D-myo-Inositol 1,3,4,6-tetrakisphosphate (BioDeep_00000005535)
Secondary id: BioDeep_00001870058
human metabolite Endogenous
代谢物信息卡片
化学式: C6H16O18P4 (499.9287)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(otcml) 38.89%
分子结构信息
SMILES: C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)O)OP(=O)(O)O)OP(=O)(O)O)O
InChI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)5(23-27(15,16)17)2(8)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4+,5-,6+
描述信息
D-myo-Inositol 1,3,4,6-tetrakisphosphate, also known as Ins(1,3,4,6)P4, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. D-myo-Inositol 1,3,4,6-tetrakisphosphate is an extremely strong acidic compound (based on its pKa). D-myo-Inositol 1,3,4,6-tetrakisphosphate participates in a number of enzymatic reactions. In particular, D-myo-inositol 1,3,4,6-tetrakisphosphate can be converted into D-myo-inositol 1,3,4,5,6-pentakisphosphate through the action of the enzyme inositol polyphosphate multikinase. In addition, D-myo-inositol 1,3,4,6-tetrakisphosphate can be biosynthesized from inositol 1,3,4-trisphosphate; which is mediated by the enzyme inositol-tetrakisphosphate 1-kinase. In humans, D-myo-inositol 1,3,4,6-tetrakisphosphate is involved in inositol phosphate metabolism and is a substrate for the tyrosine-protein kinase BTK.
1D-Myo-inositol 1,3,4,6-tetrakisphosphate is a substrate for Tyrosine-protein kinase BTK and Inositol polyphosphate multikinase. [HMDB]
同义名列表
24 个代谢物同义名
{[(1R,2s,3S,4S,5r,6R)-2,5-dihydroxy-3,4,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid; [(1R,2s,3S,4S,5r,6R)-2,5-dihydroxy-3,4,6-tris(phosphonooxy)cyclohexyl]oxyphosphonic acid; D-Myo-inositol-1,3,4,5-tetrakisphosphate octapotassium salt; D-Myo-inositol 1,3,4,5-tetrakis-*phosphate potass; 1D-Myo-inositol 1,3,4,6-tetrakisphosphoric acid; D-Myo-inositol 1,3,4,6-tetrakisphosphoric acid; Myo-inositol-1,3,4,6-tetrakisphosphoric acid; D-myo-Inositol (1,3,4,6)-tetrakisphosphate; 1D-Myo-inositol 1,3,4,6-tetrakisphosphate; Inositol-1,3,4,6-tetrakisphosphoric acid; Inositol 1,3,4,6-tetrakisphosphoric acid; D-myo-Inositol 1,3,4,6-tetrakisphosphate; Myo-inositol-1,3,4,6-tetrakisphosphate; Myo-inositol 1,3,4,6-tetrakisphosphate; D-Myo-inositol 1,3,4,6-tetraphosphate; Inositol-1,3,4,6-tetraphosphoric acid; Inositol 1,3,4,6-tetrakis(phosphate); Inositol 1,3,4,6-tetrakisphosphate; Inositol-1,3,4,6-tetrakisphosphate; Inositol 1,3,4,6-tetraphosphate; Inositol-1,3,4,6-tetraphosphate; Ins-1,3,4,6-P4; Ins(1,3,4,6)P4; ACMC-20md6o
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:16155
- KEGG: C04477
- PubChem: 121969
- PubChem: 477
- HMDB: HMDB0001187
- Metlin: METLIN63283
- DrugBank: DB04300
- MetaCyc: CPD-505
- foodb: FDB022475
- chemspider: 17216082
- CAS: 110298-84-5
- PMhub: MS000018359
- PubChem: 7097
- PDB-CCD: I4P
- 3DMET: B01746
- NIKKAJI: J488.540F
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
18 个相关的代谢反应过程信息。
Reactome(18)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Inositol phosphate metabolism:
ATP + I(3,4,5,6)P4 ⟶ ADP + I(1,3,4,5,6)P5 - Synthesis of IP3 and IP4 in the cytosol:
ATP + I(1,3,4)P3 ⟶ ADP + I(1,3,4,5)P4 - Hemostasis:
2AG + H2O ⟶ AA + Glycerol + H+ - Factors involved in megakaryocyte development and platelet production:
ATP + I(3,4,5,6)P4 ⟶ ADP + I(1,3,4,5,6)P5 - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Inositol phosphate metabolism:
ATP + I(1,3,4)P3 ⟶ ADP + I(1,3,4,5)P4 - Synthesis of IP3 and IP4 in the cytosol:
ATP + I(1,3,4)P3 ⟶ ADP + I(1,3,4,5)P4 - Hemostasis:
2AG + H2O ⟶ AA + Glycerol + H+ - Factors involved in megakaryocyte development and platelet production:
ATP + I(3,4,5,6)P4 ⟶ ADP + I(1,3,4,5,6)P5 - Hemostasis:
AMP + GTP ⟶ ADP + GDP - Factors involved in megakaryocyte development and platelet production:
AMP + GTP ⟶ ADP + GDP - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Inositol phosphate metabolism:
H2O + I4P ⟶ Ins + Pi - Synthesis of IP3 and IP4 in the cytosol:
ATP + I(1,4,5)P3 ⟶ ADP + I(1,3,4,5)P4 - Synthesis of IPs in the nucleus:
ATP + I(1,4,5)P3 ⟶ ADP + I(1,3,4,5)P4 - Synthesis of IPs in the nucleus:
ATP + I(1,4,5)P3 ⟶ ADP + I(1,3,4,5)P4 - Synthesis of IPs in the nucleus:
ATP + I(1,4,5)P3 ⟶ ADP + I(1,3,4,5)P4
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- T Balla, G Guillemette, A J Baukal, K J Catt. Formation of inositol 1,3,4,6-tetrakisphosphate during angiotensin II action in bovine adrenal glomerulosa cells.
Biochemical and biophysical research communications.
1987 Oct; 148(1):199-205. doi:
10.1016/0006-291x(87)91095-3. [PMID: 3675574] - S B Shears, J B Parry, E K Tang, R F Irvine, R H Michell, C J Kirk. Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.
The Biochemical journal.
1987 Aug; 246(1):139-47. doi:
10.1042/bj2460139. [PMID: 2823793]
