NCBI Taxonomy: 1885
Streptomyces actuosus (ncbi_taxid: 1885)
found 50 associated metabolites at species taxonomy rank level.
Ancestor: Streptomyces
Child Taxonomies: none taxonomy data.
staurosporine
2,3,10,11,12,13-hexahydro-10R-methoxy-9S-methyl-11R-methylamino-9S,13R-epoxy-1H,9H-diindolo[1,2,3-gh;3,2,1-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor D004791 - Enzyme Inhibitors Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5].
Nosiheptide
N-(3-amino-3-oxoprop-1-en-2-yl)-2-[(1S,18S,21Z,28R)-21-ethylidene-9,30-dihydroxy-18-[(1R)-1-hydroxyethyl]-40-methyl-16,19,26,31,42,46-hexaoxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decazanonacyclo[26.16.6.12,5.112,15.122,25.138,41.147,50.06,11.034,39]pentapentaconta-2(55),4,6,8,10,12(54),14,22(53),24,34(39),35,37,40,47,50-pentadecaen-8-yl]-1,3-thiazole-4-carboxamide
C51H43N13O12S6 (1221.1478317999997)
Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth[1][2].
(2s)-2-({[(3s,6s,9s,11s,15r,18s,21s,24s)-9-{[(2s,3s)-2-({[(3r,9s,12s,15s,21s,24z,27s)-27-{[(2s)-2-[(2-{[2-({2-[(2-{[(2s,3r)-2-amino-1,3-dihydroxybutylidene]amino}-1-hydroxyethylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxyethylidene)amino]-1-hydroxypropylidene]amino}-24-ethylidene-5,8,11,14,17,20,23,26-octahydroxy-21-isopropyl-9-methyl-6,18-dimethylidene-12,15-bis(2-methylpropyl)-1-thia-4,7,10,13,16,19,22,25-octaazacyclooctacosa-4,7,10,13,16,19,22,25-octaen-3-yl](hydroxy)methylidene}amino)-1-hydroxy-3-methylpentylidene]amino}-2,5,8,17,20,23,26-heptahydroxy-24-isopropyl-3,6-dimethyl-18,21-bis(2-methylpropyl)-13-thia-1,4,7,16,19,22,25-heptaazaspiro[10.15]hexacosa-1,4,7,16,19,22,25-heptaen-15-yl](hydroxy)methylidene}amino)-4-methylpentanoic acid
(2s)-2-({[(3s,6s,9s,11s,15r,18s,21s,24s)-9-{[(2s,3s)-2-({[(3r,9s,12s,15s,21s,24z,27s)-27-{[(2s)-2-[(2-{[2-({2-[(2-{[(2s,3r)-2-amino-1,3-dihydroxybutylidene]amino}-1-hydroxyethylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxyethylidene)amino]-1-hydroxypropylidene]amino}-24-ethylidene-5,8,11,14,17,20,23,26-octahydroxy-21-isopropyl-9-methyl-6,18-dimethylidene-12,15-bis(2-methylpropyl)-1-thia-4,7,10,13,16,19,22,25-octaazacyclooctacosa-4,7,10,13,16,19,22,25-octaen-3-yl](hydroxy)methylidene}amino)-1-hydroxy-3-methylpentylidene]amino}-2,5,8,17,20,23,26-heptahydroxy-24-isopropyl-3,6-dimethyl-18,21-bis(2-methylpropyl)-13-thia-1,4,7,16,19,22,25-heptaazaspiro[10.15]hexacosa-1,4,7,16,19,22,25-heptaen-15-yl](hydroxy)methylidene}amino)-4-methylpentanoic acid
2-[({2-[(21z)-21-ethylidene-9,16,19,26,30,46-hexahydroxy-18-(1-hydroxyethyl)-40-methyl-31,42-dioxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decaazanonacyclo[26.16.6.1²,⁵.1¹²,¹⁵.1²²,²⁵.1³⁸,⁴¹.1⁴⁷,⁵⁰.0⁶,¹¹.0³⁴,³⁹]pentapentaconta-2(55),4,6(11),7,9,12(54),14,16,19,22(53),24,26,34(39),35,37,40,45,47,50-nonadecaen-8-yl]-1,3-thiazol-4-yl}(hydroxy)methylidene)amino]prop-2-enimidic acid
2-[({2-[(21z)-21-ethylidene-9,16,19,26,30,46-hexahydroxy-18-(1-hydroxyethyl)-40-methyl-31,42-dioxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decaazanonacyclo[26.16.6.1²,⁵.1¹²,¹⁵.1²²,²⁵.1³⁸,⁴¹.1⁴⁷,⁵⁰.0⁶,¹¹.0³⁴,³⁹]pentapentaconta-2(55),4,6(11),7,9,12(54),14,16,19,22(53),24,26,34(39),35,37,40,45,47,50-nonadecaen-8-yl]-1,3-thiazol-4-yl}(hydroxy)methylidene)amino]prop-2-enimidic acid
