Viomycin (BioDeep_00000004707)

   


代谢物信息卡片


Tuberactinomycin B; Vinacetin A; Vioactane

化学式: C25H43N13O10 (685.3255698)
中文名称: 紫霉素
谱图信息: 最多检出来源 Macaca mulatta(otcml) 17.86%

分子结构信息

SMILES: C(C[C@@H](CC(=O)N[C@H]1CNC(=O)[C@H]([C@H]2C[C@@H](NC(=N)N2)O)NC(=O)/C(=C/NC(=O)N)/NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC1=O)N)CN
InChI: InChI=1S/C25H43N13O10/c26-3-1-2-10(27)4-16(41)32-12-6-30-23(47)18(11-5-17(42)37-24(28)36-11)38-20(44)13(7-31-25(29)48)33-21(45)14(8-39)35-22(46)15(9-40)34-19(12)43/h7,10-12,14-15,17-18,39-40,42H,1-6,8-9,26-27H2,(H,30,47)(H,32,41)(H,33,45)(H,34,43)(H,35,46)(H,38,44)(H3,28,36,37)(H3,29,31,48)/b13-7-/t10-,11+,12-,14-,15-,17-,18-/m0/s1

描述信息

A cyclic peptide antibiotic produced by the actinomycete Streptomyces puniceus, used in the treatment of tuberculosis.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors

