Zanamivir (BioDeep_00000006660)
Secondary id: BioDeep_00001868183
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(2R,3R,4S)-4-[(diaminomethylidene)amino]-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
化学式: C12H20N4O7 (332.1332)
中文名称: 扎那米韦
谱图信息:
最多检出来源 Homo sapiens(blood) 94.7%
分子结构信息
SMILES: CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N
InChI: InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1
描述信息
Zanamivir is only found in individuals that have used or taken this drug. It is a guanido-neuraminic acid that is used to inhibit neuraminidase. [PubChem]The proposed mechanism of action of zanamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release. By binding and inhibiting the neuraminidase protein, the drug renders the influenza virus unable to escape its host cell and infect others.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AH - Neuraminidase inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent
D004791 - Enzyme Inhibitors
同义名列表
33 个代谢物同义名
(2R,3R,4S)-4-[(diaminomethylidene)amino]-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid; (2R,3R,4S)-3-(Acetylamino)-4-carbamimidamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid; (2R,3R,4S)-3-(Acetylamino)-4-carbamimidamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylate; 5-(Acetylamino)-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid; 5-(Acetylamino)-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonate; 5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic acid; 5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonate; 5-Acetylamino-2,6-anhydro-4-guanidino-3,4,5-trideoxy-D-galacto-non-enoic acid; 2,3-Didehydro-2,4-dideoxy-4-guanidino-N-acetyl-D-neuraminic acid; 2,3-Didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid; 4-Guanidino-2,4-dideoxy-2,3-didehydro-N-acetylneuraminic acid; 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid; Acid, 4-guanidino-2-deoxy-2,3-didehydro-N-acetylneuraminic; 4 Guanidino 2 deoxy 2,3 didehydro N acetylneuraminic acid; 4-Guanidino-2-deoxy-2,3-didehydro-N-acetylneuraminic acid; 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminate; GlaxoSmithKline brand OF zanamivir; Glaxo wellcome brand OF zanamivir; Zanamivir glaxosmithkline brand; Biota brand OF zanamivir; Zanamivir biota brand; 4 Guanidino neu5ac2En; 4-Guanidino-neu5ac2En; Modified sialic acid; SCHEMBL3497032; Zanamavir; Zanamivir; Relenza; GANA; ZMR; GNA; Zanamivir; Zanamivir
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:50663
- KEGG: C08095
- KEGG: C72554
- KEGGdrug: D00902
- PubChem: 60855
- PubChem: 5721
- HMDB: HMDB0014698
- Metlin: METLIN66814
- DrugBank: DB00558
- ChEMBL: CHEMBL222813
- Wikipedia: Zanamivir
- MeSH: Zanamivir
- chemspider: 54842
- CAS: 139110-80-8
- CAS: 551942-41-7
- PMhub: MS000019736
- PubChem: 10295
- PDB-CCD: ZMR
- NIKKAJI: J621.505J
- NIKKAJI: J680.760G
- RefMet: Zanamivir
- KNApSAcK: 50663
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jie Wang-Jairaj, Irene Miller, Aditya Joshi, Tharaka Jayabalan, Amanda Peppercorn, Peter Zammit-Tabona, Amanda Oliver. Zanamivir aqueous solution in severe influenza: A global Compassionate Use Program, 2009-2019.
Influenza and other respiratory viruses.
2022 05; 16(3):542-551. doi:
10.1111/irv.12947. [PMID: 34939702] - Han Ju, N Arul Murugan, Lingxin Hou, Ping Li, Laura Guizzo, Ying Zhang, Chiara Bertagnin, Xiujie Kong, Dongwei Kang, Ruifang Jia, Xiuli Ma, Ruikun Du, Vasanthanathan Poongavanam, Arianna Loregian, Bing Huang, Xinyong Liu, Peng Zhan. Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Journal of medicinal chemistry.
2021 12; 64(24):17992-18009. doi:
10.1021/acs.jmedchem.1c01366. [PMID: 34735766] - Xun Lv, Pengfei Wang, Chenning Li, Shuihong Cheng, Yuhai Bi, Xuebing Li. Zanamivir-Cholesterol Conjugate: A Long-Acting Neuraminidase Inhibitor with Potent Efficacy against Drug-Resistant Influenza Viruses.
Journal of medicinal chemistry.
2021 12; 64(23):17403-17412. doi:
10.1021/acs.jmedchem.1c01531. [PMID: 34797984] - Xin Liu, Weichuan Luo, Boning Zhang, Yong Gu Lee, Imrul Shahriar, Madduri Srinivasarao, Philip S Low. Design of Neuraminidase-Targeted Imaging and Therapeutic Agents for the Diagnosis and Treatment of Influenza Virus Infections.
Bioconjugate chemistry.
2021 08; 32(8):1548-1553. doi:
10.1021/acs.bioconjchem.1c00255. [PMID: 34161726] - Bettina Sehnert, Juliane Mietz, Rita Rzepka, Stefanie Buchholz, Andrea Maul-Pavicic, Sandra Schaffer, Falk Nimmerjahn, Reinhard E Voll. Neuraminidase Inhibitor Zanamivir Ameliorates Collagen-Induced Arthritis.
International journal of molecular sciences.
2021 Jan; 22(3):. doi:
10.3390/ijms22031428. [PMID: 33572654] - Liqian Zhou, Juanjuan Wang, Guangyi Liu, Qingqing Lu, Ruyi Dong, Geng Tian, Jialiang Yang, Lihong Peng. Probing antiviral drugs against SARS-CoV-2 through virus-drug association prediction based on the KATZ method.
Genomics.
