Ethchlorvynol (BioDeep_00001867934)
Main id: BioDeep_00000006610
代谢物信息卡片
Ethchlorvynol
化学式: C7H9ClO (144.0342)
中文名称: 乙氯戊烯炔醇, 乙氯炔醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C#CC(CC)(/C=C/Cl)O
InChI: InChI=1S/C7H9ClO/c1-3-7(9,4-2)5-6-8/h1,5-6,9H,4H2,2H3/b6-5+
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
同义名列表
3 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:4882
- KEGG: C07833
- KEGGdrug: D00704
- PubChem: 5281077
- DrugBank: DB00189
- ChEMBL: CHEMBL591
- MeSH: Ethchlorvynol
- CAS: 1135334-09-6
- CAS: 113-18-8
- PubChem: 10035
- NIKKAJI: J5.130F
- RefMet: Ethchlorvynol
- KNApSAcK: 4882
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- H Tanaka, T E Dahms, E Bell, K S Naunheim, L J Baudendistel. Effect of hydroxyethyl starch on alveolar flooding in acute lung injury in dogs.
The American review of respiratory disease.
1993 Oct; 148(4 Pt 1):852-9. doi:
10.1164/ajrccm/148.4_pt_1.852. [PMID: 7692773] - K Yagi, L J Baudendistel, T E Dahms. Ibuprofen reduces ethchlorvynol lung injury: possible role of blood flow distribution.
Journal of applied physiology (Bethesda, Md. : 1985).
1992 Mar; 72(3):1156-65. doi:
10.1152/jappl.1992.72.3.1156. [PMID: 1568970] - C L Winek, W W Wahba, C L Winek. Body distribution of ethchlorvynol.
Journal of forensic sciences.
1989 May; 34(3):687-90. doi:
. [PMID: 2738567] - C L Winek, W W Wahba, L Rozin, C L Winek. Determination of ethchlorvynol in body tissues and fluids after embalmment.
Forensic science international.
1988 May; 37(3):161-6. doi:
10.1016/0379-0738(88)90180-6. [PMID: 3402856] - A H Stephenson, R S Sprague, T E Dahms, A J Lonigro. Increased leukotriene C4 in ethchlorvynol-induced acute lung injury in dogs.
Journal of applied physiology (Bethesda, Md. : 1985).
1987 Feb; 62(2):732-8. doi:
10.1152/jappl.1987.62.2.732. [PMID: 3558233] - J H Kolpek, M D Parr, M L Marshall, J A Flueck. Ethchlorvynol pharmacokinetics during long-term administration in a patient with hyperlipidemia and hypothyroidism.
Pharmacotherapy.
1986 Nov; 6(6):323-7. doi:
10.1002/j.1875-9114.1986.tb03495.x. [PMID: 3822854] - Z Forycki, F Martens, S Thalhofer, K Ibe. Tranquilizers, analgetics and antidepressants in patients treated with hemodialysis.
Blood purification.
1985; 3(1-3):109-19. doi:
10.1159/000169404. [PMID: 2869770] - R Wysolmerski, D Lagunoff, T Dahms. Ethchlorvynol-induced pulmonary edema in rats. An ultrastructural study.
The American journal of pathology.
1984 Jun; 115(3):447-57. doi:
. [PMID: 6731587] - T C Howerton, M F O'Connor, A C Collins. Lipid solubility is correlated with hypnotic and hypothermic responses of long-sleep (LS) and short-sleep (SS) mice to various depressant drugs.
The Journal of pharmacology and experimental therapeutics.
1983 Nov; 227(2):389-93. doi:
. [PMID: 6138426] - N E Gary, O Tresznewsky. Clinical aspects of drug intoxication: barbiturates and a potpourri of other sedatives, hypnotics, and tranquilizers.
Heart & lung : the journal of critical care.
1983 Mar; 12(2):122-7. doi:
NULL. [PMID: 6550044] - L Baudendistel, T E Dahms, D L Kaminski. The effect of albumin on extravascular lung water in animals and patients with low-pressure pulmonary edema.
The Journal of surgical research.
