Houttuynin (BioDeep_00000863101)

Main id: BioDeep_00000011493

 


代谢物信息卡片


4-01-00-03730 (Beilstein Handbook Reference)

化学式: C12H22O2 (198.162)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCC(=O)CC=O
InChI: InChI=1S/C12H22O2/c1-2-3-4-5-6-7-8-9-12(14)10-11-13/h11H,2-10H2,1H3



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, ALB, BCL2, CASP3, CAT, MAPK1, MAPK14, MAPK8, NOS2, PIK3CA, PRKAA2, PTGS2, TLR4
Peripheral membrane protein 2 GORASP1, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 9 AKT1, ALB, BCL2, CASP3, MAPK1, MAPK14, MAPK8, NOS2, PRKAA2
cytosol 11 AKT1, ALB, BCL2, CASP3, CAT, MAPK1, MAPK14, MAPK8, NOS2, PIK3CA, PRKAA2
dendrite 1 PRKAA2
centrosome 2 ALB, MAPK1
nucleoplasm 7 AKT1, CASP3, MAPK1, MAPK14, MAPK8, NOS2, PRKAA2
Cell membrane 3 AKT1, TLR4, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 1 GORASP1
Synapse 2 MAPK1, MAPK8
cell cortex 1 AKT1
cell surface 2 TLR4, TNF
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 4 ALB, GORASP1, MAPK1, PRKAA2
Golgi membrane 2 GORASP1, INS
neuronal cell body 3 CASP3, PRKAA2, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 NOS2
plasma membrane 6 AKT1, MAPK1, NOS2, PIK3CA, TLR4, TNF
Membrane 5 AKT1, BCL2, CAT, PRKAA2, TLR4
axon 2 MAPK8, PRKAA2
caveola 2 MAPK1, PTGS2
extracellular exosome 2 ALB, CAT
endoplasmic reticulum 3 ALB, BCL2, PTGS2
extracellular space 7 ALB, CCL20, CXCL8, IL4, IL6, INS, TNF
perinuclear region of cytoplasm 3 NOS2, PIK3CA, TLR4
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CAT, MAPK1, MAPK14
protein-containing complex 5 AKT1, ALB, BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TLR4
Secreted 6 ALB, CCL20, CXCL8, IL4, IL6, INS
extracellular region 10 ALB, CAT, CCL20, CXCL8, IL4, IL6, INS, MAPK1, MAPK14, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 MAPK1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 TLR4, TNF
microtubule cytoskeleton 1 AKT1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 2 MAPK1, TLR4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
pore complex 1 BCL2
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 2 CAT, MAPK1
spindle 2 AKT1, MAPK1
cis-Golgi network 1 GORASP1
Peroxisome 2 CAT, NOS2
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
Late endosome 1 MAPK1
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
ciliary basal body 2 AKT1, ALB
phagocytic cup 2 TLR4, TNF
mitotic spindle 1 MAPK1
cytoskeleton 1 MAPK1
centriole 1 ALB
spindle pole 2 ALB, MAPK14
blood microparticle 1 ALB
endosome lumen 1 INS
Membrane, caveola 1 MAPK1
cytoplasmic stress granule 1 PRKAA2
myelin sheath 1 BCL2
pseudopodium 1 MAPK1
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 3 CAT, MAPK1, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, IL6, INS, MAPK1, PTGS2
platelet alpha granule lumen 1 ALB
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule lumen 1 MAPK1
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Alexis Shiying Huang, Benjamin Chun-Kit Tong, Harry Chun-Hin Hung, Aston Jiaxi Wu, Olivia Ka-Yi Ho, Anna Hau-Yee Kong, Maggie Ming-Ki Leung, Jingxuan Bai, Xiuqiong Fu, Zhiling Yu, Min Li, Ting Fan Leung, Judith Choi-Wo Mak, George Pak-Heng Leung, King-Ho Cheung. Targeting calcium signaling by inositol trisphosphate receptors: A novel mechanism for the anti-asthmatic effects of Houttuynia cordata. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 May; 164(?):114935. doi: 10.1016/j.biopha.2023.114935. [PMID: 37245337]
  • Chen-Hsiang Lin, Louis Kuoping Chao, Li-Yun Lin, Chin-Sheng Wu, Lee-Ping Chu, Chien-Hsueh Huang, Hsin-Chun Chen. Analysis of Volatile Compounds from Different Parts of Houttuynia cordata Thunb. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248893. [PMID: 36558024]
  • Jiao-Jiao Li, Guo-Dong Chen, Hong-Xia Fan, Dan Hu, Zheng-Qun Zhou, Kang-Hua Lan, Hui-Ping Zhang, Hideaki Maeda, Xin-Sheng Yao, Hao Gao. Houttuynoid M, an Anti-HSV Active Houttuynoid from Houttuynia cordata Featuring a Bis-houttuynin Chain Tethered to a Flavonoid Core. Journal of natural products. 2017 11; 80(11):3010-3013. doi: 10.1021/acs.jnatprod.7b00620. [PMID: 29099182]
  • Yan Gao, Jian Ping Gao, Chang Xun Chen, Hui Lin Wang, Juan Guo, Rong Wu. Beneficial effects of houttuynin on ventricular remodeling induced by coronary artery ligation in rats. European journal of pharmacology. 2014 Oct; 740(?):200-8. doi: 10.1016/j.ejphar.2014.07.015. [PMID: 25041841]
  • Shao-Dan Chen, Ting Li, Hao Gao, Qin-Chang Zhu, Chuan-Jian Lu, Hong-Ling Wu, Tao Peng, Xin-Sheng Yao. Anti HSV-1 flavonoid derivatives tethered with houttuynin from Houttuynia cordata. Planta medica. 2013 Dec; 79(18):1742-8. doi: 10.1055/s-0033-1351051. [PMID: 24288290]
  • Zhipeng Deng, Dafang Zhong, Xiaoyan Chen. Identification of modification sites on human serum albumin and human hemoglobin adducts with houttuynin using liquid chromatography coupled with mass spectrometry. Biomedical chromatography : BMC. 2012 Nov; 26(11):1377-85. doi: 10.1002/bmc.2708. [PMID: 22334394]
  • Yun Qiu, Fu-Yuan He, Li-Min Gong, Sheng Huang, Huan Zou, Feng Chen, Jie-Ying Luo. [In vivo studies on metabolic network compatibility of herba houttuyniae injection and sodium neohouttuynin injection in rats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Sep; 33(9):1428-33. doi: NULL. [PMID: 21243773]
  • Xiaotao Duan, Dafang Zhong, Xiaoyan Chen. Derivatization of beta-dicarbonyl compound with 2,4-dinitrophenylhydrazine to enhance mass spectrometric detection: application in quantitative analysis of houttuynin in human plasma. Journal of mass spectrometry : JMS. 2008 Jun; 43(6):814-24. doi: 10.1002/jms.1382. [PMID: 18286671]
  • Jiang Meng, Xiao-ping Dong, Yi-sheng Zhou, Zhi-hong Jiang, Kelvin Sze-Yin Leung, Zhong-zhen Zhao. [Orthogonal experiment using SFE-CO2 in extraction of essential oil from fresh Houttuynia cordata and analysis of essential oil by GC-MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Feb; 32(3):215-7. doi: ". [PMID: 17432141]