ST 25:5;O8 (BioDeep_00000009401)
代谢物信息卡片
4-[(11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl)oxy]-4-oxobutanoic acid
化学式: C25H34O8 (462.2253564)
中文名称: 氢可琥珀酸酯
谱图信息:
最多检出来源 Viridiplantae(plant) 25%
分子结构信息
SMILES: CC12CCC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)COC(=O)CCC(=O)O
InChI: InChI=1S/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000893 - Anti-Inflammatory Agents
Same as: D01442
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
7 个代谢物同义名
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(hydrogensuccinate); 11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione 21-succinate; Hydrocortisone hemisuccinate; Hydrocortisone succinate; Cortisol succinate; ST 25:5;O8; 4-[(11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl)oxy]-4-oxobutanoic acid
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:31677
- KEGG: C12888
- KEGGdrug: D01442
- PubChem: 16623
- PubChem: 3643
- Metlin: METLIN41880
- DrugBank: DB14545
- ChEMBL: CHEMBL977
- LipidMAPS: LMST02030126
- CAS: 2203-97-6
- CAS: 1231184-90-9
- PMhub: MS000023181
- PubChem: 583277
- 3DMET: B04559
- NIKKAJI: J7.358J
- RefMet: Hydrocortisone succinate
- RefMet: ST 25:5;O8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A Vurmaz, E Atay. Antioxidant effects of piperine on steroid-induced hepatotoxicity.
European review for medical and pharmacological sciences.
2021 Sep; 25(17):5500-5506. doi:
10.26355/eurrev_202109_26659. [PMID: 34533800] - Ayhan Vurmaz, Reşat Duman, Mehmet Cem Sabaner, Tolga Ertekin, Abdülkadir Bilir. Antioxidant effects of piperine in in-vivo chick embryo cataract model induced by steroids.
Cutaneous and ocular toxicology.
2019 Jun; 38(2):182-189. doi:
10.1080/15569527.2019.1570521. [PMID: 30678496] - Htwe H Mon, Susan N Christo, Chi P Ndi, Marek Jasieniak, Heather Rickard, John D Hayball, Hans J Griesser, Susan J Semple. Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
Journal of natural products.
2015 Dec; 78(12):3031-40. doi:
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Domestic animal endocrinology.
2013 Aug; 45(2):98-104. doi:
10.1016/j.domaniend.2013.06.003. [PMID: 23849086] - Kelsey A Hart, Levent Dirikolu, Duncan C Ferguson, Natalie A Norton, Michelle H Barton. Daily endogenous cortisol production and hydrocortisone pharmacokinetics in adult horses and neonatal foals.
American journal of veterinary research.
2012 Jan; 73(1):68-75. doi:
10.2460/ajvr.73.1.68. [PMID: 22204290] - Jian-Hua Shi, Wen-Hua Du, Xiao-Yan Liu, Yan-Ping Fan, Xiao-Lei Hu, Hai-Yan Zhou, Huan-Bai Xu, Xiao-Mei Zhang, Ping Xiang, Feng-Ling Chen. Glucocorticoids decrease serum adiponectin level and WAT adiponectin mRNA expression in rats.
Steroids.
2010 Dec; 75(12):853-8. doi:
10.1016/j.steroids.2010.05.001. [PMID: 20471407] - Fang Deng, Ling Lu, Qin Zhang, Bo Hu, Shi-jie Wang, Na Huang. Henoch-Schönlein purpura in childhood: treatment and prognosis. Analysis of 425 cases over a 5-year period.
Clinical rheumatology.
2010 Apr; 29(4):369-74. doi:
10.1007/s10067-009-1329-2. [PMID: 20033243] - Jian-hua Lin, Zhong-lin Cui, Jie Zhou. [Glucocorticoid treatment for early postoperative cholangiole cholestasis hyperbilirubinemia after liver transplantation].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2010 Feb; 30(2):377-8. doi:
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Critical care medicine.
2009 Oct; 37(10):2727-32. doi:
10.1097/ccm.0b013e3181a592b3. [PMID: 19885996] - Wendy Saltzman, David H Abbott. Effects of elevated circulating cortisol concentrations on maternal behavior in common marmoset monkeys (Callithrix jacchus).
