Propiverine (BioDeep_00000006619)
Secondary id: BioDeep_00001868397
human metabolite Chemicals and Drugs
代谢物信息卡片
alpha-Diphenyl alpha-N-propoxyacetic acid-4(1-methylpiperidyl)ester
化学式: C23H29NO3 (367.2147)
中文名称: 丙哌维林
谱图信息:
最多检出来源 Mentha canadensis(plant) 100%
分子结构信息
SMILES: CCCOC(C(=O)OC1CCN(C)CC1)(C1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C23H29NO3/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21/h4-13,21H,3,14-18H2,1-2H3
描述信息
Propiverine is an anticholinergic drug used for the treatment of urinary urgency, frequency and urge incontinence, all symptoms of overactive bladder syndrome. A modified release preparation is also available, taken once daily.
G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals > G04BD - Drugs for urinary frequency and incontinence
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent
D000089162 - Genitourinary Agents > D064804 - Urological Agents
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:8493
- KEGG: C07852
- KEGGdrug: D08441
- PubChem: 4942
- HMDB: HMDB0041999
- Metlin: METLIN66753
- DrugBank: DB12278
- ChEMBL: CHEMBL1078261
- Wikipedia: Propiverine
- chemspider: 4773
- CAS: 60569-19-9
- PMhub: MS000019687
- PubChem: 10054
- NIKKAJI: J128.608K
- RefMet: Propiverine
- KNApSAcK: 8493
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Eu Chang Hwang, Shreyas Gandhi, Jae Hung Jung, Mari Imamura, Myung Ha Kim, Ran Pang, Philipp Dahm. Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia.
The Cochrane database of systematic reviews.
2018 10; 10(?):CD007360. doi:
10.1002/14651858.cd007360.pub3. [PMID: 30306544] - Marcia Y Maier, Lisanne Luks, Oliver R Baudendistel, Valentin Wittmann, Daniel R Dietrich. Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy.
Chemico-biological interactions.
2018 Feb; 281(?):69-80. doi:
10.1016/j.cbi.2017.12.023. [PMID: 29273565] - Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiko Noguchi, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. Pelvic venous congestion induces lower urinary tract dysfunction in rats.
Biomedical research (Tokyo, Japan).
2018; 39(6):269-277. doi:
10.2220/biomedres.39.269. [PMID: 30531156] - Lisanne Luks, Marcia Y Maier, Silvia Sacchi, Loredano Pollegioni, Daniel R Dietrich. Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon.
Archives of toxicology.
2017 Nov; 91(11):3599-3611. doi:
10.1007/s00204-017-1970-5. [PMID: 28451739] - Lisanne Luks, Silvia Sacchi, Loredano Pollegioni, Daniel R Dietrich. Novel insights into renal D-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo.
Archives of toxicology.
2017 Jan; 91(1):427-437. doi:
10.1007/s00204-016-1685-z. [PMID: 26961980] - Jing Leng, Limin Liao, Ben Wan, Chuanjun Du, Wei Li, Keji Xie, Zhoujun Shen, Zhuoqun Xu, Shiliang Wu, Zujun Fang, Lulin Ma, Shaomei Han, Cornelia Feustel, Yong Yang, Helmut Madersbacher. Results of a randomized, double-blind, active-controlled clinical trial with propiverine extended release 30 mg in patients with overactive bladder.
BJU international.
2017 Jan; 119(1):148-157. doi:
10.1111/bju.13500. [PMID: 27087507] - Saori Nishijima, Kimio Sugaya, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. Propiverine increases urethral wall catecholamine levels and bladder leak point pressure in rats.
International journal of urology : official journal of the Japanese Urological Association.
2016 Jan; 23(1):93-9. doi:
10.1111/iju.12991. [PMID: 26502799] - Wei Huang, Huantao Zong, Xin Zhou, Yong Zhang. Efficacy and safety of imidafenacin for overactive bladder in adult: a systematic review and meta-analysis.
International urology and nephrology.