2020 11; 112(6):4427-4434. doi:
10.1016/j.ygeno.2020.07.044. [PMID: 32745502] - Liva Checkmahomed, Blandine Padey, Andrés Pizzorno, Olivier Terrier, Manuel Rosa-Calatrava, Yacine Abed, Mariana Baz, Guy Boivin. In Vitro Combinations of Baloxavir Acid and Other Inhibitors against Seasonal Influenza A Viruses.
Viruses.
2020 10; 12(10):. doi:
10.3390/v12101139. [PMID: 33049959] - Chuanxiong Nie, Badri Parshad, Sumati Bhatia, Chong Cheng, Marlena Stadtmüller, Alexander Oehrl, Yannic Kerkhoff, Thorsten Wolff, Rainer Haag. Topology-Matching Design of an Influenza-Neutralizing Spiky Nanoparticle-Based Inhibitor with a Dual Mode of Action.
Angewandte Chemie (International ed. in English).
2020 09; 59(36):15532-15536. doi:
10.1002/anie.202004832. [PMID: 32421225] - Donald C Hall, Hai-Feng Ji. A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease.
Travel medicine and infectious disease.
2020 May; 35(?):101646. doi:
10.1016/j.tmaid.2020.101646. [PMID: 32294562] - Natalia A Ilyushina, Takashi E Komatsu, William L Ince, Eric F Donaldson, Nicolette Lee, Julian J O'Rear, Raymond P Donnelly. Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies.
Virology journal.
2019 11; 16(1):149. doi:
10.1186/s12985-019-1258-x. [PMID: 31783761] - Takanori Tomozawa, Kazuki Hoshino, Makoto Yamashita, Shuku Kubo. Efficacy of laninamivir octanoate in mice with advanced inflammation stage caused by infection of highly lethal influenza virus.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2019 Aug; 25(8):584-588. doi:
10.1016/j.jiac.2019.02.023. [PMID: 30935767] - R Farrukee, J Butler, P C Reading, A C Hurt. Characterization of substitutions in the neuraminidase of A(H7N9) influenza viruses selected following serial passage in the presence of different neuraminidase inhibitors.
Antiviral research.
2019 08; 168(?):68-75. doi:
10.1016/j.antiviral.2019.05.009. [PMID: 31132385] - Jing Tang, Jing Zhang, Jianfang Zhou, Wenfei Zhu, Lei Yang, Shumei Zou, Hejiang Wei, Li Xin, Weijuan Huang, Xiyan Li, Yanhui Cheng, Dayan Wang. Highly pathogenic avian influenza H7N9 viruses with reduced susceptibility to neuraminidase inhibitors showed comparable replication capacity to their sensitive counterparts.
Virology journal.
2019 07; 16(1):87. doi:
10.1186/s12985-019-1194-9. [PMID: 31266524] - Merryn Roe, Matthew Kaye, Pina Iannello, Hilda Lau, Iwona Buettner, M Ximena Tolosa, Tasoula Zakis, Vivian K Leung, Michelle K Chow. Report on influenza viruses received and tested by the Melbourne WHO Collaborating Centre for Reference and Research on Influenza in 2017.
Communicable diseases intelligence (2018).
2019 Jun; 43(?):. doi:
. [PMID: 31203585] - Khristine Kaith S Lloren, Jin Jung Kwon, Won-Suk Choi, Ju Hwan Jeong, Su Jeong Ahn, Young Ki Choi, Yun Hee Baek, Min-Suk Song. In Vitro and In Vivo Characterization of Novel Neuraminidase Substitutions in Influenza A(H1N1)pdm09 Virus Identified Using Laninamivir-Mediated In Vitro Selection.
Journal of virology.
2019 03; 93(6):. doi:
10.1128/jvi.01825-18. [PMID: 30602610] - Matthias Müller, Daniel Lauster, Helen H K Wildenauer, Andreas Herrmann, Stephan Block. Mobility-Based Quantification of Multivalent Virus-Receptor Interactions: New Insights Into Influenza A Virus Binding Mode.
Nano letters.
2019 03; 19(3):1875-1882. doi:
10.1021/acs.nanolett.8b04969. [PMID: 30719917] - Jian Zhang, Natarajan Arul Murugan, Ye Tian, Chiara Bertagnin, Zengjun Fang, Dongwei Kang, Xiujie Kong, Haiyong Jia, Zhuosen Sun, Ruifang Jia, Ping Gao, Vasanthanathan Poongavanam, Arianna Loregian, Wenfang Xu, Xiuli Ma, Xiao Ding, Bing Huang, Peng Zhan, Xinyong Liu. Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.
Journal of medicinal chemistry.
2018 11; 61(22):9976-9999. doi:
10.1021/acs.jmedchem.8b01065. [PMID: 30365885] - Hou-Wen Cheng, Hsiao-Wen Wang, Tsung-Yun Wong, Hsien-Wei Yeh, Yi-Chun Chen, Der-Zen Liu, Pi-Hui Liang. Synthesis of S-linked NeuAc-α(2-6)-di-LacNAc bearing liposomes for H1N1 influenza virus inhibition assays.
Bioorganic & medicinal chemistry.
2018 05; 26(9):2262-2270. doi:
10.1016/j.bmc.2018.02.012. [PMID: 29472127] - Ramona Trebbien, Claus Bohn Christiansen, Thea Kølsen Fischer. Antiviral resistance due to deletion in the neuraminidase gene and defective interfering-like viral polymerase basic 2 RNA of influenza A virus subtype H3N2.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2018 05; 102(?):1-6. doi:
10.1016/j.jcv.2018.02.005. [PMID: 29448067] - Almiro Tivane, Rodney Daniels, Neuza Nguenha, Loira Machalele, Afonso Nacoto, Mirela Pale, Edirsse Mateonane, Sandra Mavale, Josina Chilundo, Délcio Muteto, Judite Salência, Félix Albati, Eduardo Gudo, Tufária Mussá, John McCauley. Antigenic and genetic characterization of influenza viruses isolated in Mozambique during the 2015 season.
