hexamethonium (BioDeep_00000006516)
Volatile Flavor Compounds
代谢物信息卡片
hexamethonium
化学式: C12H30N2+2 (202.240886)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+](C)(C)CCCCCC[N+](C)(C)C
InChI: InChI=1S/C12H30N2/c1-13(2,3)11-9-7-8-10-12-14(4,5)6/h7-12H2,1-6H3/q+2
描述信息
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C66886 - Nicotinic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D005730 - Ganglionic Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents > D006584 - Hexamethonium Compounds
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
同义名列表
2 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:5700
- KEGG: C07510
- PubChem: 3604
- DrugBank: DB08960
- ChEMBL: CHEMBL100622
- ChEMBL: CHEMBL332524
- MeSH: Hexamethonium
- CAS: 60-26-4
- PMhub: MS000019565
- PubChem: 9713
- NIKKAJI: J11.056F
- RefMet: Hexamethonium
- KNApSAcK: 5700
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Daiane Cristina de Assis Braga, Paula Magalhães Gomes, Marcos Adriano Carlos Batista, Jaqueline Aparecida de Souza, Juliana Cristina Santos Almeida Bastos, Rosana Gonçalves Rodrigues-das-Dôres, Andreia Carvalho Alzamora, Gustavo Henrique Bianco de Souza, Sandra Aparecida Lima de Moura, André Talvani, Vagner Roberto Antunes, Leonardo Máximo Cardoso. Effects of Psidium guajava L. leaves extract on blood pressure control and IL-10 production in salt-dependent hypertensive rats.
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American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Jan; 296(1):R133-40. doi:
10.1152/ajpregu.00185.2008. [PMID: 18987290] - G I Nezhinskaia, A L Vladykin, N S Sapronov. [Effects of cholinergic drugs and blood plasma proteins on the development of Arthus reaction].
Eksperimental'naia i klinicheskaia farmakologiia.
2008 Nov; 71(6):31-3. doi:
. [PMID: 19140513] - Yasuaki Koga, Yoshitaka Hirooka, Shuichiro Araki, Masatsugu Nozoe, Takuya Kishi, Kenji Sunagawa. High salt intake enhances blood pressure increase during development of hypertension via oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Nov; 31(11):2075-83. doi:
10.1291/hypres.31.2075. [PMID: 19098380] - Sahar M El-Gowilly, Abdel-Rheem M Ghazal, Eman Y Gohar, Mahmoud M El-Mas. Exacerbation by nicotine of the cyclosporine A-induced impairment of beta-adrenoceptor-mediated renal vasodilation in rats.
Clinical and experimental pharmacology & physiology.
2008 Oct; 35(10):1164-71. doi:
10.1111/j.1440-1681.2008.04983.x. [PMID: 18565199] - Muhammad N Ghayur, Anwarul H Gilani, Touqeer Ahmed, Asaad Khalid, Sarfraz A Nawaz, Joseph M Agbedahunsi, Muhammad I Choudhary, Peter J Houghton. Muscarinic, Ca(++) antagonist and specific butyrylcholinesterase inhibitory activity of dried ginger extract might explain its use in dementia.
The Journal of pharmacy and pharmacology.
2008 Oct; 60(10):1375-83. doi:
10.1211/jpp/60.10.0014. [PMID: 18812031] - Cheng-Dean Shih, Daih-Huang Kuo, Chi-Wen Huang, Yu-Hua Gu, Fu-An Chen. Autonomic nervous system mediates the cardiovascular effects of Rhodiola sacra radix in rats.
Journal of ethnopharmacology.
2008 Sep; 119(2):284-90. doi:
10.1016/j.jep.2008.07.016. [PMID: 18692558] - G Boudry, C Perrier. Thyme and cinnamon extracts induce anion secretion in piglet small intestine via cholinergic pathways.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2008 Sep; 59(3):543-52. doi:
". [PMID: 18953096] - Rong-Jane Chen, Yuan-Soon Ho, How-Ran Guo, Ying-Jan Wang. Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2008 Aug; 104(2):283-93. doi:
10.1093/toxsci/kfn086. [PMID: 18448488] - Chris Pickering, Veronica Bergenheim, Helgi B Schiöth, Mia Ericson. Sensitization to nicotine significantly decreases expression of GABA transporter GAT-1 in the medial prefrontal cortex.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Aug; 32(6):1521-6. doi:
10.1016/j.pnpbp.2008.05.011. [PMID: 18565636] - Mehmet Cansev, Yesim Ozarda Ilcol, Mustafa Sertac Yilmaz, Emre Hamurtekin, Ismail H Ulus. Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system.
