Oxandrolone (BioDeep_00000006481)

 

Secondary id: BioDeep_00001867867

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,14,15-trimethyl-4-oxatetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one

化学式: C19H30O3 (306.21948299999997)
中文名称: 氧甲氢龙
谱图信息: 最多检出来源 Homo sapiens(urine) 4.9%

分子结构信息

SMILES: CC12CCC3C(C1CCC2(C)O)CCC4C3(COC(=O)C4)C
InChI: InChI=1S/C19H30O3/c1-17-11-22-16(20)10-12(17)4-5-13-14(17)6-8-18(2)15(13)7-9-19(18,3)21/h12-15,21H,4-11H2,1-3H3/t12-,13+,14-,15-,17-,18-,19-/m0/s1

描述信息

Oxandrolone is only found in individuals that have used or taken this drug. It is a synthetic hormone with anabolic and androgenic properties. [PubChem]Oxandrolones interact with androgen receptors in target tissues.
A - Alimentary tract and metabolism > A14 - Anabolic agents for systemic use > A14A - Anabolic steroids > A14AA - Androstan derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D045930 - Anabolic Agents
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D000728 - Androgens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid

同义名列表

8 个代谢物同义名

(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,14,15-trimethyl-4-oxatetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one; Oxandrolonum; Ossandrolone; Oxandrolona; Oxandrolone; Oxandrin; Lonavar; Anavar



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Caitlin Harding, Marjaana Viljanto, Charlotte Cutler, Jocelyn Habershon-Butcher, Simon Biddle, James Scarth. In vitro and in vivo metabolism of the anabolic-androgenic steroid oxandrolone in the horse. Drug testing and analysis. 2022 Jan; 14(1):39-55. doi: 10.1002/dta.3139. [PMID: 34378336]
  • Emanuel Airton de Oliveira Farias, Nielson José Silva Furtado, Isaac Yves Lopes de Macêdo, Eric de Souza Gil, Freddy Fernandes Guimarães, Ruan Sousa Bastos, Jefferson Almeida Rocha, Lívio César Cunha Nunes, Roberto Alves de Sousa Luz, Carla Eiras. Poly(Alizarin Red S) on pyrolytic graphite electrodes as a new multi-electronic system for sensing oxandrolone in urine. Biosensors & bioelectronics. 2021 Aug; 185(?):113234. doi: 10.1016/j.bios.2021.113234. [PMID: 33945892]
  • Flavio Cadegiani, Erica M Lin, Andy Goren, Carlos G Wambier. Potential risk for developing severe COVID-19 disease among anabolic steroid users. BMJ case reports. 2021 Feb; 14(2):. doi: 10.1136/bcr-2021-241572. [PMID: 33637513]
  • Jaroslav Galba, Juraj Piešťanský, Andrej Kováč, Dominika Olešová, Ondrej Cehlár, Martin Kertys, Petr Kozlík, Petra Chaľová, Barbora Tirčová, Kristián Slíž, Peter Mikuš. Fast and Sensitive Screening of Oxandrolone and Its Major Metabolite 17-Epi-Oxandrolone in Human Urine by UHPLC-MS/MS with On-Line SPE Sample Pretreatment. Molecules (Basel, Switzerland). 2021 Jan; 26(2):. doi: 10.3390/molecules26020480. [PMID: 33477515]
  • Akbar Ahmad, David N Herndon, Csaba Szabo. Oxandrolone protects against the development of multiorgan failure, modulates the systemic inflammatory response and promotes wound healing during burn injury. Burns : journal of the International Society for Burn Injuries. 2019 05; 45(3):671-681. doi: 10.1016/j.burns.2018.10.006. [PMID: 31018913]
  • Shanlee M Davis, Najiba Lahlou, Matthew Cox-Martin, Karen Kowal, Philip S Zeitler, Judith L Ross. Oxandrolone Treatment Results in an Increased Risk of Gonadarche in Prepubertal Boys With Klinefelter Syndrome. The Journal of clinical endocrinology and metabolism. 2018 09; 103(9):3449-3455. doi: 10.1210/jc.2018-00682. [PMID: 29931143]
  • Ashley N Guillory, David N Herndon, Michael B Silva, Clark R Andersen, Oscar E Suman, Celeste C Finnerty. Oxandrolone Coadministration Does Not Alter Plasma Propranolol Concentrations in Severely Burned Pediatric Patients. Journal of burn care & research : official publication of the American Burn Association. 2017 Jul; 38(4):243-250. doi: 10.1097/bcr.0000000000000494. [PMID: 28240622]
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  • Ahmed M Alkhunaizi, Mohamed A ElTigani, Rola S Rabah, Samih H Nasr. Acute bile nephropathy secondary to anabolic steroids. Clinical nephrology. 2016 Feb; 85(2):121-6. doi: 10.5414/cn108696. [PMID: 26587777]
  • Matthew W Linakis, Chris Stockmann, Sarah C Campbell, Richard V Williams, Phillip T Burch, Linda M Lambert, Catherine M T Sherwin, Christopher A Reilly, Michael G Spigarelli. Quantitative Assay Validation for Oxandrolone in Human Plasma Using LC-MS-MS. Journal of analytical toxicology. 2015 Sep; 39(7):526-31. doi: 10.1093/jat/bkv056. [PMID: 26017381]
  • Susan R Rose, Mi-Ok Kim, Leslie Korbee, Kimberly A Wilson, M Douglas Ris, Ori Eyal, Rosa Sherafat-Kazemzadeh, Sureka Bollepalli, Richard Harris, Michael R Jeng, David A Williams, Franklin O Smith. Oxandrolone for the treatment of bone marrow failure in Fanconi anemia. Pediatric blood & cancer. 2014 Jan; 61(1):11-9. doi: 10.1002/pbc.24617. [PMID: 24019220]
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  • Nighat N Kahn, Asru K Sinha, Ann M Spungen, William A Bauman. Effects of oxandrolone, an anabolic steroid, on hemostasis. American journal of hematology. 2006 Feb; 81(2):95-100. doi: 10.1002/ajh.20532. [PMID: 16432848]
  • Rene Przkora, Marc G Jeschke, Robert E Barrow, Oscar E Suman, Walter J Meyer, Celeste C Finnerty, Arthur P Sanford, Jong Lee, David L Chinkes, Ronald P Mlcak, David N Herndon. Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment. Annals of surgery. 2005 Sep; 242(3):384-9, discussion 390. doi: 10.1097/01.sla.0000180398.70103.24. [PMID: 16135924]
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