Argipressin (BioDeep_00000009494)
Secondary id: BioDeep_00001028386
human metabolite blood metabolite
代谢物信息卡片
化学式: C46H65N15O12S2 (1083.437833)
中文名称: 精氨酸加压素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
InChI: InChI=1S/C46H65N15O12S2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)
描述信息
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents > D014667 - Vasopressins
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D050034 - Antidiuretic Agents
Same as: D00101
Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.
同义名列表
16 个代谢物同义名
2-{[(1-{19-amino-13-benzyl-6,9,12,15,18-pentahydroxy-10-[2-(C-hydroxycarbonimidoyl)ethyl]-7-[(C-hydroxycarbonimidoyl)methyl]-16-[(4-hydroxyphenyl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaene-4-carbonyl}pyrrolidin-2-yl)(hydroxy)methylidene]amino}-5-carbamimidamido-N-[(C-hydroxycarbonimidoyl)methyl]pentanimidate; 1-[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide; 2-({1-[19-amino-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl]pyrrolidin-2-yl}formamido)-N-(carbamoylmethyl)-5-[(diaminomethylidene)amino]pentanamide; 8-L-Arginine vasopressin; Vasopressin, arginine; Pitressin tannic acid; Arginine vasopressin; Argipressin tannate; Pitressin tannate; Arg vasopressin; Arg-vasopressin; Argipressin; ADH; AVP; Arg8-vasopressin; Arg-vasopressin
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:34543
- KEGG: C13662
- PubChem: 8230
- HMDB: HMDB0248587
- Metlin: METLIN69618
- MeSH: Arginine Vasopressin
- chemspider: 7937
- CAS: 1356383-11-3
- CAS: 113-79-1
- PMhub: MS000023285
- PubChem: 854003
- NIKKAJI: J1.025A
- RefMet: Argipressin
- medchemexpress: HY-P0049
- KNApSAcK: 34543
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yexiu Sun, Ying Guo, He Xu, Ji Zhao, Di Wu, Jianwei Hu, Dandan Wang, Lei Wu, Hao Peng, Hongmei Li. The relationship between arginine vasopressin gene polymorphisms and plasma copeptin and hypertensive disorders of pregnancy: a nested case-control study.
Journal of hypertension.
2023 04; 41(4):608-617. doi:
10.1097/hjh.0000000000003376
. [PMID: 36723473] - Kota Kakeshita, Tsutomu Koike, Teruhiko Imamura, Hayato Fujioka, Hidenori Yamazaki, Koichiro Kinugawa. Altered arginine vasopressin-cyclic AMP-aquaporin 2 pathway in patients with chronic kidney disease.
Clinical and experimental nephrology.
2022 Aug; 26(8):788-796. doi:
10.1007/s10157-022-02220-1
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Medicine.
2022 Jul; 101(26):e29804. doi:
10.1097/md.0000000000029804
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International journal of environmental research and public health.
2022 Jun; 19(12):. doi:
10.3390/ijerph19127053
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Marine drugs.
2022 May; 20(5):. doi:
10.3390/md20050328
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Neuroscience and biobehavioral reviews.
2022 05; 136(?):104597. doi:
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Journal of pediatric endocrinology & metabolism : JPEM.
2022 Apr; 35(4):421-434. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2022 Apr; 529(?):46-60. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
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Systems biology in reproductive medicine.
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Endocrinology.
2022 01; 163(1):. doi:
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Nutrients.
2021 Dec; 13(12):. doi:
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Ecotoxicology and environmental safety.
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eLife.
2021 11; 10(?):. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112193. doi:
10.1016/j.biopha.2021.112193
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Diabetes, obesity & metabolism.
2021 10; 23(10):2215-2225. doi:
10.1111/dom.14462
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Clinical science (London, England : 1979).
