24 25-Dihydroxy VD3 (BioDeep_00000873022)

Main id: BioDeep_00000006580

 


代谢物信息卡片


24,25-Dihydroxyvitamin D3

化学式: C27H44O3 (416.3290274)
中文名称: 24,25-二羟基维生素 D3
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C1CC[C@@H](C/C/1=C/C=C/1\CCC[C@]2(C)[C@H](CC[C@@H]12)[C@H](C)CC[C@H](C(C)(C)O)O)O
InChI: InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10-,21-11+

描述信息

24,25-Dihydroxyvitamin D (24R,25(OH)2D3) circulates in blood at concentrations about 1000 times higher than 1alpha,25(OH)2D3. 24-Hydroxylase is present in the proximal convoluted tubule cells of the kidney and in virtual all target cells of 1alpha,25(OH)2D3. Interestingly, 1alpha,25(OH)2D3 is a very strong inducer of 24-hydroxylase activity and 24R,25(OH)2D3 formationand is) also parathyroid hormone (PTH) regulates 24-hydroxylase activity but in a tissue specific manner, i.e. inhibitory in the kidney while a synergistic effect together with 1alpha,25(OH)2D3 is observed in osteoblasts. Generally, 24-hydroxylation has been considered the first step in the degradation pathway of 1alpha,25(OH)2D3 and 25-(OH)D3. However, through the past decades data have accumulated that 24R,25(OH)2D3 is not merely a degradation product but has effects on its own. Classic studies have demonstrated the significance of 24R,25(OH)2D3 for normal chicken egg hatchability and calcium and phosphorus homeostasis. More recently it became apparent that 24R,25(OH)2D3 also has distinct effects on cartilage in particular the resting zone cells. 24R,25(OH)2D3 stimulates osteocalcin synthesis in human osteoblasts. 24R,25(OH)2D3 plays a role in bone metabolism but that it acts in concert with 1alpha,25(OH)2D3 to obtain an optimal effect. (PMID: 11179746 ) [HMDB]

同义名列表

3 个代谢物同义名

24,25-Dihydroxyvitamin D; 24 25-Dihydroxy VD3; 24,25-Dihydroxyvitamin D3



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

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Plant Reactome(0)

