Megestrol (BioDeep_00000006428)
代谢物信息卡片
(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
化学式: C22H30O3 (342.2195)
中文名称: 甲地孕酮
谱图信息:
最多检出来源 Mus musculus(plant) 6.52%
分子结构信息
SMILES: CC(=O)C1(O)CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC21C
InChI: InChI=1S/C22H30O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h11-12,16-18,25H,5-10H2,1-4H3/t16-,17+,18+,20-,21+,22+/m1/s1
描述信息
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03D - Progestogens > G03DB - Pregnadien derivatives
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02A - Hormones and related agents > L02AB - Progestogens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:6722
- KEGG: C07120
- KEGGdrug: D08167
- PubChem: 19090
- PubChem: 4474932
- Metlin: METLIN1112
- ChEMBL: CHEMBL4071215
- MeSH: Megestrol
- CAS: 3562-63-8
- PMhub: MS000019465
- PubChem: 9331
- LipidMAPS: LMST02030177
- NIKKAJI: J14.548C
- RefMet: Megestrol
- KNApSAcK: 6722
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maria Pia Costa-Santos, Afonso Gonçalves, Alexandre Oliveira Ferreira, Joana Nunes. Spontaneous regression of hepatocellular carcinoma: myth or reality?.
BMJ case reports.
2020 Feb; 13(2):. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Sep; 122(?):205-213. doi:
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2018 Feb; 32(2):. doi:
10.1002/bmc.4086. [PMID: 28869284] - Giovanni Grandi, Antonella Napolitano, Angelo Cagnacci. Metabolic impact of combined hormonal contraceptives containing estradiol.
Expert opinion on drug metabolism & toxicology.
2016 Jul; 12(7):779-87. doi:
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European journal of drug metabolism and pharmacokinetics.
2015 Dec; 40(4):435-42. doi:
10.1007/s13318-014-0224-7. [PMID: 25168884] - Giovanni Grandi, Antonella Napolitano, Anjeza Xholli, Alessandra Tirelli, Costantino Di Carlo, Angelo Cagnacci. Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2015 Oct; 31(10):774-8. doi:
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The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
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10.3109/13625187.2015.1050091. [PMID: 26007631] - Jianfeng Zhang, Yan Zhu, Xianying Zhou, Shufang Hao, Shuwu Xie, Jieyun Zhou, Xiangjie Guo, Zhao Li, Yunsheng Huang, Qinghua Chen. Evaluation of biodegradable microspheres containing nomegestrol acetate in a rat model of endometriosis.
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2008 May; 110(1-2):67-75. doi:
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2007 May; 14(3 Pt 1):450-4. doi:
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2007 Feb; 92(2):563-70. doi:
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Contraception.
1995 Aug; 52(2):111-4. doi:
10.1016/s0010-7824(95)00144-1. [PMID: 8536447] - J R Pasqualini, G Chetrite, B L Nguyen, C Maloche, L Delalonde, M Talbi, M C Feinstein, C Blacker, J Botella, J Paris. Estrone sulfate-sulfatase and 17 beta-hydroxysteroid dehydrogenase activities: a hypothesis for their role in the evolution of human breast cancer from hormone-dependence to hormone-independence.
The Journal of steroid biochemistry and molecular biology.
1995 Jun; 53(1-6):407-12. doi:
10.1016/0960-0760(95)00116-h. [PMID: 7626488] - K Leitzel, Y Teramoto, K Konrad, V M Chinchilli, G Volas, H Grossberg, H Harvey, L Demers, A Lipton. Elevated serum c-erbB-2 antigen levels and decreased response to hormone therapy of breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1995 May; 13(5):1129-35. doi:
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International journal of radiation oncology, biology, physics.
1995 Apr; 32(1):175-80. doi:
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International journal of clinical & laboratory research.
1995; 25(3):135-41. doi:
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Cancer chemotherapy and pharmacology.
1995; 36(4):356-9. doi:
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The Analyst.
1994 Dec; 119(12):2635-7. doi:
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Surgical oncology.
1994 Dec; 3(6):351-9. doi:
10.1016/0960-7404(94)90074-4. [PMID: 7773452] - C L Loprinzi, A M Bernath, D J Schaid, J A Malliard, L M Athmann, J C Michalak, L K Tschetter, A K Hatfield, R F Morton. Phase III evaluation of 4 doses of megestrol acetate as therapy for patients with cancer anorexia and/or cachexia.