1982 Oct; 33(4):285-93. doi:
10.1016/0022-4804(82)90041-5. [PMID: 6750242] - J L Rosenbaum, K G Barber, R M Raja, M S Kramer, M V Fernandes. The effect of human serum albumin coating on Amberlite XAD-4 resin hemoperfusion.
Transactions - American Society for Artificial Internal Organs.
1982; 28(?):333-7. doi:
NULL. [PMID: 7164259] - R P Fairman, F L Glauser, R Falls. Increases in lung lymph and albumin clearance with ethchlorvynol.
Journal of applied physiology: respiratory, environmental and exercise physiology.
1981 Jun; 50(6):1151-5. doi:
10.1152/jappl.1981.50.6.1151. [PMID: 7263375] - P Crome, G Hampel, B Widdop, R Goulding. Experience with cellulose acetate-coated activated charcoal haemoperfusion in the treatment of severe hypnotic drug intoxication.
Postgraduate medical journal.
1980 Nov; 56(661):763-6. doi:
10.1136/pgmj.56.661.763. [PMID: 7267478] - C R Abolin, T N Tozer, J C Craig, L D Gruenke. C-Glucuronidation of the acetylenic moiety of ethchlorvynol in the rabbit.
Science (New York, N.Y.).
1980 Aug; 209(4457):703-4. doi:
10.1126/science.7394528. [PMID: 7394528] - S L Dua, I Nagrawala, R Thompson. Resin hemoperfusion for ethchlorvynol.
Annals of internal medicine.
1980 Mar; 92(3):436-7. doi:
". [PMID: 7356246] - M J Zmuda. Resin hemoperfusion in dogs intoxicated with ethychlorvynol (Placidyl).
Kidney international.
1980 Mar; 17(3):303-11. doi:
10.1038/ki.1980.36. [PMID: 7401450] - N L Benowitz, J Rosenberg, S Pond. Resin hemoperfusion for ethchlorvynol.
Annals of internal medicine.
1980 Mar; 92(3):435-6. doi:
10.7326/0003-4819-92-3-435_2. [PMID: 7356245] - N Benowitz, C Abolin, T Tozer, J Rosenberg, W Rogers, S Pond, P Schoenfeld, M Humphreys. Resin hemoperfusion in ethychlorvynol overdose.
Clinical pharmacology and therapeutics.
1980 Feb; 27(2):236-42. doi:
10.1038/clpt.1980.37. [PMID: 7353346] - R I Lynn, C L Honig, P I Jatlow, A S Kliger. Resin hemoperfusion for treatment of ethchlorvynol overdose.
Annals of internal medicine.
1979 Oct; 91(4):549-53. doi:
10.7326/0003-4819-91-4-549. [PMID: 484952] - K K Kaistha, R Tadrus. Qualitative detection of placidyl (ethchlorvynol) alone or in combination with poly-drugs in drug abuse urine screening programs using ion-exchange paper and/or liquid-liquid extraction.
Journal of chromatography.
1978 Nov; 161(?):287-90. doi:
10.1016/s0021-9673(01)85238-9. [PMID: 730802] - R J Flanagan, T D Lee, D M Rutherford. Analysis of chlormethiazole, ethchlorvynol and trichloroethanol in biological fluids by gas-liquid chromatography as an aid to the diagnosis of acute poisoning.
Journal of chromatography.
1978 Jun; 153(2):473-9. doi:
10.1016/s0021-9673(00)95507-9. [PMID: 659564] - J E Millen, F L Glauser, D Smeltzer, P Egan, K Propst, P Fischer, L Dearden, P Otis. The role of leukocytes in ethchlorvynol-induced pulmonary edema.
Chest.
1978 Jan; 73(1):75-8. doi:
10.1378/chest.73.1.75. [PMID: 620561] - P Fischer, F L Glauser, J E Millen, J Lewis, P Egan. The effects of ethchlorvynol on pulmonary alveolar membrane permeability.
The American review of respiratory disease.
1977 Nov; 116(5):901-6. doi:
10.1164/arrd.1977.116.5.901. [PMID: 921065] - R J Flanagan, T D Lee. Rapid micro-method for the measurement of ethchlorvynol in blood plasma and in urine by gas-liquid chromatography.
Journal of chromatography.
