AMASTATIN (BioDeep_00000004711)
代谢物信息卡片
CHEMBL27693
化学式: C21H38N4O8 (474.26895079999997)
中文名称: N-[(2S,3R)-3-氨基-2-羟基-5-甲基-1-氧代己基]-L-缬氨酰-L-缬氨酰-L-天冬氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(CC(=O)O)C(=O)O)O)N
InChI: InChI=1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
同义名列表
3 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:2624
- KEGG: C01552
- PubChem: 439518
- Metlin: METLIN65611
- ChEMBL: CHEMBL28650
- CAS: 67655-94-1
- CAS: 67655-94-1 69400-55-
- PMhub: MS000017274
- PubChem: 4710
- KNApSAcK: C00018188
- CAS: 69400-55-1
- NIKKAJI: J18.575B
- NIKKAJI: J93.423B
- RefMet: Amastatin
- KNApSAcK: 2624
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 1883 - Streptomyces: 10.7164/ANTIBIOTICS.31.636
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kensuke Arakawa, Jennifer M S Koh, Ben Crossett, Allan M Torres, Philip W Kuchel. Detection of platypus-type L/D-peptide isomerase activity in aqueous extracts of papaya fruit.
Biotechnology letters.
2012 Sep; 34(9):1659-65. doi:
10.1007/s10529-012-0941-4. [PMID: 22648682] - Eva Szafranski-Schneider, Marc Swidergall, Fabien Cottier, Denis Tielker, Elvira Román, Jesus Pla, Joachim F Ernst. Msb2 shedding protects Candida albicans against antimicrobial peptides.
PLoS pathogens.
2012 Feb; 8(2):e1002501. doi:
10.1371/journal.ppat.1002501. [PMID: 22319443] - Matthew Hoffmann, Gondi Kumar, Peter Schafer, Dorota Cedzik, Lori Capone, Kei-Lai Fong, Zheming Gu, Dennis Heller, Hao Feng, Sekhar Surapaneni, Oscar Laskin, Anfan Wu. Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration.
Xenobiotica; the fate of foreign compounds in biological systems.
2011 Dec; 41(12):1063-75. doi:
10.3109/00498254.2011.604745. [PMID: 21859393] - Wanda Nowak, Ezequiel Dario Goldschmidt, Alejandra Georgina Falcioni, Mariana Ines Pugliese, Andrea Emilse Errasti, Facundo German Pelorosso, Federico Manuel Daray, Juan Ezequiel Gago, Rodolfo Pedro Rothlin. Functional evidence of des-Arg10-kallidin enzymatic inactivating pathway in isolated human umbilical vein.
Naunyn-Schmiedeberg's archives of pharmacology.
2007 May; 375(3):221-9. doi:
10.1007/s00210-007-0145-y. [PMID: 17372720] - Joachim F Schindler. Aminopeptidases function as endocytic receptors in the trophotaenial placenta of the goodeid fish, Ameca splendens (Teleostei: Atheriniformes).
Journal of experimental zoology. Part A, Comparative experimental biology.
2003 Oct; 299(2):213-22. doi:
10.1002/jez.a.10282. [PMID: 12975809] - M Bramucci, A Miano, L Quassinti, E Maccari, O Murri, D Amici. Degradation of thymic humoral factor gamma2 by human plasma: involvement of angiotensin converting enzyme.
Regulatory peptides.
2003 Mar; 111(1-3):199-205. doi:
10.1016/s0167-0115(02)00284-7. [PMID: 12609769] - Hye J Lee, Gordon L Amidon. The effect of enzyme inhibitor and absorption site following [D-ala2, D-leu5]enkephalin oral administration in rats.
Biopharmaceutics & drug disposition.
2002 May; 23(4):131-41. doi:
10.1002/bdd.302. [PMID: 12015787] - E P Masler, E S Kovaleva, S Sardanelli. Aminopeptidase-like activities in Caenorhabditis elegans and the soybean cyst nematode, Heterodera glycines.
Journal of helminthology.
2001 Sep; 75(3):267-72. doi:
". [PMID: 11551317] - Y Matsuda, M Katayama, I Hara, H Sato, H Tomomasa, T Iizumi, T Umeda, H Ishikawa. Inhibitors on an elastase-like enzyme activity catalyzing Suc-Ala-Ala-Pro-Leu-pNA amidolysis in human seminal plasma.
