Benzene oxide (BioDeep_00000004754)
Secondary id: BioDeep_00001868666
human metabolite blood metabolite
代谢物信息卡片
7-oxabicyclo[4.1.0]hepta-2,4-diene
化学式: C6H6O (94.0418626)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 23.26%
分子结构信息
SMILES: C1=CC2C(O2)C=C1
InChI: InChI=1S/C6H6O/c1-2-4-6-5(3-1)7-6/h1-6H
描述信息
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:2817
- KEGG: C01782
- PubChem: 104944
- HMDB: HMDB0248977
- Metlin: METLIN65651
- ChEMBL: CHEMBL297630
- chemspider: 94703
- CAS: 1488-25-1
- PMhub: MS000017343
- PubChem: 4912
- NIKKAJI: J59.393A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hasmik Grigoryan, William M B Edmands, Qing Lan, Henrik Carlsson, Roel Vermeulen, Luoping Zhang, Song-Nian Yin, Gui-Lan Li, Martyn T Smith, Nathaniel Rothman, Stephen M Rappaport. Adductomic signatures of benzene exposure provide insights into cancer induction.
Carcinogenesis.
2018 05; 39(5):661-668. doi:
10.1093/carcin/bgy042. [PMID: 29538615] - Adam T Zarth, Sharon E Murphy, Stephen S Hecht. Benzene oxide is a substrate for glutathione S-transferases.
Chemico-biological interactions.
2015 Dec; 242(?):390-5. doi:
10.1016/j.cbi.2015.11.005. [PMID: 26554337] - Giovanna Spatari, Salvatore Saitta, Francesco Cimino, Daniela Sapienza, Paolina Quattrocchi, Mariella Carrieri, Mario Barbaro, Antonella Saija, Sebastiano Gangemi. Increased serum levels of advanced oxidation protein products and glycation end products in subjects exposed to low-dose benzene.
International journal of hygiene and environmental health.
2012 Apr; 215(3):389-92. doi:
10.1016/j.ijheh.2011.11.001. [PMID: 22153878] - Yu-Sheng Lin, Roel Vermeulen, Chin H Tsai, Suramya Waidyanatha, Qing Lan, Nathaniel Rothman, Martyn T Smith, Luoping Zhang, Min Shen, Guilan Li, Songnian Yin, Sungkyoon Kim, Stephen M Rappaport. Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers.
Environmental health perspectives.
2007 Jan; 115(1):28-34. doi:
10.1289/ehp.8948. [PMID: 17366815] - Suramya Waidyanatha, Stephen M Rappaport. Investigation of cysteinyl protein adducts of benzene diolepoxide.
Chemico-biological interactions.
2005 May; 153-154(?):261-6. doi:
10.1016/j.cbi.2005.03.033. [PMID: 15935825] - Stephen M Rappaport, Suramya Waidyanatha, Karen Yeowell-O'Connell, Nathaniel Rothman, Martyn T Smith, Luoping Zhang, Qingshan Qu, Roy Shore, Guilan Li, Songnian Yin. Protein adducts as biomarkers of human benzene metabolism.
Chemico-biological interactions.
2005 May; 153-154(?):103-9. doi:
10.1016/j.cbi.2005.03.014. [PMID: 15935805] - Peter B Farmer, Balvinder Kaur, Jonathan Roach, Len Levy, Dario Consonni, Pietro A Bertazzi, Angela Pesatori, Silvia Fustinoni, Marina Buratti, Matteo Bonzini, Antonio Colombi, Todor Popov, Domenico Cavallo, Arianna Desideri, Federico Valerio, Mauro Pala, Claudia Bolognesi, Franco Merlo. The use of S-phenylmercapturic acid as a biomarker in molecular epidemiology studies of benzene.
Chemico-biological interactions.
2005 May; 153-154(?):97-102. doi:
10.1016/j.cbi.2005.03.013. [PMID: 15935804] - S V S Rana, Yeshvandra Verma. Biochemical toxicity of benzene.
Journal of environmental biology.
2005 Apr; 26(2):157-68. doi:
. [PMID: 16161967] - Qingshan Qu, Roy Shore, Guilan Li, Ximei Jin, Lung Chi Chen, Beverly Cohen, Assieh A Melikian, David Eastmond, Stephen Rappaport, Heyi Li, Doppalapudi Rupa, Suramya Waidyanatha, Songnian Yin, Huifang Yan, Min Meng, Witold Winnik, Eric S C Kwok, Yuying Li, Ruidong Mu, Bohong Xu, Xiaoling Zhang, Keqi Li. Validation and evaluation of biomarkers in workers exposed to benzene in China.
Research report (Health Effects Institute).
2003 Jun; ?(115):1-72; discussion 73. doi:
. [PMID: 12931845] - M T Smith, N Rothman. Biomarkers in the molecular epidemiology of benzene-exposed workers.
Journal of toxicology and environmental health. Part A.
2000 Nov; 61(5-6):439-45. doi:
10.1080/00984100050166460. [PMID: 11086950] - S M Rappaport, K Yeowell-O'Connell. Protein adducts as dosimeters of human exposure to styrene, styrene-7,8-oxide, and benzene.
Toxicology letters.
1999 Sep; 108(2-3):117-26. doi:
10.1016/s0378-4274(99)00080-6. [PMID: 10511253] - A B Lindstrom, K Yeowell-O'Connell, S Waidyanatha, T A McDonald, S M Rappaport. Investigation of benzene oxide in bone marrow and other tissues of F344 rats following metabolism of benzene in vitro and in vivo.
Chemico-biological interactions.
1999 Aug; 122(1):41-58. doi:
10.1016/s0009-2797(99)00104-0. [PMID: 10475614] - S Waidyanatha, K Yeowell-O'Connell, S M Rappaport. A new assay for albumin and hemoglobin adducts of 1,2- and 1,4-benzoquinones.
Chemico-biological interactions.
1998 Sep; 115(2):117-39. doi:
10.1016/s0009-2797(98)00067-2. [PMID: 9826945] - K Yeowell-O'Connell, N Rothman, M T Smith, R B Hayes, G Li, S Waidyanatha, M Dosemeci, L Zhang, S Yin, N Titenko-Holland, S M Rappaport. Hemoglobin and albumin adducts of benzene oxide among workers exposed to high levels of benzene.
Carcinogenesis.
1998 Sep; 19(9):1565-71. doi:
10.1093/carcin/19.9.1565. [PMID: 9771926] - A B Lindstrom, K Yeowell-O'Connell, S Waidyanatha, T A McDonald, B T Golding, S M Rappaport. Formation of hemoglobin and albumin adducts of benzene oxide in mouse, rat, and human blood.
Chemical research in toxicology.
1998 Apr; 11(4):302-10. doi:
10.1021/tx9701788. [PMID: 9548800] - F Oesch, P Bentley, K L Platt, M D Golan. Enzymic hydration of benzene oxide: assay and properties.
Archives of biochemistry and biophysics.
1980 Feb; 199(2):538-44. doi:
10.1016/0003-9861(80)90311-2. [PMID: 7362242]