2015 Mar; 47(3):457-64. doi:
10.1007/s11255-015-0916-1. [PMID: 25636812] - Rakan Matsui, Shinya Uchida, Noriyuki Namiki. Combination effect of physical and gustatory taste masking for propiverine hydrochloride orally disintegrating tablets on palatability.
Biological & pharmaceutical bulletin.
2015; 38(1):17-22. doi:
10.1248/bpb.b14-00467. [PMID: 25744453] - C Park, J Park, M-S Choo, J C Kim, J G Lee, J Z Lee, K-S Lee, D Y Kim, S-J Lee, J T Seo. A randomised, prospective double-blind, propiverine-controlled trial of imidafenacin in patients with overactive bladder.
International journal of clinical practice.
2014 Feb; 68(2):188-96. doi:
10.1111/ijcp.12255. [PMID: 24373019] - Rakan Matsui, Shinya Uchida, Noriyuki Namiki. In vitro and in vivo evaluation under finite conditions of a transdermal oil-in-water type emulsified formulation of propiverine hydrochloride.
Biological & pharmaceutical bulletin.
2014; 37(10):1661-7. doi:
10.1248/bpb.b14-00450. [PMID: 25273389] - M Stöhrer, G Mürtz, G Kramer, W Warnack, G Primus, V Jinga, A Manu-Marin, N Calomfirescu, G Strugala. Efficacy and tolerability of propiverine hydrochloride extended-release compared with immediate-release in patients with neurogenic detrusor overactivity.
Spinal cord.
2013 May; 51(5):419-23. doi:
10.1038/sc.2012.174. [PMID: 23338657] - Takeya Kitta, Vikas Tyagi, Masato Nanri, Mamoru Kiniwa, Katsuya Nonomura, Naoki Yoshimura. Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats.
International urogynecology journal.
2013 Apr; 24(4):683-8. doi:
10.1007/s00192-012-1924-7. [PMID: 22930215] - Saori Nishijima, Kimio Sugaya, Katsumi Kadekawa, Katsuhiro Ashitomi, Hideyuki Yamamoto. Efficacy of propiverine, an anticholinergic agent, in young and old rats.
Life sciences.
2011 Sep; 89(13-14):456-9. doi:
10.1016/j.lfs.2011.07.013. [PMID: 21819997] - Daniela Schultz-Lampel, Christian Steuber, Peter F Hoyer, Christian J Bachmann, Daniela Marschall-Kehrel, Hannsjörg Bachmann. Urinary incontinence in children.
Deutsches Arzteblatt international.
2011 Sep; 108(37):613-20. doi:
10.3238/arztebl.2011.0613. [PMID: 21977217] - Momokazu Gotoh, Osamu Yokoyama, Osamu Nishizawa. Propiverine hydrochloride in Japanese patients with overactive bladder: a randomized, double-blind, placebo-controlled trial.
International journal of urology : official journal of the Japanese Urological Association.
2011 May; 18(5):365-73. doi:
10.1111/j.1442-2042.2011.02732.x. [PMID: 21332825] - Noritaka Kamimura, Shingo Hatakeyama, Shigemasa Kudo, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Shinya Takahashi, Chikara Ohyama. [Additional effect of propiverine for naftopidil-resistant nocturia in the patient with benign prostate hypertrophy].
Hinyokika kiyo. Acta urologica Japonica.
2011 Feb; 57(2):71-6. doi:
. [PMID: 21412038] - Meihua Huang, Yuan Tian, Zunjian Zhang, Hongwen Zhang, Hui Lin. Determination of propiverine hydrochloride in human plasma by high performance liquid chromatography-tandem mass spectrometry: application to the pharmacokinetic study of a sustained release formulation.
Arzneimittel-Forschung.
2011; 61(9):494-501. doi:
10.1055/s-0031-1296223. [PMID: 22029224] - Shizuo Yamada, Yoshihiko Ito, Yuko Taki, Masanao Seki, Masato Nanri, Fumiaki Yamashita, Kayo Morishita, Ikumi Komoto, Ken-ichiro Yoshida. The N-oxide metabolite contributes to bladder selectivity resulting from oral propiverine: muscarinic receptor binding and pharmacokinetics.
Drug metabolism and disposition: the biological fate of chemicals.