2021 09; 135(18):2197-2216. doi:
10.1042/cs20210599
. [PMID: 34494083] - Shigeki Yokoyama, Teruhiko Imamura, Shigeyuki Yamashita, Toshio Doi, Kazuaki Fukahara, Naoki Yoshimura, Koichiro Kinugawa. Peak Lag Between Plasma Vasopressin and Urine Aquaporin-2 Following Cardiac Surgery.
International heart journal.
2021 Sep; 62(5):1057-1061. doi:
10.1536/ihj.21-301
. [PMID: 34544990] - Angela Kim, Joseph C Madara, Chen Wu, Mark L Andermann, Bradford B Lowell. Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality.
eLife.
2021 09; 10(?):. doi:
10.7554/elife.66609
. [PMID: 34585668] - Masaki Takiwaki, Fumio Nomura, Mamoru Satoh, Sachio Tsuchida, Kazuo Otake, Junko Takagi. Development of a sensitive liquid chromatography-tandem mass spectrometry method for quantification of human plasma arginine vasopressin.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Sep; 1181(?):122903. doi:
10.1016/j.jchromb.2021.122903
. [PMID: 34455342] - Annette Hus-Citharel, Nadine Bouby, Maithé Corbani, Julie Mion, Christiane Mendre, Judit Darusi, Csaba Tomboly, Miguel Trueba, Claudine Serradeil-Le Gal, Catherine Llorens-Cortes, Gilles Guillon. Characterization of a functional V1B vasopressin receptor in the male rat kidney: evidence for cross talk between V1B and V2 receptor signaling pathways.
American journal of physiology. Renal physiology.
2021 09; 321(3):F305-F321. doi:
10.1152/ajprenal.00081.2021
. [PMID: 34282956] - Xiangyan Jin, Woong Bin Kim, Mi-Na Kim, Won Woo Jung, Hyung Kyung Kang, Eun-Hwa Hong, Yoon Sik Kim, Wan Joo Shim, Hee Chul Han, Christopher S Colwell, Young-Beom Kim, Yang In Kim. Oestrogen inhibits salt-dependent hypertension by suppressing GABAergic excitation in magnocellular AVP neurons.
Cardiovascular research.
2021 08; 117(10):2263-2274. doi:
10.1093/cvr/cvaa271
. [PMID: 32960965] - Mitsuhiro Yoshimura, Becky Conway-Campbell, Yoichi Ueta. Arginine vasopressin: Direct and indirect action on metabolism.
Peptides.
2021 08; 142(?):170555. doi:
10.1016/j.peptides.2021.170555
. [PMID: 33905792] - Jack Whylings, Nicole Rigney, Geert J de Vries, Aras Petrulis. Reduction in vasopressin cells in the suprachiasmatic nucleus in mice increases anxiety and alters fluid intake.
Hormones and behavior.
2021 07; 133(?):104997. doi:
10.1016/j.yhbeh.2021.104997
. [PMID: 34062279] - Johannes Leierer, Paul Perco, Benedikt Hofer, Susanne Eder, Alexander Dzien, Julia Kerschbaum, Michael Rudnicki, Gert Mayer. Coregulation Analysis of Mechanistic Biomarkers in Autosomal Dominant Polycystic Kidney Disease.
International journal of molecular sciences.
2021 Jun; 22(13):. doi:
10.3390/ijms22136885
. [PMID: 34206927] - Balázs Mayer, Krisztián Németh, Miklós Krepuska, Vamsee D Myneni, Dragan Maric, John F Tisdale, Matthew M Hsieh, Naoya Uchida, Heon-Jin Lee, Michael J Nemeth, Kenn Holmbeck, Constance Tom Noguchi, Heather Rogers, Soumyadeep Dey, Arne Hansen, Jeffrey Hong, Ian Chow, Sharon Key, Ildikó Szalayova, Jerome Pagani, Károly Markó, Ian MacClain-Caldwell, Lynn Vitale-Cross, W Scott Young, Michael J Brownstein, Éva Mezey. Commentary on Winzeler et al 'Low arginine vasopressin levels in patients with diabetes insipidus are not associated with anaemia'.