INOH(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Simon Hsu, Leila R Zelnick, Yvonne S Lin, Cora M Best, Bryan R Kestenbaum, Kenneth E Thummel, Andrew N Hoofnagle, Ian H de Boer. Validation of the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio as a biomarker of 25-hydroxyvitamin D3 clearance. The Journal of steroid biochemistry and molecular biology. 2022 03; 217(?):106047. doi: 10.1016/j.jsbmb.2021.106047. [PMID: 34954017]
  • Hyun-Ki Kim, Hye Jin Chung, Hương Giang Lê, Byoung-Kuk Na, Min-Chul Cho. Serum 24,25-dihydroxyvitamin D level in general Korean population and its relationship with other vitamin D biomarkers. PloS one. 2021; 16(2):e0246541. doi: 10.1371/journal.pone.0246541. [PMID: 33606762]
  • Vito Francic, Stan R Ursem, Niek F Dirks, Martin H Keppel, Verena Theiler-Schwetz, Christian Trummer, Marlene Pandis, Valentin Borzan, Martin R Grübler, Nicolas D Verheyen, Winfried März, Andreas Tomaschitz, Stefan Pilz, Annemieke C Heijboer, Barbara Obermayer-Pietsch. The Effect of Vitamin D Supplementation on its Metabolism and the Vitamin D Metabolite Ratio. Nutrients. 2019 Oct; 11(10):. doi: 10.3390/nu11102539. [PMID: 31640241]
  • Martin Kaufmann, Corine Martineau, Alice Arabian, Mary Traynor, René St-Arnaud, Glenville Jones. Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3. The Journal of steroid biochemistry and molecular biology. 2019 04; 188(?):23-28. doi: 10.1016/j.jsbmb.2018.12.001. [PMID: 30553931]
  • G D Carter, F Ahmed, J Berry, E Cavalier, R Durazo-Arvizu, E Gunter, G Jones, J Jones, K Phinney, C T Sempos, P J Twomey, E L Williams, S A Wise. External Quality Assessment of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) assays. The Journal of steroid biochemistry and molecular biology. 2019 03; 187(?):130-133. doi: 10.1016/j.jsbmb.2018.11.010. [PMID: 30476591]
  • Suvi T Itkonen, Elina T Pajula, Kirsten G Dowling, George Lj Hull, Kevin D Cashman, Christel Je Lamberg-Allardt. Poor bioavailability of vitamin D2 from ultraviolet-irradiated D2-rich yeast in rats. Nutrition research (New York, N.Y.). 2018 11; 59(?):36-43. doi: 10.1016/j.nutres.2018.07.008. [PMID: 30442231]
  • Albert Shieh, Christina Ma, Rene F Chun, Jonas Wittwer-Schegg, Leon Swinkels, Tonnie Huijs, Jeffrey Wang, Ines Donangelo, Martin Hewison, John S Adams. Associations Between Change in Total and Free 25-Hydroxyvitamin D With 24,25-Dihydroxyvitamin D and Parathyroid Hormone. The Journal of clinical endocrinology and metabolism. 2018 09; 103(9):3368-3375. doi: 10.1210/jc.2018-00515. [PMID: 29931358]
  • Cora M Best, Eva K Pressman, Ruth Anne Queenan, Elizabeth Cooper, Françoise Vermeylen, Kimberly O O'Brien. Gestational Age and Maternal Serum 25-hydroxyvitamin D Concentration Interact to Affect the 24,25-dihydroxyvitamin D Concentration in Pregnant Adolescents. The Journal of nutrition. 2018 06; 148(6):868-875. doi: 10.1093/jn/nxy043. [PMID: 29796622]
  • Charles Ginsberg, Ronit Katz, Ian H de Boer, Bryan R Kestenbaum, Michel Chonchol, Michael G Shlipak, Mark J Sarnak, Andrew N Hoofnagle, Dena E Rifkin, Pranav S Garimella, Joachim H Ix. The 24,25 to 25-hydroxyvitamin D ratio and fracture risk in older adults: The cardiovascular health study. Bone. 2018 02; 107(?):124-130. doi: 10.1016/j.bone.2017.11.011. [PMID: 29155243]
  • Stephanie A Bora, Mary J Kennett, Philip B Smith, Andrew D Patterson, Margherita T Cantorna. The Gut Microbiota Regulates Endocrine Vitamin D Metabolism through Fibroblast Growth Factor 23. Frontiers in immunology. 2018; 9(?):408. doi: 10.3389/fimmu.2018.00408. [PMID: 29599772]
  • Neus Fabregat-Cabello, Jordi Farre-Segura, Loreen Huyghebaert, Stéphanie Peeters, Caroline Le Goff, Jean-Claude Souberbielle, Étienne Cavalier. A fast and simple method for simultaneous measurements of 25(OH)D, 24,25(OH)2D and the Vitamin D Metabolite Ratio (VMR) in serum samples by LC-MS/MS. Clinica chimica acta; international journal of clinical chemistry. 2017 Oct; 473(?):116-123. doi: 10.1016/j.cca.2017.08.024. [PMID: 28842174]
  • Zona Batacchi, Cassianne Robinson-Cohen, Andrew N Hoofnagle, Tamara Isakova, Bryan Kestenbaum, Kevin J Martin, Myles S Wolf, Ian H de Boer. Effects of Vitamin D2 Supplementation on Vitamin D3 Metabolism in Health and CKD. Clinical journal of the American Society of Nephrology : CJASN. 2017 Sep; 12(9):1498-1506. doi: 10.2215/cjn.00530117. [PMID: 28768705]
  • Jonathan C Y Tang, Holly Nicholls, Isabelle Piec, Christopher J Washbourne, John J Dutton, Sarah Jackson, Julie Greeves, William D Fraser. Reference intervals for serum 24,25-dihydroxyvitamin D and the ratio with 25-hydroxyvitamin D established using a newly developed LC-MS/MS method. The Journal of nutritional biochemistry. 2017 08; 46(?):21-29. doi: 10.1016/j.jnutbio.2017.04.005. [PMID: 28437713]
  • Anke Doyon, Bettina Schmiedchen, Anja Sander, Aysun Bayazit, Ali Duzova, Nur Canpolat, Daniela Thurn, Karolis Azukaitis, Ali Anarat, Justine Bacchetta, Sevgi Mir, Rukshana Shroff, Ebru Yilmaz, Cengiz Candan, Markus Kemper, Michel Fischbach, Gerard Cortina, Günter Klaus, Matthias Wuttke, Anna Köttgen, Anette Melk, Uwe Querfeld, Franz Schaefer. Genetic, Environmental, and Disease-Associated Correlates of Vitamin D Status in Children with CKD. Clinical journal of the American Society of Nephrology : CJASN. 2016 07; 11(7):1145-53. doi: 10.2215/cjn.10210915. [PMID: 27313313]