - Kerstin Wirkner, Attila Köfalvi, Wolfgang Fischer, Albrecht Günther, Heike Franke, Helke Gröger-Arndt, Wolfgang Nörenberg, Emília Madarász, E Sylvester Vizi, Dietmar Schneider, Beáta Sperlágh, Peter Illes. Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia.
Journal of neurochemistry.
2005 Dec; 95(5):1421-37. doi:
10.1111/j.1471-4159.2005.03465.x. [PMID: 16313518] - Zhong Xie, Richard L Huganir, Peter Penzes. Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6.
Neuron.
2005 Nov; 48(4):605-18. doi:
10.1016/j.neuron.2005.09.027. [PMID: 16301177] - An Torremans, Bart Marescau, Debby Van Dam, Chris Van Ginneken, Frans Van Meir, Pierre-Paul Van Bogaert, Rudi D'Hooge, Jan de Vente, Peter Paul De Deyn. GSA: behavioral, histological, electrophysiological and neurochemical effects.
Physiology & behavior.
2005 Feb; 84(2):251-64. doi:
10.1016/j.physbeh.2004.12.001. [PMID: 15708777] - So Young Kang, Ki Yong Lee, Sang Hyun Sung, Young Choong Kim. Four new neuroprotective dihydropyranocoumarins from Angelica gigas.
Journal of natural products.
2005 Jan; 68(1):56-9. doi:
10.1021/np049705v. [PMID: 15679317] - Hiroyuki W Kitamura, Hiroki Hamanaka, Masahiko Watanabe, Koji Wada, Chiharu Yamazaki, Shinobu C Fujita, Toshiya Manabe, Nobuyuki Nukina. Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E.
Neuroscience letters.
2004 Oct; 369(3):173-8. doi:
10.1016/j.neulet.2004.07.084. [PMID: 15464259] - Ernst Seiffert, Jens P Dreier, Sebastian Ivens, Ingo Bechmann, Oren Tomkins, Uwe Heinemann, Alon Friedman. Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004 Sep; 24(36):7829-36. doi:
10.1523/jneurosci.1751-04.2004. [PMID: 15356194] - Rachel Hopper, Barrie Lancaster, John Garthwaite. On the regulation of NMDA receptors by nitric oxide.
The European journal of neuroscience.
2004 Apr; 19(7):1675-82. doi:
10.1111/j.1460-9568.2004.03306.x. [PMID: 15078541] - F J P Miao, P G Green, N Benowitz, J D Levine. Central terminals of nociceptors are targets for nicotine suppression of inflammation.
Neuroscience.
2004; 123(3):777-84. doi:
10.1016/j.neuroscience.2003.10.027. [PMID: 14706790] - Shaul Feldman, Joseph Weidenfeld. Involvement of endogeneous glutamate in the stimulatory effect of norepinephrine and serotonin on the hypothalamo-pituitary-adrenocortical axis.
Neuroendocrinology.
2004 Jan; 79(1):43-53. doi:
10.1159/000076044. [PMID: 14755133] - Frantisek St'astný, Václav Lisý, Vladislav Mares, Vera Lisá, Vladimir J Balcar, Abel Santamaría. Quinolinic acid induces NMDA receptor-mediated lipid peroxidation in rat brain microvessels.
Redox report : communications in free radical research.
2004; 9(4):229-33. doi:
10.1179/135100004225006001. [PMID: 15479567] - Jian-Xiang Liu, Ji-Zeng Du, Sayaka Asai, Zhan-Quan Shi, Gen Watanabe, Kazuyoshi Taya. NMDA receptor antagonists reduce restraint-induced release of prolactin in male rats.
Neuro endocrinology letters.
2003 Dec; 24(6):435-9. doi:
NULL. [PMID: 15073571] - Micaela Zonta, Annalisa Sebelin, Sara Gobbo, Tommaso Fellin, Tullio Pozzan, Giorgio Carmignoto. Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes.
The Journal of physiology.
2003 Dec; 553(Pt 2):407-14. doi:
10.1113/jphysiol.2003.046706. [PMID: 14500777] - Xiang Yu, Robert C Malenka. Beta-catenin is critical for dendritic morphogenesis.