Archives of andrology.
2000 Jan; 44(1):1-9. doi:
10.1080/014850100262353. [PMID: 10690759] - L Gesualdo, E Ranieri, R Monno, M R Rossiello, M Colucci, N Semeraro, G Grandaliano, F P Schena, M Ursi, G Cerullo. Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cells.
Kidney international.
1999 Aug; 56(2):461-70. doi:
10.1046/j.1523-1755.1999.00578.x. [PMID: 10432384] - Y Q Gu, F M Holzer, L L Walling. Overexpression, purification and biochemical characterization of the wound-induced leucine aminopeptidase of tomato.
European journal of biochemistry.
1999 Aug; 263(3):726-35. doi:
10.1046/j.1432-1327.1999.00548.x. [PMID: 10469136] - K Sanderson, P E Andrén, R M Caprioli, F Nyberg. In vitro metabolism of LVV-hemorphin-7 in human plasma studied by reversed-phase high-performance liquid chromatography and micro-electrospray mass spectrometry.
Journal of chromatography. A.
1996 Aug; 743(1):207-12. doi:
10.1016/0021-9673(96)00175-6. [PMID: 8817883] - E P Masler, R M Wagner, E S Kovaleva. In vitro metabolism of an insect neuropeptide by neural membrane preparations from Lymantria dispar.
Peptides.
1996; 17(2):321-6. doi:
10.1016/0196-9781(95)02098-5. [PMID: 8801540] - C Schalk, H d'Orchymont, M F Jauch, C Tarnus. 3-Amino-2-tetralone derivatives: novel potent and selective inhibitors of aminopeptidase-M (EC 3.4.11.2).
Archives of biochemistry and biophysics.
1994 May; 311(1):42-6. doi:
10.1006/abbi.1994.1206. [PMID: 7910449] - B C Miller, D L Thiele, L B Hersh, G L Cottam. Methionine enkephalin is hydrolyzed by aminopeptidase N on CD4+ and CD8+ spleen T cells.
Archives of biochemistry and biophysics.
1994 May; 311(1):174-9. doi:
10.1006/abbi.1994.1223. [PMID: 7910448] - N M Hooper, R J Hesp, S Tieku. Metabolism of aspartame by human and pig intestinal microvillar peptidases.
The Biochemical journal.
1994 Mar; 298 Pt 3(?):635-9. doi:
10.1042/bj2980635. [PMID: 8141778] - D Godin, F Marceau, C Beaulé, F Rioux, G Drapeau. Aminopeptidase modulation of the pharmacological responses to synthetic thrombin receptor agonists.
European journal of pharmacology.
1994 Mar; 253(3):225-30. doi:
10.1016/0014-2999(94)90195-3. [PMID: 7911085] - U Zacharias, C J He, G Nguyen, J D Sraer, E Rondeau. Long-term effects of thrombin require sustained activation of the functional thrombin receptor.
FEBS letters.
1993 Nov; 334(2):225-8. doi:
10.1016/0014-5793(93)81716-d. [PMID: 8224250] - W Bawab, E Querido, P Crine, L DesGroseillers. Identification and characterization of aminopeptidases from Aplysia californica.
The Biochemical journal.
1992 Sep; 286 ( Pt 3)(?):967-75. doi:
10.1042/bj2860967. [PMID: 1417757] - N Sakata, K S Tsuchiya, Y Moriya, H Hayashi, M Hori, T Otani, M Nagai, T Aoyagi. Aminopeptidase activity of an antitumor antibiotic, C-1027.
The Journal of antibiotics.
1992 Jan; 45(1):113-7. doi:
10.7164/antibiotics.45.113. [PMID: 1548181] - V Stefanovic, P Vlahovic, N Ardaillou, R Ardaillou. Receptor-mediated induction of aminopeptidase A (APA) of human glomerular epithelial cells (HGEC) by glucocorticoids.
FEBS letters.
1991 Dec; 294(3):171-4. doi:
10.1016/0014-5793(91)80661-l. [PMID: 1756856] - L H Wang, S Ahmad, I F Benter, A Chow, S Mizutani, P E Ward. Differential processing of substance P and neurokinin A by plasma dipeptidyl(amino)peptidase IV, aminopeptidase M and angiotensin converting enzyme.
Peptides.
