Testolactone (BioDeep_00000004865)

 

Secondary id: BioDeep_00000410542, BioDeep_00000637509

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydro-2H-naphtho[2,1-f]chromene-2,8(4bH)-dione

化学式: C19H24O3 (300.1725)
中文名称: 睾内酯, 睾丸内酯
谱图信息: 最多检出来源 Homo sapiens(urine) 30.43%

分子结构信息

SMILES: CC12CCC3C(C1CCC(=O)O2)CCC4=CC(=O)C=CC34C
InChI: InChI=1S/C19H24O3/c1-18-9-7-13(20)11-12(18)3-4-14-15(18)8-10-19(2)16(14)5-6-17(21)22-19/h7,9,11,14-16H,3-6,8,10H2,1-2H3/t14-,15+,16+,18+,19+/m1/s1

描述信息

Testolactone is only found in individuals that have used or taken this drug. It is an antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer. [PubChem]Although the precise mechanism by which testolactone produces its clinical antineoplastic effects has not been established, its principal action is reported to be inhibition of steroid aromatase activity and consequent reduction in estrone synthesis from adrenal androstenedione, the major source of estrogen in postmenopausal women. Based on in vitro studies, the aromatase inhibition may be noncompetitive and irreversible. This phenomenon may account for the persistence of testolactones effect on estrogen synthesis after drug withdrawal.
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D000970 - Antineoplastic Agents

同义名列表

27 个代谢物同义名

(4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydro-2H-naphtho[2,1-f]chromene-2,8(4bH)-dione; (1R,2S,7S,10S,11R)-7,11-dimethyl-6-oxatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-12,15-diene-5,14-dione; 13-hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid delta-lactone; 13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid Δ-lactone; 13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oate delta-lactone; 13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oate Δ-lactone; 3-oxo-13,17-secoandrosta-1,4-dieno-17,13alpha-lactone; D-homo-17a-oxaandrosta-1,4-diene-3,17-dione; delta1-Dehydrotestololactone; 1,2-didehydrotestololactone; 1,2-Dehydrotestololactone; Δ1-Dehydrotestololactone; Delta(1)-testololactone; 1-dehydrotestololactone; 1-Dehydrotestolactone; delta(1)-Testolactone; 1 Dehydrotestolactone; delta1-Testololactone; delta1-Testolactone; Δ(1)-testololactone; Δ1-Testololactone; Δ1-Testolactone; Testolactone; D-homo; Teslac; Testolactone; Testolactone



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, AR, CAT, DLK1, ESR1, LPO, OAZ1, PGR, TRPC6
Peripheral membrane protein 2 ESR1, LPL
Endoplasmic reticulum membrane 1 CYP19A1
Nucleus 5 ALB, AR, ESR1, OAZ1, PGR
cytosol 8 ALB, AR, CAT, ESR1, LIPE, OAZ1, PGR, PRKCQ
centrosome 1 ALB
nucleoplasm 3 AR, ESR1, PGR
Cell membrane 5 ESR1, LHCGR, LIPE, LPL, TRPC6
Cytoplasmic side 1 ESR1
Multi-pass membrane protein 3 CYP19A1, LHCGR, TRPC6
cell surface 1 LPL
Golgi apparatus 2 ALB, ESR1
Golgi membrane 1 INS
Cytoplasm, cytosol 1 LIPE
endosome 1 LHCGR
plasma membrane 8 AR, ESR1, KNG1, LHCGR, LPL, PGR, PRKCQ, TRPC6
Membrane 7 AR, CAT, CYP19A1, DLK1, ESR1, LIPE, TRPC6
basolateral plasma membrane 1 LPO
caveola 1 LIPE
extracellular exosome 5 ALB, CAT, KNG1, LPO, SHBG
endoplasmic reticulum 2 ALB, CYP19A1
extracellular space 9 ALB, DLK1, GNRH1, INS, KNG1, LHCGR, LPA, LPL, LPO
mitochondrion 1 CAT
protein-containing complex 4 ALB, AR, CAT, ESR1
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 CYP19A1
Secreted 6 ALB, CGB5, INS, LPL, LPO, SHBG
extracellular region 10 ALB, CAT, CGB5, GNRH1, INS, KNG1, LPA, LPL, LPO, SHBG
Single-pass membrane protein 1 DLK1
mitochondrial outer membrane 1 PGR
mitochondrial matrix 1 CAT
Extracellular side 1 LPL
anchoring junction 1 ALB
transcription regulator complex 1 ESR1
centriolar satellite 2 LHCGR, PRKCQ
Secreted, extracellular space, extracellular matrix 1 LPL
chylomicron 1 LPL
very-low-density lipoprotein particle 1 LPL
slit diaphragm 1 TRPC6
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 KNG1
nuclear speck 1 AR
receptor complex 1 LHCGR
ciliary basal body 1 ALB
chromatin 3 AR, ESR1, PGR
centriole 1 ALB
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
blood microparticle 2 ALB, KNG1
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
euchromatin 1 ESR1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, INS, KNG1
platelet alpha granule lumen 2 ALB, KNG1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
[Isoform 1]: Nucleus 1 ESR1
catalase complex 1 CAT
catalytic complex 1 LPL
[Isoform 4]: Mitochondrion outer membrane 1 PGR
plasma lipoprotein particle 1 LPA
cation channel complex 1 TRPC6
ciliary transition fiber 1 ALB


文献列表

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  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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