Ethylene oxide (BioDeep_00000006201)
Secondary id: BioDeep_00000653667, BioDeep_00000866918
human metabolite blood metabolite
代谢物信息卡片
Dimethylene oxide
化学式: C2H4O (44.0262)
中文名称: 环氧乙烷标准溶液, 环氧乙烷
谱图信息:
最多检出来源 Homo sapiens(blood) 48.71%
分子结构信息
SMILES: C1CO1
InChI: InChI=1S/C2H4O/c1-2-3-1/h1-2H2
描述信息
Flavouring ingredient. It is used in food processing as a solubiliser, stabiliser, processing aid, wetting agent, surfactant, defoaming agent and dough conditioner.
D000890 - Anti-Infective Agents
D004202 - Disinfectants
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:27561
- KEGG: C06548
- KEGGdrug: D03474
- PubChem: 6354
- HMDB: HMDB0255987
- Metlin: METLIN66425
- ChEMBL: CHEMBL1743219
- Wikipedia: Oxirane
- MeSH: Ethylene Oxide
- foodb: FDB003358
- chemspider: 6114
- CAS: 11104-97-5
- CAS: 75-21-8
- PMhub: MS000019214
- PubChem: 8778
- 3DMET: B00967
- NIKKAJI: J1.942I
- KNApSAcK: 27561
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
41 个相关的代谢反应过程信息。
Reactome(40)
- Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Biological oxidations:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + progesterone ⟶ 11DCORST + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Biological oxidations:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Phase I - Functionalization of compounds:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Cytochrome P450 - arranged by substrate type:
11DCORT + H+ + Oxygen + TPNH ⟶ CORT + H2O + TPN - Xenobiotics:
CAF + H+ + Oxygen + TPNH ⟶ CH2O + H2O + Paraxanthine + TPN - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Biological oxidations:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Phase I - Functionalization of compounds:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Cytochrome P450 - arranged by substrate type:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN - Xenobiotics:
H+ + Oxygen + TPNH + aflatoxin B1 ⟶ AFXBO + H2O + TPN
BioCyc(1)
- ethene and chloroethene degradation:
H+ + NADH + O2 + ethene ⟶ H2O + NAD+ + ethylene oxide
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 155022 - Terminalia chebula: 10.4103/0974-8490.112421
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- I M Tucker, A Burley, R E Petkova, S L Hosking, J R P Webster, P X Li, K Ma, J Doutch, J Penfoldoo, R K Thomas. Self-assembly in escin-nonionic surfactant mixtures: From micelles to vesicles.
Journal of colloid and interface science.
2022 Nov; 626(?):305-313. doi:
10.1016/j.jcis.2022.06.122. [PMID: 35792461] - Xu Zhu, Xiangying Kong, Mengli Chen, Shi Shi, Iokfai Cheang, Qingqing Zhu, Xinyi Lu, Xin Yue, Yuan Tang, Shengen Liao, Yanli Zhou, Haifeng Zhang, Wenming Yao, Xinli Li. Blood ethylene oxide, systemic inflammation, and serum lipid profiles: Results from NHANES 2013-2016.
Chemosphere.
2022 Jul; 299(?):134336. doi:
10.1016/j.chemosphere.2022.134336. [PMID: 35337822] - Nicholas J Van Zee, Amanda S Peroutka, Adelyn Crabtree, Marc A Hillmyer, Timothy P Lodge. Lipid Membrane Binding and Cell Protection Efficacy of Poly(1,2-butylene oxide)-b-poly(ethylene oxide) Copolymers.
Biomacromolecules.
2022 03; 23(3):1433-1442. doi:
10.1021/acs.biomac.1c01661. [PMID: 35132851] - Sandip Kumar Lahiri, Somnath Chowdhury, Abhiram Hens, Kartik Chandra Ghanta. Modeling and multi-objective optimization of commercial ethylene oxide reactor to strike a delicate balance between profit and negative environmental impact.
Environmental science and pollution research international.
2022 Mar; 29(14):20035-20047. doi:
10.1007/s11356-021-12504-w. [PMID: 33521907] - Nika Marušič, Ziliang Zhao, Lado Otrin, Rumiana Dimova, Ivan Ivanov, Kai Sundmacher. Fusion-Induced Growth of Biomimetic Polymersomes: Behavior of Poly(dimethylsiloxane)-Poly(ethylene oxide) Vesicles in Saline Solutions Under High Agitation.