2010 Aug; 38(8):1314-21. doi:
10.1124/dmd.110.033233. [PMID: 20483954] - Werner Siegmund, Ulla Sillén, Göran Läckgren, Frieder Schnabel, Gerd Mürtz, Cornelia Feustel. Pharmacokinetics and pharmacodynamics of propiverine in children aged between 5 and 10 years with symptoms of overactive bladder.
Clinical pharmacokinetics.
2010 May; 49(5):335-42. doi:
10.2165/11319990-000000000-00000. [PMID: 20384395] - Xiaofan Sui, Jin Sun, Haiyan Li, Yongjun Wang, Jianfang Liu, Xiaohong Liu, Wenping Zhang, Lijiang Chen, Zhonggui He. Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
European journal of medicinal chemistry.
2009 Nov; 44(11):4455-60. doi:
10.1016/j.ejmech.2009.06.004. [PMID: 19586686] - Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Minoru Miyazato, Hideki Mukouyama. Relationship between lower urinary tract symptoms and urinary ATP in patients with benign prostatic hyperplasia or overactive bladder.
Biomedical research (Tokyo, Japan).
2009 Oct; 30(5):287-94. doi:
10.2220/biomedres.30.287. [PMID: 19887725] - D Tomalik-Scharte, D Lütjohann, O Doroshyenko, D Frank, A Jetter, U Fuhr. Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric?.
Clinical pharmacology and therapeutics.
2009 Aug; 86(2):147-53. doi:
10.1038/clpt.2009.72. [PMID: 19458613] - Saladin Helmut Alloussi, Gerd Mürtz, Silvia Gitzhofer, Robert Eichel, Christoph Lang, Helmut Madersbacher, Gerhard Strugala, Schahnaz Alloussi. Failure of monotherapy in primary monosymptomatic enuresis: a combined desmopressin and propiverine treatment regimen improves efficacy outcomes.
BJU international.
2009 Jun; 103(12):1706-12. doi:
10.1111/j.1464-410x.2008.08285.x. [PMID: 19154456] - Teruhiko Yokoyama, Katsutoshi Uematsu, Toyohiko Watanabe, Katsumi Sasaki, Hiromi Kumon, Atsushi Nagai. Naftopidil and propiverine hydrochloride for treatment of male lower urinary tract symptoms suggestive of benign prostatic hyperplasia and concomitant overactive bladder: a prospective randomized controlled study.
Scandinavian journal of urology and nephrology.
2009; 43(4):307-14. doi:
10.1080/00365590902836740. [PMID: 19396723] - D R Dietrich, A H Heussner, E O'Brien, T Gramatté, M Runkel, S Rumpf, B W Day. Propiverine-induced accumulation of nuclear and cytosolic protein in F344 rat kidneys: isolation and identification of the accumulating protein.
Toxicology and applied pharmacology.
2008 Dec; 233(3):411-9. doi:
10.1016/j.taap.2008.09.014. [PMID: 18929589] - Karen May, Kristin Westphal, Thomas Giessmann, Danilo Wegner, Ulrike Adam, Markus M Lerch, Reinhard Oertel, Rolf W Warzok, Werner Weitschies, Manfred Braeter, Werner Siegmund. Disposition and antimuscarinic effects of the urinary bladder spasmolytics propiverine: influence of dosage forms and circadian-time rhythms.
Journal of clinical pharmacology.
2008 May; 48(5):570-9. doi:
10.1177/0091270008315314. [PMID: 18319360] - Kimio Sugaya, Saori Nishijima, Shinsuke Tasaki, Katsumi Kadekawa, Minoru Miyazato, Yoshihide Ogawa. Effects of propiverine and naftopidil on the urinary ATP level and bladder activity after bladder stimulation in rats.
Neuroscience letters.
