Ethchlorvynol (BioDeep_00000006610)
Secondary id: BioDeep_00001867934
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
beta-Chlorovinyl ethyl ethynyl carbinol
化学式: C7H9ClO (144.0342)
中文名称: 乙氯戊烯炔醇, 乙氯炔醇
谱图信息:
最多检出来源 Homo sapiens(blood) 99.15%
分子结构信息
SMILES: C#CC(CC)(/C=C/Cl)O
InChI: InChI=1S/C7H9ClO/c1-3-7(9,4-2)5-6-8/h1,5-6,9H,4H2,2H3
描述信息
Ethchlorvynol is only found in individuals that have used or taken this drug. It is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. [Wikipedia]Although the exact mechanism of action is unknown, ethchlorvynol appears to depress the central nervous system in a manner similar to that of barbiturates. Barbiturates bind at a distinct binding sites associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
同义名列表
25 个代谢物同义名
beta-Chlorovinyl ethyl ethynyl carbinol; Ethyl beta-chlorovinyl ethynyl carbinol; b-Chlorovinyl ethyl ethynyl carbinol; 1-Chloro-3-ethyl-pent-1-en-4-yn-3-ol; Β-chlorovinyl ethyl ethynyl carbinol; Ethyl b-chlorovinyl ethynyl carbinol; Ethyl β-chlorovinyl ethynyl carbinol; 1-chloro-3-ethylpent-1-en-4-yn-3-ol; 1-Chloro-3-ethyl-1-penten-4-yn-3-ol; 3-(beta-Chlorovinyl)-1-pentyn-3-ol; 3-(Β-chlorovinyl)-1-pentyn-3-ol; 3-(b-Chlorovinyl)-1-pentyn-3-ol; Aethyl-chlorvynol; Ethchlorvynolum; Ethchlorovynol; Ethychlorvynol; Ethochlorvynol; Ethchlorvinol; Etchlorvinolo; Ethchlorvinyl; Ethchlorvynol; Ethclorvynol; Etclorvinol; Ethchlorvynol; Ethchlorvynol
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:4882
- KEGG: C07833
- KEGGdrug: D00704
- PubChem: 5281077
- HMDB: HMDB0014335
- Metlin: METLIN4015
- DrugBank: DB00189
- ChEMBL: CHEMBL591
- Wikipedia: Ethchlorvynol
- MeSH: Ethchlorvynol
- chemspider: 4444534
- CAS: 1135334-09-6
- CAS: 113-18-8
- PMhub: MS000019678
- PubChem: 10035
- NIKKAJI: J5.130F
- RefMet: Ethchlorvynol
- KNApSAcK: 4882
分类词条
相关代谢途径
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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The American review of respiratory disease.
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Journal of applied physiology (Bethesda, Md. : 1985).
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Journal of forensic sciences.
1989 May; 34(3):687-90. doi:
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Forensic science international.
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Journal of applied physiology (Bethesda, Md. : 1985).
1987 Feb; 62(2):732-8. doi:
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Pharmacotherapy.
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Blood purification.
1985; 3(1-3):109-19. doi:
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The American journal of pathology.
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Heart & lung : the journal of critical care.
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The Journal of surgical research.
1982 Oct; 33(4):285-93. doi:
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Transactions - American Society for Artificial Internal Organs.
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Journal of applied physiology: respiratory, environmental and exercise physiology.
1981 Jun; 50(6):1151-5. doi:
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Postgraduate medical journal.
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Science (New York, N.Y.).
1980 Aug; 209(4457):703-4. doi:
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Annals of internal medicine.
1980 Mar; 92(3):436-7. doi:
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Kidney international.
1980 Mar; 17(3):303-11. doi:
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Annals of internal medicine.
1980 Mar; 92(3):435-6. doi:
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Clinical pharmacology and therapeutics.
1980 Feb; 27(2):236-42. doi:
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Annals of internal medicine.
1979 Oct; 91(4):549-53. doi:
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Journal of chromatography.
1978 Nov; 161(?):287-90. doi:
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Journal of chromatography.
1978 Jun; 153(2):473-9. doi:
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Chest.