Macromolecular rapid communications.
2022 Mar; 43(5):e2100712. doi:
10.1002/marc.202100712. [PMID: 34820929] - Rashmi Seneviratne, Rosa Catania, Michael Rappolt, Lars J C Jeuken, Paul A Beales. Membrane mixing and dynamics in hybrid POPC/poly(1,2-butadiene-block-ethylene oxide) (PBd-b-PEO) lipid/block co-polymer giant vesicles.
Soft matter.
2022 Feb; 18(6):1294-1301. doi:
10.1039/d1sm01591e. [PMID: 35048939] - Masaki Hashiyada, Hiroaki Nakanishi, Minoru Asogawa, Atsushi Akane, Kazuyuki Saito, Hayato Miyachi, Motoki Osawa. Removal effect of DNA contamination by hydrogen peroxide plasma compared to ethylene-oxide gas.
Legal medicine (Tokyo, Japan).
2022 Feb; 54(?):102009. doi:
10.1016/j.legalmed.2021.102009. [PMID: 34979459] - Mahmood Rasool, Arif Malik, Muhammad Abdul Basit Ashraf, Rabia Mubbin, Ujala Ayyaz, Sulayman Waquar, Muhammad Asif, Muhammad Umar, Gan Siew Hua, Zafar Iqbal, Hina Alam, Niaz M Achakzai. Phytochemical analysis and protective effects of Vaccinium macrocarpon (cranberry) in rats (Rattus norvegicus) following ethylene oxide-induced oxidative insult.
Bioengineered.
2021 12; 12(1):4593-4604. doi:
10.1080/21655979.2021.1955528. [PMID: 34346287] - Thomas Bessaire, Thomas Stroheker, Bjorn Eriksen, Claudia Mujahid, Yves-Alexis Hammel, Jesus Varela, Thierry Delatour, Alexandre Panchaud, Pascal Mottier, Richard H Stadler. Analysis of ethylene oxide in ice creams manufactured with contaminated carob bean gum (E410).
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2021 Dec; 38(12):2116-2127. doi:
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Environmental science and pollution research international.
2021 Dec; 28(45):64921-64928. doi:
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Environmental science and pollution research international.
2021 Dec; 28(48):68551-68559. doi:
10.1007/s11356-021-15444-7. [PMID: 34273079] - Shima Eldurini, Bothaina M Abd El-Hady, Medhat W Shafaa, Abdul Aziz M Gad, Emad Tolba. A multicompartment vascular implant of electrospun wintergreen oil/ polycaprolactone fibers coated with poly(ethylene oxide).
Biomedical journal.
2021 10; 44(5):589-597. doi:
10.1016/j.bj.2020.04.008. [PMID: 32389823] - Alexandra Peters, Rafael Palomo, Hervé Ney, Nasim Lotfinejad, Walter Zingg, Pierre Parneix, Didier Pittet. The COVID-19 pandemic and N95 masks: reusability and decontamination methods.
Antimicrobial resistance and infection control.
2021 05; 10(1):83. doi:
10.1186/s13756-021-00921-y. [PMID: 34051855] - Max A Schumm, Joseph E Hadaya, Nisha Mody, Bethany A Myers, Melinda Maggard-Gibbons. Filtering Facepiece Respirator (N95 Respirator) Reprocessing: A Systematic Review.
JAMA.
2021 Apr; 325(13):1296-1317. doi:
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Mar; 104(?):41-44. doi:
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Langmuir : the ACS journal of surfaces and colloids.
2021 02; 37(7):2362-2375. doi:
10.1021/acs.langmuir.0c03302. [PMID: 33570419] - Adriana Cristina de Oliveira, Thabata Coaglio Lucas. Is it possible to decontaminate N95 masks in pandemic times? integrative literature review.
Revista gaucha de enfermagem.
2021; 42(spe):e20200146. doi:
10.1590/1983-1447.2021.20200146. [PMID: 33787720] - Emily E Sickbert-Bennett, James M Samet, Phillip W Clapp, Hao Chen, Jon Berntsen, Kirby L Zeman, Haiyan Tong, David J Weber, William D Bennett. Filtration Efficiency of Hospital Face Mask Alternatives Available for Use During the COVID-19 Pandemic.
JAMA internal medicine.
