3,3',4,4'-Tetrachlorobiphenyl (BioDeep_00000008468)
Secondary id: BioDeep_00001873780
human metabolite blood metabolite Industrial Pollutants Volatile Flavor Compounds
代谢物信息卡片
3,4,3,4-Tetra coplanar polychlorinated biphenyl
化学式: C12H6Cl4 (289.92235960000005)
中文名称: 3,3,4,4-四氯联苯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1C2=CC(=C(C=C2)Cl)Cl)Cl)Cl
InChI: InChI=1S/C12H6Cl4/c13-9-3-1-7(5-11(9)15)8-2-4-10(14)12(16)6-8/h1-6H
描述信息
D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:1367
- KEGG: C11057
- PubChem: 36187
- HMDB: HMDB0246009
- Metlin: METLIN68802
- ChEMBL: CHEMBL344161
- chemspider: 33281
- CAS: 32598-13-3
- PMhub: MS000022089
- PubChem: 13239
- NIKKAJI: J70.045B
- KNApSAcK: 1367
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qing Huang, Cao Fang. Degradation of 3,3',4,4'-tetrachlorobiphenyl (PCB77) by dielectric barrier discharge (DBD) non-thermal plasma: Degradation mechanism and toxicity evaluation.
The Science of the total environment.
2020 Oct; 739(?):139926. doi:
10.1016/j.scitotenv.2020.139926. [PMID: 32540661] - Md Saydur Rahman, Richard J Kline, Omar A Vázquez, Izhar A Khan, Peter Thomas. Molecular characterization and expression of arginine vasotocin V1a2 receptor in Atlantic croaker brain: Potential mechanisms of its downregulation by PCB77.
Journal of biochemical and molecular toxicology.
2020 Jul; 34(7):e22500. doi:
10.1002/jbt.22500. [PMID: 32220049] - Meriem Koual, German Cano-Sancho, Anne-Sophie Bats, Céline Tomkiewicz, Yael Kaddouch-Amar, Nathalie Douay-Hauser, Charlotte Ngo, Hélène Bonsang, Myriam Deloménie, Fabrice Lecuru, Bruno Le Bizec, Philippe Marchand, Jeremie Botton, Robert Barouki, Jean-Philippe Antignac, Xavier Coumoul. Associations between persistent organic pollutants and risk of breast cancer metastasis.
Environment international.
2019 11; 132(?):105028. doi:
10.1016/j.envint.2019.105028. [PMID: 31382183] - Yulang Chi, Hongou Wang, Yi Lin, Yanyang Lu, Qiansheng Huang, Guozhu Ye, Sijun Dong. Gut microbiota characterization and lipid metabolism disorder found in PCB77-treated female mice.
Toxicology.
2019 05; 420(?):11-20. doi:
10.1016/j.tox.2019.03.011. [PMID: 30935970] - Chen Tu, Luyao Ma, Pengpeng Guo, Fang Song, Ying Teng, Haibo Zhang, Yongming Luo. Rhizoremediation of a dioxin-like PCB polluted soil by alfalfa: Dynamic characterization at temporal and spatial scale.
Chemosphere.
2017 Dec; 189(?):517-524. doi:
10.1016/j.chemosphere.2017.09.091. [PMID: 28961537] - N Ramanujam, M Sivaselvakumar, S Ramalingam. Fast and parallel determination of PCB 77 and PCB 180 in plasma using ultra performance liquid chromatography with diode array detection: A pharmacokinetic study in Swiss albino mouse.
Biomedical chromatography : BMC.
2017 Nov; 31(11):. doi:
10.1002/bmc.4000. [PMID: 28485018] - Ke Su, Xifeng Lv, Hui Song, Xuesong Luo, Cheng Chen. PCB77 Inducing Renal Tubular Cell Apoptosis.
Ultrastructural pathology.
2015 May; 39(3):192-7. doi:
10.3109/01913123.2014.973130. [PMID: 25347139] - Hongtao Shang, Yingming Li, Thanh Wang, Pu Wang, Haidong Zhang, Qinghua Zhang, Guibin Jiang. The presence of polychlorinated biphenyls in yellow pigment products in China with emphasis on 3,3'-dichlorobiphenyl (PCB 11).
Chemosphere.