Oncology.
1994 Oct; 51 Suppl 1(?):2-7. doi:
10.1159/000227407. [PMID: 7970505] - A Logmans, H V Mous, M Bontenbal, H Beerman, M van Lent. Results of curettage for postmenopausal vaginal bleeding in women treated with tamoxifen and megestrol acetate for progressive metastatic breast carcinoma.
European journal of obstetrics, gynecology, and reproductive biology.
1994 Sep; 56(3):173-6. doi:
10.1016/0028-2243(94)90166-x. [PMID: 7821489] - J Botella, E Duranti, I Duc, A M Cognet, R Delansorne, J Paris. Inhibition by nomegestrol acetate and other synthetic progestins on proliferation and progesterone receptor content of T47-D human breast cancer cells.
The Journal of steroid biochemistry and molecular biology.
1994 Jul; 50(1-2):41-7. doi:
10.1016/0960-0760(94)90170-8. [PMID: 8049131] - K K Graham, D J Mikolich, A E Fisher, M R Posner, M N Dudley. Pharmacologic evaluation of megestrol acetate oral suspension in cachectic AIDS patients.
Journal of acquired immune deficiency syndromes.
1994 Jun; 7(6):580-6. doi:
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Research in veterinary science.
1994 Mar; 56(2):175-8. doi:
10.1016/0034-5288(94)90101-5. [PMID: 8191007] - E Ezan, H Benech, R Bucourt, T Ardouin, C Tchernatinsky, J L Thomas, J Paris, J M Grognet. Enzyme immunoassay for nomegestrol acetate in human plasma.
The Journal of steroid biochemistry and molecular biology.
1993 Oct; 46(4):507-14. doi:
10.1016/0960-0760(93)90105-6. [PMID: 8217881] - P Dorangeon, J L Thomas, H Choisy, M Lumbroso, M C Hazard. Effects of nomegestrol acetate on carbohydrate metabolism.
Diabete & metabolisme.
1993 Sep; 19(5):441-5. doi:
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Journal of the American Veterinary Medical Association.
1993 Jul; 203(2):254-8. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1993 Apr; 11(4):762-7. doi:
10.1200/jco.1993.11.4.762. [PMID: 8478668] - D G McLeod. Antiandrogenic drugs.
Cancer.
1993 Feb; 71(3 Suppl):1046-9. doi:
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Journal of reproduction and fertility. Supplement.
1993; 47(?):165-73. doi:
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Life sciences.
1993; 53(21):1643-50. doi:
10.1016/0024-3205(93)90188-9. [PMID: 7694027] - C L Loprinzi, M D Jensen, N S Jiang, D J Schaid. Effect of megestrol acetate on the human pituitary-adrenal axis.
Mayo Clinic proceedings.
1992 Dec; 67(12):1160-2. doi:
10.1016/s0025-6196(12)61145-8. [PMID: 1469926] - N S Tchekmedyian, C Halpert, J Ashley, D Heber. Nutrition in advanced cancer: anorexia as an outcome variable and target of therapy.
JPEN. Journal of parenteral and enteral nutrition.
1992 Nov; 16(6 Suppl):88S-92S. doi:
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Clinical pharmacokinetics.
1992 May; 22(5):327-58. doi:
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Journal of the American Veterinary Medical Association.
1992 Mar; 200(6):797-801. doi:
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Cancer.
1992 Mar; 69(5):1268-74. doi:
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Acta oncologica (Stockholm, Sweden).
1992; 31(7):709-22. doi:
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Maturitas.
1991 Dec; 14(1):43-8. doi:
10.1016/0378-5122(91)90146-h. [PMID: 1791771] - P M Venner. Therapeutic options in treatment of advanced carcinoma of the prostate.
Seminars in oncology.
1990 Dec; 17(6 Suppl 9):73-7. doi:
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British journal of cancer.
1990 Nov; 62(5):822-5. doi:
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Biochemistry and cell biology = Biochimie et biologie cellulaire.
1990 Oct; 68(10):1181-8. doi:
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British journal of cancer.
1990 Sep; 62(3):420-4. doi:
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Journal of chromatography.
1990 Jul; 529(1):145-54. doi:
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Journal of steroid biochemistry.
1990 Jun; 36(1-2):99-104. doi:
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Journal of steroid biochemistry.
1990 Jun; 36(1-2):105-9. doi:
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