1978 Jan; 73(1):75-8. doi:
10.1378/chest.73.1.75. [PMID: 620561] - P Fischer, F L Glauser, J E Millen, J Lewis, P Egan. The effects of ethchlorvynol on pulmonary alveolar membrane permeability.
The American review of respiratory disease.
1977 Nov; 116(5):901-6. doi:
10.1164/arrd.1977.116.5.901. [PMID: 921065] - R J Flanagan, T D Lee. Rapid micro-method for the measurement of ethchlorvynol in blood plasma and in urine by gas-liquid chromatography.
Journal of chromatography.
1977 Jul; 137(1):119-26. doi:
10.1016/s0021-9673(00)89246-8. [PMID: 561113] - L C Dearden, F L Glauser, D Smeltzer. The effect of ethchlorvynol on pulmonary ultrastructure in dogs.
The American journal of pathology.
1977 Jun; 87(3):525-36. doi:
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Kidney international. Supplement.
1976 Dec; ?(7):S333-7. doi:
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Kidney international. Supplement.
1976 Dec; ?(7):S338-40. doi:
NULL. [PMID: 1070558] - J L Rosenbaum, M S Kramer, R Raja, S Winsten, F Dalal. Hemoperfusion for acute drug intoxication.
Kidney international. Supplement.
1976 Dec; ?(7):S341-2. doi:
NULL. [PMID: 1070559] - J M White. Letter: Ethchlorvynol interference with oxidimetric determination of ethanol in urine.
Clinical chemistry.
1976 May; 22(5):694. doi:
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Canadian Anaesthetists' Society journal.
1976 Mar; 23(2):170-5. doi:
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Clinical chemistry.
1975 Jun; 21(7):894-5. doi:
10.1093/clinchem/21.7.894. [PMID: 1132140] - J M White, M H Graves. The detection of sedative-hypnotic drugs in the impaired driver.
Journal of chromatographic science.
1974 May; 12(5):219-24. doi:
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Clinical chemistry.
1974 Feb; 20(2):212-6. doi:
10.1093/clinchem/20.2.212. [PMID: 4812998] - J E Wallace, H E Hamilton, J A Riloff, K Blum. Spectrophotometric determination of ethchlorvynol in biologic specimens.
Clinical chemistry.
1974 Feb; 20(2):159-62. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1974 Jan; 50(1):19-30. doi:
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CRC critical reviews in clinical laboratory sciences.
1973 Dec; 4(4):357-82. doi:
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Pediatrics.
1973 Nov; 52(5):714-6. doi:
NULL. [PMID: 4744665] - C S Frings, C A Queen. Letter: Elimination of interference by phenazopyridine hydrochloride ('Pyridium') in determining ethchlorvynol ('Placidyl').
Clinical chemistry.
1973 Sep; 19(9):1086. doi:
NULL. [PMID: 4744817] - P Haux. Ethchlorvynol (Placidyl) estimation in urine and serum.
Clinica chimica acta; international journal of clinical chemistry.
1973 Jan; 43(1):139-41. doi:
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Clinical chemistry.
1972 Nov; 18(11):1440. doi:
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The Medical journal of Australia.
1972 Sep; 2(13):702-4. doi:
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Clinical chemistry.
1972 Jun; 18(6):591-2. doi:
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The British journal of dermatology.
1972 Mar; 86(3):313-6. doi:
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Journal of pharmaceutical sciences.
1972 Feb; 61(2):169-71. doi:
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Journal of pharmaceutical sciences.
1971 Feb; 60(2):261-3. doi:
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American journal of clinical pathology.
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JAMA.
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1969 Jul; 15(7):591-9. doi:
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Journal of forensic sciences.
1969 Apr; 14(2):235-54. doi:
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Anesthesiology.
1969 Jan; 30(1):107-11. doi:
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Clinical pediatrics.
1968 Dec; 7(12):739-41. doi:
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Journal of forensic sciences.
1968 Oct; 13(4):532-6. doi:
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Journal of pharmaceutical sciences.
1968 Jan; 57(1):185-6. doi:
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Canadian Medical Association journal.
1966 Nov; 95(19):954-6. doi:
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Annals of internal medicine.
1966 Jun; 64(6):1229-36. doi:
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