Nature neuroscience.
2003 Nov; 6(11):1169-77. doi:
10.1038/nn1132. [PMID: 14528308] - Qing Hui Chen, Joseph R Haywood, Glenn M Toney. Sympathoexcitation by PVN-injected bicuculline requires activation of excitatory amino acid receptors.
Hypertension (Dallas, Tex. : 1979).
2003 Oct; 42(4):725-31. doi:
10.1161/01.hyp.0000085197.20043.44. [PMID: 12900439] - Ryota Taguchi, Hiroyuki Nishikawa, Toshiaki Kume, Taro Terauchi, Shuji Kaneko, Hiroshi Katsuki, Masahiro Yonaga, Hachiro Sugimoto, Akinori Akaike. Serofendic acid prevents acute glutamate neurotoxicity in cultured cortical neurons.
European journal of pharmacology.
2003 Sep; 477(3):195-203. doi:
10.1016/j.ejphar.2003.08.027. [PMID: 14522357] - Mayandi Sivaguru, Sharon Pike, Walter Gassmann, Tobias I Baskin. Aluminum rapidly depolymerizes cortical microtubules and depolarizes the plasma membrane: evidence that these responses are mediated by a glutamate receptor.
Plant & cell physiology.
2003 Jul; 44(7):667-75. doi:
10.1093/pcp/pcg094. [PMID: 12881494] - Rudi D'Hooge, Gerda Van de Vijver, Pierre-Paul Van Bogaert, Bart Marescau, Raymond Vanholder, Peter P De Deyn. Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.
Kidney international.
2003 May; 63(5):1764-75. doi:
10.1046/j.1523-1755.2003.00912.x. [PMID: 12675852] - C-Q Gao, J-M Kaufman. Stimulation of luteinizing hormone secretion by N-methyl-D,L-aspartic acid in the adult male guinea-pig: incomplete blockade by gonadotropin-releasing hormone receptor antagonism.
Journal of neuroendocrinology.
2003 May; 15(5):516-20. doi:
10.1046/j.1365-2826.2003.01024.x. [PMID: 12694377] - Chiye Aoki, Sho Fujisawa, Veera Mahadomrongkul, Priti J Shah, Karim Nader, Alev Erisir. NMDA receptor blockade in intact adult cortex increases trafficking of NR2A subunits into spines, postsynaptic densities, and axon terminals.
Brain research.
2003 Feb; 963(1-2):139-49. doi:
10.1016/s0006-8993(02)03962-8. [PMID: 12560119] - Erik Harvey-Girard, Robert J Dunn. Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor.
Journal of neurophysiology.
2003 Feb; 89(2):822-32. doi:
10.1152/jn.00629.2002. [PMID: 12574460] - So Ra Kim, Ki Yong Lee, Kyung Ah Koo, Sang Hyun Sung, Na-Gyong Lee, Jinwoong Kim, Young Choong Kim. Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.
Journal of natural products.
2002 Nov; 65(11):1696-9. doi:
10.1021/np0202172. [PMID: 12444706] - A Richard Rutter, Fiona M Freeman, F Anne Stephenson. Further characterization of the molecular interaction between PSD-95 and NMDA receptors: the effect of the NR1 splice variant and evidence for modulation of channel gating.
Journal of neurochemistry.
2002 Jun; 81(6):1298-307. doi:
10.1046/j.1471-4159.2002.00923.x. [PMID: 12068077] - Long Chen, Charles R Yang. Interaction of dopamine D1 and NMDA receptors mediates acute clozapine potentiation of glutamate EPSPs in rat prefrontal cortex.
Journal of neurophysiology.
2002 May; 87(5):2324-36. doi:
10.1152/jn.2002.87.5.2324. [PMID: 11976371] - Henry U Weigt, Michael Georgieff, Cordian Beyer, Karl J Föhr. Activation of neuronal N-methyl-D-aspartate receptor channels by lipid emulsions.
Anesthesia and analgesia.
2002 Feb; 94(2):331-7, table of contents. doi:
10.1097/00000539-200202000-00018. [PMID: 11812693] - S A Menzikov, O V Menzikova. Effect of activators and blockers of ligand-regulated ion channels on the activity of the Cl-stimulated Mg2+-ATPase of the plasma membrane fraction from bream (Abramis brama L.) brain.
