Nitroglycerin (BioDeep_00000006501)

 

Secondary id: BioDeep_00001867866

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1,3-bis(nitrooxy)propan-2-yl nitrate

化学式: C3H5N3O9 (227.00258000000002)
中文名称: 硝酸甘油, 硝化甘油
谱图信息: 最多检出来源 Homo sapiens(blood) 51.79%

分子结构信息

SMILES: C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
InChI: InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2

描述信息

Nitroglycerin is only found in individuals that have used or taken this drug. It is a volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. [PubChem]Similar to other nitrites and organic nitrates, nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3,5-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AE - Muscle relaxants
C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases > C01DA - Organic nitrates
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D053834 - Explosive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

62 个代谢物同义名

1,3-bis(nitrooxy)propan-2-yl nitrate; Propane-1,2,3-triyl trinitric acid; 1,2,3-Propanetrioltrinitric acid; Propane-1,2,3-triyl trinitrate; Glycerol, nitric acid triester; 1,2,3-Propanetriyl nitric acid; 1,2,3-Propanetriyl trinitrate; 1,2,3-Propanetrioltrinitrate; 1,2,3-Propanetriyl nitrate; Glycerol, nitrate triester; Glycerol trinitric acid; Glycerin trinitric acid; Glyceryl trinitric acid; Nitroglycerin ointment; Trinitrate, glyceryl; Glycerin trinitrate; Glyceryl trinitrate; Glycerol trinitrate; Trinitroglycerol; Trinitroglycerin; Transderm-nitro; Transderm nitro; Nitroglycerine; Nitroglycerol; Nitroderm TTS; nitroglycerin; Nitrolingual; Trinitrolong; Perlinganit; Gilustenon; Rectogesic; Nitroglyn; Nitro dur; Nitrangin; Nitroderm; Nitro-bid; Natispray; Nitro-dur; Nitrostat; Nitro bid; Trinitrin; Nitrospan; Nitrocard; Nitromist; Sustonit; Anginine; Susadrin; Dynamite; Nitrolan; NitroDur; Minitran; NitroBid; Nitrong; Sustak; Sustac; Nitrol; Tridil; NTG; TNG; NG; Nitroglycerin; Nitroglycerin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(0)

PlantCyc(0)

