Tranylcypromine (BioDeep_00000006431)

 

Secondary id: BioDeep_00001868179

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1R,2S)-rel-2-phenyl-cyclopropanamine, monohydrochloride

化学式: C9H11N (133.0891446)
中文名称: 2-苯基环丙烷-1-胺
谱图信息: 最多检出来源 Viridiplantae(plant) 3.77%

分子结构信息

SMILES: C1C(C1N)C2=CC=CC=C2
InChI: InChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2

描述信息

A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AF - Monoamine oxidase inhibitors, non-selective
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors

同义名列表

18 个代谢物同义名

(1R,2S)-rel-2-phenyl-cyclopropanamine, monohydrochloride; GlaxoSmithKline brand OF tranylcypromine sulfate; SmithKline brand OF tranylcypromine sulfate; Goldshield brand OF tranylcypromine sulfate; Esparma brand OF tranylcypromine sulfate; Allphar brand OF tranylcypromine sulfate; Link brand OF tranylcypromine sulfate; (1R)-2-phenylcyclopropan-1-amine; trans-2-Phenylcyclopropylamine; trans 2 Phenylcyclopropylamine; 2-Phenyl cyclo propan-1-amine; Sulfate, tranylcypromine; Tranylcypromine sulfate; tranylcypromine; Parnic acid; Transamine; Jatrosom; Parnate



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sara Silva, Joana Marto, Lídia M Gonçalves, Diana Duarte, O Salomé G P Soares, Francisco Vasques-Nóvoa, António J Almeida, Nuno Vale. New Peptide Functionalized Nanostructured Lipid Carriers with CNS Drugs and Evaluation Anti-proliferative Activity. International journal of molecular sciences. 2022 Jun; 23(13):. doi: 10.3390/ijms23137109. [PMID: 35806112]
  • Sven Ulrich, Daniela Hock, Volker Guth, Aydin Erenmemisoglu, Bernhard Scheidel. Insufficient recovery of monoamine oxidase in a bioequivalence study of the monoamine oxidase inhibitor tranylcypromine: Recommendation of the tranylcypromine enantiomer test. International journal of clinical pharmacology and therapeutics. 2022 May; 60(5):242-252. doi: 10.5414/cp204169. [PMID: 35279222]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Maxi Wass, Stefanie Göllner, Birgit Besenbeck, Richard F Schlenk, Petra Mundmann, Joachim R Göthert, Richard Noppeney, Christoph Schliemann, Jan-Henrik Mikesch, Georg Lenz, Martin Dugas, Martin Wermke, Christoph Röllig, Martin Bornhäuser, Hubert Serve, Uwe Platzbecker, Kathrin I Foerster, Jürgen Burhenne, Walter E Haefeli, Lutz P Müller, Mascha Binder, Caroline Pabst, Carsten Müller-Tidow. A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy. Leukemia. 2021 03; 35(3):701-711. doi: 10.1038/s41375-020-0892-z. [PMID: 32561840]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Alexander Dmitriev, Dmitry Filimonov, Alexey Lagunin, Dmitry Karasev, Pavel Pogodin, Anastasiya Rudik, Vladimir Poroikov. Prediction of Severity of Drug-Drug Interactions Caused by Enzyme Inhibition and Activation. Molecules (Basel, Switzerland). 2019 Oct; 24(21):. doi: 10.3390/molecules24213955. [PMID: 31683720]
  • Ali Reza Fakhari, Hasan Mohammadi Kosalar, Sajad Asadi, Kobra Sadat Hasheminasab. Surfactant-assisted electromembrane extraction combined with cyclodextrin-modified capillary electrophoresis for the separation and quantification of Tranylcypromine enantiomers in biological samples. Journal of separation science. 2018 Jan; 41(2):475-482. doi: 10.1002/jssc.201700488. [PMID: 28988449]
  • Sven Ulrich, Roland Ricken, Mazda Adli. Tranylcypromine in mind (Part I): Review of pharmacology. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2017 08; 27(8):697-713. doi: 10.1016/j.euroneuro.2017.05.007. [PMID: 28655495]
  • Maryam Akhgari, Farzaneh Jokar, Afshar Etemadi-Aleagha, Ali Ghasemi. Discrimination Between Drug Abuse and Medical Therapy: Case report of a tranylcypromine overdose-related fatality. Sultan Qaboos University medical journal. 2017 May; 17(2):e213-e217. doi: 10.18295/squmj.2016.17.02.013. [PMID: 28690895]
  • S Blazevic, I Erjavec, M Brizic, S Vukicevic, D Hranilovic. Molecular background and physiological consequences of altered peripheral serotonin homeostasis in adult rats perinatally treated with tranylcypromine. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2015 Aug; 66(4):529-37. doi: . [PMID: 26348077]
  • Vijayata Singh, Zeeshan Zahoor Banday, Ashis Kumar Nandi. Exogenous application of histone demethylase inhibitor trans-2-phenylcyclopropylamine mimics FLD loss-of-function phenotype in terms of systemic acquired resistance in Arabidopsis thaliana. Plant signaling & behavior. 2014; 9(9):e29658. doi: 10.4161/psb.29658. [PMID: 25763701]
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  • Dubravka Hranilovic, Sofia Blazevic, Nedjeljka Ivica, Lipa Cicin-Sain, Darko Oreskovic. The effects of the perinatal treatment with 5-hydroxytryptophan or tranylcypromine on the peripheral and central serotonin homeostasis in adult rats. Neurochemistry international. 2011 Aug; 59(2):202-7. doi: 10.1016/j.neuint.2011.05.003. [PMID: 21672593]
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  • Pinelopi Lundquist, Magnus Roman, Stina Syvänen, Per Hartvig, Gunnar Blomquist, Margareta Hammarlund-Udenaes, Bengt Långström. Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration: positron emission tomography studies in monkeys and rats. Synapse (New York, N.Y.). 2007 Jun; 61(6):440-9. doi: 10.1002/syn.20382. [PMID: 17372973]
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  • Tom K Birkenhäger, Walter W van den Broek, Paul G Mulder, Jan A Bruijn, Peter Moleman. Efficacy and tolerability of tranylcypromine versus phenelzine: a double-blind study in antidepressant-refractory depressed inpatients. The Journal of clinical psychiatry. 2004 Nov; 65(11):1505-10. doi: 10.4088/jcp.v65n1110. [PMID: 15554763]
  • Shinichi Yoshida, Thomas C Rosen, Oliver G J Meyer, Milton J Sloan, Song Ye, Günter Haufe, Kenneth L Kirk. Fluorinated phenylcyclopropylamines. Part 3: Inhibition of monoamine oxidase A and B. Bioorganic & medicinal chemistry. 2004 May; 12(10):2645-52. doi: 10.1016/j.bmc.2004.03.010. [PMID: 15110846]
  • Shinichi Yoshida, Oliver G J Meyer, Thomas C Rosen, Günter Haufe, Song Ye, Milton J Sloan, Kenneth L Kirk. Fluorinated phenylcyclopropylamines. 1. Synthesis and effect of fluorine substitution at the cyclopropane ring on inhibition of microbial tyramine oxidase. Journal of medicinal chemistry. 2004 Mar; 47(7):1796-806. doi: 10.1021/jm030398k. [PMID: 15027872]
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  • Nathalie Ginovart, Alan A Wilson, Jeffrey H Meyer, Doug Hussey, Sylvain Houle. [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats. Synapse (New York, N.Y.). 2003 Feb; 47(2):123-33. doi: 10.1002/syn.10155. [PMID: 12454950]
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