Foscarnet (BioDeep_00000006162)

 

Secondary id: BioDeep_00001867901

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


Dihydroxyphosphinecarboxylic acid oxide

化学式: CH3O5P (125.9718)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 41.08%

分子结构信息

SMILES: C(=O)(O)P(=O)(O)O
InChI: InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)

描述信息

Foscarnet is only found in individuals that have used or taken this drug. It is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV. [PubChem]Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AD - Phosphonic acid derivatives
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97453 - Non-nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent

同义名列表

32 个代谢物同义名

Dihydroxyphosphinecarboxylic acid oxide; Foscarnet manganese (2+) (2:3) salt; Foscarnet magnesium (2:3) salt; Sodium hexahydrate, foscarnet; Hexahydrate, foscarnet sodium; Tripotassium salt, foscarnet; Foscarnet calcium (2:3) salt; Foscarnet sodium hexahydrate; Foscarnet tripotassium salt; Phosphonoformate, trisodium; Foscarnet barium (2:3) salt; Trisodium phosphonoformate; Trilithium salt, foscarnet; Trisodium salt, foscarnet; Foscarnet trilithium salt; Phgosphonocarboxylic acid; Disodium salt, foscarnet; Foscarnet trisodium salt; Foscarnet disodium salt; Phosphonomethanoic acid; Carboxyphosphonic acid; Phosphonoformic acid; Phosphonomethanoate; Carboxyphosphonate; Sodium, foscarnet; Phosphonoformate; Foscarnet sodium; Foscarmet; foscarnet; Foscavir; PF; Phosphonoformate



