Acetylleucine (BioDeep_00000606749)

   


代谢物信息卡片


Acetyl-DL-leucine

化学式: C8H15NO3 (173.1052)
中文名称: N-乙酰-DL-亮氨酸, 乙酰亮氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)O)NC(=O)C
InChI: InChI=1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)

描述信息

N - Nervous system > N07 - Other nervous system drugs > N07C - Antivertigo preparations > N07CA - Antivertigo preparations

同义名列表

3 个代谢物同义名

Acetylleucine; Acetyl-DL-leucine; Acetylleucine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 FES, MTOR, PIK3CA, SOD1
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 1 MTOR
Nucleus 2 MTOR, SOD1
cytosol 5 FES, MTOR, PIK3CA, SLC2A1, SOD1
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 2 MTOR, SOD1
Cell membrane 1 SLC2A1
Cytoplasmic side 1 MTOR
lamellipodium 1 PIK3CA
Multi-pass membrane protein 5 CACNA1I, NPC1, SLC22A6, SLC22A8, SLC2A1
Golgi apparatus membrane 1 MTOR
Golgi apparatus 2 FES, NPC1
Golgi membrane 2 MTOR, SLC2A1
lysosomal membrane 3 EGF, MTOR, NPC1
neuronal cell body 1 SOD1
sarcolemma 1 SLC2A1
Lysosome 4 HEXB, IL4I1, MTOR, NPC1
Presynapse 1 SLC2A1
acrosomal vesicle 2 HEXB, IL4I1
plasma membrane 8 CACNA1I, EGF, FES, NPC1, PIK3CA, SLC22A6, SLC22A8, SLC2A1
Membrane 9 CACNA1I, CYB5D2, EGF, FES, HEXB, MTOR, NPC1, SLC22A6, SLC2A1
apical plasma membrane 2 SLC22A8, SLC2A1
basolateral plasma membrane 3 SLC22A6, SLC22A8, SLC2A1
caveola 2 SLC22A6, SLC2A1
extracellular exosome 7 EGF, HEXB, NPC1, SLC22A6, SLC22A8, SLC2A1, SOD1
Lysosome membrane 2 MTOR, NPC1
endoplasmic reticulum 1 NPC1
extracellular space 3 EGF, IL10, SOD1
lysosomal lumen 1 HEXB
perinuclear region of cytoplasm 2 NPC1, PIK3CA
intercalated disc 2 PIK3CA, SLC2A1
mitochondrion 1 SOD1
protein-containing complex 2 SLC22A6, SOD1
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 3 CYB5D2, IL10, IL4I1
extracellular region 7 CYB5D2, EGF, HEXB, IL10, IL4I1, NPC1, SOD1
cytoplasmic side of plasma membrane 1 FES
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
mitochondrial matrix 1 SOD1
photoreceptor inner segment 1 SLC2A1
Z disc 1 SLC2A1
cytoplasmic vesicle 2 FES, SOD1
microtubule cytoskeleton 1 FES
axon cytoplasm 1 SOD1
midbody 1 SLC2A1
Membrane raft 1 NPC1
Cytoplasm, cytoskeleton 1 FES
focal adhesion 1 FES
Peroxisome 1 SOD1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
mitochondrial intermembrane space 1 SOD1
lateral plasma membrane 1 SLC22A8
dendrite cytoplasm 1 SOD1
Late endosome membrane 1 NPC1
cytoskeleton 1 FES
Cytoplasmic vesicle, secretory vesicle, acrosome 1 IL4I1
blood microparticle 1 SLC2A1
sperm midpiece 1 IL4I1
Basolateral cell membrane 2 SLC22A6, SLC22A8
nuclear envelope 2 MTOR, NPC1
Endomembrane system 3 CYB5D2, MTOR, NPC1
female germ cell nucleus 1 SLC2A1
Melanosome 1 SLC2A1
basal plasma membrane 1 SLC22A6
azurophil granule 1 HEXB
cortical actin cytoskeleton 1 SLC2A1
platelet alpha granule lumen 1 EGF
voltage-gated calcium channel complex 1 CACNA1I
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule lumen 1 HEXB
immunological synapse 1 IL4I1
clathrin-coated endocytic vesicle membrane 1 EGF
Basal cell membrane 1 SLC22A6
female pronucleus 1 SLC2A1
Cytoplasmic vesicle, phagosome 1 MTOR
beta-N-acetylhexosaminidase complex 1 HEXB
Cytoplasmic vesicle, secretory vesicle, Cortical granule 1 HEXB
cortical granule 1 HEXB
glucose transporter complex 1 SLC2A1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Grant C Churchill, Michael Strupp, Antony Galione, Frances M Platt. Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance. PloS one. 2020; 15(2):e0229585. doi: 10.1371/journal.pone.0229585. [PMID: 32108176]
  • Hasene Keskin Çavdar, Derya Koçak Yanık, Fahrettin Göğüş, Sibel Fadıloğlu. A Novel Modified Lipid: Enzymatic Esterification of 2-Monoacylglycerol with N-acetyl-l-leucine. Journal of food science. 2018 Mar; 83(3):597-604. doi: 10.1111/1750-3841.14070. [PMID: 29437236]
  • Anthony J Lee, David W A Beno, Xiaolin Zhang, Robin Shapiro, Mark Mason, Tanita Mason-Bright, Bruce Surber, Neilé K Edens. A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite. Amino acids. 2015 May; 47(5):917-24. doi: 10.1007/s00726-015-1920-6. [PMID: 25618754]
  • T Gopinath, Nathaniel J Traaseth, Kaustubh Mote, Gianluigi Veglia. Sensitivity enhanced heteronuclear correlation spectroscopy in multidimensional solid-state NMR of oriented systems via chemical shift coherences. Journal of the American Chemical Society. 2010 Apr; 132(15):5357-63. doi: 10.1021/ja905991s. [PMID: 20345172]
  • T Gopinath, Gianluigi Veglia. Sensitivity enhancement in static solid-state NMR experiments via single- and multiple-quantum dipolar coherences. Journal of the American Chemical Society. 2009 Apr; 131(16):5754-6. doi: 10.1021/ja900096d. [PMID: 19351170]
  • D H Jones, S J Opella. Application of Maximum Entropy reconstruction to PISEMA spectra. Journal of magnetic resonance (San Diego, Calif. : 1997). 2006 Mar; 179(1):105-13. doi: 10.1016/j.jmr.2005.11.014. [PMID: 16343957]