2020 12; 180(12):1607-1612. doi:
10.1001/jamainternmed.2020.4221. [PMID: 32780113] - Rui Ma, Yongwei Li, Jialin Wang, Pei Yang, Kunzheng Wang, Wei Wang. Incorporation of nanosized calcium silicate improved osteointegration of polyetheretherketone under diabetic conditions.
Journal of materials science. Materials in medicine.
2020 Oct; 31(11):98. doi:
10.1007/s10856-020-06435-0. [PMID: 33130931] - Jaroslav Mráz, Iveta Hanzlíková, Šárka Dušková, Monika Tvrdíková, Igor Linhart. N-(2-Hydroxyethyl)-l-valyl-l-leucine: a novel urinary biomarker of ethylene oxide exposure in humans.
Toxicology letters.
2020 Jun; 326(?):18-22. doi:
10.1016/j.toxlet.2020.03.004. [PMID: 32145395] - William A Rutala, Maria F Gergen, Emily E Sickbert-Bennett, David J Weber. Comparative evaluation of the microbicidal activity of low-temperature sterilization technologies to steam sterilization.
Infection control and hospital epidemiology.
2020 04; 41(4):391-395. doi:
10.1017/ice.2020.2. [PMID: 32098638] - Wenjia Zhang, Joseph M Metzger, Benjamin J Hackel, Frank S Bates, Timothy P Lodge. Influence of the Headgroup on the Interaction of Poly(ethylene oxide)-Poly(propylene oxide) Block Copolymers with Lipid Bilayers.
The journal of physical chemistry. B.
2020 03; 124(12):2417-2424. doi:
10.1021/acs.jpcb.0c00553. [PMID: 32175743] - Anand Kumar, Samantha B Kasloff, Anders Leung, Todd Cutts, James E Strong, Kevin Hills, Frank X Gu, Paul Chen, Gloria Vazquez-Grande, Barret Rush, Sylvain Lother, Kimberly Malo, Ryan Zarychanski, Jay Krishnan. Decontamination of N95 masks for re-use employing 7 widely available sterilization methods.
PloS one.
2020; 15(12):e0243965. doi:
10.1371/journal.pone.0243965. [PMID: 33326504] - Jaroslav Mráz, Iveta Hanzlíková, Igor Linhart, Šárka Dušková, Ludmila Dabrowská, Kamil Hejl. N-(2-Hydroxyethyl)-L-valyl-L-leucine in rat urine as a hydrolytic cleavage product of ethylene oxide adduct with globin.
Archives of toxicology.
2019 03; 93(3):603-613. doi:
10.1007/s00204-019-02388-8. [PMID: 30666356] - Kaori Funatsu, Hideaki Kiminami, Yoshihiko Abe, John F Carpenter. Impact of Ethylene Oxide Sterilization of Polymer-Based Prefilled Syringes on Chemical Degradation of a Model Therapeutic Protein During Storage.
Journal of pharmaceutical sciences.
2019 Jan; 108(1):770-774. doi:
10.1016/j.xphs.2018.09.029. [PMID: 30296419] - Adnan Hut, Dogan Yildirim, Turgut Donmez, Cihad Tatar, Semih Mirapoglu, Rukiye Nilgun Erdogan, Zumrut Mine Isık Saglam, Huseyin Kilincaslan. The Effect of Sterilization Methods of Endoscopic Instruments on the Body: A Study on Rat Model.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2018 Jun; 31(3):218-225. doi:
10.1080/08941939.2017.1315470. [PMID: 28441065] - Marat I Kamalov, Trinh Đặng, Natalia V Petrova, Alexander V Laikov, Duong Luong, Rezeda A Akhmadishina, Andrei N Lukashkin, Timur I Abdullin. Self-assembled nanoformulation of methylprednisolone succinate with carboxylated block copolymer for local glucocorticoid therapy.
Colloids and surfaces. B, Biointerfaces.
2018 Apr; 164(?):78-88. doi:
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Langmuir : the ACS journal of surfaces and colloids.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Sep; 1063(?):11-17. doi:
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Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation.
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Biomedical materials (Bristol, England).
2017 01; 12(1):015017. doi:
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PloS one.
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Contact dermatitis.
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Physiologia plantarum.
2016 Mar; 156(3):338-50. doi:
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Chemico-biological interactions.
2015 Nov; 241(?):87-93. doi:
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Journal of agricultural and food chemistry.
2015 Jul; 63(29):6588-95. doi:
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Nanomedicine : nanotechnology, biology, and medicine.
