Prenalterol (BioDeep_00000006525)
代谢物信息卡片
prenalterol-d7
化学式: C12H19NO3 (225.1365)
中文名称: 普瑞特罗
谱图信息:
最多检出来源 Homo sapiens(COVID-19)(not specific) 25%
分子结构信息
SMILES: CC(C)NCC(COC1=CC=C(C=C1)O)O
InChI: InChI=1S/C12H19NO3/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12/h3-6,9,11,13-15H,7-8H2,1-2H3/t11-/m0/s1
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CA - Adrenergic and dopaminergic agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D020011 - Protective Agents > D002316 - Cardiotonic Agents
D002317 - Cardiovascular Agents
Prenalterol is a selective β1-adrenergic receptor agonist. Prenalterol has no effect on gut smooth muscle contractile activity. Prenalterol can be used for researching cardiovascular disease[1].
同义名列表
5 个代谢物同义名
prenalterol-d7; Prenalterol; H-80/62; Prenalterol; Prenalterol
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:8391
- KEGG: C07533
- PubChem: 42396
- Metlin: METLIN66670
- DrugBank: DB13777
- ChEMBL: CHEMBL1160714
- MeSH: Prenalterol
- CAS: 57526-81-5
- PMhub: MS000019574
- PubChem: 9736
- NIKKAJI: J11.867B
- medchemexpress: HY-112071
- KNApSAcK: 8391
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- F A Aly, S A Al-Tamimi, A A Alwarthan. Determination of phenolic sympathomimetic drugs in pharmaceutical samples and biological fluids by flow-injection chemiluminescence.
Journal of AOAC International.
2000 Nov; 83(6):1299-305. doi:
10.1093/jaoac/83.6.1299. [PMID: 11128130] - F A Aly. Fluorimetric determination of prenalterol hydrochloride in pharmaceuticals and biological fluids based on its oxidation reaction by hexacyanoferrate(III).
Journal of pharmaceutical and biomedical analysis.
1999 Nov; 21(3):483-9. doi:
10.1016/s0731-7085(99)00144-2. [PMID: 10701414] - F A Aly. Spectrofluorimetric determination of prenalterol hydrochloride in pharmaceutical preparations and biological fluids.
Journal of pharmaceutical and biomedical analysis.
1999 Jan; 18(6):993-7. doi:
10.1016/s0731-7085(98)00108-3. [PMID: 9925334] - R F Kirby, A K Johnson. Effects of sympathetic activation on plasma renin activity in the developing rat.
The Journal of pharmacology and experimental therapeutics.
1990 Apr; 253(1):152-7. doi:
NULL. [PMID: 2184217] - L Westman, P O Järnberg. Effects of prenalterol on renal function in patients after major vascular surgery.
Critical care medicine.
1988 May; 16(5):499-503. doi:
10.1097/00003246-198805000-00007. [PMID: 3359788] - C Tantucci, F Santeusanio, M Beschi, M Castellano, C Sorbini, V Grassi. Metabolic and hormonal effects of preferential beta 1 and beta 2-adrenoceptor stimulation in man.
Journal of endocrinological investigation.
1988 Apr; 11(4):279-87. doi:
10.1007/bf03350152. [PMID: 2842389] - C G Wathen, I G Mackay, D R Glover, J E Roulston. Effect of the partial beta-agonist prenalterol on plasma renin activity in patients with left ventricular failure.
Clinica chimica acta; international journal of clinical chemistry.
1987 Jan; 162(1):97-100. doi:
10.1016/0009-8981(87)90237-3. [PMID: 3542308] - S Al-Damluji, L Perry, S Tomlin, P Bouloux, A Grossman, L H Rees, G M Besser. Alpha-adrenergic stimulation of corticotropin secretion by a specific central mechanism in man.
Neuroendocrinology.
1987 Jan; 45(1):68-76. doi:
10.1159/000124705. [PMID: 3027604] - S Sire, J P Amlie, S Simonsen. The immediate haemodynamic and electrophysiological response to prenalterol during fixed rate pacing in patients with chronic ischaemic heart disease.
Acta pharmacologica et toxicologica.