代谢反应

30 个相关的代谢反应过程信息。

Reactome(28)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Min Xu, Jiayan Zhang, Zhenhua Shi, Ziyang He, Yijing Zhao, Xiaoyang Ling, Wenhua Wang, Mingjie Gong. Amelioration of nitroglycerin-induced migraine in mice via Wuzhuyu decoction: Inhibition of the MZF1/PGK1 pathway and activation of NRF2 antioxidant response. Journal of ethnopharmacology. 2024 May; 326(?):117930. doi: 10.1016/j.jep.2024.117930. [PMID: 38373662]
  • Rosaria Greco, Chiara Demartini, Miriam Francavilla, Anna Maria Zanaboni, Sara Facchetti, Michela Palmisani, Valentina Franco, Cristina Tassorelli. Effects of the Dual FAAH/MAGL Inhibitor AKU-005 on Trigeminal Hyperalgesia in Male Rats. Cells. 2024 May; 13(10):. doi: 10.3390/cells13100830. [PMID: 38786051]
  • Guangshuang Lu, Shaobo Xiao, Fanchao Meng, Leyi Zhang, Yan Chang, Jinjing Zhao, Nan Gao, Wenjie Su, Xinghao Guo, Yingyuan Liu, Chenhao Li, Wenjing Tang, Liping Zou, Shengyuan Yu, Ruozhuo Liu. AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization. The journal of headache and pain. 2024 Mar; 25(1):29. doi: 10.1186/s10194-024-01739-w. [PMID: 38454376]
  • Hui Cai, Shuxia Chen, Dongxiao Wang. Sudden diffuse spasm of multiple coronary arteries: A case report. Medicine. 2024 Jan; 103(2):e36889. doi: 10.1097/md.0000000000036889. [PMID: 38215100]
  • Takayuki Yamaji, Farina Mohamad Yusoff, Shinji Kishimoto, Masato Kajikawa, Kenichi Yoshimura, Yukiko Nakano, Chikara Goto, Takahiro Harada, Aya Mizobuchi, Shunsuke Tanigawa, Tatsuya Maruhashi, Yukihito Higashi. Association of cumulative low-density lipoprotein cholesterol exposure with vascular function. Journal of clinical lipidology. 2023 Dec; ?(?):. doi: 10.1016/j.jacl.2023.12.006. [PMID: 38185588]
  • Chao Ma, Chunran Zhu, Yajun Zhang, Mei Yu, Yizhi Song, Yulong Chong, Yan Yang, Chan Zhu, Yucui Jiang, Changming Wang, Shuo Cheng, Keke Jia, Guang Yu, Jia Li, Zongxiang Tang. Gastrodin alleviates NTG-induced migraine-like pain via inhibiting succinate/HIF-1α/TRPM2 signaling pathway in trigeminal ganglion. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Dec; 125(?):155266. doi: 10.1016/j.phymed.2023.155266. [PMID: 38241917]
  • Min Xu, Zhenhua Shi, Ziyang He, Xiaoyang Ling, Wenhua Wang, Hua Liu, Mingjie Gong. Rutaecarpine alleviates migraine in nitroglycerin-induced mice by regulating PTEN/PGK1 signaling pathway to activate NRF2 antioxidant system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115300. doi: 10.1016/j.biopha.2023.115300. [PMID: 37557014]
  • Qiangyuan Tian, Xiangkong Song, Liqiang Wu, Hongyan Shi. The efficacy of glyceryl trinitrate for acute intracerebral hemorrhage: A systematic review and meta-analysis. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2023 Jul; ?(?):. doi: 10.17219/acem/168430. [PMID: 37486700]
  • Rosaria Greco, Miriam Francavilla, Chiara Demartini, Anna Maria Zanaboni, Sara Facchetti, Michela Palmisani, Valentina Franco, Cristina Tassorelli. Activity of FAAH-Inhibitor JZP327A in an Experimental Rat Model of Migraine. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210102. [PMID: 37373250]
  • Yamin Luo, Yuehua Qiu, Ranran Zhou, Yao Zhang, Xuenian Ji, Zijian Liu, Ran Li, Yi Zhang, Feng Yang, Jianchen Hou, Shujing Zhang, Tieshan Wang, Haochong Song, Xiaohua Tao. Shaoyao Gancao decoction alleviates the central hyperalgesia of recurrent NTG-induced migraine in rats by regulating the NGF/TRPV1/COX-2 signal pathway. Journal of ethnopharmacology. 2023 Jun; ?(?):116781. doi: 10.1016/j.jep.2023.116781. [PMID: 37315643]
