6,7-Dimethyl-8-(1-D-ribityl)lumazine (BioDeep_00000005485)

 

Secondary id: BioDeep_00001869239

human metabolite Endogenous Volatile Flavor Compounds


代谢物信息卡片


2,4(1H,3H)-Pteridinedione, 6,7-dimethyl-8-(2,3,4,5-tetrahydroxypentyl)-, [2S-(2R*,3R*,4S*)]-

化学式: C13H18N4O6 (326.12262880000003)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.13%

分子结构信息

SMILES: CC1=C(C)N(C[C@H](O)[C@H](O)[C@H](O)CO)C2=NC(=O)NC(=O)C2=N1
InChI: InChI=1S/C13H18N4O6/c1-5-6(2)17(3-7(19)10(21)8(20)4-18)11-9(14-5)12(22)16-13(23)15-11/h7-8,10,18-21H,3-4H2,1-2H3,(H,16,22,23)/t7-,8+,10-/m0/s1

描述信息

6,7-Dimethyl-8-(1-D-ribityl)lumazine belongs to the class of organic compounds known as pteridines and derivatives. These are polycyclic aromatic compounds containing a pteridine moiety, which consists of a pyrimidine fused to a pyrazine ring to form pyrimido(4,5-b)pyrazine. 6,7-Dimethyl-8-(1-D-ribityl)lumazine is an extremely weak basic (essentially neutral) compound (based on its pKa). 6,7-Dimethyl-8-(1-D-ribityl)lumazine exists in all living organisms, ranging from bacteria to humans. In humans, 6,7-dimethyl-8-(1-D-ribityl)lumazine is involved in riboflavin metabolism. Outside of the human body, 6,7-dimethyl-8-(1-D-ribityl)lumazine has been detected, but not quantified in, several different foods, such as quinoa, arrowhead, conchs, watermelons, and Elliotts blueberries. This could make 6,7-dimethyl-8-(1-D-ribityl)lumazine a potential biomarker for the consumption of these foods. 6,7-Dimethyl-8-(1-D-ribityl)lumazine is an intermediate in riboflavin metabolism. 6,7-Dimethyl-8-(1-D-ribityl)lumazine is the second to last step in the synthesis of ribitol and is converted from 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine via the enzyme riboflavin synthase beta chain. It is then converted into riboflavin via the enzyme riboflavin synthase alpha chain (EC 2.5.1.9).
6,7-Dimethyl-8-(1-D-ribityl)lumazine is an intermediate in riboflavin metabolism. 6,7-Dimethyl-8-(1-D-ribityl)lumazine is the second to last step in the synthesis of ribitol and is converted from 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine via the enzyme riboflavin synthase beta chain. It is then

同义名列表

16 个代谢物同义名

2,4(1H,3H)-Pteridinedione, 6,7-dimethyl-8-(2,3,4,5-tetrahydroxypentyl)-, [2S-(2R*,3R*,4S*)]-; 6,7-dimethyl-8-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]-2,3,4,8-tetrahydropteridine-2,4-dione; 1-Deoxy-1-(3,4-dihydro-6,7-dimethyl-2,4-dioxo-8(2H)-pteridinyl)-D-ribitol; 6,7-Dimethyl-8-ribityllumazine, 14C-labeled; 6,7-Dimethyl-8-ribityllumazine, (D)-isomer; 6,7-Dimethyl-8-(1’-D-ribityl)lumazine; 6,7-Dimethyl-8-(1-D-ribityl)lumazine; 6,7-Dimethyl-8-(D-ribityl)lumazine; 6,7-Dimethyl-8-D-ribityllumazine; 6,7-Dimethyl-8-ribityllumazine; 6,7-Dimethylribityllumazine; 6,7-Dimethylribolumazine; SCHEMBL16812918; RL-6,7-DiMe; DMDRL; 6,7-Dimethyl-8-(D-ribityl)lumazine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

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BioCyc(0)

PlantCyc(0)

代谢反应

232 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(1)

Plant Reactome(222)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(8)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Lars Kjer-Nielsen, Onisha Patel, Alexandra J Corbett, Jérôme Le Nours, Bronwyn Meehan, Ligong Liu, Mugdha Bhati, Zhenjun Chen, Lyudmila Kostenko, Rangsima Reantragoon, Nicholas A Williamson, Anthony W Purcell, Nadine L Dudek, Malcolm J McConville, Richard A J O'Hair, George N Khairallah, Dale I Godfrey, David P Fairlie, Jamie Rossjohn, James McCluskey. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature. 2012 Nov; 491(7426):717-23. doi: 10.1038/nature11605. [PMID: 23051753]
  • Sebastián Klinke, Vanesa Zylberman, Hernán R Bonomi, Ilka Haase, Beatriz G Guimarães, Bradford C Braden, Adelbert Bacher, Markus Fischer, Fernando A Goldbaum. Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales. Journal of molecular biology. 2007 Oct; 373(3):664-80. doi: 10.1016/j.jmb.2007.08.021. [PMID: 17854827]
  • Patricia Puig, F W Alexander Tempels, Francesc Borrull, Marta Calull, Carme Aguilar, Govert W Somsen, Gerhardus J de Jong. On-line coupling of solid-phase extraction and capillary electrophoresis for the determination of cefoperazone and ceftiofur in plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Sep; 856(1-2):365-70. doi: 10.1016/j.jchromb.2007.05.030. [PMID: 17572160]
  • Markus Fischer, Ilka Haase, Richard Feicht, Nicholas Schramek, Peter Köhler, Peter Schieberle, Adelbert Bacher. Evolution of vitamin B2 biosynthesis: riboflavin synthase of Arabidopsis thaliana and its inhibition by riboflavin. Biological chemistry. 2005 May; 386(5):417-28. doi: 10.1515/bc.2005.050. [PMID: 15927885]
  • H MITSUDA, Y SUZUKI, F KAWAI. BIOGENESIS OF RIBOFLAVIN IN GREEN LEAVES. V. ABSENCE OF THE EFFECT OF CYSTEINE AND ASCORBIC ACID ON THE ENZYMATIC CONVERSION OF 6,7-DIMETHYL-8-RIBITYLLUMAZINE TO RIBOFLAVIN UNDER ANAEROBIC CONDITION. The Journal of vitaminology. 1963 Jun; 9(?):121-4. doi: ". [PMID: 14066698]