1986 Jan; 58(1):43-8. doi:
10.1111/j.1600-0773.1986.tb00068.x. [PMID: 3953293] - E J Sainsbury, J J Ashley. Curve-fitting in pharmacokinetics--a comparison between gamma- and biexponential fits.
European journal of clinical pharmacology.
1986; 30(2):243-4. doi:
10.1007/bf00614312. [PMID: 3709654] - E Lyrenäs, H Abrahamsson, G Dotevall. Rectosigmoid motility response to beta-adrenoceptor stimulation in patients with the irritable bowel syndrome.
Scandinavian journal of gastroenterology.
1985 Dec; 20(10):1163-8. doi:
10.3109/00365528509089270. [PMID: 2869573] - H H Vincent, A J Man in't Veld, F Boomsma, M A Schalekamp. Prevention of epinephrine-induced hypokalemia by nonselective beta blockers.
The American journal of cardiology.
1985 Aug; 56(6):10D-14D. doi:
10.1016/0002-9149(85)91108-7. [PMID: 2863970] - K R Schwarz, M Hofmann, W Mäurer, C Kadel, K von Olshausen, B Rauch, W Kübler. [Chronic therapy of congestive cardiomyopathy: effects of prenalterol and digoxin].
Zeitschrift fur Kardiologie.
1985 Jul; 74(7):374-83. doi:
. [PMID: 3929486] - E J Sainsbury, D Fitzpatrick, H Ikram, M G Nicholls, E A Espiner, J J Ashley. Pharmacokinetics and plasma-concentration-effect relationships of prenalterol in cardiac failure.
European journal of clinical pharmacology.
1985; 28(4):397-403. doi:
10.1007/bf00544357. [PMID: 2863151] - M C Petch, C Wisbey, O Ormerod, C Scott, R M Goodfellow. Acute haemodynamic effects of oral prenalterol in severe heart failure.
British heart journal.
1984 Jul; 52(1):49-52. doi:
10.1136/hrt.52.1.49. [PMID: 6146324] - M D Johnson, J W Freese, D E Schmitt. Effects of a beta 1-adrenoceptor agonist, prenalterol, on renal function and renin secretion rate in anesthetized dogs.
Journal of cardiovascular pharmacology.
1984 Jul; 6(4):627-33. doi:
10.1097/00005344-198407000-00012. [PMID: 6206317] - P O Lagerström, P Carlebom, A F Clarke, D B Jack. Determination of prenalterol in plasma and urine by liquid chromatography with electrochemical detection.
Journal of chromatography.
1984 Apr; 307(1):230-4. doi:
10.1016/s0378-4347(00)84094-3. [PMID: 6144691] - A Heath, P Mårin, I Sjöstrand. Inotropic effect of prenalterol in amitriptyline poisoning.
Intensive care medicine.
1984; 10(4):209-11. doi:
10.1007/bf00259441. [PMID: 6147367] - J Goovaerts, C Verfaillie, D Knockaert, R Fagard, R Fiocchi, A Amery, P Lijnen. Prenalterol in the treatment of orthostatic hypotension in Shy-Drager syndrome.
Acta cardiologica.
1984; 39(2):147-55. doi:
. [PMID: 6145274] - H H Vincent, F Boomsma, A J Man in't Veld, F H Derkx, G J Wenting, M A Schalekamp. Effects of selective and nonselective beta-agonists on plasma potassium and norepinephrine.
Journal of cardiovascular pharmacology.
1984 Jan; 6(1):107-14. doi:
NULL. [PMID: 6199591] - S Rasmussen, P F Høilund-Carlsen, B Hesse, O J Hartling, J Fabricius, H Dige-Petersen, J Giese. Dose-response relationship in normal subjects of prenalterol, a beta-adrenergic agonist with positive inotropic and resistance lowering effects.
European journal of clinical pharmacology.
1984; 27(5):539-43. doi:
10.1007/bf00556889. [PMID: 6151507] - J H Vincent, F Boomsma, A J Man in 't Veld, M A Schalekamp. Beta-receptor stimulation by adrenaline elevates plasma noradrenaline and enhances the pressor responses to cold exposure and isometric exercise.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
1983 Dec; 1(2):74-6. doi:
. [PMID: 6152740] - G Jennings, A Bobik, C Oddie, M Hargreaves, P Korner. Cardioselectivity of prenalterol and isoproterenol.