  • Bin Zhou, Cheng-Li Lin, Shinsuke Kojima, Masanori Fukushima, Chung Y Hsu. Risk factors of dementia in patients with cerebral vascular diseases based on Taiwan National Health Insurance data. Dementia and geriatric cognitive disorders. 2023 Mar; ?(?):. doi: 10.1159/000530102. [PMID: 36948166]
  • Yue Yang, Ke Feng, Yuting Lei, Li Qiu, Chengjiang Liu, Guofeng Li. Comparing the efficacy and safety of different analgesic strategies after open hemorrhoidectomy: a systematic review and network meta-analysis. International journal of colorectal disease. 2023 Jan; 38(1):4. doi: 10.1007/s00384-022-04294-5. [PMID: 36609578]
  • Qiping Mao, Yushun Cui, Hui Du, Jiahui Wu, Maofu Zhou, Hui Ouyang, Yuling Feng, Shiling Yang. San Pian decoction can treat nitroglycerin-induced migraine in rats by inhibiting the PI3K/AKT and MAPK signaling pathways. Journal of ethnopharmacology. 2022 Oct; 296(?):115470. doi: 10.1016/j.jep.2022.115470. [PMID: 35738471]
  • Zixin Li, Luchen Shan, Pei Yu. Preventive effect of tetramethylpyrazine on nitroglycerin-tolerance in rats by improving oxidative stress and ribosome homeostasis. Biochemical and biophysical research communications. 2022 08; 618(?):141-147. doi: 10.1016/j.bbrc.2022.06.013. [PMID: 35724458]
  • Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Miriam Francavilla, Angelo Reggiani, Natalia Realini, Rita Scarpelli, Daniele Piomelli, Cristina Tassorelli. Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine. The journal of headache and pain. 2022 Jul; 23(1):79. doi: 10.1186/s10194-022-01449-1. [PMID: 35799128]
  • Elena Gerasimova, Olga Yakovleva, Daniel Enikeev, Ksenia Bogatova, Anton Hermann, Rashid Giniatullin, Guzel Sitdikova. Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats. Biomolecules. 2022 05; 12(5):. doi: 10.3390/biom12050735. [PMID: 35625662]
  • Chi Teng Vong, Yulong Chen, Zhejie Chen, Caifang Gao, Fengqing Yang, Shengpeng Wang, Yitao Wang. Classical prescription Dachuanxiong Formula delays nitroglycerin-induced pain response in migraine mice through reducing endothelin-1 level and regulating fatty acid biosynthesis. Journal of ethnopharmacology. 2022 Apr; 288(?):114992. doi: 10.1016/j.jep.2022.114992. [PMID: 35032586]
  • Mohan Jc, Arun Chopra, Hiremath Js, Ajay Mahajan, Tiny Nair, Saumitra Ray, Muralitharan Tr, Ajay Pandey, Sameer Srivastava, Y Shiva Kumar, Girish Navasundi, Deepak Rajan Das, Mahesh V Abhyankar, Santosh Revankar, Pradip Mate. Experts' Consensus on Use of Long-Acting Nitroglycerine in the Management of Angina and Chronic Coronary Syndrome in India. The Journal of the Association of Physicians of India. 2022 Mar; 70(3):11-12. doi: . [PMID: 35438293]
  • Erkan Kilinc, Seyit Ankarali, Ibrahim Ethem Torun, Yasar Dagistan. Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine. The European journal of neuroscience. 2022 02; 55(4):1015-1031. doi: 10.1111/ejn.14897. [PMID: 32639078]
  • Hao Chen, Xueqian Tang, Jin Li, Bangyan Hu, Wenqin Yang, Meng Zhan, Tengyun Ma, Shijun Xu. IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine. The journal of headache and pain. 2022 Jan; 23(1):1. doi: 10.1186/s10194-021-01374-9. [PMID: 34979902]
  • Xiao Jin, Shengjie Yang, Jing Lu, Yujuan Li, Yixi Zhao, Dan Li, Xinyue Wang, Longtao Liu, Min Wu. Exploring the therapeutic mechanism of Baduanjin in the treatment of elderly stable angina pectoris based on the gut microbiota-lipid metabolism spectrum: Study protocol for a randomized controlled trial. Frontiers in public health. 2022; 10(?):1027839. doi: 10.3389/fpubh.2022.1027839. [PMID: 36388277]