1977 Jul; 137(1):119-26. doi:
10.1016/s0021-9673(00)89246-8. [PMID: 561113] - L C Dearden, F L Glauser, D Smeltzer. The effect of ethchlorvynol on pulmonary ultrastructure in dogs.
The American journal of pathology.
1977 Jun; 87(3):525-36. doi:
NULL. [PMID: 869012] - B H Barbour, A M LaSette, A Koffler. Fixed-bed charcoal hemoperfusion for the treatment of drug overdose.
Kidney international. Supplement.
1976 Dec; ?(7):S333-7. doi:
NULL. [PMID: 1070557] - R Goulding. Experience with hemoperfusion in drug abuse.
Kidney international. Supplement.
1976 Dec; ?(7):S338-40. doi:
NULL. [PMID: 1070558] - J L Rosenbaum, M S Kramer, R Raja, S Winsten, F Dalal. Hemoperfusion for acute drug intoxication.
Kidney international. Supplement.
1976 Dec; ?(7):S341-2. doi:
NULL. [PMID: 1070559] - J M White. Letter: Ethchlorvynol interference with oxidimetric determination of ethanol in urine.
Clinical chemistry.
1976 May; 22(5):694. doi:
. [PMID: 1261026] - M J DIAMIND, Y S Brownstone, G Erceg, H Kieraszewicz, M Keeri-Szanto. The reduction of coma time in lipophilic drug overdose using castor oil.
Canadian Anaesthetists' Society journal.
1976 Mar; 23(2):170-5. doi:
10.1007/bf03005688. [PMID: 3270] - D J Pochopien. Rate of decrease in serum ethchlorvynol concentrations after extreme overdosage-a case study.
Clinical chemistry.
1975 Jun; 21(7):894-5. doi:
10.1093/clinchem/21.7.894. [PMID: 1132140] - J M White, M H Graves. The detection of sedative-hypnotic drugs in the impaired driver.
Journal of chromatographic science.
1974 May; 12(5):219-24. doi:
10.1093/chromsci/12.5.219. [PMID: 4833005] - M A Evenson, M A Poquette. Rapid gas chromatographic method for quantitation of ethchlorvynol ('Placidyl') in serum.
Clinical chemistry.
1974 Feb; 20(2):212-6. doi:
10.1093/clinchem/20.2.212. [PMID: 4812998] - J E Wallace, H E Hamilton, J A Riloff, K Blum. Spectrophotometric determination of ethchlorvynol in biologic specimens.
Clinical chemistry.
1974 Feb; 20(2):159-62. doi:
10.1093/clinchem/20.2.159. [PMID: 4812989] - P Jatlow, D Seligson. Application of a digital computer to emergency toxicology.
Clinica chimica acta; international journal of clinical chemistry.
1974 Jan; 50(1):19-30. doi:
10.1016/0009-8981(74)90073-4. [PMID: 4816440] - C S Frings. Drug screening.
CRC critical reviews in clinical laboratory sciences.
1973 Dec; 4(4):357-82. doi:
10.3109/10408367309151559. [PMID: 4614940] - B H Rumack, P A Walravens. Neonatal withdrawal following maternal ingestion of ethchlorvynol (Placidyl).
Pediatrics.
1973 Nov; 52(5):714-6. doi:
NULL. [PMID: 4744665] - C S Frings, C A Queen. Letter: Elimination of interference by phenazopyridine hydrochloride ('Pyridium') in determining ethchlorvynol ('Placidyl').
Clinical chemistry.
1973 Sep; 19(9):1086. doi:
NULL. [PMID: 4744817] - P Haux. Ethchlorvynol (Placidyl) estimation in urine and serum.
Clinica chimica acta; international journal of clinical chemistry.
1973 Jan; 43(1):139-41. doi:
10.1016/0009-8981(73)90128-9. [PMID: 4710815] - C S Frings, C A Queen. Preparation and use of a urine control for certain drugs of abuse.
Clinical chemistry.
1972 Nov; 18(11):1440. doi:
NULL. [PMID: 4652845] - J K Dawborn, A Turner, G Pattison. Ethchlorvynol as a sedative in patients with renal failure.
The Medical journal of Australia.