PloS one.
2018; 13(7):e0201248. doi:
10.1371/journal.pone.0201248. [PMID: 30048502] - Won-Suk Choi, Ju Hwan Jeong, Jin Jung Kwon, Su Jeong Ahn, Khristine Kaith S Lloren, Hyeok-Il Kwon, Hee Bok Chae, Jungwon Hwang, Myung Hee Kim, Chul-Joong Kim, Richard J Webby, Elena A Govorkova, Young Ki Choi, Yun Hee Baek, Min-Suk Song. Screening for Neuraminidase Inhibitor Resistance Markers among Avian Influenza Viruses of the N4, N5, N6, and N8 Neuraminidase Subtypes.
Journal of virology.
2018 01; 92(1):. doi:
10.1128/jvi.01580-17. [PMID: 29046464] - Kaoru Toyama, Hidetoshi Furuie, Hitoshi Ishizuka. Intrapulmonary Pharmacokinetics of Laninamivir, a Neuraminidase Inhibitor, after a Single Nebulized Administration of Laninamivir Octanoate in Healthy Japanese Subjects.
Antimicrobial agents and chemotherapy.
2018 01; 62(1):. doi:
10.1128/aac.01722-17. [PMID: 29061751] - Mitsuru Tsuji, Nongluk Sriwilaijaroen, Hideo Inoue, Kazuhiko Miki, Kaoru Kinoshita, Kiyotaka Koyama, Kimio Furuhata, Yasuo Suzuki, Kunio Takahashi. Synthesis and anti-influenza virus evaluation of triterpene-sialic acid conjugates.
Bioorganic & medicinal chemistry.
2018 01; 26(1):17-24. doi:
10.1016/j.bmc.2017.09.038. [PMID: 29198893] - Junhyung Cho, Hwajung Yi, Eun Young Jang, Mi-Seon Lee, Joo-Yeon Lee, Chun Kang, Chan Hee Lee, Kisoon Kim. Mycophenolic mofetil, an alternative antiviral and immunomodulator for the highly pathogenic avian influenza H5N1 virus infection.
Biochemical and biophysical research communications.
2017 12; 494(1-2):298-304. doi:
10.1016/j.bbrc.2017.10.037. [PMID: 29017920] - Stefanie Quosdorf, Anja Schuetz, Herbert Kolodziej. Different Inhibitory Potencies of Oseltamivir Carboxylate, Zanamivir, and Several Tannins on Bacterial and Viral Neuraminidases as Assessed in a Cell-Free Fluorescence-Based Enzyme Inhibition Assay.
Molecules (Basel, Switzerland).
2017 Nov; 22(11):. doi:
10.3390/molecules22111989. [PMID: 29149072] - Abraham Ochoa, Enrique Álvarez-Bohórquez, Eduardo Castillero, Luis F Olguin. Detection of Enzyme Inhibitors in Crude Natural Extracts Using Droplet-Based Microfluidics Coupled to HPLC.
Analytical chemistry.
2017 05; 89(9):4889-4896. doi:
10.1021/acs.analchem.6b04988. [PMID: 28374582] - Takashi Azuma, Mao Ishida, Kanae Hisamatsu, Ayami Yunoki, Kana Otomo, Mari Kunitou, Mai Shimizu, Kaori Hosomaru, Shiori Mikata, Yoshiki Mino. Fate of new three anti-influenza drugs and one prodrug in the water environment.
Chemosphere.
2017 Feb; 169(?):550-557. doi:
10.1016/j.chemosphere.2016.11.102. [PMID: 27898328] - Ramona Trebbien, Svend Stenvang Pedersen, Kristine Vorborg, Kristina Træholt Franck, Thea Kølsen Fischer. Development of oseltamivir and zanamivir resistance in influenza A(H1N1)pdm09 virus, Denmark, 2014.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.
2017 Jan; 22(3):. doi:
10.2807/1560-7917.es.2017.22.3.30445. [PMID: 28128091] - Anja Hoffmann, Dennis Schade, Johannes Kirchmair, Bernd Clement, Andreas Sauerbrei, Michaela Schmidtke. Platform for determining the inhibition profile of neuraminidase inhibitors in an influenza virus N1 background.
Journal of virological methods.
2016 11; 237(?):192-199. doi:
10.1016/j.jviromet.2016.09.014. [PMID: 27659246] - Lifeng Fu, Yuhai Bi, Yan Wu, Shanshan Zhang, Jianxun Qi, Yan Li, Xuancheng Lu, Zhenning Zhang, Xun Lv, Jinghua Yan, George F Gao, Xuebing Li. Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses.
Journal of medicinal chemistry.
2016 07; 59(13):6303-12. doi:
10.1021/acs.jmedchem.6b00537. [PMID: 27341624] - Nongluk Sriwilaijaroen, Sadagopan Magesh, Akihiro Imamura, Hiromune Ando, Hideharu Ishida, Miho Sakai, Erika Ishitsubo, Takanori Hori, Setsuko Moriya, Takeshi Ishikawa, Kazuo Kuwata, Takato Odagiri, Masato Tashiro, Hiroaki Hiramatsu, Kenji Tsukamoto, Taeko Miyagi, Hiroaki Tokiwa, Makoto Kiso, Yasuo Suzuki. A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions.
Journal of medicinal chemistry.
2016 05; 59(10):4563-77. doi:
10.1021/acs.jmedchem.5b01863. [PMID: 27095056] - Benjamin Bailly, Larissa Dirr, Ibrahim M El-Deeb, Ralf Altmeyer, Patrice Guillon, Mark von Itzstein. A dual drug regimen synergistically blocks human parainfluenza virus infection.
