Mequitazine (BioDeep_00000009382)
Secondary id: BioDeep_00000858514
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H22N2S (322.1503612)
中文名称: 美喹他嗪
谱图信息:
最多检出来源 Homo sapiens(blood) 46.15%
分子结构信息
SMILES: C(C1CN2CCC1CC2)N1C2=CC=CC=C2SC2=CC=CC=C12
InChI: InChI=1S/C20H22N2S/c1-3-7-19-17(5-1)22(18-6-2-4-8-20(18)23-19)14-16-13-21-11-9-15(16)10-12-21/h1-8,15-16H,9-14H2
描述信息
Mequitazine is a histamine H1 antagonist (antihistamine). It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AD - Phenothiazine derivatives
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Same as: D01324
Mequitazine is a potent, and long-acting histamine H1 antagonist.
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:31821
- KEGG: C12755
- PubChem: 4066
- HMDB: HMDB0015204
- Metlin: METLIN69479
- DrugBank: DB01071
- ChEMBL: CHEMBL73451
- Wikipedia: Mequitazine
- chemspider: 3926
- CAS: 29216-28-2
- PMhub: MS000023161
- PubChem: 583144
- NIKKAJI: J342.305K
- medchemexpress: HY-B2168
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee. A novel and sensitive UPLC-MS/MS method to determine mequitazine in rat plasma and urine: Validation and its application to pharmacokinetic studies.
Biomedical chromatography : BMC.
2019 Oct; 33(10):e4627. doi:
10.1002/bmc.4627. [PMID: 31222787] - Sung-Hoon Ahn, Han-Joo Maeng. Quantification of mequitazine in human plasma by gas chromatography- quadrupole mass spectrometry and its application to a human pharmacokinetic study.
Biomedical chromatography : BMC.
2016 Apr; 30(4):574-8. doi:
10.1002/bmc.3585. [PMID: 26268745] - Hironori Sagara, Tatsuo Yukawa, Ryuichi Kashima, Takenori Okada, Takeshi Fukuda. Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.
Allergology international : official journal of the Japanese Society of Allergology.
2009 Jun; 58(2):277-87. doi:
10.2332/allergolint.08-oa-0058. [PMID: 19390239] - Oh-Seung Kwon, Hye-Jung Kim, Heesoo Pyo, Suk-Jae Chung, Youn Bok Chung. Determination of mequitazine in human plasma by gas-chromatography/mass spectrometry with ion-trap detector and its pharmacokinetics after oral administration to volunteers.
Archives of pharmacal research.
2005 Oct; 28(10):1190-5. doi:
10.1007/bf02972985. [PMID: 16276978] - P Casha, O Bernard, M C Galland, P Pisano, I Koné-Paut, R Vialet, A Durand, J L Bernard. [Status epilepticus in an asthmatic child].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
1994 Sep; 1(9):816-8. doi:
. [PMID: 7842125] - K Tasaka, M Akagi, M Mio, K Izushi, I Aoki. Anti-platelet activating factor, anti-leukotriene D4 and some other antiallergic activities of mequitazine.
Arzneimittel-Forschung.
1990 Oct; 40(10):1092-7. doi:
. [PMID: 1705425] - T Hasegawa, K Takagi, T Kuzuya, M Nadai, R Apichartpichean, I Muraoka. Effect of mequitazine on the pharmacokinetics of theophylline in asthmatic patients.
European journal of clinical pharmacology.
1990; 38(3):255-8. doi:
10.1007/bf00315026. [PMID: 2340844] - A Malet i Casajuana, J Ruiz de León, A Valero Santiago, J Sanosa Valls, M Zamorano Calderón, P A García Calderón. "In vivo" and "in vitro" evaluation of four antihistamines (astemizole, azatadine, mequitazine, terfenadine).
Allergologia et immunopathologia.
1989 Mar; 17(2):85-93. doi:
. [PMID: 2476015] - P Ylitalo, K Nieminen, G Wilén-Rosenqvist, J B Fourtillan, J Girault, L Ylitalo, J S Pukander, P H Karma. Serum levels and urinary excretion of mequitazine after a single oral dose.
International journal of clinical pharmacology research.
1989; 9(5):305-8. doi:
. [PMID: 2576245] - J B Fourtillan, J Girault, S Bouquet, M A Lefèbvre. Determination of mequitazin in human plasma and urine by capillary column gas-liquid chromatography-mass spectrometry.
Journal of chromatography.
1984 Aug; 309(2):391-6. doi:
10.1016/0378-4347(84)80048-1. [PMID: 6148351] - J Demaubeuge, D Tennstedt, R Broux. Does mast cell protection plus mediator antagonism surpass the effect of a classic antihistaminic in the treatment of chronic urticaria? A double-blind comparison of oxatomide and mequitazine.
Dermatologica.
1982 Jun; 164(6):386-94. doi:
10.1159/000250123. [PMID: 6126399] - J Yano, H Igo, K Shiraiwa, M Miura, H Watanabe, T Morino, K Matsumoto, K Hayano. [Subacute toxicity and recovery tests of mequitazine in beagle dogs (author's transl)].
The Journal of toxicological sciences.
1981 May; 6(2):129-57. doi:
10.2131/jts.6.129. [PMID: 6115947] - A Uzan, C Gueremy, G Le Fur. [Biotransformation of 10-(3-quinuclidinylmethyl)phenothiazine (LM 209), a new anti-allergy agent and the distribution and excretion of its metabolites].
Xenobiotica; the fate of foreign compounds in biological systems.
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10.3109/00498257609151678. [PMID: 997584]