  • Ayesha Rahman Ahmed, Senty Vun-Sang, Mohammad Iqbal. Therapeutic role of nitroglycerin against copper-nitrilotriacetate induced hepatic and renal damage. Human & experimental toxicology. 2022 Jan; 41(?):9603271221131312. doi: 10.1177/09603271221131312. [PMID: 36305384]
  • Wayne Kaesemeyer, Tatsiana Suvorava. Treating Acute Decompensated Heart Failure in Patients with COVID-19 Using Intravenous Nitroglycerin in 5\% Glutathione. American journal of cardiovascular drugs : drugs, devices, and other interventions. 2021 Nov; 21(6):589-593. doi: 10.1007/s40256-021-00474-w. [PMID: 33748918]
  • Yener Yazğan, Mustafa Nazıroğlu. Involvement of TRPM2 in the Neurobiology of Experimental Migraine: Focus on Oxidative Stress and Apoptosis. Molecular neurobiology. 2021 Nov; 58(11):5581-5601. doi: 10.1007/s12035-021-02503-w. [PMID: 34370177]
  • Benjamin Karfunkle, Joseph Gill, Stephanie Shirey, Richard Gordon. COVID-19 Acute Respiratory Distress Syndrome and Pulmonary Embolism: A Case Report of Nebulized Nitroglycerin and Systemic Thrombolysis For Right Ventricular Failure. The Journal of emergency medicine. 2021 11; 61(5):e103-e107. doi: 10.1016/j.jemermed.2021.07.014. [PMID: 34479748]
  • A Gajos-Draus, M Duda, A Beresewicz. Exercise and nitrite prevent and Nω-nitrol-L-arginine methyl ester reproduces imbalance in the nuclear factor-κB/NADPH oxidase 2 and nuclear factor erythroid 2-related factor 2/NADPH oxidase 4/endothelial nitric oxide synthase systems in diabetes. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2021 10; 72(5):. doi: 10.26402/jpp.2021.5.03. [PMID: 35158330]
  • Komal Latif, Arif-Ullah Khan, Muhammad Izhar Ul Haque, Komal Naeem. Bergapten Attenuates Nitroglycerin-Induced Migraine Headaches through Inhibition of Oxidative Stress and Inflammatory Mediators. ACS chemical neuroscience. 2021 09; 12(18):3303-3313. doi: 10.1021/acschemneuro.1c00146. [PMID: 34455773]
  • Roberto De Icco, Rosaria Greco, Chiara Demartini, Pietro Vergobbi, Annamaria Zanaboni, Elena Tumelero, Angelo Reggiani, Natalia Realini, Grazia Sances, Valentina Grillo, Marta Allena, Cristina Tassorelli. Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks. Pain. 2021 09; 162(9):2376-2385. doi: 10.1097/j.pain.0000000000002223. [PMID: 33587406]
  • Wael Talaat, Sohila ElOnsy, Reda Mohammed Keshk. Fluorescent sensing for some nitric oxide donors in dosage forms and biological matrices. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Aug; 257(?):119788. doi: 10.1016/j.saa.2021.119788. [PMID: 33894636]
  • Gökhan Yilmaz, Yusuf Tanrikulu. Short-term Results of Platelet-Rich Plasma in the Treatment of Chronic Anal Fissure: Randomized Controlled Clinical Study. Diseases of the colon and rectum. 2021 06; 64(6):714-723. doi: 10.1097/dcr.0000000000001903. [PMID: 33399410]
  • Qi Huang, Wen Ting Wang, Shi Sheng Wang, De An Pei, Xiang Qian Sui. Cardiovascular magnetic resonance image analysis and mechanism study for the changes after treatments for primary microvascular angina pectoris. Medicine. 2021 May; 100(21):e26038. doi: 10.1097/md.0000000000026038. [PMID: 34032727]
  • Ersin Cagri Simsek, Cenk Sari, Murat Kucukokur, Cenk Ekmekci, Ayfer Colak, Oner Ozdogan. Endothelial dysfunction in patients with myocardial ischemia or infarction and nonobstructive coronary arteries. Journal of clinical ultrasound : JCU. 2021 May; 49(4):334-340. doi: 10.1002/jcu.22902. [PMID: 32776332]
  • Melina Lopez, Pedro F Malacarne, Anna Gajos-Draus, Xinxin Ding, Andreas Daiber, Jon O Lundberg, Stefan Offermanns, Ralf P Brandes, Flávia Rezende. Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases. British journal of pharmacology. 2021 04; 178(7):1495-1506. doi: 10.1111/bph.15362. [PMID: 33450066]
