Cucurbitacin C (BioDeep_00000006984)

 

Secondary id: BioDeep_00000636708, BioDeep_00000896119

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(3E)-6-[5,13-Dihydroxy-1-(hydroxymethyl)-6,6,11,15-tetramethyl-17-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-14-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetic acid

化学式: C32H48O8 (560.3349008)
中文名称: 葫芦素C
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.13%

分子结构信息

SMILES: CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CCC(C4(C)C)O)CO)C)C)O)O
InChI: InChI=1S/C32H48O8/c1-18(34)40-27(2,3)14-13-24(37)31(8,39)26-21(35)15-29(6)22-11-9-19-20(10-12-23(36)28(19,4)5)32(22,17-33)25(38)16-30(26,29)7/h9,13-14,20-23,26,33,35-36,39H,10-12,15-17H2,1-8H3/b14-13+/t20-,21-,22+,23+,26+,29+,30-,31+,32+/m1/s1

描述信息

Cucurbitacin C is found in cucumber. Cucurbitacin C is a constituent of Cucurbitaceae, e.g. Cucumis sativus (cucumber)
Constituent of Cucurbitaceae, e.g. Cucumis sativus (cucumber). Cucurbitacin C is found in cucumber and fruits.

同义名列表

5 个代谢物同义名

(3E)-6-[5,13-Dihydroxy-1-(hydroxymethyl)-6,6,11,15-tetramethyl-17-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-14-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetic acid; (3E)-6-[5,13-dihydroxy-1-(hydroxymethyl)-6,6,11,15-tetramethyl-17-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-14-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate; Cucurbitacine (c); cucurbitacin c; FT-0777847



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dongchao Xu, Ajuan Liu, Qiang Liu, Hongchen Zhang, Mengyao Tian, Ying Bian, Xiaofeng Zhang, Meidan Ying, Hongzhang Shen. Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis. Biochemical pharmacology. 2023 Sep; ?(?):115810. doi: 10.1016/j.bcp.2023.115810. [PMID: 37717690]
  • Yongshuo Ma, Dawei Li, Yang Zhong, Xiaohan Wang, Legong Li, Anne Osbourn, William J Lucas, Sanwen Huang, Yi Shang. Vacuolar MATE/DTX protein-mediated cucurbitacin C transport is co-regulated with bitterness biosynthesis in cucumber. The New phytologist. 2023 Feb; ?(?):. doi: 10.1111/nph.18786. [PMID: 36732026]
  • Jun He, Harro J Bouwmeester, Marcel Dicke, Iris F Kappers. Transcriptional and metabolite analysis reveal a shift in direct and indirect defences in response to spider-mite infestation in cucumber (Cucumis sativus). Plant molecular biology. 2020 Jul; 103(4-5):489-505. doi: 10.1007/s11103-020-01005-y. [PMID: 32306368]
  • Dawei Li, Yongshuo Ma, Yuan Zhou, Junbo Gou, Yang Zhong, Lingling Zhao, Lida Han, Sergey Ovchinnikov, Ling Ma, Sanwen Huang, Per Greisen, Yi Shang. A structural and data-driven approach to engineering a plant cytochrome P450 enzyme. Science China. Life sciences. 2019 07; 62(7):873-882. doi: 10.1007/s11427-019-9538-3. [PMID: 31119558]
  • Zhiqiang Liu, Yawen Li, Chunyu Cao, Shan Liang, Yongshuo Ma, Xin Liu, Yanxi Pei. The role of H2S in low temperature-induced cucurbitacin C increases in cucumber. Plant molecular biology. 2019 Apr; 99(6):535-544. doi: 10.1007/s11103-019-00834-w. [PMID: 30707394]
  • Yang Zhong, Xiaofeng Xue, Zhiqiang Liu, Yongshuo Ma, Kewu Zeng, Lida Han, Jingjing Qi, Dae-Kyun Ro, Søren Bak, Sanwen Huang, Yuan Zhou, Yi Shang. Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3. Molecular plant. 2017 07; 10(7):1000-1003. doi: 10.1016/j.molp.2017.02.005. [PMID: 28263794]
  • Yi Shang, Yongshuo Ma, Yuan Zhou, Huimin Zhang, Lixin Duan, Huiming Chen, Jianguo Zeng, Qian Zhou, Shenhao Wang, Wenjia Gu, Min Liu, Jinwei Ren, Xingfang Gu, Shengping Zhang, Ye Wang, Ken Yasukawa, Harro J Bouwmeester, Xiaoquan Qi, Zhonghua Zhang, William J Lucas, Sanwen Huang. Plant science. Biosynthesis, regulation, and domestication of bitterness in cucumber. Science (New York, N.Y.). 2014 Nov; 346(6213):1084-8. doi: 10.1126/science.1259215. [PMID: 25430763]
  • Zhi-Xing Qing, Yuan Zhou, Xiu-Bin Liu, Pi Cheng, Jian-Guo Zeng. 23,24-Dihydrocucurbitacin C: a new compound regarded as the next metabolite of cucurbitacin C. Natural product research. 2014; 28(15):1165-70. doi: 10.1080/14786419.2014.921787. [PMID: 24896808]
  • Shamim Sahranavard, Farzaneh Naghibi, Karsten Siems, Kristina Jenett-Siems. New cucurbitane-type triterpenoids from Bryonia aspera. Planta medica. 2010 Jul; 76(10):1014-7. doi: 10.1055/s-0029-1240840. [PMID: 20108178]
  • A G Balkema-Boomstra, S Zijlstra, F W A Verstappen, H Inggamer, P E Mercke, M A Jongsma, H J Bouwmeester. Role of cucurbitacin C in resistance to spider mite (Tetranychus urticae) in cucumber (Cucumis sativus L.). Journal of chemical ecology. 2003 Jan; 29(1):225-35. doi: 10.1023/a:1021945101308. [PMID: 12647864]