2007 Dec; 429(2-3):142-6. doi:
10.1016/j.neulet.2007.10.003. [PMID: 17997223] - R Oertel, B Kilian, W Siegmund, W Kirch. Determination of propiverine and its metabolites in rat samples by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2007 May; 1149(1):121-6. doi:
10.1016/j.chroma.2006.11.021. [PMID: 17141252] - Osamu Maruyama, Yoshio Kawachi, Kisaburo Hanazawa, Kazuo Koizumi, Ryo Yamashita, Sosuke Sugimura, Shin-ichi Honda, Yoshiki Sugiyama, Toshihiko Saitoh, Kensho Noto. Naftopidil monotherapy vs naftopidil and an anticholinergic agent combined therapy for storage symptoms associated with benign prostatic hyperplasia: A prospective randomized controlled study.
International journal of urology : official journal of the Japanese Urological Association.
2006 Oct; 13(10):1280-5. doi:
10.1111/j.1442-2042.2006.01538.x. [PMID: 17010005] - Eunmi Ban, Jeong-Eun Maeng, Jong Soo Woo, Chong-Kook Kim. Sensitive column-switching high-performance liquid chromatography method for determination of propiverine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Feb; 831(1-2):230-5. doi:
10.1016/j.jchromb.2005.12.005. [PMID: 16406746] - D Tomalik-Scharte, A Jetter, M Kinzig-Schippers, A Skott, F Sörgel, T Klaassen, D Kasel, S Harlfinger, O Doroshyenko, D Frank, J Kirchheiner, M Bräter, K Richter, T Gramatté, U Fuhr. Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Dec; 33(12):1859-66. doi:
10.1124/dmd.105.005272. [PMID: 16183781] - Takahide Sugiyama, Nobutaka Shimizu, Kiyoshi Hashimoto, Nobuhiro Yoshioka, Tadashi Hanai, Seiji Matsumoto, Hirotsugu Uemura. [Pharmacological evaluation of efficacy and safety of propiverine hydrochloride in patients of overactive bladder--relationship between urodynamic observation and propiverine pharmacokinetics--].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2005 Nov; 96(7):670-7. doi:
10.5980/jpnjurol1989.96.670. [PMID: 16363652] - Kyu-Sung Lee, Myung-Soo Choo, Duk-Yoon Kim, Joon Chul Kim, Hyung-Jee Kim, Kweon Sik Min, Jong Bouk Lee, Hee Jong Jeong, Tack Lee, Won Hee Park. Combination treatment with propiverine hydrochloride plus doxazosin controlled release gastrointestinal therapeutic system formulation for overactive bladder and coexisting benign prostatic obstruction: a prospective, randomized, controlled multicenter study.
The Journal of urology.
2005 Oct; 174(4 Pt 1):1334-8. doi:
10.1097/01.ju.0000173630.94559.fd. [PMID: 16145414] - Sung-Hee Cho, Hun-Woo Lee, Ho-Taek Im, Wan-Su Park, Minsun Baek, Kyung-Tae Lee. Quantification of propiverine by liquid chromatography/electrospray tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy subjects.
Journal of pharmaceutical and biomedical analysis.
2005 Sep; 39(3-4):670-6. doi:
10.1016/j.jpba.2005.03.038. [PMID: 15936164] - Klaus-Peter Jünemann, Michael Halaska, Tomas Rittstein, Gerd Mürtz, Frieder Schnabel, Rainer Brünjes, Wojciech Nurkiewicz. Propiverine versus tolterodine: efficacy and tolerability in patients with overactive bladder.
European urology.
2005 Sep; 48(3):478-82. doi:
10.1016/j.eururo.2005.04.023. [PMID: 15967567] - Mitchell R Humphreys, Yuri E Reinberg. Contemporary and emerging drug treatments for urinary incontinence in children.
Paediatric drugs.
2005; 7(3):151-62. doi:
10.2165/00148581-200507030-00002. [PMID: 15977961] - Arne-Daniela Marschall-Kehrel, Gerd Mürtz, Guus Kramer, Klaus-Peter Jünemann, Helmut Madersbacher. An empirical treatment algorithm for incontinent children.
The Journal of urology.