  • Benjamin T Daxon, Erin Lark, Luke J Matzek, Amanda R Fields, Kyle J Haselton. Nebulized Nitroglycerin for Coronavirus Disease 2019-Associated Acute Respiratory Distress Syndrome: A Case Report. A&A practice. 2021 Feb; 15(2):e01376. doi: 10.1213/xaa.0000000000001376. [PMID: 33560642]
  • Xiaodong Qiu, Zhiying Tan, Wenhao Tang, Hui Ye, Xinjian Lu. Effects of controlled hypotension with restrictive transfusion on intraoperative blood loss and systemic oxygen metabolism in elderly patients who underwent lumbar fusion. Trials. 2021 Jan; 22(1):99. doi: 10.1186/s13063-020-05015-5. [PMID: 33509270]
  • Hung-Ruei Tzeng, Ming Tatt Lee, Pi-Chuan Fan, Daniel E Knutson, Tzu-Hsuan Lai, Werner Sieghart, James Cook, Lih-Chu Chiou. α6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2021 01; 18(1):569-585. doi: 10.1007/s13311-020-00951-1. [PMID: 33111258]
  • Fang Lu, Wen-Jun Zhang, Shuo Zhai, Yue-Wen Sun, Qiu-Jing Chen, Xiao-Lin Yang, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan. Anti-migraine effect of wine-processed Radix scutellariae: Pharmacodynamic verification in nitroglycerin-induced rats and correlation study between compounds dissolution and the fractal dimension. Journal of ethnopharmacology. 2020 Dec; 263(?):113131. doi: 10.1016/j.jep.2020.113131. [PMID: 32730879]
  • Li Zhong, Jieqin Zhuang, Zilin Jin, Yanhong Chen, Bojun Chen. Effect of Chinese medicine for promoting blood circulation on microvascular angina: A systematic review and meta-analysis. The American journal of emergency medicine. 2020 12; 38(12):2681-2692. doi: 10.1016/j.ajem.2020.07.072. [PMID: 33046314]
  • Abbas Raisi, Arash Kheradmand, Ghasem Farjanikish, Farshid Davoodi, Shayan Taheri. Nitroglycerin ameliorates sperm parameters, oxidative stress and testicular injury following by testicular torsion/detorsion in male rats. Experimental and molecular pathology. 2020 12; 117(?):104563. doi: 10.1016/j.yexmp.2020.104563. [PMID: 33147433]
  • Mark Weingarten, Brian Abittan, Ryan Rivera-Oyola, Abraham I Abittan, Michael Weingarten, Mark Lebwohl. Treatment of COVID-19 induced chilblains with topical nitroglycerin. International journal of dermatology. 2020 Dec; 59(12):1522-1524. doi: 10.1111/ijd.15253. [PMID: 33084032]
  • Shinji Kishimoto, Kenji Oki, Tatsuya Maruhashi, Masato Kajikawa, Haruki Hashimoto, Yuji Takaeko, Takahiro Harada, Takayuki Yamaji, Yiming Han, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Farina Mohamad Yusoff, Ayumu Nakashima, Yukihito Higashi. A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma. The Journal of clinical endocrinology and metabolism. 2020 11; 105(11):. doi: 10.1210/clinem/dgaa561. [PMID: 32818224]
  • Daniel H Craighead, Kaitlin A Freeberg, Douglas R Seals. Vascular Endothelial Function in Midlife/Older Adults Classified According to 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines. Journal of the American Heart Association. 2020 09; 9(17):e016625. doi: 10.1161/jaha.120.016625. [PMID: 32815446]
  • Darren Mullane, Martin Lenihan, Ciara Hanley, Tom Wall, Irmina Bukowska, Michael Griffin, Georgina Flood. Efficacy of Glyceryl trinitrate (GTN) to facilitate the rewarming process during cardiopulmonary bypass. Journal of cardiothoracic surgery. 2020 Aug; 15(1):214. doi: 10.1186/s13019-020-01258-0. [PMID: 32778123]
