bulbocapnine (BioDeep_00000007320)

   

natural product


代谢物信息卡片


d-Bulbocapnine

化学式: C19H19NO4 (325.1314)
中文名称: 空褐麟碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCC2=CC3=C(C4=C2C1CC5=C4C(=C(C=C5)OC)O)OCO3
InChI: InChI=1S/C19H19NO4/c1-20-6-5-11-8-14-19(24-9-23-14)17-15(11)12(20)7-10-3-4-13(22-2)18(21)16(10)17/h3-4,8,12,21H,5-7,9H2,1-2H3

描述信息

An aporphine alkaloid that has been isolated from Corydalis and exhibits inhibitory activity against enzymes such as tyrosine 3-monooxygenase and diamine oxidase.

同义名列表

3 个代谢物同义名

bulbocapnine; d-Bulbocapnine; Bulbocapnine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

57 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 AXIN2, CYP2C19, DBH
Peripheral membrane protein 2 ACHE, AOC1
Endoplasmic reticulum membrane 4 CYP19A1, CYP2C19, DRD1, RAC2
Nucleus 3 ACHE, AXIN2, DRD1
cytosol 2 AXIN2, RAC2
dendrite 1 DRD2
centrosome 1 AXIN2
Cell membrane 6 ACHE, ADRB3, AOC1, DRD1, DRD2, ITPRIP
lamellipodium 1 RAC2
Multi-pass membrane protein 4 ADRB3, CYP19A1, DRD1, DRD2
Golgi apparatus membrane 1 DRD2
Synapse 3 ACHE, DBH, DRD2
cell surface 1 ACHE
glutamatergic synapse 2 DRD1, DRD2
Golgi apparatus 1 ACHE
Golgi membrane 2 DRD2, INS
neuromuscular junction 1 ACHE
presynaptic membrane 2 DRD1, DRD2
acrosomal vesicle 1 DRD2
plasma membrane 10 ACHE, ADRB3, AOC1, AXIN2, BCHE, CYP2C19, DRD1, DRD2, ITPRIP, RAC2
synaptic vesicle membrane 1 DRD2
Membrane 4 ACHE, CYP19A1, DBH, ITPRIP
axon 1 DRD2
extracellular exosome 2 AOC1, RAC2
endoplasmic reticulum 2 CYP19A1, DBH
extracellular space 6 ACHE, AOC1, BCHE, CPA6, DBH, INS
perinuclear region of cytoplasm 1 ACHE
bicellular tight junction 1 AOC1
intracellular membrane-bounded organelle 2 CYP2C19, DBH
Microsome membrane 1 CYP19A1
Single-pass type I membrane protein 1 ITPRIP
Secreted 5 ACHE, BCHE, DBH, INS, PRB1
extracellular region 6 ACHE, AOC1, BCHE, DBH, INS, PRB1
mitochondrial outer membrane 1 RAC2
Extracellular side 2 ACHE, AOC1
centriolar satellite 1 DBH
ciliary membrane 2 DRD1, DRD2
Secreted, extracellular space, extracellular matrix 1 CPA6
dendritic spine 2 DRD1, DRD2
perikaryon 1 DRD2
beta-catenin destruction complex 1 AXIN2
Single-pass type II membrane protein 1 DBH
postsynaptic membrane 2 DRD1, DRD2
focal adhesion 1 RAC2
GABA-ergic synapse 2 DRD1, DRD2
Peroxisome 1 AOC1
basement membrane 1 ACHE
Cell projection, dendritic spine 1 DRD1
lateral plasma membrane 1 DRD2
Nucleus outer membrane 1 ITPRIP
nuclear outer membrane 1 ITPRIP
receptor complex 1 ADRB3
cilium 2 DRD1, DRD2
phagocytic vesicle membrane 1 RAC2
Secreted, extracellular space 1 AOC1
blood microparticle 1 BCHE
non-motile cilium 2 DRD1, DRD2
Lipid-anchor, GPI-anchor 1 ACHE
sperm flagellum 1 DRD2
nuclear envelope 1 RAC2
endosome lumen 1 INS
Cell projection, dendrite 1 DRD1
side of membrane 1 ACHE
secretory granule lumen 2 DBH, INS
secretory granule membrane 1 DBH
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 BCHE, INS
axon terminus 1 DRD2
specific granule lumen 1 AOC1
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
nuclear envelope lumen 1 BCHE
synaptic cleft 1 ACHE
dopaminergic synapse 1 DRD2
Cytoplasmic vesicle, secretory vesicle membrane 1 DBH