Scientific reports.
2016 Apr; 6(?):24138. doi:
10.1038/srep24138. [PMID: 27053240] - Ahmed M Tolah, Esam I Azhar, Anwar M Hashem. Susceptibility of influenza viruses circulating in Western Saudi Arabia to neuraminidase inhibitors.
Saudi medical journal.
2016 Apr; 37(4):461-5. doi:
10.15537/smj.2016.4.14837. [PMID: 27052292] - Siriwan Charyasriwong, Takahiro Haruyama, Nobuyuki Kobayashi. In vitro evaluation of the antiviral activity of methylglyoxal against influenza B virus infection.
Drug discoveries & therapeutics.
2016 ; 10(4):201-10. doi:
10.5582/ddt.2016.01045. [PMID: 27558282] - Naoko Ito, Masatoki Sato, Nobuo Momoi, Yoshimichi Aoyagi, Kisei Endo, Mina Chishiki, Yukihiko Kawasaki, Mitsuaki Hosoya. Influenza A H1N1 pdm09-associated myocarditis during zanamivir therapy.
Pediatrics international : official journal of the Japan Pediatric Society.
2015 Dec; 57(6):1172-4. doi:
10.1111/ped.12712. [PMID: 26482326] - Dennis Schade, Jürke Kotthaus, Lukas Riebling, Joscha Kotthaus, Helge Müller-Fielitz, Walter Raasch, Anja Hoffmann, Michaela Schmidtke, Bernd Clement. Zanamivir Amidoxime- and N-Hydroxyguanidine-Based Prodrug Approaches to Tackle Poor Oral Bioavailability.
Journal of pharmaceutical sciences.
2015 Sep; 104(9):3208-19. doi:
10.1002/jps.24508. [PMID: 26037932] - Byung Soon Hwang, In-Kyoung Lee, Hwa Jung Choi, Bong-Sik Yun. Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
Bioorganic & medicinal chemistry letters.
2015 Aug; 25(16):3256-60. doi:
10.1016/j.bmcl.2015.05.081. [PMID: 26077494] - Tatiana Baranovich, Justin Bahl, Bindumadhav M Marathe, Marie Culhane, Evelyn Stigger-Rosser, Daniel Darnell, Bryan S Kaplan, James F Lowe, Richard J Webby, Elena A Govorkova. Influenza A viruses of swine circulating in the United States during 2009-2014 are susceptible to neuraminidase inhibitors but show lineage-dependent resistance to adamantanes.
Antiviral research.
2015 May; 117(?):10-9. doi:
10.1016/j.antiviral.2015.02.004. [PMID: 25701593] - Andrew J Burnham, Jianling Armstrong, Anice C Lowen, Robert G Webster, Elena A Govorkova. Competitive fitness of influenza B viruses with neuraminidase inhibitor-resistant substitutions in a coinfection model of the human airway epithelium.
Journal of virology.
2015 Apr; 89(8):4575-87. doi:
10.1128/jvi.02473-14. [PMID: 25673705] - Jennifer L McKimm-Breschkin, Susan Barrett. Neuraminidase mutations conferring resistance to laninamivir lead to faster drug binding and dissociation.
Antiviral research.
2015 Feb; 114(?):62-6. doi:
10.1016/j.antiviral.2014.12.004. [PMID: 25499124] - Li-Li Shi, Yue Cao, Xiao-Yin Zhu, Jing-Hao Cui, Qing-Ri Cao. Optimization of process variables of zanamivir-loaded solid lipid nanoparticles and the prediction of their cellular transport in Caco-2 cell model.
International journal of pharmaceutics.
2015 Jan; 478(1):60-69. doi:
10.1016/j.ijpharm.2014.11.017. [PMID: 25448568] - Martina Morokutti-Kurz, Marielle König-Schuster, Christiane Koller, Christine Graf, Philipp Graf, Norman Kirchoff, Benjamin Reutterer, Jan-Marcus Seifert, Hermann Unger, Andreas Grassauer, Eva Prieschl-Grassauer, Sabine Nakowitsch. The Intranasal Application of Zanamivir and Carrageenan Is Synergistically Active against Influenza A Virus in the Murine Model.
PloS one.
2015; 10(6):e0128794. doi:
10.1371/journal.pone.0128794. [PMID: 26053018] - Karen Little, Sook-Kwan Leang, Jeff Butler, Chantal Baas, Bruce Harrower, Jenny Mosse, Ian G Barr, Aeron C Hurt. Zanamivir-resistant influenza viruses with Q136K or Q136R neuraminidase residue mutations can arise during MDCK cell culture creating challenges for antiviral susceptibility monitoring.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.
2015; 20(45):. doi:
10.2807/1560-7917.es.2015.20.45.30060. [PMID: 26608955] - Hideyuki Ikematsu, Naoki Kawai, Norio Iwaki, Seizaburo Kashiwagi. In vitro neuraminidase inhibitory activity of four neuraminidase inhibitors against clinical isolates of influenza virus in the Japanese 2012-2013 season.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2015 Jan; 21(1):39-42. doi:
10.1016/j.jiac.2014.08.030. [PMID: 25277670] - Mahmoud Arastoo, Hamid Reza Khorram Khorshid. Do we need a replacement medication for influenza with good efficacy?.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2014 Dec; 22(?):84. doi:
10.1186/s40199-014-0084-3. [PMID: 25523212] - E Bart Tarbet, Stephanie Hamilton, Almut H Vollmer, Angela Luttick, Wy Ching Ng, Melinda Pryor, Brett L Hurst, Simon Crawford, Donald F Smee, Simon P Tucker. A zanamivir dimer with prophylactic and enhanced therapeutic activity against influenza viruses.