Clinical pharmacology and therapeutics.
1983 Dec; 34(6):749-57. doi:
10.1038/clpt.1983.245. [PMID: 6641090] - W L Henrich, W B Campbell. The systemic beta-adrenergic pathway to renin secretion: relationships with the renal prostaglandin system.
Endocrinology.
1983 Dec; 113(6):2247-54. doi:
10.1210/endo-113-6-2247. [PMID: 6139275] - L Corea, M Bentivoglio, P Verdecchia, M Provvidenza. Acute effects of beta 1 agonism with prenalterol on catecholamine circulating levels in patients with congestive heart failure.
Giornale italiano di cardiologia.
1983 Nov; 13(11):330-4. doi:
. [PMID: 6141975] - I Hilakivi. The role of beta- and alpha-adrenoceptors in the regulation of the stages of the sleep-waking cycle in the cat.
Brain research.
1983 Oct; 277(1):109-18. doi:
10.1016/0006-8993(83)90912-5. [PMID: 6315136] - U Dahlström, J H Atterhög, L Jorfeldt. Hemodynamics and leg muscle metabolism at rest and during exercise in young healthy men after prenalterol.
Clinical pharmacology and therapeutics.
1983 Jun; 33(6):701-9. doi:
10.1038/clpt.1983.96. [PMID: 6851402] - P Kulling, L Eleborg, H Persson. Beta-adrenoceptor blocker intoxication: epidemiological data. Prenalterol as an alternative in the treatment of cardiac dysfunction.
Human toxicology.
1983 Apr; 2(2):175-81. doi:
10.1177/096032718300200202. [PMID: 6134663] - D Fitzpatrick, H Ikram, M G Nicholls, E A Espiner. Hemodynamic, hormonal and electrolyte responses to prenalterol infusion in heart failure.
Circulation.
1983 Mar; 67(3):613-9. doi:
10.1161/01.cir.67.3.613. [PMID: 6821903] - C J Wallin, J Hulting. Massive metoprolol poisoning treated with prenalterol.
Acta medica Scandinavica.
1983; 214(3):253-5. doi:
10.1111/j.0954-6820.1983.tb08604.x. [PMID: 6660032] - T Pedersen, K Cleemann-Rasmussen, I Brynjolf, H Ording, P E Nielsen, K Rasmussen. Effects of prenalterol on cardiac performance and transmural myocardial perfusion in patients with chronic renal failure.
European journal of clinical pharmacology.
1983; 25(3):287-92. doi:
10.1007/bf01037935. [PMID: 6628515] - P O Järnberg, L Westman. Effects of prenalterol on renal function in normal man.
Acta anaesthesiologica Scandinavica.
1982 Dec; 26(6):603-6. doi:
10.1111/j.1399-6576.1982.tb01824.x. [PMID: 6130667] - C J Oddie, G P Jackman, A Bobik. Determination of prenalterol in plasma by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography.
1982 Sep; 231(2):473-7. doi:
10.1016/s0378-4347(00)81875-7. [PMID: 7130326] - M Ervik, K Kylberg-Hanssen, P O Lagerström. Assay of prenalterol in plasma and urine by gas chromatography-mass spectrometry.
Journal of chromatography.
1982 Apr; 229(1):87-94. doi:
10.1016/s0378-4347(00)86039-9. [PMID: 7085836] - K J Hoffmann, A Arfwidsson, K O Borg. The metabolic disposition of the selective beta 1-adrenoceptor agonist prenalterol in mice, rats, dogs, and humans.
Drug metabolism and disposition: the biological fate of chemicals.
1982 Mar; 10(2):173-9. doi:
NULL. [PMID: 6124405] - N Lustenberger. Haemodynamic effects of prenalterol in patients on dialysis.
Acta medica Scandinavica. Supplementum.