1991 Nov; 12(6):1357-64. doi:
10.1016/0196-9781(91)90220-j. [PMID: 1726123] - J Rehbock, G Wunderer. Degradation of Ile-Ser-Bradykinin by enzymes in human serum and ascites.
Biochemical pharmacology.
1991 Mar; 41(6-7):1081-3. doi:
10.1016/0006-2952(91)90218-t. [PMID: 2009076] - M Shimamura, T Hazato, T Iwaguchi. Enkephalin-degrading aminopeptidase in the longitudinal muscle layer of guinea pig small intestine: its properties and action on neuropeptides.
Journal of biochemistry.
1991 Mar; 109(3):492-7. doi:
10.1093/oxfordjournals.jbchem.a123409. [PMID: 1679058] - T Okuyama, S Ishiura, M Nojima, T Tsukahara, M Yanagida, H Sugita. Aminopeptidase A in human placenta and pregnant serum.
Clinica chimica acta; international journal of clinical chemistry.
1991 Feb; 196(2-3):207-15. doi:
10.1016/0009-8981(91)90074-m. [PMID: 2029785] - J E Odoom, I D Campbell, J C Ellory, G F King. Characterization of peptide fluxes into human erythrocytes. A proton-n.m.r. study.
The Biochemical journal.
1990 Apr; 267(1):141-7. doi:
10.1042/bj2670141. [PMID: 2327979] - S Ahmad, P E Ward. Role of aminopeptidase activity in the regulation of the pressor activity of circulating angiotensins.
The Journal of pharmacology and experimental therapeutics.
1990 Feb; 252(2):643-50. doi:
. [PMID: 1968973] - O H Drummer, S Kourtis, H Johnson. Effect of chronic enalapril treatment on enzymes responsible for the catabolism of angiotensin I and formation of angiotensin II.
Biochemical pharmacology.
1990 Feb; 39(3):513-8. doi:
10.1016/0006-2952(90)90058-s. [PMID: 2407244] - R H Abhold, M J Sullivan, J W Wright, J W Harding. Binding, degradation and pressor activity of angiotensins II and III after aminopeptidase inhibition with amastatin and bestatin.
The Journal of pharmacology and experimental therapeutics.
1987 Sep; 242(3):957-62. doi:
. [PMID: 3656120] - M Ishida, M Ogawa, T Mori, T Mega. Determination and characterization of succinyl tri-alanine p-nitroanilide hydrolyzing metalloendopeptidase in serum.
Enzyme.
1987; 37(4):202-7. doi:
10.1159/000469263. [PMID: 3111843] - H H Bausback, P E Ward. Degradation of low-molecular-weight opioid peptides by vascular plasma membrane aminopeptidase M.
Biochimica et biophysica acta.
1986 Jul; 882(3):437-44. doi:
10.1016/0304-4165(86)90268-0. [PMID: 2873842] - M Narita, K Aoyagi, S Ohba, S Tojo. Elastase-type activity in human radial artery in patients with chronic renal failure.
Nephron.
1986; 43(2):123-7. doi:
10.1159/000183810. [PMID: 3635713] - R Matsas, S L Stephenson, J Hryszko, A J Kenny, A J Turner. The metabolism of neuropeptides. Phase separation of synaptic membrane preparations with Triton X-114 reveals the presence of aminopeptidase N.
The Biochemical journal.
1985 Oct; 231(2):445-9. doi:
10.1042/bj2310445. [PMID: 2865952] - J C Hafkenscheid, B E Kohler. A continuous method for the determination of leucine aminopeptidase in human serum with L-leucinamide as substrate.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1985 Jul; 23(7):393-8. doi:
10.1515/cclm.1985.23.7.393. [PMID: 4045387] - S Kanda, K Sudo, T Kanno. A specific kinetic assay for tripeptide aminopeptidase in serum.
Clinical chemistry.
1984 Jun; 30(6):843-6. doi:
. [PMID: 6723039] - H Sakura, H Kobayashi, S Mizutani, N Sakura, T Hashimoto, Y Kawashima. Kinetic properties of placental aminopeptidase A: N-terminal degradation of angiotensin II.
Biochemistry international.
1983 May; 6(5):609-15. doi:
. [PMID: 6679727] - H Tobe, F Kojima, T Aoyagi, H Umezawa. Purification by affinity chromatography using amastatin and properties of aminopeptidase A from pig kidney.
Biochimica et biophysica acta.
1980 Jun; 613(2):459-68. doi:
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