Psychoneuroendocrinology.
2009 Sep; 34(8):1222-34. doi:
10.1016/j.psyneuen.2009.03.012. [PMID: 19362777] - Sebastián Tornero Patricio, José Antonio Bermúdez de la Vega, Daniel Nehme Alvarez, Francisco Javier Gentil González, María Dolores Lluch Fernández, José González Hachero. [Primary adrenal insufficiency as the form of onset of adrenoleukodystrophy in a 4-year-old boy].
Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion.
2009 Jan; 56(1):40-2. doi:
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Critical care medicine.
2008 Nov; 36(11):3043-7. doi:
10.1097/ccm.0b013e318186f5b2. [PMID: 18824917] - Makoto Ando, In-Sam Park, Naoki Wada, Yukihiro Takahashi. Steroid supplementation: a legitimate pharmacotherapy after neonatal open heart surgery.
The Annals of thoracic surgery.
2005 Nov; 80(5):1672-8; discusison 1678. doi:
10.1016/j.athoracsur.2005.04.035. [PMID: 16242437] - Lawrence A Trissel, Christopher A Saenz. Physical compatibility of antithymocyte globulin (rabbit) with heparin sodium and hydrocortisone sodium succinate.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2003 Aug; 60(16):1650-2. doi:
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Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2003 Jun; 9(2):160-4. doi:
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Journal of immunoassay & immunochemistry.
2003; 24(2):191-203. doi:
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2003; 24(3):301-9. doi:
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Journal of immunoassay & immunochemistry.
2003; 24(2):205-17. doi:
10.1081/ias-120020085. [PMID: 12778972] - Nethnapha Paredes, Ling Xu, Leslie R Berry, Anthony K C Chan. The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces.
British journal of haematology.
2003 Jan; 120(2):315-24. doi:
10.1046/j.1365-2141.2003.03971.x. [PMID: 12542493] - Luminiţa Pleşca-Manea, Alina Elena Pârvu, M Pârvu, M Taămaş, R Buia, M Puia. Effects of Melilotus officinalis on acute inflammation.
Phytotherapy research : PTR.
2002 Jun; 16(4):316-9. doi:
10.1002/ptr.875. [PMID: 12112285] - T Nishimura, T Nakano. Nuclear localization of bovine immunoglobulin G (bIgG) in the liver of rats injected with hydrocortisone-bIgG conjugate intravenously.
Okajimas folia anatomica Japonica.
2001 Oct; 78(4):107-14. doi:
10.2535/ofaj1936.78.4_107. [PMID: 11774745] - H A Lincoff, I Kreissig, N Lincoff, R Silverman, J Nisselbaum. Elevated concentration of intraocular cortisol obtained by sequential parabulbar injection in rabbit model.
Klinische Monatsblatter fur Augenheilkunde.
2001 Jun; 218(6):445-50. doi:
10.1055/s-2001-16260. [PMID: 11488012] - R F Gagnon, M L Halperin. Possible mechanisms to explain the absence of hyperkalaemia in Addison's disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2001 Jun; 16(6):1280-4. doi:
10.1093/ndt/16.6.1280. [PMID: 11390735] - H Watanabe, H Kosano, H Nishigori. Steroid-induced short term diabetes in chick embryo: reversible effects of insulin on metabolic changes and cataract formation.
Investigative ophthalmology & visual science.
2000 Jun; 41(7):1846-52. doi:
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Australian veterinary journal.
1999 May; 77(5):316-7. doi:
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The Journal of clinical endocrinology and metabolism.
1998 Feb; 83(2):626-31. doi:
10.1210/jcem.83.2.4547. [PMID: 9467584] - J A Posener, J J Schildkraut, G H Williams, A F Schatzberg. Cortisol feedback effects on plasma corticotropin levels in healthy subjects.
Psychoneuroendocrinology.
1997 Apr; 22(3):169-76. doi:
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Experimental eye research.
