Glyceollin II (BioDeep_00000008084)

 

Secondary id: BioDeep_00001872107

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


17,17-dimethyl-3,12,16-trioxapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-1(13),4(9),5,7,14,18,20-heptaene-6,10-diol

化学式: C20H18O5 (338.1154)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 30.37%

分子结构信息

SMILES: C12OC(C)(C)C=CC=1C=C1[C@]3([H])OC4C=C(O)C=CC=4[C@]3(O)COC1=C2
InChI: InChI=1S/C20H18O5/c1-19(2)6-5-11-7-13-16(9-15(11)25-19)23-10-20(22)14-4-3-12(21)8-17(14)24-18(13)20/h3-9,18,21-22H,10H2,1-2H3

描述信息

Phytoalexin from Glycine max (soybean). Glyceollin II is found in soy bean, fats and oils, and pulses.
Glyceollin II is found in fats and oils. Phytoalexin from Glycine max (soybean).

同义名列表

6 个代谢物同义名

17,17-dimethyl-3,12,16-trioxapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-1(13),4(9),5,7,14,18,20-heptaene-6,10-diol; 3,3-Dimethyl-3H,7H-benzofuro[3,2-c]pyrano[3,2-g][1]benzopyran-7a,10(12ah)-diol, 9ci; (-)-Glyceollin II; SCHEMBL12315038; Glyceollin II; (-)-Glyceollin II



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(2)

代谢反应

10 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(8)

  • glyceollin biosynthesis: (6αS,11αS)-4-dimethylallyl-3,6α,9-trihydroxypterocarpan + H+ + NADPH + O2 ⟶ H2O + NADP+ + glyceollin I
  • glyceollin biosynthesis: (6αS,11αS)-4-dimethylallyl-3,6α,9-trihydroxypterocarpan + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + glyceollin I
  • glyceollin biosynthesis: (6αS,11αS)-4-dimethylallyl-3,6α,9-trihydroxypterocarpan + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + glyceollin I
  • superpathway of pterocarpan biosynthesis (via daidzein): (6αS,11αS)-2-dimethylallyl-3,6α,9-trihydroxypterocarpan + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + glyceollin II
  • glyceollin biosynthesis: (6αS,11αS)-2-dimethylallyl-3,6α,9-trihydroxypterocarpan + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + glyceollin II
  • glyceollin biosynthesis: (6αS,11αS)-4-dimethylallyl-3,6α,9-trihydroxypterocarpan + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + glyceollin I
  • superpathway of pterocarpan biosynthesis (via daidzein): 2,4',7-trihydroxyisoflavanone ⟶ H2O + daidzein
  • glyceollin biosynthesis: (6αS,11αS)-4-dimethylallyl-3,6α,9-trihydroxypterocarpan + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ H2O + an oxidized [NADPH-hemoprotein reductase] + glyceollin I

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

43 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AHR, FDPS, PCSK9, SREBF2, TLR3, TLR4
Endosome membrane 2 TLR3, TLR4
Endoplasmic reticulum membrane 3 CD4, SREBF2, TLR3
Nucleus 2 AHR, SREBF2
cytosol 3 AHR, FDPS, SREBF2
nucleoplasm 3 AHR, FDPS, SREBF2
Cell membrane 5 CD4, CD8A, SELL, TLR4, TNF
Multi-pass membrane protein 1 SREBF2
Golgi apparatus membrane 1 SREBF2
cell surface 4 ITGAX, PCSK9, TLR4, TNF
Golgi apparatus 1 PCSK9
Golgi membrane 3 INS, SREBF2, TLR3
lysosomal membrane 2 PCSK9, TLR3
neuronal cell body 1 TNF
Lysosome 1 PCSK9
endosome 1 PCSK9
plasma membrane 8 CD4, CD8A, ITGAX, PCSK9, SELL, TLR3, TLR4, TNF
Membrane 4 FDPS, ITGAX, TLR3, TLR4
extracellular exosome 1 BMP3
endoplasmic reticulum 2 PCSK9, SREBF2
extracellular space 7 BMP3, IL17A, INS, PCSK9, SELL, TLR3, TNF
perinuclear region of cytoplasm 2 PCSK9, TLR4
protein-containing complex 1 AHR
intracellular membrane-bounded organelle 1 SREBF2
Single-pass type I membrane protein 6 CD4, CD8A, ITGAX, SELL, TLR3, TLR4
Secreted 4 BMP3, IL17A, INS, PCSK9
extracellular region 6 BMP3, CD8A, IL17A, INS, PCSK9, TNF
Single-pass membrane protein 1 TLR3
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 1 FDPS
transcription regulator complex 1 AHR
external side of plasma membrane 7 CD4, CD8A, IL17A, ITGAX, SELL, TLR4, TNF
Early endosome 4 CD4, PCSK9, TLR3, TLR4
COPII-coated ER to Golgi transport vesicle 1 PCSK9
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 CD4, TNF
extracellular matrix 1 TLR3
Peroxisome 1 FDPS
Cell projection, ruffle 1 TLR4
Late endosome 1 PCSK9
ruffle 1 TLR4
receptor complex 2 CD8A, TLR4
chromatin 2 AHR, SREBF2
phagocytic cup 2 TLR4, TNF
endosome lumen 1 INS
aryl hydrocarbon receptor complex 1 AHR
tertiary granule membrane 1 ITGAX
lipopolysaccharide receptor complex 1 TLR4
plasma membrane raft 1 CD8A
secretory granule lumen 1 INS
secretory granule membrane 2 ITGAX, SELL
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 CD4, INS, PCSK9
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ER to Golgi transport vesicle membrane 1 SREBF2
clathrin-coated endocytic vesicle membrane 1 CD4
ficolin-1-rich granule membrane 1 ITGAX
endolysosome membrane 2 PCSK9, TLR3
SREBP-SCAP-Insig complex 1 SREBF2
[Isoform 1]: Cell membrane 1 CD8A
extrinsic component of external side of plasma membrane 1 PCSK9
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF2
integrin complex 1 ITGAX
PCSK9-LDLR complex 1 PCSK9
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
integrin alphaX-beta2 complex 1 ITGAX
PCSK9-AnxA2 complex 1 PCSK9
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
[Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane 1 SREBF2
[Processed sterol regulatory element-binding protein 2]: Nucleus 1 SREBF2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Haiqiu Huang, Zhuohong Xie, Stephen M Boue, Deepak Bhatnagar, Wallace Yokoyama, Liangli Lucy Yu, Thomas T Y Wang. Cholesterol-lowering activity of soy-derived glyceollins in the golden Syrian hamster model. Journal of agricultural and food chemistry. 2013 Jun; 61(24):5772-82. doi: 10.1021/jf400557p. [PMID: 23697397]
  • Hyo Jung Kim, Hwa-Jin Suh, Choong Hwan Lee, Jeong Hwan Kim, Sun Chul Kang, Sunmin Park, Jong-Sang Kim. Antifungal activity of glyceollins isolated from soybean elicited with Aspergillus sojae. Journal of agricultural and food chemistry. 2010 Sep; 58(17):9483-7. doi: 10.1021/jf101694t. [PMID: 20666365]