European journal of pharmacology.
2008 Jul; 589(1-3):315-22. doi:
10.1016/j.ejphar.2008.05.017. [PMID: 18561911] - Mahmoud M El-Mas, Sahar M El-Gowilly, Eman Y Gohar, Abdel-Rheem M Ghazal. Pharmacological characterization of cellular mechanisms of the renal vasodilatory effect of nicotine in rats.
European journal of pharmacology.
2008 Jul; 588(2-3):294-300. doi:
10.1016/j.ejphar.2008.04.048. [PMID: 18533147] - Shoshiro Okada, Naoko Yamaguchi-Shima, Takahiro Shimizu, Junichi Arai, Lu Lianyi, Hiroshi Wakiguchi, Kunihiko Yokotani. Role of brain nicotinic acetylcholine receptor in centrally administered corticotropin-releasing factor-induced elevation of plasma corticosterone in rats.
European journal of pharmacology.
2008 Jun; 587(1-3):322-9. doi:
10.1016/j.ejphar.2008.03.005. [PMID: 18423439] - Jessica Diaz, Wei Ni, Janice Thompson, Andrew King, Gregory D Fink, Stephanie W Watts. 5-Hydroxytryptamine lowers blood pressure in normotensive and hypertensive rats.
The Journal of pharmacology and experimental therapeutics.
2008 Jun; 325(3):1031-8. doi:
10.1124/jpet.108.136226. [PMID: 18305011] - John Ciriello, L Pastor Solano-Flores, M Patricia Rosas-Arellano, Gilbert J Kirouac, Tanja Babic. Medullary pathways mediating the parasubthalamic nucleus depressor response.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Apr; 294(4):R1276-84. doi:
10.1152/ajpregu.00437.2007. [PMID: 18287224] - DaZheng Wu, Zhibi Hu. Rutaecarpine induces chloride secretion across rat isolated distal colon.
The Journal of pharmacology and experimental therapeutics.
2008 Apr; 325(1):256-66. doi:
10.1124/jpet.107.131961. [PMID: 18187619] - Ko Yu Liu, Yang-Chang Wu, I-Min Liu, Wen Chen Yu, Juei-Tang Cheng. Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rats.
Neuroscience letters.
2008 Mar; 434(2):195-9. doi:
10.1016/j.neulet.2008.01.054. [PMID: 18304730] - Yesim Ozarda Ilcol, Mehmet Cansev, Mustafa Sertac Yilmaz, Emre Hamurtekin, Ismail H Ulus. Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: muscarinic and nicotinic acetylcholine receptors are both involved in their actions.
Neuroscience letters.
2008 Jan; 431(1):71-6. doi:
10.1016/j.neulet.2007.11.024. [PMID: 18162319] - M Cansev, Y O Ilcol, M S Yilmaz, E Hamurtekin, I H Ulus. Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations.
Autonomic & autacoid pharmacology.
2008 Jan; 28(1):41-58. doi:
10.1111/j.1474-8673.2007.00416.x. [PMID: 18257750] - Mehmet Cansev, Mustafa Sertac Yilmaz, Yesim Ozarda Ilcol, Emre Hamurtekin, Ismail Hakki Ulus. Cardiovascular effects of CDP-choline and its metabolites: involvement of peripheral autonomic nervous system.
European journal of pharmacology.
2007 Dec; 577(1-3):129-42. doi:
10.1016/j.ejphar.2007.08.029. [PMID: 17884041] - Tetsuro Shirasaka, De-Lai Qiu, Hiroshi Kannan, Mayumi Takasaki. The effects of centrally administered dexmedetomidine on cardiovascular and sympathetic function in conscious rats.