Cell projection, cilium membrane 1 DRD1
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
transport vesicle membrane 1 DBH
NADPH oxidase complex 1 RAC2
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
G protein-coupled receptor complex 2 DRD1, DRD2
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Fatma Gizem Avci, Nihat Alpagu Sayar, Berna Sariyar Akbulut. An OMIC approach to elaborate the antibacterial mechanisms of different alkaloids. Phytochemistry. 2018 May; 149(?):123-131. doi: 10.1016/j.phytochem.2017.12.023. [PMID: 29494814]
  • Helene de Wet, Fanie R van Heerden, Ben-Erik van Wyk. Alkaloidal variation in cissampelos capensis (Menispermaceae). Molecules (Basel, Switzerland). 2011 Apr; 16(4):3001-9. doi: 10.3390/molecules16043001. [PMID: 21475122]
  • Robert Nawrot, Maria Wolun-Cholewa, Wojciech Bialas, Danuta Wyrzykowska, Stanislaw Balcerkiewicz, Anna Gozdzicka-Jozefiak. Cytotoxic activity of proteins isolated from extracts of Corydalis cava tubers in human cervical carcinoma HeLa cells. BMC complementary and alternative medicine. 2010 Dec; 10(?):78. doi: 10.1186/1472-6882-10-78. [PMID: 21167042]
  • M H Salehi Sourmaghi, B Azadi, Gh Amin, M Amini, M Sharifzadeh. The first phytochemical report of Galanthus transcaucasicus Fomin. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2010; 18(2):124-7. doi: . [PMID: 22615606]
  • Strahil Berkov, Jaume Bastida, Milena Nikolova, Francesc Viladomat, Carles Codina. Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts. Phytochemical analysis : PCA. 2008 Sep; 19(5):411-9. doi: 10.1002/pca.1066. [PMID: 18446766]
  • Anne Adsersen, Anne Kjølbye, Ole Dall, Anna K Jäger. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort. Journal of ethnopharmacology. 2007 Aug; 113(1):179-82. doi: 10.1016/j.jep.2007.05.006. [PMID: 17574358]
  • K S Chen, Y C Wu, C M Teng, F N Ko, T S Wu. Bioactive alkaloids from Illigera luzonensis. Journal of natural products. 1997 Jun; 60(6):645-7. doi: 10.1021/np9700735. [PMID: 9214740]
  • S Arakawa, N Yago, S Isobe, R Ohkawa, H Mori, S Okinaga. [Dopamine increases the ovarian progesterone synthesis of PMSG-treated rats by regulating 3 beta-HSD activity]. Nihon Naibunpi Gakkai zasshi. 1994 May; 70(4):447-56. doi: 10.1507/endocrine1927.70.4_447. [PMID: 7958094]
  • I Gyertyán, L Petöcz, J Bajnógel, Z Szücs, M Hegedüs, K Gyüre, I Gacsályi, D Krizsán, M I Fekete. Possible involvement of the dopaminergic system in the mode of action of the potential antidepressant trazium esilate. Arzneimittel-Forschung. 1989 Jul; 39(7):775-81. doi: . [PMID: 2551306]
  • M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study. Cancer treatment reports. 1979 Sep; 63(9-10):1663-7. doi: . [PMID: 91435]
  • G OTTAVIANO, P PAPPALARDO. Pharmacological research on bulbocapnine; influence of prolonged bulbocapnine treatment on blood serum cholinesterase. Acta neurologica. 1947 Sep; 2(5):705-10. doi: . [PMID: 18903231]
  • G OTTAVIANO, P PAPPALARDO. Pharmacological research on bulbocapnine, the trend of calcium and potassium on the dog's blood serum during prolonged treatment with bulbocapnine. Acta neurologica. 1947 Mar; 2(2):194-8. doi: NULL. [PMID: 20261799]