2004 Jun; 171(6 Pt 2):2667-71. doi:
10.1097/01.ju.0000109641.77820.46. [PMID: 15118448] - Ikumi Komoto, Ken-ichiro Yoshida, Eiji Matsushima, Kazumasa Yamashita, Tsutomu Aikawa, Shunji Akashi. Validation of a simple liquid chromatography-tandem mass spectrometric method for the determination of propiverine hydrochloride and its N-oxide metabolite in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Jan; 799(1):141-7. doi:
10.1016/j.jchromb.2003.10.029. [PMID: 14659446] - T Oka, K Nakano, T Kirimoto, N Matsuura. Effects of antimuscarinic drugs on both urinary frequency and cognitive impairment in conscious, nonrestrained rats.
Japanese journal of pharmacology.
2001 Sep; 87(1):27-33. doi:
10.1254/jjp.87.27. [PMID: 11676195] - H Madersbacher, M Halaska, R Voigt, S Alloussi, K Höfner. A placebo-controlled, multicentre study comparing the tolerability and efficacy of propiverine and oxybutynin in patients with urgency and urge incontinence.
BJU international.
1999 Oct; 84(6):646-51. doi:
10.1046/j.1464-410x.1999.00251.x. [PMID: 10510109] - M Stöhrer, H Madersbacher, R Richter, J Wehnert, K Dreikorn. Efficacy and safety of propiverine in SCI-patients suffering from detrusor hyperreflexia--a double-blind, placebo-controlled clinical trial.
Spinal cord.
1999 Mar; 37(3):196-200. doi:
10.1038/sj.sc.3100750. [PMID: 10213329] - M Siepmann, A Nokhodian, D Thümmler, W Kirch. Pharmacokinetics and safety of propiverine in patients with fatty liver disease.
European journal of clinical pharmacology.
1998 Nov; 54(9-10):767-71. doi:
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Hinyokika kiyo. Acta urologica Japonica.
1998 Sep; 44(9):687-93. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
1998 Apr; 708(1-2):325-9. doi:
10.1016/s0378-4347(97)00630-0. [PMID: 9653982] - M Halaska, A Martan, R Voigt, F Kaplan, K Raus, J Masata, J Klemenc. [Tolerance and effectiveness of propiverine hydrochloride in 752 patients with symptoms of detrusor hyperactivity and increased sensitivity and irritability of the urinary bladder: results of a study monitoring drug utilization].
Ceska gynekologie.
1997 Oct; 62(5):259-64. doi:
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The Journal of pharmacy and pharmacology.
1997 Mar; 49(3):270-2. doi:
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European journal of drug metabolism and pharmacokinetics.
1993 Jul; 18(3):265-72. doi:
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The Journal of toxicological sciences.
1990 May; 15(2):107-44. doi:
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Hinyokika kiyo. Acta urologica Japonica.
1990 Apr; 36(4):517-23. doi:
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The Journal of toxicological sciences.
1989 Oct; 14 Suppl 2(?):13-59. doi:
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The Journal of toxicological sciences.
1989 Oct; 14 Suppl 2(?):111-60. doi:
10.2131/jts.14.supplementii_111. [PMID: 2607551] - K Yamashita, H Yada, K Irimura, A Maruden, K Morita. [Thirteen-week oral toxicity study of propiverine hydrochloride in dogs].
The Journal of toxicological sciences.
1989 Oct; 14 Suppl 2(?):61-109. doi:
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The Journal of toxicological sciences.
1989 Oct; 14 Suppl 2(?):1-11. doi:
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1989 Aug; 94(2):145-50. doi:
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The Journal of toxicological sciences.
1989 May; 14(2):143-51. doi:
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European journal of drug metabolism and pharmacokinetics.
1988 Apr; 13(2):81-90. doi:
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Die Pharmazie.
1988 Feb; 43(2):96-8. doi:
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Die Pharmazie.
1988 Feb; 43(2):91-5. doi:
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Journal of chromatography.
1987 Sep; 420(1):43-52. doi:
10.1016/0378-4347(87)80153-6. [PMID: 3667829] - G Otto-Unger. [Treatment of the unstable bladder in children with the anticholinergic agent propiverin hydrochloride (mictonorm/mictonets)].
Zeitschrift fur Urologie und Nephrologie.
1985 Mar; 78(3):145-52. doi:
NULL. [PMID: 4002894]