Anesthesia and analgesia.
2007 Dec; 105(6):1722-8, table of contents. doi:
10.1213/01.ane.0000286230.02948.77. [PMID: 18042874] - Taehyeon M Cho, Ning Peng, John T Clark, Lea Novak, Sanya Roysommuti, Jeevan Prasain, J Michael Wyss. Genistein attenuates the hypertensive effects of dietary NaCl in hypertensive male rats.
Endocrinology.
2007 Nov; 148(11):5396-402. doi:
10.1210/en.2007-0245. [PMID: 17673523] - Y O Ilcol, M Cansev, M S Yilmaz, E Hamurtekin, I H Ulus. Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system.
Archives of physiology and biochemistry.
2007 Oct; 113(4-5):186-201. doi:
10.1080/13813450701531243. [PMID: 17917852] - Ryan M Fryer, Jason A Segreti, Deborah L Widomski, Pamela H Franklin, Patricia N Banfor, Kristin A Koch, Masaki Nakane, J Ruth Wu-Wong, Bryan F Cox, Glenn A Reinhart. Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet.
The Journal of pharmacology and experimental therapeutics.
2007 Oct; 323(1):217-26. doi:
10.1124/jpet.107.123901. [PMID: 17636005] - Xuping Bao, Chuanyi M Lu, Fujun Liu, Yusu Gu, Nancy D Dalton, Bo-Qing Zhu, Elyse Foster, Ju Chen, Joel S Karliner, John Ross, Paul C Simpson, Michael G Ziegler. Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse.
Circulation.
2007 Aug; 116(9):1024-31. doi:
10.1161/circulationaha.107.696005. [PMID: 17698731] - C Y Maeda, B D Schaan, E M Oliveira, V L Oliveira, K De Angelis, M C Irigoyen. Chronic salt loading and cardiovascular-associated changes in experimental diabetes in rats.
Clinical and experimental pharmacology & physiology.
2007 Jul; 34(7):574-80. doi:
10.1111/j.1440-1681.2007.04625.x. [PMID: 17581211] - Raphael R de A Freitas, Karen L Lopes, Bruno A Carillo, Cassia T Bergamaschi, Adriana K Carmona, Dulce E Casarini, Luzia Furukawa, Joel C Heimann, Ruy R Campos, Miriam S Dolnikoff. Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats.
American journal of hypertension.
2007 Jun; 20(6):692-8. doi:
10.1016/j.amjhyper.2007.01.014. [PMID: 17531930] - Galina I Nezhinskaya, Aleksandr L Vladykin, Nikolay S Sapronov. Cholinergic modulation of anaphylactic shock: plasma proteins influence.
Life sciences.
2007 May; 80(24-25):2342-6. doi:
10.1016/j.lfs.2007.04.013. [PMID: 17499313] - Shayne F Andrew, Thu T Dinh, Sue Ritter. Localized glucoprivation of hindbrain sites elicits corticosterone and glucagon secretion.
American journal of physiology. Regulatory, integrative and comparative physiology.
2007 May; 292(5):R1792-8. doi:
10.1152/ajpregu.00777.2006. [PMID: 17218439] - Mamoru Tanida, Jiao Shen, Yuko Horii, Morihiro Matsuda, Shinji Kihara, Toru Funahashi, Iichiro Shimomura, Hajime Sawai, Yutaka Fukuda, Yuji Matsuzawa, Katsuya Nagai. Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats.
Experimental biology and medicine (Maywood, N.J.).
2007 Mar; 232(3):390-7. doi:
NULL. [PMID: 17327472] - Daniel B Zoccal, Leni G H Bonagamba, Fabíola R T Oliveira, José Antunes-Rodrigues, Benedito H Machado. Increased sympathetic activity in rats submitted to chronic intermittent hypoxia.
Experimental physiology.