1972 Sep; 2(13):702-4. doi:
10.5694/j.1326-5377.1972.tb103503.x. [PMID: 5084967] - J W Cantrell, N E Hopkins, C A Queen, C S Frings. Effect of phenazopyridine hydrochloride ('Pyridium') on determination of ethchlorvynol ('Placidyl').
Clinical chemistry.
1972 Jun; 18(6):591-2. doi:
10.1093/clinchem/18.6.591. [PMID: 5026773] - J Almeyda, A Levantine. Drug reactions. XVII. Cutaneous reactions to barbiturates, chloral hydrate and its derivatives.
The British journal of dermatology.
1972 Mar; 86(3):313-6. doi:
10.1111/j.1365-2133.1972.tb02239.x. [PMID: 4259714] - P F Gibson, N Wright. Ethchlorvynol in biological fluids: specificity of assay methods.
Journal of pharmaceutical sciences.
1972 Feb; 61(2):169-71. doi:
10.1002/jps.2600610204. [PMID: 5059776] - L M Cummins, Y C Martin, E E Scherfling. Serum and urine levels of ethchlorvynol in man.
Journal of pharmaceutical sciences.
1971 Feb; 60(2):261-3. doi:
10.1002/jps.2600600222. [PMID: 5572450] - C S Frings, P S Cohen. Rapid colorimetric method for the quantitative determination of ethchlorvynol (Placidyl) in serum and urine.
American journal of clinical pathology.
1970 Dec; 54(6):833-6. doi:
10.1093/ajcp/54.6.833. [PMID: 5484037] - K Sterling, S Refetoff, H A Selenkow. T3 thyrotoxicosis. Thyrotoxicosis due to elevated serum triiodothyronine levels.
JAMA.
1970 Jul; 213(4):571-5. doi:
10.1001/jama.213.4.571. [PMID: 4193903] - S L Tompsett. The detection of basic and other drugs in urine bdistillation and UV spectrophotometry.
Clinical chemistry.
1969 Jul; 15(7):591-9. doi:
10.1093/clinchem/15.7.591. [PMID: 5794152] - R Maes, N Hodnett, H Landesman, G Kananen, B Finkle, I Sunshine. The gas chromatographic determination of selected sedatives (ethchlorvynol, paraldehyde, meprobamate, and Carisoprodol) in biological material.
Journal of forensic sciences.
1969 Apr; 14(2):235-54. doi:
. [PMID: 5782014] - J Hedley-Whyte, L H Laasberg. Ethchlorvynol poisoning: gas liquid chromatography in management.
Anesthesiology.
1969 Jan; 30(1):107-11. doi:
NULL. [PMID: 5812460] - J S Hyde, A G Lawrence, J B Moles. Ethchlorvynol intoxication. Successful treatment by exchange transfusion and peritoneal dialysis.
Clinical pediatrics.
1968 Dec; 7(12):739-41. doi:
10.1177/000992286800701211. [PMID: 5725786] - R H Cravey, R C Baselt. Studies of the body distribution of ethchlorvynol.
Journal of forensic sciences.
1968 Oct; 13(4):532-6. doi:
NULL. [PMID: 5743572] - D W Robinson. Method for determining ethchlorvynol in urine and serum by gas chromatography.
Journal of pharmaceutical sciences.
1968 Jan; 57(1):185-6. doi:
10.1002/jps.2600570143. [PMID: 5652130] - R I Ogilvie, D E Douglas, J R Lochead, M D Moscovich, M Kaye. Ethchlorvynol (Placidyl) intoxication and its treatment by hemodialysis.
Canadian Medical Association journal.
1966 Nov; 95(19):954-6. doi:
. [PMID: 5922910] - F B Westervelt. Ethchlorvynol (Placidyl) intoxication. Experience with five patients, including treatment with hemodialysis.
Annals of internal medicine.
1966 Jun; 64(6):1229-36. doi:
10.7326/0003-4819-64-6-1229. [PMID: 5933423] - J E WALLACE, W J WILSON, E V DAHL. A RAPID AND SPECIFIC METHOD FOR DETERMINING ETHCHLORVYNOL.
Journal of forensic sciences.
1964 Jul; 9(3):342-52. doi:
NULL. [PMID: 14193208]