  • Kristofer F Nilsson, Waldemar Gozdzik, Stanislaw Zielinski, Kornel Ratajczak, Sofie P Göranson, Sylwia Rodziewicz, Piotr Harbut, Barbara Barteczko-Grajek, Johanna Albert, Claes Frostell. Pulmonary Vasodilation by Intravenous Infusion of Organic Mononitrites Of 1,2-Propanediol in Acute Pulmonary Hypertension Induced by Aortic Cross Clamping and Reperfusion: A Comparison With Nitroglycerin in Anesthetized Pigs. Shock (Augusta, Ga.). 2020 07; 54(1):119-127. doi: 10.1097/shk.0000000000001436. [PMID: 31425404]
  • Jiacheng Lin, Xu Zhang, Chaotong Li, Yingyan Zhang, Hanzhi Lu, Jiwei Chen, Zeyu Li, Xuejun Yang, Zhongping Wu. Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response. Journal of ethnopharmacology. 2020 May; 254(?):112727. doi: 10.1016/j.jep.2020.112727. [PMID: 32147481]
  • Ying-Hsuan Tai, You-Hsiang Chu, Hsiang-Ling Wu, Su-Man Lin, Mei-Yung Tsou, Cheng-Hsiung Huang, Hsiao-Huang Chang, Chih-Cherng Lu. High-dose nitroglycerin administered during rewarming preserves erythrocyte deformability in cardiac surgery with cardiopulmonary bypass. Microcirculation (New York, N.Y. : 1994). 2020 05; 27(4):e12608. doi: 10.1111/micc.12608. [PMID: 31991513]
  • Marwa Zayed, Heba Nassar, Ahmed Hasanin, Amany H Saleh, Passaint Hassan, Dalia Saad, Sahar Mahmoud, Ghada Abo Bakr, Eman Fouad, Norhan Saleh, Maha Ismail, Hani El-Hadi. Effects of nitroglycerin versus labetalol on peripheral perfusion during deliberate hypotension for sinus endoscopic surgery: a randomized, controlled, double-blinded trial. BMC anesthesiology. 2020 04; 20(1):85. doi: 10.1186/s12871-020-01006-w. [PMID: 32303182]
  • Ya Min Luo, Xiao Qiao Ren, Xue Qin Yang, Hui Rong Song, Ran Li, Ming Hui Gao, Yi Ran Li, Ran Ran Zhou, Lei Ma, Shu Jing Zhang, Ruan Juan Dong, Dong Yu Ge, Chun Guo Wang, Qing Jia Ren, Xiao Hua Tao. Tibetan medicine Ru-yi-Zhen-bao Pills exhibits anti-migraine effect through mediating PAG anti-nociceptive channel. Journal of ethnopharmacology. 2020 Mar; 249(?):112437. doi: 10.1016/j.jep.2019.112437. [PMID: 31794788]
  • Yong-Song Xu, Feng Qiu, Sha Wu, Rui He, Mu-Xin Gong, Zhi-Min Wang. [UPLC-MS/MS determination of active components from Wuzhuyu Decoction in plasma and brain tissues of nitroglycerin-induced migraine rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Feb; 45(3):645-654. doi: 10.19540/j.cnki.cjcmm.20190624.502. [PMID: 32237525]
  • Erkan Kilinc, Fatma Tore, Yasar Dagistan, Guler Bugdayci. Thymoquinone Inhibits Neurogenic Inflammation Underlying Migraine Through Modulation of Calcitonin Gene-Related Peptide Release and Stabilization of Meningeal Mast Cells in Glyceryltrinitrate-Induced Migraine Model in Rats. Inflammation. 2020 Feb; 43(1):264-273. doi: 10.1007/s10753-019-01115-w. [PMID: 31707574]
  • Tianbao Lai, Liangyi Chen, Xingyu Chen, Jianquan He, Peiyu Lv, Hua Ge. Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF-кB signaling. Molecular and cellular biochemistry. 2019 Nov; 461(1-2):205-212. doi: 10.1007/s11010-019-03603-x. [PMID: 31420791]
  • Fatemeh Ahmadi, Saeed Hajihashemi, Ali Rahbari, Fatemeh Ghanbari. Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats. Drug research. 2019 Oct; 69(11):612-620. doi: 10.1055/a-0958-1987. [PMID: 31315134]
  • Tatsuya Nagano, Kentaro Ushijima, Naoyuki Taga, Mamoru Takeuchi, Masa-Aki Kawada, Kenichi Aizawa, Yasushi Imai, Akio Fujimura. Influence of the aldehyde dehydrogenase 2 polymorphism on the vasodilatory effect of nitroglycerin in infants with congenital heart disease and pulmonary arterial hypertension. European journal of clinical pharmacology. 2019 Oct; 75(10):1361-1367. doi: 10.1007/s00228-019-02709-x. [PMID: 31250045]
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