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CD34, FGF2, MT4, MTOR, PRKX
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 2 CD4, MTOR
Nucleus 5 FGF2, MT4, MTOR, POU1F1, PRKX
cytosol 4 AVP, MTOR, POU1F1, SLC34A1
dendrite 2 AVP, MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 4 MTOR, POU1F1, PRKX, SLC34A1
Cell membrane 4 CD4, CD8A, SLC20A2, SLC34A1
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 3 SLC20A2, SLC34A1, SLC34A2
Golgi apparatus membrane 1 MTOR
cell surface 1 SLC34A1
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
Lysosome 2 CD34, MTOR
endosome 1 SLC34A1
plasma membrane 7 CD34, CD4, CD8A, IFNLR1, SLC20A2, SLC34A1, SLC34A2
Membrane 5 CD34, IFNLR1, MTOR, SLC20A2, SLC34A2
apical plasma membrane 4 CD34, SLC20A2, SLC34A1, SLC34A2
brush border 2 SLC34A1, SLC34A2
extracellular exosome 2 BMP3, SLC20A2
Lysosome membrane 1 MTOR
extracellular space 8 AVP, BMP3, CSF3, CXCL8, FGF2, IL2, IL6, PTH
lysosomal lumen 1 CSF3
perinuclear region of cytoplasm 2 CD34, SLC34A1
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 4 CD34, CD4, CD8A, IFNLR1
Secreted 7 AVP, BMP3, CSF3, CXCL8, FGF2, IL2, IL6
extracellular region 10 AVP, BMP3, CD34, CD8A, CSF3, CXCL8, FGF2, IL2, IL6, PTH
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
[Isoform 2]: Secreted 1 CD8A
external side of plasma membrane 3 CD34, CD4, CD8A
Early endosome 1 CD4
vesicle 2 SLC34A1, SLC34A2
Apical cell membrane 3 SLC20A2, SLC34A1, SLC34A2
Membrane raft 1 CD4
Nucleus, PML body 1 MTOR
PML body 1 MTOR
secretory granule 1 AVP
nuclear speck 1 SLC34A1
receptor complex 1 CD8A
chromatin 1 POU1F1
mitotic spindle 1 SLC34A1
brush border membrane 3 SLC20A2, SLC34A1, SLC34A2
intercellular bridge 1 CD34
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
basal plasma membrane 1 CD34
plasma membrane raft 1 CD8A
endoplasmic reticulum lumen 2 CD4, IL6
neuronal dense core vesicle 1 AVP
clathrin-coated endocytic vesicle membrane 2 AVP, CD4
[Isoform 1]: Cell membrane 1 CD8A
Cytoplasmic vesicle, phagosome 1 MTOR
endocytic vesicle lumen 1 CSF3
T cell receptor complex 2 CD4, CD8A
interleukin-6 receptor complex 1 IL6
glomerular endothelium fenestra 1 CD34
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Yi Zhang, Lei Fang, Yi Zhou, Yongqing Zhang, Bing Liang, Chuanzhu Yan, Ling Li. A case report of long-delayed diagnosis of pseudorabies virus encephalitis with endophthalmitis: lessons from metagenomic next generation sequencing. BMC neurology. 2023 May; 23(1):192. doi: 10.1186/s12883-023-03227-1. [PMID: 37194001]
  • Kei Irie, Nobuhiro Hiramoto, Takayuki Ishikawa, Shoji Fukushima. Use of liquid chromatography-tandem mass spectrometry for foscarnet quantification in human serum and cerebrospinal fluid. Rapid communications in mass spectrometry : RCM. 2022 Apr; 36(7):e9255. doi: 10.1002/rcm.9255. [PMID: 35001441]
  • Ryo Inose, Katsuyuki Takahashi, Masaya Takahashi, Takashi Sugimoto, Satoru Nanno, Masayuki Hino, Katsuya Nagayama. Long-term use of foscarnet is associated with an increased incidence of acute kidney injury in hematopoietic stem cell transplant patients: A retrospective observational study. Transplant infectious disease : an official journal of the Transplantation Society. 2022 Apr; 24(2):e13804. doi: 10.1111/tid.13804. [PMID: 35114030]
  • Minwen Ding, Qian Zhang, Minmin Zhang, Xinxin Jiang, Mengjing Wang, Li Ni, Wen Gong, Bihong Huang, Jing Chen. Phosphate Overload Stimulates Inflammatory Reaction via PiT-1 and Induces Vascular Calcification in Uremia. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2022 03; 32(2):178-188. doi: 10.1053/j.jrn.2021.03.008. [PMID: 34688540]
  • Elena Rho, Bettina Näf, Thomas F Müller, Rudolf P Wüthrich, Thomas Schachter, Seraina von Moos. Use of letermovir-valganciclovir combination as a step-down treatment after foscarnet for ganciclovir-resistant CMV infection in kidney transplant recipients. Clinical transplantation. 2021 11; 35(11):e14401. doi: 10.1111/ctr.14401. [PMID: 34181768]
  • Paul E Rosenstiel, Glen S Markowitz, Brigani Amante. An Unusual Cause of Kidney Allograft Dysfunction. Kidney360. 2021 07; 2(7):1207-1208. doi: 10.34067/kid.0001062021. [PMID: 35368358]
  • Walter Domingo, Isabelle T Nguyen, Joyce J Johnsrud, Janice Wes Brown. Continuous-Infusion Foscarnet Facilitates Administration in Hematopoietic Stem Cell Transplantation Patients. Transplantation and cellular therapy. 2021 07; 27(7):622.e1-622.e5. doi: 10.1016/j.jtct.2021.03.018. [PMID: 33891883]
  • Francesco Baldo, Nicolás M Suárez, Andrew J Davison, Davide Zanon, Egidio Barbi, Natalia Maximova. Post-HSCT graft failure due to refractory human cytomegalovirus successfully treated with haploidentical donor-derived immunoglobulins and stem cell graft infusion: A case report. Antiviral research. 2021 04; 188(?):105024. doi: 10.1016/j.antiviral.2021.105024. [PMID: 33577809]