The Journal of antimicrobial chemotherapy.
2014 Aug; 69(8):2164-74. doi:
10.1093/jac/dku127. [PMID: 24777908] - Ilona Bereczki, Máté Kicsák, Laura Dobray, Anikó Borbás, Gyula Batta, Sándor Kéki, Éva Nemes Nikodém, Eszter Ostorházi, Ferenc Rozgonyi, Evelien Vanderlinden, Lieve Naesens, Pál Herczegh. Semisynthetic teicoplanin derivatives as new influenza virus binding inhibitors: synthesis and antiviral studies.
Bioorganic & medicinal chemistry letters.
2014 Aug; 24(15):3251-4. doi:
10.1016/j.bmcl.2014.06.018. [PMID: 24974341] - Ken Watanabe, Ratika Rahmasari, Ayaka Matsunaga, Takahiro Haruyama, Nobuyuki Kobayashi. Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey.
Archives of medical research.
2014 Jul; 45(5):359-65. doi:
10.1016/j.arcmed.2014.05.006. [PMID: 24880005] - Wael M Abdel-Mageed, Soad A H Bayoumi, Caixia Chen, Christopher J Vavricka, Li Li, Ajamaluddin Malik, Huanqin Dai, Fuhang Song, Luoqiang Wang, Jingyu Zhang, George F Gao, Yali Lv, Lihong Liu, Xueting Liu, Hanaa M Sayed, Lixin Zhang. Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity.
Bioorganic & medicinal chemistry.
2014 Apr; 22(7):2236-43. doi:
10.1016/j.bmc.2014.02.014. [PMID: 24613627] - Dennis Schade, Joscha Kotthaus, Lukas Riebling, Jürke Kotthaus, Helge Müller-Fielitz, Walter Raasch, Oliver Koch, Nora Seidel, Michaela Schmidtke, Bernd Clement. Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A.
Journal of medicinal chemistry.
2014 Feb; 57(3):759-69. doi:
10.1021/jm401492x. [PMID: 24422530] - K Sleeman, V P Mishin, Z Guo, R J Garten, A Balish, A M Fry, J Villanueva, J Stevens, L V Gubareva. Antiviral susceptibility of variant influenza A(H3N2)v viruses isolated in the United States from 2011 to 2013.
Antimicrobial agents and chemotherapy.
2014; 58(4):2045-51. doi:
10.1128/aac.02556-13. [PMID: 24449767] - Can Li, Chuangen Li, Anna J X Zhang, Kelvin K W To, Andrew C Y Lee, Houshun Zhu, Hazel W L Wu, Jasper F W Chan, Honglin Chen, Ivan F N Hung, Lanjuan Li, Kwok-Yung Yuen. Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor.
PloS one.
2014; 9(9):e107966. doi:
10.1371/journal.pone.0107966. [PMID: 25232731] - Goran Orozovic, Kanita Orozovic, Josef D Järhult, Björn Olsen. Study of oseltamivir and zanamivir resistance-related mutations in influenza viruses isolated from wild mallards in Sweden.
PloS one.
2014; 9(2):e89306. doi:
10.1371/journal.pone.0089306. [PMID: 24558492] - Vasiliy P Mishin, Katrina Sleeman, Marnie Levine, Paul J Carney, James Stevens, Larisa V Gubareva. The effect of the MDCK cell selected neuraminidase D151G mutation on the drug susceptibility assessment of influenza A(H3N2) viruses.
Antiviral research.
2014 Jan; 101(?):93-6. doi:
10.1016/j.antiviral.2013.11.001. [PMID: 24239666] - Daisuke Tamura, Ha T Nguyen, Katrina Sleeman, Marnie Levine, Vasiliy P Mishin, Hua Yang, Zhu Guo, Margaret Okomo-Adhiambo, Xiyan Xu, James Stevens, Larisa V Gubareva. Cell culture-selected substitutions in influenza A(H3N2) neuraminidase affect drug susceptibility assessment.
Antimicrobial agents and chemotherapy.
2013 Dec; 57(12):6141-6. doi:
10.1128/aac.01364-13. [PMID: 24080660] - Seiichiro Fujisaki, Masaki Imai, Emi Takashita, Tae Taniwaki, Hong Xu, Noriko Kishida, Masaru Yokoyama, Hironori Sato, Masato Tashiro, Takato Odagiri. Mutations at the monomer-monomer interface away from the active site of influenza B virus neuraminidase reduces susceptibility to neuraminidase inhibitor drugs.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2013 Oct; 19(5):891-5. doi:
10.1007/s10156-013-0589-6. [PMID: 23529501] - Francisco López-Medrano, Elisa Cordero, Joan Gavaldá, Josep M Cruzado, M Ángeles Marcos, Pilar Pérez-Romero, Nuria Sabé, Miguel Ángel Gómez-Bravo, Juan Francisco Delgado, Evelyn Cabral, Jordi Carratalá. Management of influenza infection in solid-organ transplant recipients: consensus statement of the Group for the Study of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI).
Enfermedades infecciosas y microbiologia clinica.
2013 Oct; 31(8):526.e1-526.e20. doi:
10.1016/j.eimc.2013.01.013. [PMID: 23528341] - Jennifer L McKimm-Breschkin, Janelle Williams, Susan Barrett, Kim Jachno, Mandy McDonald, Peter G Mohr, Takehiko Saito, Masato Tashiro. Reduced susceptibility to all neuraminidase inhibitors of influenza H1N1 viruses with haemagglutinin mutations and mutations in non-conserved residues of the neuraminidase.
The Journal of antimicrobial chemotherapy.
