Apraclonidine (BioDeep_00000006574)

 

Secondary id: BioDeep_00001868224

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine

化学式: C9H10Cl2N4 (244.0282)
中文名称: 阿可乐定
谱图信息: 最多检出来源 Homo sapiens(blood) 73.58%

分子结构信息

SMILES: C1CN=C(N1)Nc1c(cc(cc1Cl)N)Cl
InChI: InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,12H2,(H2,13,14,15)

描述信息

Apraclonidine is only found in individuals that have used or taken this drug.Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy.Apraclonidine is a relatively selective alpha2 adrenergic receptor agonist that stimulates alpha1 receptors to a lesser extent. It has a peak ocular hypotensive effect occurring at two hours post-dosing. The exact mechanism of action is unknown, but fluorophotometric studies in animals and humans suggest that Apraclonidine has a dual mechanism of action by reducing aqueous humor production through the constriction of afferent ciliary process vessels, and increasing uveoscleral outflow.
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EA - Sympathomimetics in glaucoma therapy
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists

同义名列表

12 个代谢物同义名

2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; 2-(4-Amino-2,6-dichloro)phenyliminoimidazolidine; Apraclonidine hydrochloride; Para-aminoclonidine; 4-Aminoclonidine; p-Aminoclonidine; Apraclonidinum; apraclonidine; Apraclonidina; Iopidine; Iopimax; Apraclonidine



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ADRA1A, ADRA2A, GNAQ, GTPBP4, ID1, ID3, LPO, VEGFA
Peripheral membrane protein 1 AOC1
Endosome membrane 1 ADRB2
Endoplasmic reticulum membrane 1 IZUMO1
Nucleus 8 ADRA1A, ADRB2, GNAQ, GTPBP4, ID1, ID3, MPO, VEGFA
cytosol 2 ADRA1A, GTPBP4
nucleoplasm 5 ADRA1A, GTPBP4, ID1, ID3, MPO
Cell membrane 10 ADRA1A, ADRA1D, ADRA2A, ADRB2, ADRB3, AOC1, GNAQ, GPC3, IZUMO1, OXTR
Lipid-anchor 1 GNAQ
Multi-pass membrane protein 7 ADRA1A, ADRA1D, ADRA2A, ADRB2, ADRB3, CACNA1I, OXTR
Synapse 1 GNAQ
cell surface 2 GPC3, VEGFA
glutamatergic synapse 1 ADRA2A
Golgi apparatus 4 ADRB2, GNAQ, NPY, VEGFA
Golgi membrane 1 INS
lysosomal membrane 1 GNAQ
neuronal cell body 1 ADRA2A
Lysosome 2 ADRB2, MPO
acrosomal vesicle 1 IZUMO1
endosome 1 ADRB2
plasma membrane 11 ADRA1A, ADRA1D, ADRA2A, ADRB2, ADRB3, AOC1, CACNA1I, GNAQ, GPC3, IZUMO1, OXTR
Membrane 7 ADRB2, CACNA1I, GNAQ, GTPBP4, IZUMO1, OXTR, VEGFA
apical plasma membrane 2 ADRB2, OXTR
basolateral plasma membrane 2 ADRA2A, LPO
caveola 1 ADRA1A
extracellular exosome 4 AOC1, GNAQ, LPO, MPO
endoplasmic reticulum 1 VEGFA
extracellular space 6 AOC1, INS, LPO, MPO, NPY, VEGFA
lysosomal lumen 1 GPC3
perinuclear region of cytoplasm 1 GTPBP4
adherens junction 2 OXTR, VEGFA
bicellular tight junction 1 AOC1
intracellular membrane-bounded organelle 2 ADRA1A, MPO
Single-pass type I membrane protein 1 IZUMO1
Secreted 5 INS, LPO, NPY, VEGFA, VIP
extracellular region 7 AOC1, INS, LPO, MPO, NPY, VEGFA, VIP
Extracellular side 2 AOC1, GPC3
photoreceptor outer segment 1 GNAQ
Nucleus membrane 2 ADRA1A, GNAQ
nuclear membrane 3 ADRA1A, GNAQ, GTPBP4
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 GTPBP4
Early endosome 1 ADRB2
presynaptic active zone membrane 1 ADRA2A
GABA-ergic synapse 2 ADRA2A, NPY
extracellular matrix 1 VEGFA
Peroxisome 1 AOC1
collagen-containing extracellular matrix 1 GPC3
secretory granule 2 MPO, VEGFA
receptor complex 3 ADRA2A, ADRB2, ADRB3
neuron projection 1 VIP
Secreted, extracellular space 1 AOC1
Nucleus, nucleolus 1 GTPBP4
Lipid-anchor, GPI-anchor 1 GPC3
endosome lumen 1 INS
microvillus 1 OXTR
Membrane, caveola 1 ADRA1A
heterotrimeric G-protein complex 1 GNAQ
side of membrane 1 GPC3
azurophil granule 1 MPO
secretory granule lumen 1 INS
Golgi lumen 2 GPC3, INS
endoplasmic reticulum lumen 2 GPC3, INS
platelet alpha granule lumen 1 VEGFA
axon terminus 1 ADRA2A
voltage-gated calcium channel complex 1 CACNA1I
specific granule lumen 1 AOC1
transport vesicle 1 INS
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 ADRA2A
neuronal dense core vesicle 2 ADRB2, NPY
clathrin-coated endocytic vesicle membrane 1 ADRB2
phagocytic vesicle lumen 1 MPO
dopaminergic synapse 1 ADRA2A
acrosomal membrane 1 IZUMO1
Cytoplasmic vesicle, secretory vesicle, acrosome membrane 1 IZUMO1
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
protein complex involved in cell-cell adhesion 1 IZUMO1


文献列表

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