Cinnavalininate (BioDeep_00000005893)

 

Secondary id: BioDeep_00001868701

human metabolite Endogenous natural product


代谢物信息卡片


2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid

化学式: C14H8N2O6 (300.0382348)
中文名称: 朱砂精酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.78%

分子结构信息

SMILES: C1=CC(=C2C(=C1)OC3=CC(=O)C(=C(C3=N2)C(=O)O)N)C(=O)O
InChI: InChI=1S/C14H8N2O6/c15-10-6(17)4-8-12(9(10)14(20)21)16-11-5(13(18)19)2-1-3-7(11)22-8/h1-4H,15H2,(H,18,19)(H,20,21)

描述信息

Cinnavalininate is an intermediate in the tryptophan metabolic pathway [Kegg: C05640]. It is generated from 3-hydroxyanthranilate via the enzyme catalase (EC:1.11.1.6). [HMDB]
Cinnavalininate is an intermediate in the tryptophan metabolic pathway [Kegg: C05640]. It is generated from 3-hydroxyanthranilate via the enzyme catalase (EC:1.11.1.6).
Cinnabarinic acid is a specific orthosteric agonist of mGlu4 by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis[1].

同义名列表

8 个代谢物同义名

2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid; 2-amino-3-oxo-3H-Phenoxazin-1,9-dicarboxylic acid; 2-amino-3H-Phenoxazin-one-1,9-dicarboxylic acid; Cinnavalininic acid; Cinnabarinic acid; Cinnavalininate; Cinnabarinate; Cinnavalininate



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

8 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(5)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shanshan Hu, Changhua Hu, Liyong Luo, Haotian Zhang, Sibo Zhao, Zhonghua Liu, Liang Zeng. Pu-erh tea increases the metabolite Cinnabarinic acid to improve circadian rhythm disorder-induced obesity. Food chemistry. 2022 Nov; 394(?):133500. doi: 10.1016/j.foodchem.2022.133500. [PMID: 35749873]
  • Nikhil Y Patil, Iulia Rus, Emma Downing, Ashok Mandala, Jacob E Friedman, Aditya D Joshi. Cinnabarinic Acid Provides Hepatoprotection Against Nonalcoholic Fatty Liver Disease. The Journal of pharmacology and experimental therapeutics. 2022 10; 383(1):32-43. doi: 10.1124/jpet.122.001301. [PMID: 35933113]
  • Merilin Kakoti, Samim Dullah, Dibya Jyoti Hazarika, Madhumita Barooah, Robin Chandra Boro. Cinnabarinic acid from Trametes coccinea fruiting bodies exhibits antibacterial activity through inhibiting the biofilm formation. Archives of microbiology. 2022 Feb; 204(3):173. doi: 10.1007/s00203-022-02782-4. [PMID: 35165789]
  • Daniel A Dias, Sylvia Urban. HPLC and NMR studies of phenoxazone alkaloids from Pycnoporus cinnabarinus. Natural product communications. 2009 Apr; 4(4):489-98. doi: . [PMID: 19475991]
  • Y Nagamura, K Uesugi, J Naito, I Ishiguro. Cinnabarinic acid was formed in damaged mitochondria and its effect on mitochondrial respiration. Advances in experimental medicine and biology. 1999; 467(?):419-23. doi: 10.1007/978-1-4615-4709-9_53. [PMID: 10721084]