2013 Oct; 68(10):2210-21. doi:
10.1093/jac/dkt205. [PMID: 23759505] - J N Makau, K Watanabe, N Kobayashi. Anti-influenza activity of Alchemilla mollis extract: possible virucidal activity against influenza virus particles.
Drug discoveries & therapeutics.
2013 Oct; 7(5):189-95. doi:
10.5582/ddt.2013.v7.5.189. [PMID: 24270383] - H-L Yen, J L McKimm-Breschkin, K-T Choy, D D Y Wong, P P H Cheung, J Zhou, I H Ng, H Zhu, R J Webby, Y Guan, R G Webster, J S M Peiris. Resistance to neuraminidase inhibitors conferred by an R292K mutation in a human influenza virus H7N9 isolate can be masked by a mixed R/K viral population.
mBio.
2013 Jul; 4(4):. doi:
10.1128/mbio.00396-13. [PMID: 23860768] - Stephen Weller, Lori S Jones, Yu Lou, Amanda Peppercorn, Judith Ng-Cashin. Pharmacokinetics of zanamivir following intravenous administration to subjects with and without renal impairment.
Antimicrobial agents and chemotherapy.
2013 Jul; 57(7):2967-71. doi:
10.1128/aac.02330-12. [PMID: 23587959] - Y Shida, K Hara, S Nohda, T Soutome, T Hirama. The pharmacokinetic and safety profiles of zanamivir after single and repeat intravenous administration in healthy Japanese males.
Journal of clinical pharmacy and therapeutics.
2013 Jun; 38(3):236-40. doi:
10.1111/jcpt.12056. [PMID: 23489210] - Jin-Hyo Kim, Ricardo Resende, Tom Wennekes, Hong-Ming Chen, Nicole Bance, Sabrina Buchini, Andrew G Watts, Pat Pilling, Victor A Streltsov, Martin Petric, Richard Liggins, Susan Barrett, Jennifer L McKimm-Breschkin, Masahiro Niikura, Stephen G Withers. Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity.
Science (New York, N.Y.).
2013 Apr; 340(6128):71-5. doi:
10.1126/science.1232552. [PMID: 23429702] - Enguang Feng, Woo-Jin Shin, Xuelian Zhu, Jian Li, Deju Ye, Jiang Wang, Mingyue Zheng, Jian-Ping Zuo, Kyoung Tai No, Xian Liu, Weiliang Zhu, Wei Tang, Baik-Lin Seong, Hualiang Jiang, Hong Liu. Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.
Journal of medicinal chemistry.
2013 Feb; 56(3):671-84. doi:
10.1021/jm3009713. [PMID: 23330908] - Kazutaka Yoshihara, Hitoshi Ishizuka, Yuichi Kubo. Population pharmacokinetics of laninamivir and its prodrug laninamivir octanoate in healthy subjects and in adult and pediatric patients with influenza virus infection.
Drug metabolism and pharmacokinetics.
2013; 28(5):416-26. doi:
10.2133/dmpk.dmpk-12-rg-115. [PMID: 23574886] - Christopher J Vavricka, Yue Liu, Hiromasa Kiyota, Nongluk Sriwilaijaroen, Jianxun Qi, Kosuke Tanaka, Yan Wu, Qing Li, Yan Li, Jinghua Yan, Yasuo Suzuki, George F Gao. Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors.
Nature communications.
2013; 4(?):1491. doi:
10.1038/ncomms2487. [PMID: 23422659] - Füsun Göktaş, Evelien Vanderlinden, Lieve Naesens, Nesrin Cesur, Zafer Cesur. Microwave assisted synthesis and anti-influenza virus activity of 1-adamantyl substituted N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives.
Bioorganic & medicinal chemistry.
2012 Dec; 20(24):7155-9. doi:
10.1016/j.bmc.2012.09.064. [PMID: 23117173] - Chia Min Lee, Alisha K Weight, Jayanta Haldar, Ling Wang, Alexander M Klibanov, Jianzhu Chen. Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection.
Proceedings of the National Academy of Sciences of the United States of America.
2012 Dec; 109(50):20385-90. doi:
10.1073/pnas.1219155109. [PMID: 23185023] - Seiichiro Fujisaki, Emi Takashita, Masaru Yokoyama, Tae Taniwaki, Hong Xu, Noriko Kishida, Hironori Sato, Masato Tashiro, Masaki Imai, Takato Odagiri. A single E105K mutation far from the active site of influenza B virus neuraminidase contributes to reduced susceptibility to multiple neuraminidase-inhibitor drugs.
Biochemical and biophysical research communications.
2012 Dec; 429(1-2):51-6. doi:
10.1016/j.bbrc.2012.10.095. [PMID: 23131559] - Ting-Jen R Cheng, Steven Weinheimer, E Bart Tarbet, Jia-Tsrong Jan, Yih-Shyun E Cheng, Jiun-Jie Shie, Chun-Lin Chen, Chih-An Chen, Wei-Che Hsieh, Pei-Wei Huang, Wen-Hao Lin, Shi-Yun Wang, Jim-Min Fang, Oliver Yoa-Pu Hu, Chi-Huey Wong. Development of oseltamivir phosphonate congeners as anti-influenza agents.
Journal of medicinal chemistry.