2014 Mar; 98(?):44-50. doi:
10.1016/j.chemosphere.2013.09.075. [PMID: 24231041] - Yoshihisa Kato, Koichi Haraguchi, Mao Onishi, Shinichi Ikushiro, Tetsuya Endo, Chiho Ohta, Nobuyuki Koga, Shizuo Yamada, Masakuni Degawa. 3,3',4,4'-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in C57BL/6 and DBA/2 mice occurs mainly through enhanced accumulation of thyroxine in the liver.
Biological & pharmaceutical bulletin.
2014; 37(3):504-9. doi:
10.1248/bpb.b13-00775. [PMID: 24351552] - Lei Wang, Shuping Zhang, Ronghai Lin, Long Li, Daoqiang Zhang, Xinghong Li, Sijin Liu. PCB-77 disturbs iron homeostasis through regulating hepcidin gene expression.
Gene.
2013 Dec; 532(1):146-51. doi:
10.1016/j.gene.2013.09.023. [PMID: 24055725] - Nicki A Baker, Victoria English, Manjula Sunkara, Andrew J Morris, Kevin J Pearson, Lisa A Cassis. Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes.
The Journal of nutritional biochemistry.
2013 Dec; 24(12):2168-74. doi:
10.1016/j.jnutbio.2013.08.009. [PMID: 24231106] - Nicki A Baker, Michael Karounos, Victoria English, Jun Fang, Yinan Wei, Arnold Stromberg, Manjula Sunkara, Andrew J Morris, Hollie I Swanson, Lisa A Cassis. Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice.
Environmental health perspectives.
2013 Jan; 121(1):105-10. doi:
10.1289/ehp.1205421. [PMID: 23099484] - Fadheela Al-Salman, Nick Plant. Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner.
Toxicology and applied pharmacology.
2012 Aug; 263(1):7-13. doi:
10.1016/j.taap.2012.05.016. [PMID: 22664347] - Rance Nault, Samar Al-Hameedi, Thomas W Moon. Effects of polychlorinated biphenyls on whole animal energy mobilization and hepatic cellular respiration in rainbow trout, Oncorhynchus mykiss.
Chemosphere.
2012 May; 87(9):1057-62. doi:
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2012 Mar; 155(2):300-6. doi:
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Chemistry Central journal.
2011 Dec; 5(?):87. doi:
10.1186/1752-153x-5-87. [PMID: 22185578] - Violeta Arsenescu, Razvan Arsenescu, Madhura Parulkar, Michael Karounos, Xuan Zhang, Nicki Baker, Lisa A Cassis. Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice.
Toxicology and applied pharmacology.
2011 Nov; 257(1):148-54. doi:
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Environmental research.
2011 Apr; 111(3):337-47. doi:
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Environment international.
2010 Nov; 36(8):893-900. doi:
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Environment international.
2010 Nov; 36(8):880-3. doi:
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Environmental science & technology.
2009 Oct; 43(19):7503-9. doi:
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Toxicology letters.
2009 Sep; 189(2):96-101. doi:
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Toxicology and applied pharmacology.
2009 May; 237(1):1-7. doi:
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Microbial cell factories.
2009 Jan; 8(?):5. doi:
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Chemico-biological interactions.
2008 Nov; 176(2-3):71-8. doi:
10.1016/j.cbi.2008.08.007. [PMID: 18786521] - Richard M Green, Nikolas J Hodges, J Kevin Chipman, Michael R O'Donovan, Mark Graham. Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls.
Mutagenesis.
2008 Nov; 23(6):457-63. doi:
10.1093/mutage/gen035. [PMID: 18583386] - Violeta Arsenescu, Razvan I Arsenescu, Victoria King, Hollie Swanson, Lisa A Cassis. Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis.
Environmental health perspectives.
2008 Jun; 116(6):761-8. doi:
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2007; 21(2):68-75. doi:
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General and comparative endocrinology.
2005 Aug; 143(1):1-9. doi:
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Chemosphere.
2004 Feb; 54(5):611-8. doi:
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1996 Jan; 113(1):51-9. doi:
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1989 Nov; 19(11):1307-18. doi:
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1989 Sep; 100(2):315-27. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
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1989; 17(3):536-44. doi:
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1988 Aug; 50(3):317-30. doi:
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1988 Jun; 9(6):919-24. doi:
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Toxicology letters.
1988 Apr; 41(1):77-86. doi:
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1988; 68(3-4):203-17. doi:
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1987 Jul; 89(3):370-7. doi:
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1986 Dec; 86(3):380-90. doi:
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Toxicology and applied pharmacology.
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