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Colloids and surfaces. B, Biointerfaces.
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Journal of oleo science.
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Langmuir : the ACS journal of surfaces and colloids.
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Biomaterials.
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Applied spectroscopy.
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International journal of pharmaceutics.
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Biomaterials.
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Analytica chimica acta.
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International journal of pharmaceutics.
2012 Oct; 436(1-2):631-5. doi:
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American journal of veterinary research.
2012 Oct; 73(10):1665-9. doi:
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Talanta.
2012 Aug; 98(?):211-9. doi:
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The Knee.
2012 Aug; 19(4):306-15. doi:
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Accounts of chemical research.
2012 Jul; 45(7):1057-66. doi:
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Clinical orthopaedics and related research.
2012 Jul; 470(7):1826-33. doi:
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Revista da Escola de Enfermagem da U S P.
2012 Jun; 46(3):597-603. doi:
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Arhiv za higijenu rada i toksikologiju.
2012 Jun; 63(2):107-15. doi:
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Bioorganic & medicinal chemistry.
2012 Apr; 20(8):2490-7. doi:
10.1016/j.bmc.2012.03.015. [PMID: 22459210] - Ishrat Jabeen, Karin Pleban, Uwe Rinner, Peter Chiba, Gerhard F Ecker. Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Journal of medicinal chemistry.
2012 Apr; 55(7):3261-73. doi:
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Carcinogenesis.
2012 Apr; 33(4):804-9. doi:
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Artificial organs.
2012 Mar; 36(3):E28-38. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2012 Feb; 158(1):165-70. doi:
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Journal of agricultural and food chemistry.
2012 Feb; 60(7):1688-94. doi:
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Artificial cells, blood substitutes, and immobilization biotechnology.
2012 Feb; 40(1-2):14-27. doi:
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Journal of materials science. Materials in medicine.
2012 Feb; 23(2):293-305. doi:
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Carcinogenesis.
2012 Jan; 33(1):101-7. doi:
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Pharmaceutical research.
2012 Jan; 29(1):285-305. doi:
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Journal of pharmacy & bioallied sciences.
2012 Jan; 4(1):2-9. doi:
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Journal of oleo science.
2012; 61(5):255-66. doi:
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Preparative biochemistry & biotechnology.
2012; 42(1):44-59. doi:
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International journal of nanomedicine.
2012; 7(?):3421-32. doi:
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International journal of nanomedicine.
2012; 7(?):61-71. doi:
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Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca.
2012; 79(3):213-21. doi:
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Macromolecular bioscience.
2011 Oct; 11(10):1378-86. doi:
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Toxins.
2011 09; 3(9):1065-88. doi:
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Hemodialysis international. International Symposium on Home Hemodialysis.
2011 Jul; 15(3):399-403. doi:
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Bioconjugate chemistry.
2011 Jun; 22(6):1239-48. doi:
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International journal of pharmaceutics.
2011 Jun; 411(1-2):1-9. doi:
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International journal of hygiene and environmental health.
2011 Jun; 214(3):196-204. doi:
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Acta biomaterialia.
2011 Jun; 7(6):2492-8. doi:
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Journal of medicinal chemistry.
2011 May; 54(9):3109-52. doi:
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Toxicology letters.
2011 May; 202(3):237-43. doi:
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Phytochemistry.
2011 May; 72(7):579-86. doi:
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ACS applied materials & interfaces.
2011 Mar; 3(3):697-704. doi:
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International journal of molecular sciences.
2011 Feb; 12(2):1371-88. doi:
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Marine drugs.
2011 Feb; 9(2):224-41. doi:
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Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
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Colloids and surfaces. B, Biointerfaces.
2011 Feb; 82(2):450-5. doi:
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German medical science : GMS e-journal.
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Journal of colloid and interface science.
2011 Jan; 353(2):380-91. doi:
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Macromolecular bioscience.
2011 Jan; 11(1):13-21. doi:
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Journal of biomedicine & biotechnology.
2011; 2011(?):196565. doi:
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Sensors (Basel, Switzerland).
2011; 11(10):9667-84. doi:
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International journal of nanomedicine.
2011; 6(?):2567-80. doi:
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Sensors (Basel, Switzerland).
2011; 11(5):5253-69. doi:
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Molecular pharmaceutics.
2010 Dec; 7(6):1959-73. doi:
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Intensive care medicine.
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Transplantation proceedings.
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