2012 Oct; 55(20):8657-70. doi:
10.1021/jm3008486. [PMID: 23009169] - Jing Ge, Fengmao Liu, Eric H Holmes, Gary K Ostrander, Qing X Li. Aqueous normal phase liquid chromatography coupled with tandem time-of-flight quadrupole mass spectrometry for determination of zanamivir in human serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Oct; 906(?):58-62. doi:
10.1016/j.jchromb.2012.08.020. [PMID: 22947416] - Shigeki Nabeshima, Kenichiro Kashiwagi, Kazuhiko Ajisaka, Shinta Masui, Hiroaki Takeoka, Hideyuki Ikematsu, Seizaburo Kashiwagi. A randomized, controlled trial comparing traditional herbal medicine and neuraminidase inhibitors in the treatment of seasonal influenza.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2012 Aug; 18(4):534-43. doi:
10.1007/s10156-012-0378-7. [PMID: 22350323] - Deju Ye, Woo-Jin Shin, Ning Li, Wei Tang, Enguang Feng, Jian Li, Pei-Lan He, Jian-Ping Zuo, Hanjo Kim, Ky-Youb Nam, Weiliang Zhu, Baik-Lin Seong, Kyoung Tai No, Hualiang Jiang, Hong Liu. Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.
European journal of medicinal chemistry.
2012 Aug; 54(?):764-70. doi:
10.1016/j.ejmech.2012.06.033. [PMID: 22795831] - Hideyuki Ikematsu, Naoki Kawai, Seizaburo Kashiwagi. In vitro neuraminidase inhibitory activities of four neuraminidase inhibitors against influenza viruses isolated in the 2010-2011 season in Japan.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2012 Aug; 18(4):529-33. doi:
10.1007/s10156-012-0377-8. [PMID: 22370919] - Avinash K Shetty, Gregory A Ross, Thomas Pranikoff, Larissa V Gubareva, Catherine Sechrist, Derek M Guirand, Jon Abramson, Jen-Jar Lin. Oseltamivir-resistant 2009 H1N1 influenza pneumonia during therapy in a renal transplant recipient.
Pediatric transplantation.
2012 Aug; 16(5):E153-7. doi:
10.1111/j.1399-3046.2011.01489.x. [PMID: 22764830] - Hitoshi Ishizuka, Kaoru Toyama, Satoshi Yoshiba, Hiromi Okabe, Hidetoshi Furuie. Intrapulmonary distribution and pharmacokinetics of laninamivir, a neuraminidase inhibitor, after a single inhaled administration of its prodrug, laninamivir octanoate, in healthy volunteers.
Antimicrobial agents and chemotherapy.
2012 Jul; 56(7):3873-8. doi:
10.1128/aac.06456-11. [PMID: 22526307] - Henry J Tsai, Li-Ann Chi, Alice L Yu. Monoclonal antibodies targeting the synthetic peptide corresponding to the polybasic cleavage site on H5N1 influenza hemagglutinin.
Journal of biomedical science.
2012 Apr; 19(?):37. doi:
10.1186/1423-0127-19-37. [PMID: 22471562] - Stéphane G Paquette, David Banner, Zhen Zhao, Yuan Fang, Stephen S H Huang, Alberto J Leόn, Derek C K Ng, Raquel Almansa, Ignacio Martin-Loeches, Paula Ramirez, Lorenzo Socias, Ana Loza, Jesus Blanco, Paola Sansonetti, Jordi Rello, David Andaluz, Bianche Shum, Salvatore Rubino, Raul Ortiz de Lejarazu, Dat Tran, Giovanni Delogu, Giovanni Fadda, Sigmund Krajden, Barry B Rubin, Jesús F Bermejo-Martin, Alyson A Kelvin, David J Kelvin. Interleukin-6 is a potential biomarker for severe pandemic H1N1 influenza A infection.
PloS one.
2012; 7(6):e38214. doi:
10.1371/journal.pone.0038214. [PMID: 22679491] - Jovana Cukuranovic, Sladjana Ugrenovic, Ivan Jovanovic, Milan Visnjic, Vladisav Stefanovic. Viral infection in renal transplant recipients.
TheScientificWorldJournal.
2012; 2012(?):820621. doi:
10.1100/2012/820621. [PMID: 22654630] - Masaya Fukushi, Makoto Yamashita, Tohru Miyoshi-Akiyama, Shuku Kubo, Kenji Yamamoto, Koichiro Kudo. Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with lethal influenza H1N1 Virus.
PloS one.
2012; 7(8):e42419. doi:
10.1371/journal.pone.0042419. [PMID: 22879974] - Mary K McCarthy, Jason B Weinberg. Eicosanoids and respiratory viral infection: coordinators of inflammation and potential therapeutic targets.
Mediators of inflammation.
2012; 2012(?):236345. doi:
10.1155/2012/236345. [PMID: 22665949] - Ulrike Grienke, Michaela Schmidtke, Susanne von Grafenstein, Johannes Kirchmair, Klaus R Liedl, Judith M Rollinger. Influenza neuraminidase: a druggable target for natural products.
Natural product reports.
2012 Jan; 29(1):11-36. doi:
10.1039/c1np00053e. [PMID: 22025274] - James B Hudson. Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases.
Journal of biomedicine & biotechnology.
2012; 2012(?):769896. doi:
10.1155/2012/769896. [PMID: 22131823] - Wen He, Huamin Han, Wei Wang, Bin Gao. Anti-influenza virus effect of aqueous extracts from dandelion.
Virology journal.
2011 Dec; 8(?):538. doi:
10.1186/1743-422x-8-538. [PMID: 22168277] - Satoko Nishida, Ryuji Fukazawa, Takehide Imai, Sachiyo Takeda, Jun Hayakawa, Hodaka Takeuchi, Kiwako Shimizu, Yasuhiko Kawakami, Masato Takase. Serum KL-6 and surfactant protein D in children with 2009 pandemic H1N1 influenza infection.
Pediatrics international : official journal of the Japan Pediatric Society.
2011 Dec; 53(6):910-4. doi:
10.1111/j.1442-200x.2011.03398.x. [PMID: 21605280] - Quattrocchi Manuela, Lobreglio Gianbattista, Leuzzi Gianpiero, De Donno Antonella. Evaluation of immune responses to seasonal influenza vaccination in healthy volunteers in South Apulia, Italy: a pilot study.