Biochemistry. Biokhimiia.
2002 Feb; 67(2):233-9. doi:
10.1023/a:1014422332601. [PMID: 11952420] - Y F Li, W G Mayhan, K P Patel. NMDA-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide.
American journal of physiology. Heart and circulatory physiology.
2001 Dec; 281(6):H2328-36. doi:
10.1152/ajpheart.2001.281.6.h2328. [PMID: 11709399] - D P Li, D B Averill, H L Pan. Differential roles for glutamate receptor subtypes within commissural NTS in cardiac-sympathetic reflex.
American journal of physiology. Regulatory, integrative and comparative physiology.
2001 Sep; 281(3):R935-43. doi:
10.1152/ajpregu.2001.281.3.r935. [PMID: 11507011] - J M Langosch, X Y Zhou, M Heinen, S S Chatterjee, M Nöldner, J Walden. Effects of Hypericum perforatum L. on evoked potentials in guinea pig hippocampal slices.
Pharmacopsychiatry.
2001 Jul; 34 Suppl 1(?):S83-8. doi:
10.1055/s-2001-15511. [PMID: 11518083] - J H Jo, E J Park, J K Lee, M W Jung, C J Lee. Lipopolysaccharide inhibits induction of long-term potentiation and depression in the rat hippocampal CA1 area.
European journal of pharmacology.
2001 Jun; 422(1-3):69-76. doi:
10.1016/s0014-2999(01)01075-5. [PMID: 11430915] - S Eliasof, H B McIlvain, R E Petroski, A C Foster, J Dunlop. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems.
Journal of neurochemistry.
2001 Apr; 77(2):550-7. doi:
10.1046/j.1471-4159.2001.00253.x. [PMID: 11299317] - K Nakashima, H Katsukawa, K Sasamoto, Y Ninomiya. Behavioral taste similarities and differences among monosodium L-glutamate and glutamate receptor agonists in C57BL mice.
Journal of nutritional science and vitaminology.
2001 Apr; 47(2):161-6. doi:
10.3177/jnsv.47.161. [PMID: 11508708] - A Santamaría, S Galván-Arzate, V Lisý, S F Ali, H M Duhart, L Osorio-Rico, C Ríos, F St'astný. Quinolinic acid induces oxidative stress in rat brain synaptosomes.
Neuroreport.
2001 Mar; 12(4):871-4. doi:
10.1097/00001756-200103260-00049. [PMID: 11277599] - T Ravizza, D Moneta, B Bottazzi, G Peri, C Garlanda, E Hirsch, G J Richards, A Mantovani, A Vezzani. Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
Neuroscience.
2001; 105(1):43-53. doi:
10.1016/s0306-4522(01)00177-4. [PMID: 11483299] - M García-Gallo, M M Behrens, J Renart, M Díaz-Guerra. Expression of N-methyl-D-aspartate receptors using vaccinia virus causes excitotoxic death in human kidney cells.
Journal of cellular biochemistry.
1999 Jan; 72(1):135-44. doi:
10.1002/(sici)1097-4644(19990101)72:1<135::aid-jcb14>3.0.co;2-m. [PMID: 10025674] - F W Holtsberg, M R Steiner, K Furukawa, J N Keller, M P Mattson, S M Steiner. Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium.
Journal of neurochemistry.
1997 Jul; 69(1):68-75. doi:
10.1046/j.1471-4159.1997.69010068.x. [PMID: 9202295] - M Arslan, C R Pohl, M S Smith, T M Plant. Studies of the role of the N-methyl-D-aspartate (NMDA) receptor in the hypothalamic control of prolactin secretion.
Life sciences.
1992; 50(4):295-300. doi:
10.1016/0024-3205(92)90337-o. [PMID: 1531081] - M Arslan, C R Pohl, T M Plant. DL-2-amino-5-phosphonopentanoic acid, a specific N-methyl-D-aspartic acid receptor antagonist, suppresses pulsatile LH release in the rat.
Neuroendocrinology.
1988 May; 47(5):465-8. doi:
10.1159/000124951. [PMID: 2840595]