  • Jerica Pleško, Damjan Kovač, Zoran Arsov, Jelka Lindič, Andrej Škoberne, Dušan Ferluga, Nika Kojc. Glomerular and tubulointerstitial foscarnet nephropathy of kidney allograft with emphasis on ultrastructural findings: A case report. Clinical nephrology. 2021 Sup; 96(1):127-132. doi: 10.5414/cnp96s23. [PMID: 34643504]
  • Gena G Foster, Michael J Grant, Samantha M Thomas, Blake Cameron, Doug Raiff, Kelly Corbet, Gavin Loitsch, Christopher Ferreri, Mitchell Horwitz. Treatment with Foscarnet after Allogeneic Hematopoietic Cell Transplant (Allo-HCT) Is Associated with Long-Term Loss of Renal Function. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2020 09; 26(9):1597-1606. doi: 10.1016/j.bbmt.2020.05.007. [PMID: 32450288]
  • Y Uwai, R Kondo, T Suzuki, T Kawasaki, T Nabekura. Potent Inhibition of Biphasic Tubular Reabsorption of Lithium by Acetazolamide and Foscarnet in Rats. Physiological research. 2020 08; 69(4):645-651. doi: 10.33549/physiolres.934285. [PMID: 32584131]
  • Ryosuke Ota, Atsushi Hirata, Keisuke Noto, Satoshi Yokoyama, Kouichi Hosomi, Mitsutaka Takada, Hiroshi Matsuoka. Relationship between serum calcium and creatinine in hematopoietic stem cell transplantation patients treated with foscarnet
. International journal of clinical pharmacology and therapeutics. 2020 May; 58(5):274-281. doi: 10.5414/cp203650. [PMID: 32101522]
  • Masaya Takahashi, Katsuyuki Takahashi, Ryo Inose, Takashi Sugimoto, Hideo Koh, Masayuki Hino, Katsuya Nagayama. Safety profile of the concomitant use of foscarnet and aerosolized pentamidine in allogeneic hematopoietic stem cell transplantation recipients. Transplant infectious disease : an official journal of the Transplantation Society. 2020 Feb; 22(1):e13239. doi: 10.1111/tid.13239. [PMID: 31883423]
  • Po Yee Mia Leung, Thomas Tran, Adam Testro, Kathy Paizis, Jason Kwong, John B Whitlam. Ganciclovir-resistant post-transplant cytomegalovirus infection due to combined deletion mutation at codons 595-596 of the UL97 gene. Transplant infectious disease : an official journal of the Transplantation Society. 2019 Dec; 21(6):e13168. doi: 10.1111/tid.13168. [PMID: 31498954]
  • Michael L Spinner, Simon W Lam, Christine E Koval, Vasilios Athans. Recommended foscarnet dose is not associated with improved outcomes in cytomegalovirus salvage therapy. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 2019 11; 120(?):12-16. doi: 10.1016/j.jcv.2019.09.001. [PMID: 31514101]
  • Y Nawashiro, K Shiraki, S Yamamoto, K Takizawa, Y Sasada, M Suehiro, K Miura, M Hattori, T Daikoku, M Hisano. Persistent Primary Cytomegalovirus Infection After Deceased Donor Kidney Transplant: Ganciclovir Susceptibility of Human Cytomegalovirus With UL97 D605E Mutation: A Case Report. Transplantation proceedings. 2018 Dec; 50(10):3932-3936. doi: 10.1016/j.transproceed.2018.09.010. [PMID: 30577289]
  • Masao Ogata, Kuniko Takano, Yukiyoshi Moriuchi, Tadakazu Kondo, Toshimitsu Ueki, Nobuaki Nakano, Takehiko Mori, Nobuhiko Uoshima, Koji Nagafuji, Satoshi Yamasaki, Yasuhiko Shibasaki, Rika Sakai, Koji Kato, Ilseung Choi, Yumi Jo, Tetsuya Eto, Shinichi Kako, Kumi Oshima, Takahiro Fukuda. Effects of Prophylactic Foscarnet on Human Herpesvirus-6 Reactivation and Encephalitis in Cord Blood Transplant Recipients: A Prospective Multicenter Trial with an Historical Control Group. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2018 06; 24(6):1264-1273. doi: 10.1016/j.bbmt.2018.02.008. [PMID: 29454651]
  • Kevin J Filipski, Matthew F Sammons, Samit K Bhattacharya, Jane Panteleev, Janice A Brown, Paula M Loria, Markus Boehm, Aaron C Smith, Andre Shavnya, Edward L Conn, Kun Song, Yan Weng, Carie Facemire, Harald Jüppner, Valerie Clerin. Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS medicinal chemistry letters. 2018 May; 9(5):440-445. doi: 10.1021/acsmedchemlett.8b00013. [PMID: 29795756]
  • M Cintra-Cabrera, A Suárez-Benjumea, G Bernal-Blanco, F M González-Roncero, N G Toapanta-Gaibor, M Súñer-Poblet, M Á Pérez-Valdivia, F Fernández-Cuenca, M Á Gentil-Govantes, J L Rocha-Castilla. Resistant Cytomegalovirus Infection After Renal Transplantation: Literature Review. Transplantation proceedings. 2018 Mar; 50(2):575-577. doi: 10.1016/j.transproceed.2017.09.058. [PMID: 29579856]
  • Toshimitsu Ueki, Kenichi Hoshi, Yuki Hiroshima, Masahiko Sumi, Naoaki Ichikawa, Masao Ogata, Takako Satou, Takahiro Fukuda, Hikaru Kobayashi. Analysis of five cases of human herpesvirus-6 myelitis among 121 cord blood transplantations. International journal of hematology. 2018 Mar; 107(3):363-372. doi: 10.1007/s12185-017-2347-5. [PMID: 29022282]
