Quisqualic_acid (BioDeep_00000000685)

 

Secondary id: BioDeep_00000182828, BioDeep_00000264848

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid(Quisqualic acid)

化学式: C5H7N3O5 (189.0386)
中文名称: (+)使君子氨酸, 使君子氨酸, 异喹啉酸(mM/ml)
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 37.5%

分子结构信息

SMILES: C(C(C(=O)O)N)N1C(=O)NC(=O)O1
InChI: InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1

描述信息

Quisqualic acid is a non-proteinogenic alpha-amino acid.
Quisqualic acid is an agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.
An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018690 - Excitatory Amino Acid Agonists
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID Q003
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica[1][2].
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica[1][2].
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica[1][2].

同义名列表

43 个代谢物同义名

2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid(Quisqualic acid); 1,2,4-Oxadiazolidine-2-propanoic acid, alpha-amino-3,5-dioxo-, (S)-; (l)-(+)-alpha-amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid; (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID; (2S)-2-azaniumyl-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoate; (2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid; (S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid; (L)-(+)-?-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid; (S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoicacid; 2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid; 2-amino-3-(3,5-dioxo[1,2,4]oxadiazolidin-2-yl)propionic acid; L-Alanine, 3-(3-hydroxy-5-oxo-1,2,4-oxadiazol-2(5H)-yl)-; .BETA.-(3,5-DIOXO-1,2,4-OXODIAZOLIDIN-2-YL)-L-ALANINE; 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine; ISOPROPYL3-ACETYLPYRIDINE-2-CARBOXYLATE; ASNFTDCKZKHJSW-REOHCLBHSA-N; Quisqualic acid, powder; QUISQUALIC ACID [MI]; (+)-Quisqualic acid; Quisqualinic acid; L-Quisqualic acid; D-Quisqualic acid; L-quisqualic-acid; [3H]quisqualate; UNII-8OC22C1B99; Quisqualic acid; QUISQUALICACID; Quisqualate, L; Lopac0_001039; Tox21_501039; PDSP1_000814; PDSP2_000801; Quisqualate; 8OC22C1B99; AC1ODZB5; C5H7N3O5; 2jbk; 1mm6; 1mm7; 1p1o; 2or4; QUS; Quisqualic acid



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CA1, CA3, CHAT, GRM5, ITPR3
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 2 GRIA1, ITPR3
Nucleus 6 ACHE, CHAT, FOS, GRM1, PLCZ1, REPIN1
cytosol 9 CA1, CA3, CHAT, FOS, GRIA1, NGF, PLCZ1, PRKCQ, REPIN1
dendrite 6 GRIA1, GRIA2, GRM1, GRM2, GRM5, NGF
nucleoplasm 4 FOS, ITPR3, PLCZ1, REPIN1
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 9 ACHE, GRIA1, GRIA2, GRID1, GRM1, GRM2, GRM3, GRM4, GRM5
Early endosome membrane 1 GRIA1
Multi-pass membrane protein 9 GRIA1, GRIA2, GRID1, GRM1, GRM2, GRM3, GRM4, GRM5, ITPR3
Synapse 5 ACHE, CHAT, GRIA1, GRM2, TAC1
cell surface 2 ACHE, GRIA1
dendritic shaft 2 GRIA1, GRM5
glutamatergic synapse 6 GRIA1, GRID1, GRM1, GRM2, GRM3, GRM5
Golgi apparatus 1 ACHE
neuromuscular junction 2 ACHE, GRIA1
neuronal cell body 5 GRIA1, GRIA2, GRM5, ITPR3, TAC1
postsynapse 2 GRIA2, GRM5
presynaptic membrane 2 GRM2, GRM3
synaptic vesicle 1 NGF
Cytoplasm, cytosol 1 REPIN1
Presynapse 2 GRIA1, GRM4
plasma membrane 12 ACHE, EDNRA, GRIA1, GRIA2, GRID1, GRM1, GRM2, GRM3, GRM4, GRM5, ITPR3, PRKCQ
synaptic vesicle membrane 1 GRIA1
Membrane 8 ACHE, GRIA1, GRIA2, GRM2, GRM3, GRM4, GRM5, ITPR3
axon 4 GRM2, GRM3, NGF, TAC1
brush border 1 ITPR3
extracellular exosome 2 CA1, GRID1
endoplasmic reticulum 2 FOS, ITPR3
extracellular space 3 ACHE, NGF, TAC1
perinuclear region of cytoplasm 2 ACHE, PLCZ1
Schaffer collateral - CA1 synapse 2 GRM1, GRM5
postsynaptic density 3 GRIA1, GRIA2, GRM3
pronucleus 1 PLCZ1
Secreted 2 ACHE, NGF
extracellular region 3 ACHE, NGF, TAC1
excitatory synapse 2 GRIA1, GRIA2
neuronal cell body membrane 1 GRIA1
Extracellular side 1 ACHE
centriolar satellite 1 PRKCQ
nuclear membrane 1 REPIN1
external side of plasma membrane 2 GRIA1, GRIA2
dendritic spine 4 GRIA1, GRIA2, GRM3, GRM5
cytoplasmic vesicle 1 GRM4
nucleolus 2 ITPR3, PLCZ1
neuron spine 1 GRIA1
apical part of cell 1 ITPR3
cell-cell junction 1 GRIA1
recycling endosome 1 GRIA1
postsynaptic membrane 5 GRIA1, GRIA2, GRID1, GRM2, GRM3
presynaptic active zone membrane 1 GRIA1
Cytoplasm, perinuclear region 1 PLCZ1
GABA-ergic synapse 1 GRID1
basement membrane 1 ACHE
sarcoplasmic reticulum 1 ITPR3
Cell projection, dendritic spine 1 GRIA1
nuclear outer membrane 1 ITPR3
Postsynaptic cell membrane 4 GRIA1, GRIA2, GRID1, GRM1
receptor complex 1 ITPR3
neuron projection 1 CHAT
chromatin 1 FOS
Chromosome 1 REPIN1
postsynaptic density, intracellular component 1 GRIA1
Lipid-anchor, GPI-anchor 1 ACHE
Recycling endosome membrane 1 GRIA1
endosome lumen 1 NGF
AMPA glutamate receptor complex 2 GRIA1, GRIA2
Cell projection, dendrite 2 GRIA1, GRM2
side of membrane 1 ACHE
synaptic membrane 1 GRIA1
secretory granule membrane 1 ITPR3
Golgi lumen 1 NGF
nuclear matrix 1 FOS
endocytic vesicle membrane 2 GRIA1, GRIA2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GRIA1
postsynaptic density membrane 5 GRIA1, GRIA2, GRID1, GRM1, GRM5
postsynaptic endocytic zone 1 GRIA2
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
ER to Golgi transport vesicle membrane 1 GRIA1
platelet dense tubular network membrane 1 ITPR3
synaptic cleft 1 ACHE
protein-DNA complex 1 FOS
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
dendritic spine membrane 1 GRIA1
astrocyte projection 3 GRM2, GRM3, GRM5
transcription factor AP-1 complex 1 FOS
transport vesicle membrane 1 ITPR3
sperm head 1 PLCZ1
asymmetric synapse 1 GRIA2
proximal dendrite 1 GRIA1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform H]: Cell membrane 1 ACHE
axonal spine 1 GRIA1
perisynaptic space 1 GRIA1
G protein-coupled receptor dimeric complex 1 GRM1
G protein-coupled receptor homodimeric complex 1 GRM1


文献列表

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