1996 Dec; 63(6):673-81. doi:
10.1006/exer.1996.0161. [PMID: 9068374] - B A Mohamed. Examining of changes in continuous GMK cell cultures treated with hydrocortisonum hemisuccinatum, propranolol and diazepam.
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina.
1996; 51(?):81-8. doi:
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Endocrine research.
1995 Aug; 21(3):569-82. doi:
10.1080/07435809509030474. [PMID: 7588427] - H Nishigori, J W Lee, M Iwatsuru. Glucocorticoid-induced cataract of the developing chick embryo-prevention by propylene glycol.
Ophthalmic research.
1995; 27(6):350-5. doi:
10.1159/000267747. [PMID: 8927308] - B A Mohamed. [Examination of changes in continuous culture of GMK cells under the influence of Hydrocortisone hemisuccinate, propranolol and diazepam].
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina.
1995; 50(?):173-8. doi:
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Research in veterinary science.
1994 Nov; 57(3):349-52. doi:
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The Journal of steroid biochemistry and molecular biology.
1994 Feb; 48(2-3):271-6. doi:
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Anticancer research.
1993 Nov; 13(6A):2053-8. doi:
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Hormone research.
1992; 37(6):212-6. doi:
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Current eye research.
1991 Jul; 10(7):629-35. doi:
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British journal of haematology.
1991 Jun; 78(2):229-35. doi:
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Contributions to nephrology.
1991; 92(?):182-90. doi:
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1990 Dec; 6(4):294-8, 319. doi:
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Japanese heart journal.
1990 Jan; 31(1):109-13. doi:
10.1536/ihj.31.109. [PMID: 2159572] - P Kongtawelert, P M Brooks, P Ghosh. Pentosan polysulfate (Cartrophen) prevents the hydrocortisone induced loss of hyaluronic acid and proteoglycans from cartilage of rabbit joints as well as normalizes the keratan sulfate levels in their serum.
The Journal of rheumatology.
1989 Nov; 16(11):1454-9. doi:
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Surgery.
1989 May; 105(5):593-7. doi:
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The Journal of clinical endocrinology and metabolism.
1988 Dec; 67(6):1146-8. doi:
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The Cornell veterinarian.
1988 Jul; 78(3):243-52. doi:
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The Journal of endocrinology.
1988 Jun; 117(3):373-8. doi:
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Antimicrobial agents and chemotherapy.
1987 Nov; 31(11):1816-21. doi:
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Infection and immunity.
1987 Oct; 55(10):2359-63. doi:
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Developmental biology.
1987 Sep; 123(1):59-62. doi:
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Clinical chemistry.
1987 Aug; 33(8):1412-5. doi:
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Hinyokika kiyo. Acta urologica Japonica.
1986 Dec; 32(12):1799-812. doi:
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Cell biochemistry and function.
1986 Oct; 4(4):277-81. doi:
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American journal of veterinary research.
1986 May; 47(5):997-1001. doi:
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Comparative biochemistry and physiology. A, Comparative physiology.
1986; 83(3):409-13. doi:
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The Journal of allergy and clinical immunology.
1985 Feb; 75(2):304-12. doi:
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Annales de medecine interne.
1985; 136(3):213-5. doi:
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The American journal of physiology.
1984 Oct; 247(4 Pt 1):G427-31. doi:
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Immunology.
1984 Sep; 53(1):43-53. doi:
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Ophthalmic research.
1984; 16(4):190-3. doi:
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The Journal of clinical endocrinology and metabolism.
1983 Sep; 57(3):671-3. doi:
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Infection and immunity.
1983 Feb; 39(2):630-7. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1982 Apr; 120(3):341-53. doi:
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The British journal of dermatology.
1982 Jan; 106(1):65-75. doi:
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Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1981 Feb; 19(2):75-9. doi:
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The Journal of toxicological sciences.
1980 Nov; 5(4):303-9. doi:
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The Journal of clinical endocrinology and metabolism.
1978 Nov; 47(5):1137-40. doi:
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Doklady Akademii nauk SSSR.
1975 Aug; 223(5):1256-9. doi:
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