C51H43N13O12S6 (1221.1478317999997)
(2s,3r,4r,6r)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),16,20(27),21(26),22,24-decaen-16-ol
(2s,3r,4r,6r)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),16,20(27),21(26),22,24-decaen-16-ol
2-[({2-[(1s,18s,21z,28s,30s)-21-ethylidene-9,16,19,26,30,46-hexahydroxy-18-[(1s)-1-hydroxyethyl]-40-methyl-31,42-dioxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decaazanonacyclo[26.16.6.1²,⁵.1¹²,¹⁵.1²²,²⁵.1³⁸,⁴¹.1⁴⁷,⁵⁰.0⁶,¹¹.0³⁴,³⁹]pentapentaconta-2(55),4,6(11),7,9,12(54),14,16,19,22(53),24,26,34(39),35,37,40,45,47,50-nonadecaen-8-yl]-1,3-thiazol-4-yl}(hydroxy)methylidene)amino]prop-2-enimidic acid
2-[({2-[(1s,18s,21z,28s,30s)-21-ethylidene-9,16,19,26,30,46-hexahydroxy-18-[(1s)-1-hydroxyethyl]-40-methyl-31,42-dioxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decaazanonacyclo[26.16.6.1²,⁵.1¹²,¹⁵.1²²,²⁵.1³⁸,⁴¹.1⁴⁷,⁵⁰.0⁶,¹¹.0³⁴,³⁹]pentapentaconta-2(55),4,6(11),7,9,12(54),14,16,19,22(53),24,26,34(39),35,37,40,45,47,50-nonadecaen-8-yl]-1,3-thiazol-4-yl}(hydroxy)methylidene)amino]prop-2-enimidic acid
C51H43N13O12S6 (1221.1478317999997)
2-[({2-[21-ethylidene-9,16,19,26,30,46-hexahydroxy-18-(1-hydroxyethyl)-40-methyl-31,42-dioxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decaazanonacyclo[26.16.6.1²,⁵.1¹²,¹⁵.1²²,²⁵.1³⁸,⁴¹.1⁴⁷,⁵⁰.0⁶,¹¹.0³⁴,³⁹]pentapentaconta-2(55),4,6(11),7,9,12(54),14,16,19,22(53),24,26,34(39),35,37,40,45,47,50-nonadecaen-8-yl]-1,3-thiazol-4-yl}(hydroxy)methylidene)amino]prop-2-enimidic acid
2-[({2-[21-ethylidene-9,16,19,26,30,46-hexahydroxy-18-(1-hydroxyethyl)-40-methyl-31,42-dioxo-32-oxa-3,13,23,43,49-pentathia-7,17,20,27,45,51,52,53,54,55-decaazanonacyclo[26.16.6.1²,⁵.1¹²,¹⁵.1²²,²⁵.1³⁸,⁴¹.1⁴⁷,⁵⁰.0⁶,¹¹.0³⁴,³⁹]pentapentaconta-2(55),4,6(11),7,9,12(54),14,16,19,22(53),24,26,34(39),35,37,40,45,47,50-nonadecaen-8-yl]-1,3-thiazol-4-yl}(hydroxy)methylidene)amino]prop-2-enimidic acid
C51H43N13O12S6 (1221.1478317999997)
(2e,4e,6e)-7-[(1s,2r,6r)-4-{[(2e,4e)-5-cyclohexyl-1-hydroxypenta-2,4-dien-1-ylidene]amino}-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-2-yl]-n-(2-hydroxy-5-oxocyclopent-1-en-1-yl)hepta-2,4,6-trienimidic acid
(2e,4e,6e)-7-[(1s,2r,6r)-4-{[(2e,4e)-5-cyclohexyl-1-hydroxypenta-2,4-dien-1-ylidene]amino}-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-2-yl]-n-(2-hydroxy-5-oxocyclopent-1-en-1-yl)hepta-2,4,6-trienimidic acid
(2e,4e,6e)-7-(4-{[(2e,4e)-5-cyclohexyl-1-hydroxypenta-2,4-dien-1-ylidene]amino}-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-2-yl)-n-(2-hydroxy-5-oxocyclopent-1-en-1-yl)hepta-2,4,6-trienimidic acid
(2e,4e,6e)-7-(4-{[(2e,4e)-5-cyclohexyl-1-hydroxypenta-2,4-dien-1-ylidene]amino}-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-2-yl)-n-(2-hydroxy-5-oxocyclopent-1-en-1-yl)hepta-2,4,6-trienimidic acid
(2s)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),16,20(27),21(26),22,24-decaen-16-ol
(2s)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),16,20(27),21(26),22,24-decaen-16-ol
3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),16,20(27),21(26),22,24-decaen-16-ol
3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1²,⁶.0⁷,²⁸.0⁸,¹³.0¹⁵,¹⁹.0²⁰,²⁷.0²¹,²⁶]nonacosa-8(13),9,11,14(28),15(19),16,20(27),21(26),22,24-decaen-16-ol