Illudin S (BioDeep_00000007545)

   


代谢物信息卡片


(-)-1alpha,7beta,12-trihydroxy-2,9-illudadien-8-one

化学式: C15H20O4 (264.1362)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C2C(=CC(C)(CO)C2O)C(=O)C(C)(O)C12CC2
InChI: InChI=1S/C15H20O4/c1-8-10-9(6-13(2,7-16)12(10)18)11(17)14(3,19)15(8)4-5-15/h6,12,16,18-19H,4-5,7H2,1-3H3/t12-,13+,14+/m1/s1

描述信息

D000970 - Antineoplastic Agents

同义名列表

5 个代谢物同义名

Illudin S; (-)-1alpha,7beta,12-trihydroxy-2,9-illudadien-8-one; (-)-Illudin S; NSC626369; Illudin S



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ABCB1, AKR1B1, ERCC1, ERCC2, GTF2H5, NQO1, PTGR1, RAD18, TENT4A, XDH, XPC
Nucleus 12 DDB2, ERCC1, ERCC2, ERCC3, ERCC4, GTF2H5, NQO1, RAD18, RAD23B, TENT4A, XPA, XPC
cytosol 8 AKR1A1, AKR1B1, ERCC2, GSR, NQO1, RAD23B, XDH, XPC
dendrite 1 NQO1
nuclear body 1 RAD18
centrosome 1 RAD18
nucleoplasm 12 AKR1B1, DDB2, ERCC1, ERCC2, ERCC3, ERCC4, GTF2H5, RAD18, RAD23B, TENT4A, XPA, XPC
Cell membrane 2 ABCB1, CPD
Multi-pass membrane protein 1 ABCB1
Synapse 2 AKR1A1, NQO1
cell junction 1 DDB2
cell surface 1 ABCB1
Golgi apparatus 1 TENT4A
neuronal cell body 1 NQO1
Cytoplasm, cytosol 2 AKR1A1, NQO1
plasma membrane 3 ABCB1, CPD, XPC
Membrane 3 ABCB1, CPD, NQO1
apical plasma membrane 2 ABCB1, AKR1A1
extracellular exosome 6 ABCB1, AKR1A1, AKR1B1, CPD, GSR, PTGR1
extracellular space 4 AKR1A1, AKR1B1, CPD, XDH
mitochondrion 3 AKR1B1, GSR, XPC
protein-containing complex 1 DDB2
intracellular membrane-bounded organelle 1 XPC
Single-pass type I membrane protein 1 CPD
mitochondrial matrix 1 GSR
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 RAD18
nuclear membrane 1 TENT4A
external side of plasma membrane 1 GSR
nucleolus 3 GTF2H5, TENT4A, XPC
Apical cell membrane 2 ABCB1, AKR1A1
Cytoplasm, cytoskeleton, spindle 1 ERCC2
spindle 1 ERCC2
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
chromatin 2 DDB2, XPC
Chromosome 3 DDB2, ERCC4, XPC
[Isoform 3]: Nucleus 1 ERCC1
chromosome, telomeric region 2 ERCC1, ERCC4
site of double-strand break 1 RAD18
intercellular bridge 1 XPA
Nucleus, nucleoplasm 1 TENT4A
replication fork 1 RAD18
proteasome complex 1 RAD23B
transcription factor TFIID complex 3 ERCC2, ERCC3, GTF2H5
[Isoform 2]: Cytoplasm 1 ERCC1
[Isoform 1]: Nucleus 1 ERCC1
external side of apical plasma membrane 1 ABCB1
nuclear inclusion body 1 RAD18
site of DNA damage 2 DDB2, XPC
[Isoform 4]: Nucleus 1 ERCC1
MMXD complex 1 ERCC2
transcription preinitiation complex 1 ERCC3
ERCC4-ERCC1 complex 2 ERCC1, ERCC4
nucleotide-excision repair complex 3 ERCC1, ERCC4, XPC
nucleotide-excision repair factor 1 complex 3 ERCC1, ERCC4, XPA
CAK-ERCC2 complex 1 ERCC2
transcription factor TFIIH core complex 3 ERCC2, ERCC3, GTF2H5
transcription factor TFIIH holo complex 3 ERCC2, ERCC3, GTF2H5
nucleotide-excision repair factor 3 complex 1 ERCC3
XPC complex 2 RAD23B, XPC
TRAMP complex 1 TENT4A
Cul4A-RING E3 ubiquitin ligase complex 1 DDB2
Cul4-RING E3 ubiquitin ligase complex 1 DDB2
Cul4B-RING E3 ubiquitin ligase complex 1 DDB2
nucleotide-excision repair factor 2 complex 1 XPC
Rad6-Rad18 complex 1 RAD18


文献列表

  • Christina Nord, Audrius Menkis, Anders Broberg. Cytotoxic Illudane Sesquiterpenes from the Fungus Granulobasidium vellereum (Ellis and Cragin) Jülich. Journal of natural products. 2015 Nov; 78(11):2559-64. doi: 10.1021/acs.jnatprod.5b00500. [PMID: 26575435]
  • Virginie Poindessous, Florence Koeppel, Eric Raymond, Martine Comisso, Stephen J Waters, Annette K Larsen. Marked activity of irofulven toward human carcinoma cells: comparison with cisplatin and ecteinascidin. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 Jul; 9(7):2817-25. doi: ". [PMID: 12855662]
  • K Tanaka, S Miyasaka, T Inoue. Histopathological effects of illudin S, a toxic substance of poisonous mushroom, in rat. Human & experimental toxicology. 1996 Apr; 15(4):289-93. doi: 10.1177/096032719601500403. [PMID: 8845217]
  • K Tanaka, T Inoue, Y Tezuka, T Kikuchi. Metabolism of illudin S, a toxic substance of Lampteromyces japonicus: urinary excretion of mercapturic acids in rat. Xenobiotica; the fate of foreign compounds in biological systems. 1996 Mar; 26(3):347-54. doi: 10.3109/00498259609046713. [PMID: 8730925]
  • K Tanaka, T Inoue, M Kanai, T Kikuchi. Metabolism of illudin S, a toxic substance of Lampteromyces japonicus. IV. Urinary excretion of an illudin S metabolite in rat. Xenobiotica; the fate of foreign compounds in biological systems. 1994 Dec; 24(12):1237-43. doi: 10.3109/00498259409038679. [PMID: 7771110]