Glutarimide (BioDeep_00000006451)
Secondary id: BioDeep_00001868534
human metabolite blood metabolite
代谢物信息卡片
化学式: C5H7NO2 (113.0477)
中文名称: 戊二酰亚胺
谱图信息:
最多检出来源 Homo sapiens(blood) 67.79%
分子结构信息
SMILES: C1CC(=O)NC(=O)C1
InChI: InChI=1S/C5H7NO2/c7-4-2-1-3-5(8)6-4/h1-3H2,(H,6,7,8)
描述信息
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:5435
- KEGG: C07275
- PubChem: 70726
- HMDB: HMDB0252816
- Metlin: METLIN66616
- ChEMBL: CHEMBL3763941
- Wikipedia: Glutarimide
- chemspider: 63891
- CAS: 1121-89-7
- PMhub: MS000019494
- PubChem: 9484
- PDB-CCD: 9UZ
- NIKKAJI: J137.949F
- KNApSAcK: 5435
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Eric J N Helfrich, Reiko Ueoka, Marc G Chevrette, Franziska Hemmerling, Xiaowen Lu, Stefan Leopold-Messer, Hannah A Minas, Adrien Y Burch, Steven E Lindow, Jörn Piel, Marnix H Medema. Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria.
Nature communications.
2021 03; 12(1):1422. doi:
10.1038/s41467-021-21163-x. [PMID: 33658492] - Beth Ndunda, Moses K Langat, John M Wanjohi, Jacob O Midiwo, Leonidah O Kerubo. Alienusolin, a new 4α-deoxyphorbol ester derivative, and crotonimide C, a new glutarimide alkaloid from the Kenyan Croton alienus.
Planta medica.
2013 Dec; 79(18):1762-6. doi:
10.1055/s-0033-1351044. [PMID: 24356872] - Rosana N S Peixoto, Giselle M S P Guilhon, Maria das Graças B Zoghbi, Isabella S Araújo, Ana Paula T Uetanabaro, Lourivaldo S Santos, Davi do S B Brasil. Volatiles, a glutarimide alkaloid and antimicrobial effects of Croton pullei (Euphorbiaceae).
Molecules (Basel, Switzerland).
2013 Mar; 18(3):3195-205. doi:
10.3390/molecules18033195. [PMID: 23481881] - Nianhang Chen, Lian Wen, Henry Lau, Sekhar Surapaneni, Gondi Kumar. Pharmacokinetics, metabolism and excretion of [(14)C]-lenalidomide following oral administration in healthy male subjects.
Cancer chemotherapy and pharmacology.
2012 Mar; 69(3):789-97. doi:
10.1007/s00280-011-1760-3. [PMID: 22037879] - Indra Sandal, Amita Bhattacharya, Uksha Saini, Devinder Kaur, Shveta Sharma, Ashu Gulati, Jonnala K Kumar, Neeraj Kumar, Jyotsna Dayma, Pralay Das, Bikram Singh, Paramvir S Ahuja. Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound.
BMC chemical biology.
2011 May; 11(?):1. doi:
10.1186/1472-6769-11-1. [PMID: 21624145] - Yuling Jiao, Elliot M Meyerowitz. Cell-type specific analysis of translating RNAs in developing flowers reveals new levels of control.
Molecular systems biology.
2010 Oct; 6(?):419. doi:
10.1038/msb.2010.76. [PMID: 20924354] - Walid Sadok, Thomas R Sinclair. Transpiration response of 'slow-wilting' and commercial soybean (Glycine max (L.) Merr.) genotypes to three aquaporin inhibitors.
Journal of experimental botany.
2010 Mar; 61(3):821-9. doi:
10.1093/jxb/erp350. [PMID: 19969533] - Xiaoli Meng, James L Maggs, David C Pryde, Simon Planken, Rosalind E Jenkins, Torren M Peakman, Kevin Beaumont, Christopher Kohl, B Kevin Park, Andrew V Stachulski. Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.
Journal of medicinal chemistry.
2007 Nov; 50(24):6165-76. doi:
10.1021/jm0706766. [PMID: 17985860] - Ashraf Ghanem. Exploring solvent versatility in immobilized cellulose-based chiral stationary phase for the enantioselective liquid chromatographic resolution of racemates.
Journal of separation science.
2007 May; 30(7):1019-28. doi:
10.1002/jssc.200600357. [PMID: 17566336] - Hiromasa Kiyota. Synthesis of naturally derived bioactive compounds of agricultural interest.
Bioscience, biotechnology, and biochemistry.
2006 Feb; 70(2):317-24. doi:
10.1271/bbb.70.317. [PMID: 16495645] - David J Fox, Jill Reckless, Sibylle M Wilbert, Ian Greig, Stuart Warren, David J Grainger. Identification of 3-(acylamino)azepan-2-ones as stable broad-spectrum chemokine inhibitors resistant to metabolism in vivo.
Journal of medicinal chemistry.
2005 Feb; 48(3):867-74. doi:
10.1021/jm049365a. [PMID: 15689171] - Alírica I Suárez, Zuleyma Blanco, Franco Delle Monache, Reinaldo S Compagnone, Francisco Arvelo. Three new glutarimide alkaloids from Croton cuneatus.
Natural product research.
2004 Oct; 18(5):421-6. doi:
10.1080/14786410310001622004. [PMID: 15248609] - F A Aboagye, G H Sam, G Massiot, C Lavaud. Julocrotine, a glutarimide alkaloid from Croton membranaceus.
Fitoterapia.
2000 Aug; 71(4):461-2. doi:
10.1016/s0367-326x(00)00141-6. [PMID: 10925028] - W Blom, A C Polder-Mol, H H Kelholt-Dijkman, L Hierck, J G Huijmans. The detection of abnormal metabolites in MCAD deficiency: a new method.
Journal of inherited metabolic disease.
1990; 13(3):315-20. doi:
10.1007/bf01799384. [PMID: 1977955]