Clinical endocrinology.
2021 05; 94(5):888-890. doi:
10.1111/cen.14377
. [PMID: 33314284] - Daisuke Hagiwara, Masayoshi Tochiya, Yoshinori Azuma, Tetsuro Tsumura, Yuichi Hodai, Yohei Kawaguchi, Takashi Miyata, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Hiroshi Takagi, Yoshihiro Ito, Shintaro Iwama, Hidetaka Suga, Ryoichi Banno, Hiroshi Arima. Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons.
Peptides.
2021 05; 139(?):170517. doi:
10.1016/j.peptides.2021.170517
. [PMID: 33647312] - Raj Makwana, John Loy, Miriam Adebibe, Kalpana Devalia, Paul Lr Andrews, Gareth J Sanger. Copeptin, a surrogate marker of arginine8 vasopressin, has no ability to modulate human and mouse gastric motility.
European journal of pharmacology.
2021 Feb; 892(?):173740. doi:
10.1016/j.ejphar.2020.173740
. [PMID: 33220268] - Adrien Flahault, Pierre-Emmanuel Girault-Sotias, Mathilde Keck, Rodrigo Alvear-Perez, Nadia De Mota, Lucie Estéoulle, Sridévi M Ramanoudjame, Xavier Iturrioz, Dominique Bonnet, Catherine Llorens-Cortes. A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia.
Nature communications.
2021 01; 12(1):305. doi:
10.1038/s41467-020-20560-y
. [PMID: 33436646] - Konstantinos Kamperis. Nocturnal enuresis in children: The role of arginine-vasopressin.
Handbook of clinical neurology.
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Handbook of clinical neurology.
2021; 181(?):261-273. doi:
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Journal of immunology research.
2021; 2021(?):5529784. doi:
10.1155/2021/5529784
. [PMID: 34926704] - Hanna Szmygin, Joanna Szydełko, Beata Matyjaszek-Matuszek. Copeptin as a novel biomarker of cardiometabolic syndrome.
Endokrynologia Polska.
2021; 72(5):566-571. doi:
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Biologie aujourd'hui.
2021; 215(3-4):119-132. doi:
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Frontiers in endocrinology.
2021; 12(?):627343. doi:
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Neuroendocrinology.
2021; 111(3):237-248. doi:
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Cells.
2020 12; 9(12):. doi:
10.3390/cells9122622
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Pituitary.
2020 Dec; 23(6):681-690. doi:
10.1007/s11102-020-01076-6
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Pediatric research.
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Zhen ci yan jiu = Acupuncture research.
2020 Nov; 45(11):895-901. doi:
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Scientific reports.
2020 11; 10(1):19730. doi:
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American journal of physiology. Renal physiology.
2020 11; 319(5):F746-F753. doi:
10.1152/ajprenal.00339.2020
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The Journal of clinical endocrinology and metabolism.
2020 11; 105(11):. doi:
10.1210/clinem/dgaa568
. [PMID: 32835363] - Yi-Kyeong Jeong, Ye-In Oh, Kun-Ho Song, Kyoung Won Seo. Evaluation of salivary vasopressin as an acute stress biomarker in healthy dogs with stress due to noise and environmental challenges.
BMC veterinary research.
2020 Sep; 16(1):331. doi:
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. [PMID: 32917190] - Rosario Barranco, Francesco Ventura, Tony Fracasso. Immunohistochemical renal expression of aquaporin 2, arginine-vasopressin, vasopressin receptor 2, and renin in saltwater drowning and freshwater drowning.
International journal of legal medicine.
2020 Sep; 134(5):1733-1740. doi:
10.1007/s00414-020-02274-4
. [PMID: 32240384] - Zahra Nouri, Xue-Ying Zhang, De-Hua Wang. The physiological and molecular mechanisms to maintain water and salt homeostasis in response to high salt intake in Mongolian gerbils (Meriones unguiculatus).
