Olivacine (BioDeep_00000007248)

   

natural product


代谢物信息卡片


6H-Pyrido[4,3-b]carbazole,1,5-dimethyl-

化学式: C17H14N2 (246.1157)
中文名称: 1,5-二甲基-6H-吡啶并[4,3-b]咔唑
谱图信息: 最多检出来源 Viridiplantae(plant) 88%

分子结构信息

SMILES: CC1=C(C=CN=C2C)C2=CC3=C1NC4=C3C=CC=C4
InChI: InChI=1S/C17H14N2/c1-10-12-7-8-18-11(2)14(12)9-15-13-5-3-4-6-16(13)19-17(10)15/h3-9,18H,1-2H3

描述信息

D000970 - Antineoplastic Agents > D000972 - Antineoplastic Agents, Phytogenic > D004611 - Ellipticines

同义名列表

3 个代谢物同义名

6H-Pyrido[4,3-b]carbazole,1,5-dimethyl-; Olivacine; Olivacine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, CYP1A1, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2E1, CYP3A4, ITPR3
Peripheral membrane protein 4 ACHE, CYP1A1, CYP2B6, CYP2E1
Endoplasmic reticulum membrane 11 CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2E1, CYP3A4, FMO3, ITPR3, NRAS
Mitochondrion membrane 1 TSPO
Nucleus 2 ACHE, TOP1
cytosol 2 NRAS, TSPO
mitochondrial membrane 1 TSPO
nucleoplasm 2 ITPR3, TOP1
Cell membrane 3 ABCB1, ACHE, NRAS
Lipid-anchor 1 NRAS
Cytoplasmic side 1 NRAS
Early endosome membrane 1 GPNMB
Multi-pass membrane protein 4 ABCB1, ATP4A, ITPR3, TSPO
Golgi apparatus membrane 1 NRAS
Synapse 1 ACHE
cell surface 2 ABCB1, ACHE
Golgi apparatus 2 ACHE, NRAS
Golgi membrane 1 NRAS
mitochondrial inner membrane 2 CYP1A1, CYP2E1
neuromuscular junction 1 ACHE
neuronal cell body 1 ITPR3
plasma membrane 9 ABCB1, ACHE, ATP4A, BCHE, CYP2C19, CYP2C9, GPNMB, ITPR3, NRAS
Membrane 9 ABCB1, ACHE, ATP4A, CYP2A6, CYP3A4, GPNMB, ITPR3, NRAS, TSPO
apical plasma membrane 2 ABCB1, ATP4A
brush border 1 ITPR3
extracellular exosome 3 ABCB1, NRAS, TSPO
endoplasmic reticulum 3 FMO3, ITPR3, TSPO
extracellular space 3 ACHE, ATP4A, BCHE
perinuclear region of cytoplasm 1 ACHE
mitochondrion 2 CYP1A1, TSPO
intracellular membrane-bounded organelle 10 CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C9, CYP2E1, CYP3A4, FMO3, TSPO
Microsome membrane 7 CYP1A1, CYP1A2, CYP2B6, CYP2C9, CYP2E1, CYP3A4, FMO3
Single-pass type I membrane protein 1 GPNMB
Secreted 2 ACHE, BCHE
extracellular region 2 ACHE, BCHE
Single-pass membrane protein 1 FMO3
mitochondrial outer membrane 1 TSPO
Extracellular side 1 ACHE
perikaryon 1 TOP1
nucleolus 2 ITPR3, TOP1
Melanosome membrane 1 GPNMB
P-body 1 TOP1
apical part of cell 1 ITPR3
Apical cell membrane 2 ABCB1, ATP4A
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
basement membrane 1 ACHE
sarcoplasmic reticulum 1 ITPR3
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
Chromosome 1 TOP1
Nucleus, nucleolus 1 TOP1
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
fibrillar center 1 TOP1
Nucleus, nucleoplasm 1 TOP1
tertiary granule membrane 1 NRAS
side of membrane 1 ACHE
secretory granule membrane 1 ITPR3
endoplasmic reticulum lumen 1 BCHE
male germ cell nucleus 1 TOP1
nuclear envelope lumen 1 BCHE
platelet dense tubular network membrane 1 ITPR3
cytoplasmic microtubule 1 CYP2A6
synaptic cleft 1 ACHE
protein-DNA complex 1 TOP1
external side of apical plasma membrane 1 ABCB1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
transport vesicle membrane 1 ITPR3
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
potassium:proton exchanging ATPase complex 1 ATP4A
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Andreia Montoia, Luiz F Rocha E Silva, Zelina E Torres, David S Costa, Marycleuma C Henrique, Emerson S Lima, Marne C Vasconcellos, Rita C Z Souza, Monica R F Costa, Andriy Grafov, Iryna Grafova, Marcos N Eberlin, Wanderli P Tadei, Rodrigo C N Amorim, Adrian M Pohlit. Antiplasmodial activity of synthetic ellipticine derivatives and an isolated analog. Bioorganic & medicinal chemistry letters. 2014 Jun; 24(12):2631-4. doi: 10.1016/j.bmcl.2014.04.070. [PMID: 24813729]
  • L F Rocha e Silva, A Montoia, R C N Amorim, M R Melo, M C Henrique, S M Nunomura, M R F Costa, V F Andrade Neto, D S Costa, G Dantas, J Lavrado, R Moreira, A Paulo, A C Pinto, W P Tadei, R S Zacardi, M N Eberlin, A M Pohlit. Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Dec; 20(1):71-6. doi: 10.1016/j.phymed.2012.09.008. [PMID: 23092722]
  • Beata Tylińska, Ryszard Jasztold-Howorko, Henryk Mastalarz, Dagmara Kłopotowska, Beata Filip, Joanna Wietrzyk. Synthesis and structure-activity relationship analysis of new olivacine derivatives. Acta poloniae pharmaceutica. 2010 Sep; 67(5):495-502. doi: . [PMID: 20873417]
  • M C Chevallier-Multon, A Jacquemin-Sablon, R Besselièvre, H P Husson, J B Le Pecq. Comparative cytotoxicities of a series of ellipticine and olivacine derivatives on multidrug resistant cells of human and murine origins. Anti-cancer drug design. 1990 Nov; 5(4):319-35. doi: . [PMID: 1981310]