Nosiheptide (BioDeep_00000009066)

   

Chemicals and Drugs


代谢物信息卡片


N-(3-amino-3-oxoprop-1-en-2-yl)-2-[(1S,18S,21Z,28R)-21-ethylidene-9,30-dihydroxy-18-[(1R)-1-hydroxyethyl]-40-methyl-16,19,26,31,42,46-hexaoxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decazanonacyclo[26.16.6.12,5.112,15.122,25.138,41.147,50.06,11.034,39]pentapentaconta-2(55),4,6,8,10,12(54),14,22(53),24,34(39),35,37,40,47,50-pentadecaen-8-yl]-1,3-thiazole-4-carboxamide

化学式: C51H43N13O12S6 (1221.1478)
中文名称: 那西肽
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C(NC(=O)c1csc(-c2nc3c(cc2O)-c2nc(cs2)C(=O)NC(C(C)O)C(=O)NC(=CC)c2nc(cs2)C(=O)NC2CC(O)C(=O)OCc4cccc5[nH]c(c(C)c45)C(=O)SCC(NC(=O)c4csc2n4)c2nc-3cs2)n1)C(=N)O
InChI: InChI=1S/C51H43N13O12S6/c1-5-23-46-60-28(14-79-46)41(70)56-25-10-33(67)50(74)76-11-21-7-6-8-24-34(21)18(2)35(54-24)51(75)82-17-31(57-42(71)29-15-80-47(25)61-29)48-58-26(12-78-48)37-22(45-59-30(13-77-45)43(72)64-36(20(4)65)44(73)55-23)9-32(66)38(63-37)49-62-27(16-81-49)40(69)53-19(3)39(52)68/h5-9,12-16,20,25,31,33,36,54,65-67H,3,10-11,17H2,1-2,4H3,(H2,52,68)(H,53,69)(H,55,73)(H,56,70)(H,57,71)(H,64,72)/b23-5-/t20-,25-,31+,33?,36+/m1/s1

描述信息

Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth[1][2].

同义名列表

5 个代谢物同义名

N-(3-amino-3-oxoprop-1-en-2-yl)-2-[(1S,18S,21Z,28R)-21-ethylidene-9,30-dihydroxy-18-[(1R)-1-hydroxyethyl]-40-methyl-16,19,26,31,42,46-hexaoxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decazanonacyclo[26.16.6.12,5.112,15.122,25.138,41.147,50.06,11.034,39]pentapentaconta-2(55),4,6,8,10,12(54),14,22(53),24,34(39),35,37,40,47,50-pentadecaen-8-yl]-1,3-thiazole-4-carboxamide; Nosiheptide; Multhiomycin; RP 9671; Nosiheptide



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 RPL11, RPS12, SLC2A2
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 2 CYP1B1, HMGCR
Nucleus 2 ANKRD42, FABP2
cytosol 5 APOA1, FABP2, MAT1A, RPL11, RPS12
nucleoplasm 2 RPL11, RPS12
Cell membrane 1 SLC2A2
Multi-pass membrane protein 4 HMGCR, SLC15A1, SLC2A2, SLC5A1
Golgi apparatus 1 RPS12
plasma membrane 4 APOA1, SLC15A1, SLC2A2, SLC5A1
Membrane 6 CYP1B1, HMGCR, RPL11, RPS12, SLC15A1, SLC2A2
apical plasma membrane 3 SLC15A1, SLC2A2, SLC5A1
brush border 2 SLC15A1, SLC2A2
extracellular exosome 5 APOA1, CPB2, RPL11, SLC5A1, SPINK1
endoplasmic reticulum 1 HMGCR
extracellular space 2 APOA1, CPB2
perinuclear region of cytoplasm 1 SLC5A1
mitochondrion 1 CYP1B1
protein-containing complex 1 RPL11
intracellular membrane-bounded organelle 2 CYP1B1, RPS12
Microsome membrane 1 CYP1B1
Secreted 2 APOA1, SPINK1
extracellular region 2 APOA1, CPB2
Extracellular vesicle 1 APOA1
chylomicron 1 APOA1
high-density lipoprotein particle 1 APOA1
low-density lipoprotein particle 1 APOA1
very-low-density lipoprotein particle 1 APOA1
cytoplasmic vesicle 1 APOA1
nucleolus 2 RPL11, RPS12
Early endosome 2 APOA1, SLC5A1
cell-cell junction 1 SLC2A2
Apical cell membrane 2 SLC15A1, SLC5A1
intracellular vesicle 1 SLC5A1
peroxisomal membrane 1 HMGCR
collagen-containing extracellular matrix 1 APOA1
brush border membrane 1 SLC5A1
Nucleus, nucleolus 2 RPL11, RPS12
blood microparticle 1 APOA1
microvillus 1 FABP2
Peroxisome membrane 1 HMGCR
secretory granule lumen 1 APOA1
endoplasmic reticulum lumen 1 APOA1
endocytic vesicle 1 APOA1
small-subunit processome 1 RPS12
ribonucleoprotein complex 1 RPL11
cytosolic ribosome 2 RPL11, RPS12
spherical high-density lipoprotein particle 1 APOA1
endocytic vesicle lumen 1 APOA1
ribosome 1 RPL11
cytosolic large ribosomal subunit 1 RPL11
apical cortex 1 FABP2
cytosolic small ribosomal subunit 1 RPS12
intracellular organelle 1 SLC5A1
methionine adenosyltransferase complex 1 MAT1A


文献列表

  • Han-Tsung Wang, Yi-Hung Li, I-Pin Chou, Ya-Hui Hsieh, Bao-Ji Chen, Ching-Yi Chen. Albusin B modulates lipid metabolism and increases antioxidant defense in broiler chickens by a proteomic approach. Journal of the science of food and agriculture. 2013 Jan; 93(2):284-92. doi: 10.1002/jsfa.5754. [PMID: 22729694]
  • F Benazet, J R Cartier. Effect of nosiheptide as a feed additive in chicks on the quantity, duration, prevalence of excretion, and resistance to antibacterial agents of Salmonella typhimurium; on the proportion of Escherichia coli and other coliforms resistant to antibacterial agents; and on their degree and spectrum of resistance. Poultry science. 1980 Jul; 59(7):1405-15. doi: 10.3382/ps.0591405. [PMID: 6994088]