Journal of clinical medicine research.
2011 Dec; 3(6):291-5. doi:
10.4021/jocmr647w. [PMID: 22393340] - Andrea Pontoriero, Elsa Baumeister, Ana M Campos, Vilma L Savy. Virological surveillance and antiviral resistance of human influenza virus in Argentina, 2005-2008.
Revista panamericana de salud publica = Pan American journal of public health.
2011 Dec; 30(6):634-40. doi:
10.1590/s1020-49892011001200023. [PMID: 22358415] - Qingri Cao, Haining Wu, Li Zhu, Dan Wu, Yunfeng Zhu, Zhixin Zhu, Jinghao Cui. Preparation and evaluation of zanamivir-loaded solid lipid nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society.
2011 Nov; 152 Suppl 1(?):e2-4. doi:
10.1016/j.jconrel.2011.08.085. [PMID: 22195851] - Keith A Rodvold, Liz Yoo, Jomy M George. Penetration of anti-infective agents into pulmonary epithelial lining fluid: focus on antifungal, antitubercular and miscellaneous anti-infective agents.
Clinical pharmacokinetics.
2011 Nov; 50(11):689-704. doi:
10.2165/11592900-000000000-00000. [PMID: 21973267] - Mark J Shelton, Mark Lovern, Judith Ng-Cashin, Lori Jones, Elizabeth Gould, Jennifer Gauvin, Keith A Rodvold. Zanamivir pharmacokinetics and pulmonary penetration into epithelial lining fluid following intravenous or oral inhaled administration to healthy adult subjects.
Antimicrobial agents and chemotherapy.
2011 Nov; 55(11):5178-84. doi:
10.1128/aac.00703-11. [PMID: 21896909] - Sandy Bowkalow, Martin Brauer, Walter Gross, Ekkehard Schleussner. Severe H1N1-infection during pregnancy.
Archives of gynecology and obstetrics.
2011 Nov; 284(5):1133-5. doi:
10.1007/s00404-011-1967-x. [PMID: 21748316] - Rakesh Jaiswal, Sagar Deshpande, Nikolai Kuhnert. Profiling the chlorogenic acids of Rudbeckia hirta, Helianthus tuberosus, Carlina acaulis and Symphyotrichum novae-angliae leaves by LC-MS(n).
Phytochemical analysis : PCA.
2011 Sep; 22(5):432-41. doi:
10.1002/pca.1299. [PMID: 21495103] - Sasithon Pukrittayakamee, Podjanee Jittamala, Kasia Stepniewska, Niklas Lindegardh, Sunee Chueasuwanchai, Wattana Leowattana, Aphiradee Phakdeeraj, Sutatip Permpunpanich, Warunee Hanpithakpong, Wirichada Pan-Ngum, Caroline Fukuda, Salwaluk Panapipat, Pratap Singhasivanon, Nicholas J White, Nicholas P J Day. An open-label crossover study to evaluate potential pharmacokinetic interactions between oral oseltamivir and intravenous zanamivir in healthy Thai adults.
Antimicrobial agents and chemotherapy.
2011 Sep; 55(9):4050-7. doi:
10.1128/aac.00159-11. [PMID: 21690287] - Jian Tao, Jing Yang, Chaoyin Chen, Xiaomei Cao, Shenglan Zhao, Kunlong Ben. Evaluation of Cynanchum otophyllum glucan sulfate against human immunodeficiency virus and herpes simplex virus as a microbicide agent.
Indian journal of pharmacology.
2011 Sep; 43(5):536-40. doi:
10.4103/0253-7613.84967. [PMID: 22021996] - Hiroshi Ushirogawa, Masanobu Ohuchi. Novel antiviral activity of neuraminidase inhibitors against an avian influenza a virus.
Virology journal.
2011 Aug; 8(?):411. doi:
10.1186/1743-422x-8-411. [PMID: 21851647] - Seung-Dok Hong, Seong-Hwan Park, Seung-Ji Kang, Yong Soo Kwon, Seung-Jung Kee, Kyung-Hwa Park, Sook-In Jung, Hee-Chang Jang. First Fatal Oseltamivir-Resistant 2009 Pandemic Influenza A (H1N1) Case in an Adult in Korea.
Chonnam medical journal.
2011 Aug; 47(2):127-9. doi:
10.4068/cmj.2011.47.2.127. [PMID: 22111074] - Woo Hyun Cho, Yun Seong Kim, Doo Soo Jeon, Ji Eun Kim, Kun Il Kim, Hee Yun Seol, Ki Uk Kim, Hye Kyung Park, Min Ki Lee, Soon Kew Park, Yeon Joo Jeong. Outcome of pandemic H1N1 pneumonia: clinical and radiological findings for severity assessment.
The Korean journal of internal medicine.
2011 Jun; 26(2):160-7. doi:
10.3904/kjim.2011.26.2.160. [PMID: 21716592] - Hitoshi Ishizuka, Satoshi Yoshiba, Kazutaka Yoshihara, Hiromi Okabe. Assessment of the effects of renal impairment on the pharmacokinetic profile of laninamivir, a novel neuraminidase inhibitor, after a single inhaled dose of its Prodrug, CS-8958.
Journal of clinical pharmacology.
2011 Feb; 51(2):243-51. doi:
10.1177/0091270010361914. [PMID: 20197485] - Wei Chen, Chi Eung Danforn Lim, Hong-Jun Kang, Jianping Liu. Chinese herbal medicines for the treatment of type A H1N1 influenza: a systematic review of randomized controlled trials.
PloS one.
2011; 6(12):e28093. doi:
10.1371/journal.pone.0028093. [PMID: 22164232]