  • Yuichi Uwai, Tatsuya Kawasaki, Tomohiro Nabekura. Nonlinear disposition of lithium in rats and saturation of its tubular reabsorption by the sodium-phosphate cotransporter as a cause. Biopharmaceutics & drug disposition. 2018 Feb; 39(2):83-87. doi: 10.1002/bdd.2116. [PMID: 29214648]
  • K M Baradhi, R L Aure, J-M El-Amm. High-dose Valganciclovir Treatment for Resistant Cytomegalovirus Colitis due to UL97 and UL54 Mutations. Transplantation proceedings. 2018 Jan; 50(1):142-144. doi: 10.1016/j.transproceed.2017.11.013. [PMID: 29407298]
  • Lorraine Py Kwan, Maggie My Mok, Bo Ying Choy, Tak Mao Chan. Acute kidney injury in a renal transplant recipient due to concomitant use of vancomycin and foscarnet. Nephrology (Carlton, Vic.). 2017 10; 22(10):821-822. doi: 10.1111/nep.12947. [PMID: 28921753]
  • I A Echenique, D Beltran, L Ramirez-Ruiz, N Najafian, N Agrawal. Ganciclovir Dosing Strategies and Development of Cytomegalovirus Resistance in a Kidney Transplant Recipient: A Case Report. Transplantation proceedings. 2017 Sep; 49(7):1560-1564. doi: 10.1016/j.transproceed.2017.02.046. [PMID: 28838440]
  • J Bruminhent, P Rotjanapan, S P Watcharananan. Epidemiology and Outcome of Ganciclovir-Resistant Cytomegalovirus Infection After Solid Organ Transplantation: A Single Transplant Center Experience in Thailand. Transplantation proceedings. 2017 06; 49(5):1048-1052. doi: 10.1016/j.transproceed.2017.03.053. [PMID: 28583524]
  • Scott D Schoenberger, Stephen J Kim, Jennifer E Thorne, Prithvi Mruthyunjaya, Steven Yeh, Sophie J Bakri, Justis P Ehlers. Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology. Ophthalmology. 2017 03; 124(3):382-392. doi: 10.1016/j.ophtha.2016.11.007. [PMID: 28094044]
  • Janine Mihm, Sarah Leyking, Jan Dirks, Sigrun Smola, Danilo Fliser, Urban Sester, Martina Sester, Heinrike Wilkens, Jürgen Rissland. Immune-based guidance of foscarnet treatment duration in a transplant recipient with ganciclovir-resistant cytomegalovirus infection. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 2016 09; 82(?):5-8. doi: 10.1016/j.jcv.2016.06.013. [PMID: 27389910]
  • Qinglan Guo, Adam D Tomich, Christi L McElheny, Vaughn S Cooper, Nicole Stoesser, Minggui Wang, Nicolas Sluis-Cremer, Yohei Doi. Glutathione-S-transferase FosA6 of Klebsiella pneumoniae origin conferring fosfomycin resistance in ESBL-producing Escherichia coli. The Journal of antimicrobial chemotherapy. 2016 09; 71(9):2460-5. doi: 10.1093/jac/dkw177. [PMID: 27261267]
  • Tristan Delory, Emmanuelle Papot, Christophe Rioux, Charlotte Charpentier, Claire Auge-Courtoi, Florence Michard, Gilles Peytavin, Diane Descamps, Sophie Matheron, Yazdan Yazdanpanah. Foscarnet, zidovudine and dolutegravir combination efficacy and tolerability for late stage HIV salvage therapy: A case-series experience. Journal of medical virology. 2016 Jul; 88(7):1204-10. doi: 10.1002/jmv.24442. [PMID: 26636432]
  • Daiki Iwami, Yayoi Ogawa, Hiromi Fujita, Ken Morita, Hajime Sasaki, Yuichiro Oishi, Haruka Higuchi, Kanako Hatanaka, Nobuo Shinohara. Successful treatment with foscarnet for ganciclovir-resistant cytomegalovirus infection in a kidney transplant recipient: A case report. Nephrology (Carlton, Vic.). 2016 Jul; 21 Suppl 1(?):63-6. doi: 10.1111/nep.12767. [PMID: 26970406]
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  • Yuichi Uwai, Tatsuya Kawasaki, Tomohiro Nabekura. Foscarnet, an inhibitor of the sodium-phosphate cotransporter NaPi-IIa, inhibits phosphorylation of glycogen synthase kinase-3β by lithium in the rat kidney cortex. Drug metabolism and pharmacokinetics. 2016 Jun; 31(3):256-9. doi: 10.1016/j.dmpk.2016.02.003. [PMID: 27238574]
  • G W Kang, H L Hong, I H Lee, K S Ahn, J D Kim, D L Choi. Ganciclovir and Foscarnet Therapy of Cytomegalovirus-Associated Meningoencephalitis in a Hemodialysis Patient With Liver Transplantation: Case Report. Transplantation proceedings. 2016 May; 48(4):1208-11. doi: 10.1016/j.transproceed.2016.01.021. [PMID: 27320588]
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  • Carole Philipponnet, Pierre-Antoine Michel, Michel Daudon, Isabelle Brocheriou, Jean-Jacques Boffa. Intravascular foscarnet crystal precipitation causing multiorgan failure. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2015 Jan; 65(1):152-5. doi: 10.1053/j.ajkd.2014.07.024. [PMID: 25301103]
  • Chandrav De, Dongmei Liu, Bo Zheng, Uma S Singh, Satish Chavre, Catherine White, Robert D Arnold, Fred K Hagen, Chung K Chu, Jennifer F Moffat. β-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism. Antiviral research. 2014 Oct; 110(?):10-9. doi: 10.1016/j.antiviral.2014.07.007. [PMID: 25051026]
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