1982; 659(?):157-67. doi:
10.1111/j.0954-6820.1982.tb00844.x. [PMID: 6127886] - G Klein, A Wirtzfeld, G Schmidt, T Zilker. Metabolic effects of prenalterol in healthy volunteers.
Acta medica Scandinavica. Supplementum.
1982; 659(?):137-46. doi:
10.1111/j.0954-6820.1982.tb00842.x. [PMID: 6127884] - G Klein, A Wirtzfeld, G Bozler, O Rönn, C Graffner. Compartment model of prenalterol.
Acta medica Scandinavica. Supplementum.
1982; 659(?):99-107. doi:
10.1111/j.0954-6820.1982.tb00839.x. [PMID: 6127903] - H Leinberger, W Mäurer, H Haueisen, G Schuler, W Kübler. Dose-dependent haemodynamic response to prenalterol in patients with congestive heart failure.
Acta medica Scandinavica. Supplementum.
1982; 659(?):299-306. doi:
10.1111/j.0954-6820.1982.tb00854.x. [PMID: 6127896] - G Johnsson. Pharmacodynamic effects of prenalterol in healthy subjects.
Acta medica Scandinavica. Supplementum.
1982; 659(?):109-22. doi:
10.1111/j.0954-6820.1982.tb00840.x. [PMID: 6127882] - M F Shiu, M A Ireland, W A Littler. Hemodynamic effects of atrial pacing and prenalterol infusion in patients taking beta-adrenergic blocking drugs.
Circulation.
1981 Dec; 64(6):1135-41. doi:
10.1161/01.cir.64.6.1135. [PMID: 6117380] - U Kopp, M Aurell, L Svensson, B Ablad. Effect of prenalterol, a beta-1-adrenoceptor agonist, on renin secretion rate in the anaesthetized dog.
Acta pharmacologica et toxicologica.
1981 Sep; 49(3):230-5. doi:
10.1111/j.1600-0773.1981.tb00898.x. [PMID: 6121458] - D Oltmanns, H A Wester, R Stein. [Echocardiographic measurements of hemodynamic effects and pharmacokinetics of prenalterol (author's transl)].
Zeitschrift fur Kardiologie.
1981 May; 70(5):394-8. doi:
NULL. [PMID: 6115520] - S Reiz, M Duchek, Y Kerkoff, B Olson. Non-cardiogenic pulmonary oedema. A serious complication of transurethral prostatectomy. A case report.
Acta anaesthesiologica Scandinavica.
1981 Apr; 25(2):166-8. doi:
10.1111/j.1399-6576.1981.tb01629.x. [PMID: 7324825] - P H Degen, M Ervik. Determination of prenalterol in plasma and in urine by gas-liquid chromatography.
Journal of chromatography.
1981 Mar; 222(3):437-44. doi:
10.1016/s0378-4347(00)84144-4. [PMID: 7228951] - C Graffner, K J Hoffmann, G Johnsson, P Lundborg, O Rönn. Pharmacokinetic studies in man of the selective beta 1-adrenoceptor agonist, prenalterol.
European journal of clinical pharmacology.
1981; 20(2):91-7. doi:
10.1007/bf00607143. [PMID: 6114866] - A Weiss, B Pfister, P Imhof, P H Degen, D Burckhardt, U C Dubach. Haemodynamic effects, plasma concentrations and tolerance of orally administered prenalterol in man.
European journal of clinical pharmacology.
1980 Nov; 18(5):383-90. doi:
10.1007/bf00636789. [PMID: 6108221] - O Rönn, E Fellenius, C Graffner, G Johnsson, P Lundborg, L Svensson. Metabolic and haemodynamic effects and pharmacokinetics of a new selective beta 1-adrenoceptor agonist, prenalterol, in man.
European journal of clinical pharmacology.
1980 Feb; 17(2):81-6. doi:
10.1007/bf00562614. [PMID: 6102914] - S Reiz, A Friedman. Hemodynamic and cardiometabolic effects of prenalterol in patients with gram negative septic shock.
Acta anaesthesiologica Scandinavica.
1980; 24(1):5-10. doi:
10.1111/j.1399-6576.1980.tb01495.x. [PMID: 7376804]