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2020 09; 190(5):641-654. doi:
10.1007/s00360-020-01287-0
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Brain structure & function.
2020 Sep; 225(7):2219-2238. doi:
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Peptides.
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Domestic animal endocrinology.
2020 07; 72(?):106427. doi:
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Journal of the American Society of Nephrology : JASN.
2020 07; 31(7):1555-1568. doi:
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International immunopharmacology.
2020 Jun; 83(?):106427. doi:
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Journal of the American Heart Association.
2020 05; 9(10):e014950. doi:
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Hormones and behavior.
2020 05; 121(?):104715. doi:
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Scientific reports.
2020 04; 10(1):7269. doi:
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Medicina (Kaunas, Lithuania).
2020 Apr; 56(4):. doi:
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Endocrine journal.
2020 Mar; 67(3):267-274. doi:
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Nutrients.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Mar; 1141(?):122024. doi:
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European journal of applied physiology.
2020 Mar; 120(3):635-642. doi:
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Pediatrics international : official journal of the Japan Pediatric Society.
2020 Mar; 62(3):363-370. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
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The Journal of endocrinology.
2020 01; 244(1):201-211. doi:
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Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2020 01; 190(1):49-62. doi:
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The Journal of international medical research.
2020 Jan; 48(1):300060519894448. doi:
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American journal of physiology. Heart and circulatory physiology.
2020 01; 318(1):H124-H134. doi:
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Vitamins and hormones.
2020; 113(?):217-238. doi:
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Frontiers in endocrinology.
2020; 11(?):43. doi:
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Vitamins and hormones.
2020; 112(?):95-117. doi:
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Translational psychiatry.
2019 12; 9(1):330. doi:
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The journal of trauma and acute care surgery.
2019 12; 87(6):1346-1353. doi:
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Diabetic medicine : a journal of the British Diabetic Association.
2019 11; 36(11):1408-1411. doi:
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The Journal of clinical endocrinology and metabolism.
2019 11; 104(11):5406-5420. doi:
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International journal of molecular sciences.
2019 Oct; 20(21):. doi:
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Chinese journal of integrative medicine.
2019 Oct; 25(10):763-769. doi:
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Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2019 Sep; 39(9):1099-1106. doi:
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Reviews in endocrine & metabolic disorders.
2019 09; 20(3):283-294. doi:
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Reviews in endocrine & metabolic disorders.
2019 09; 20(3):295-302. doi:
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Life sciences.
2019 Aug; 231(?):116493. doi:
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The Journal of clinical endocrinology and metabolism.
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American journal of physiology. Renal physiology.
2019 08; 317(2):F375-F387. doi:
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ACS chemical neuroscience.
2019 07; 10(7):3132-3142. doi:
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Nutrients.
2019 Jul; 11(7):. doi:
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European journal of endocrinology.
2019 Jul; 181(1):23-30. doi:
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Pediatric cardiology.
2019 Jun; 40(5):1046-1056. doi:
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Peptides.
2019 05; 115(?):8-14. doi:
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Heart and vessels.
2019 May; 34(5):809-814. doi:
10.1007/s00380-018-1309-z
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The journal of physiological sciences : JPS.
2019 May; 69(3):531-541. doi:
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American journal of physiology. Renal physiology.
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2019 04; 39(2):221-228. doi:
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Inflammation.
2019 Apr; 42(2):618-627. doi:
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Scientific reports.
2019 03; 9(1):5153. doi:
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Biochimie.
2019 Mar; 158(?):191-198. doi:
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Psychoneuroendocrinology.
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Shock (Augusta, Ga.).
2019 03; 51(3):348-355. doi:
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BMC research notes.
2019 Feb; 12(1):72. doi:
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Acta physiologica (Oxford, England).
2019 02; 225(2):e13191. doi:
10.1111/apha.13191
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Medicine.
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