2007 Jan; 92(1):79-85. doi:
10.1113/expphysiol.2006.035501. [PMID: 17085676] - Jacqueline K Phillips, Deborah Hopwood, Rhonda A Loxley, Kamaljit Ghatora, Jason D Coombes, Ying Sin Tan, Joanne L Harrison, Douglas J McKitrick, Vasyl Holobotvskyy, Leonard F Arnolda, Gopala K Rangan. Temporal relationship between renal cyst development, hypertension and cardiac hypertrophy in a new rat model of autosomal recessive polycystic kidney disease.
Kidney & blood pressure research.
2007; 30(3):129-44. doi:
10.1159/000101828. [PMID: 17446713] - Saad Lahlou, Carlos Antônio de Barros Correia, Márcio Vasconcelos Dos Santos, Jorge Maurício David, Juceni Pereira David, Glória Pinto Duarte, Pedro Jorge Caldas Magalhães. Mechanisms underlying the cardiovascular effects of a labdenic diterpene isolated from Moldenhawera nutans in normotensive rats.
Vascular pharmacology.
2007 Jan; 46(1):60-6. doi:
10.1016/j.vph.2006.06.010. [PMID: 16875882] - Zike Feng, Dorthe Carlson, Hanne Damgaard Poulsen. Zinc attenuates forskolin-stimulated electrolyte secretion without involvement of the enteric nervous system in small intestinal epithelium from weaned piglets.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2006 Nov; 145(3):328-33. doi:
10.1016/j.cbpa.2006.07.006. [PMID: 16962349] - Jean Eric Ghia, Patricia Blennerhassett, Harry Kumar-Ondiveeran, Elena F Verdu, Stephen M Collins. The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model.
Gastroenterology.
2006 Oct; 131(4):1122-30. doi:
10.1053/j.gastro.2006.08.016. [PMID: 17030182] - Xiao-Rong Chang, Jie Yan, Yan-Ling Zhao, Jiang-Shang Li, Jian-Hua Liu, Jun-Feng He. Effect of electroacupuncture at Sibai on the gastric myoelectric activities of denervated rats.
World journal of gastroenterology.
2006 Sep; 12(36):5897-901. doi:
10.3748/wjg.v12.i36.5897. [PMID: 17007061] - Shan Jin, Mei Li, Mei-Ling Lin, Yong-Hui Ding, Song-Yi Qu, Wei Li, Tian-Zhen Zheng. Effect of Fructus Psoraleae on motility of gallbladder isolated smooth muscle strips from guinea pigs.
World journal of gastroenterology.
2006 Aug; 12(32):5214-8. doi:
10.3748/wjg.v12.i32.5214. [PMID: 16937536] - Jen-Hao Hsu, Yang-Chang Wu, I-Min Liu, Juei-Tang Cheng. Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis.
Neuroscience letters.
2006 Aug; 404(1-2):112-6. doi:
10.1016/j.neulet.2006.05.025. [PMID: 16759806] - Chang-Chih Chen, I-Min Liu. Release of acetylcholine by Hon-Chi to raise insulin secretion in Wistar rats.
Neuroscience letters.
2006 Aug; 404(1-2):117-21. doi:
10.1016/j.neulet.2006.05.024. [PMID: 16762503] - Miguel Carro-Juárez, Isaac Lobatón, Octavio Benítez, Alejandra Espíritu. Pro-ejaculatory effect of the aqueous crude extract of cihuapatli (Montanoa tomentosa) in spinal male rats.
Journal of ethnopharmacology.
2006 Jun; 106(1):111-6. doi:
10.1016/j.jep.2005.12.011. [PMID: 16442762] - Shingo Takatori, Yoshito Zamami, Mitsunobu Mio, Yuji Kurosaki, Hiromu Kawasaki. Chronic hyperinsulinemia enhances adrenergic vasoconstriction and decreases calcitonin gene-related peptide-containing nerve-mediated vasodilation in pithed rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2006 May; 29(5):361-8. doi:
10.1291/hypres.29.361. [PMID: 16832157] - Laura Grasa, M Pilar Arruebo, Miguel A Plaza, M Divina Murillo. PGE(2) receptors and their intracellular mechanisms in rabbit small intestine.
Prostaglandins & other lipid mediators.
2006 May; 79(3-4):206-17. doi:
10.1016/j.prostaglandins.2006.01.001. [PMID: 16647635]