同义名列表

2 个代谢物同义名

Viomycin; Tuberactinomycin B; Vinacetin A; Vioactane



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • L J Norcia, A M Silvia, J P Dirlam, R C Schnur, J M Bergeron, J A Retsema, S F Hayashi. In vitro microbiological characterization of novel cyclic homopentapeptides, CP-101,680 and CP-163,234, for animal health use. The Journal of antibiotics. 1999 Nov; 52(11):1007-16. doi: 10.7164/antibiotics.52.1007. [PMID: 10656573]
  • H Tanimori, T Kitagawa. A new liquid-phase enzyme immunoassay for rabbit IgM antibodies and its application for comparing the specificity of IgM and IgG antibodies contained in the same antiserum. Journal of immunological methods. 1990 May; 129(2):233-42. doi: 10.1016/0022-1759(90)90444-z. [PMID: 2161882]
  • R W Steiner, A S Omachi. A Bartter's-like syndrome from capreomycin, and a similar gentamicin tubulopathy. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1986 Mar; 7(3):245-9. doi: 10.1016/s0272-6386(86)80012-9. [PMID: 2420173]
  • K Okumura, H Yamakita, A Kamiya, R Hori. Effects of nephrotoxic compounds on active uptake of drugs in isolated renal tubules in rabbits. Biochemical pharmacology. 1984 Jul; 33(13):2055-9. doi: 10.1016/0006-2952(84)90573-2. [PMID: 6331456]
  • W Jao, J R Manaligod, L T Gerardo, M M Castillo. Myeloid bodies in drug-induced acute tubular necrosis. The Journal of pathology. 1983 Jan; 139(1):33-40. doi: 10.1002/path.1711390104. [PMID: 6298392]
  • J S Schwartz, J S Kempa, E C Vasilomanolakis, J P Szidon, F L Coe, W Jao. Viomycin-induced electrolyte abnormalities. Respiration; international review of thoracic diseases. 1980; 40(5):284-92. doi: 10.1159/000194291. [PMID: 6262892]
  • T Kitagawa, T Fujitake, H Taniyama, T Aikawa. Enzyme immunoassay of viomycin. New cross-linking reagent for enzyme labelling and a preparation method for antiserum to viomycin. Journal of biochemistry. 1978 May; 83(5):1493-501. doi: 10.1093/oxfordjournals.jbchem.a132059. [PMID: 207686]
  • R N Busygina. [Changes in radiosotope renogram in patients with destructive tuberculosis of the lungs in the course of tuberculostatic therapy]. Problemy tuberkuleza. 1977 Aug; ?(8):32-5. doi: NULL. [PMID: 198770]
  • T Rathlev. Investigations on in vitro survival and virulence of T. pallidum under aerobiosis. The British journal of venereal diseases. 1975 Oct; 51(5):296-300. doi: 10.1136/sti.51.5.296. [PMID: 172190]
  • D Hasegawa, T Sakurada, F Yamasaku, J Wada, H Takeda. [Toxicological studies of tuberactinomycin-N on rat kidney (author's transl)]. Kekkaku : [Tuberculosis]. 1974 May; 49(5):127-32. doi: NULL. [PMID: 4369703]
  • M Igarashi. Vestibular ototoxicity in primates. Audiology : official organ of the International Society of Audiology. 1973 Sep; 12(5):337-49. doi: 10.3109/00206097309071649. [PMID: 4355297]
  • V S Pugachev, M D Lysiuk. [Levels of florimycin in tissues of healthy mice following administration by various routes]. Antibiotiki. 1972 Jul; 17(7):638-41. doi: NULL. [PMID: 4347624]
  • L Ebringer. Are plastids derived from prokaryotic micro-organisms? Action of antibiotics on chloroplasts of Euglena gracilis. Journal of general microbiology. 1972 Jun; 71(1):35-52. doi: 10.1099/00221287-71-1-35. [PMID: 4339049]
  • O M Krepak, I A Storozhev. [Study of the functional state of the liver in animals under the effect of streptomycin, D-cycloserine, kanamycin and florimycin. Effect of antibiotics on blood plasma proteins]. Antibiotiki. 1970 Sep; 15(9):814-8. doi: . [PMID: 4099113]
  • M M Pyle. Ethambutol and viomycin. The Medical clinics of North America. 1970 Sep; 54(5):1317-27. doi: . [PMID: 4319383]
  • S Hokama. Experimental studies on the combined effect of kanamycin and viomycin. The Japanese journal of tuberculosis and chest diseases. 1970 Jul; 16(1):62-9. doi: NULL. [PMID: 4320009]
  • M Lucchesi. The antimycobacterial activity of capreomycin. Antibiotica et chemotherapia. Fortschritte. Advances. Progres. 1970; 16(?):27-31. doi: 10.1159/000386800. [PMID: 4108891]
  • K Grossgebauer, H Langmaack. [Modification of the pyrogenic effect of influenza viruses with various biologically active compounds]. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale. 1970; 212(2):424-9. doi: ". [PMID: 4315446]
  • J J Debain, G Freyss, H Poulain. [Gentamicin and auricular toxicity]. Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris. 1969 Sep; 86(9):584-8. doi: NULL. [PMID: 4311950]
  • I Strauss. [Tuberculostatic tolerance of a tuberculous kidney]. Zeitschrift fur Urologie und Nephrologie. 1969; 62(9):651-6. doi: NULL. [PMID: 4325816]
  • A Radecki, H Kanwiszer, A Donderowicz, E Krzanowska. [Toxic reactions during treatment with viomycin in pulmonary tuberculosis]. Gruzlica i choroby pluc; tuberculosis et pneumonologia. 1968 Apr; 36(4):323-7. doi: . [PMID: 4300342]
  • A M Kharitonova. [On the nephrotic action of antibiotics]. Antibiotiki. 1967 Sep; 12(9):830-6. doi: NULL. [PMID: 4171895]
  • P Hörstrup, H J Klein. [Drop-like storage of fluorescent-dye labeled protein corpuscles in the proximal kidney tubules]. Frankfurter Zeitschrift fur Pathologie. 1967; 76(4):405-10. doi: NULL. [PMID: 4298020]
  • W Wessel. [Electron microscopic contribution to the acute and chronic mercury bichloride and viomycin poisoning of the kidneys]. Verhandlungen der Deutschen Gesellschaft fur Pathologie. 1967; 51(?):313-6. doi: NULL. [PMID: 4175827]
  • A V Kosolaoova. [Comparative study of the clearance of blood serum from kanamycin and florimycin (viomycin) in rabbits]. Antibiotiki. 1966 Sep; 11(9):823-8. doi: NULL. [PMID: 4297490]
  • O M Krepak. [The effect of D-cycloserin and florimycin on the activity of glutamate aspartate transaminase in blood serum of albino mice]. Antibiotiki. 1966 Apr; 11(4):347-50. doi: . [PMID: 4293568]
  • H J Klein, E Steinbach, N Schümmelfeder. [Ultrastructural and histochemical studies of incipient viomycin nephrosis]. Frankfurter Zeitschrift fur Pathologie. 1966; 75(5):432-45. doi: . [PMID: 16300337]
  • G A Tomkins, J Ferguson. Growth of diploid and heteroploid tissue cultures in the presence of some antibiotics. The Australian journal of experimental biology and medical science. 1965 Dec; 43(6):743-50. doi: 10.1038/icb.1965.59. [PMID: 4161004]
  • J G GOW. RENAL CALCIFICATION IN GENITO-URINARY TUBERCULOSIS. The British journal of surgery. 1965 Apr; 52(?):283-8. doi: 10.1002/bjs.1800520410. [PMID: 14271089]
  • J F Daly, N L Cohen. Viomycin ototoxicity in man: a cupulometric study. Transactions of the American Otological Society. 1965; 53(?):150-63. doi: . [PMID: 4284238]
  • R Caesar. [Significance of lysosomes for the formal genesis of viomycin nephrosis]. Verhandlungen der Deutschen Gesellschaft fur Pathologie. 1965; 49(?):157-62. doi: . [PMID: 4160537]
  • H J Klein, N Schümmelfeder. [Ultrastructural and histochemical early changes in viomycin nephrosis]. Verhandlungen der Deutschen Gesellschaft fur Pathologie. 1965; 49(?):174-8. doi: . [PMID: 4160540]
  • I DEGREEF. THE OTOTOXICITY OF KANAMYCIN. A THEORETICAL AND EXPERIMENTAL STUDY. Acta oto-rhino-laryngologica Belgica. 1964; 18(?):415-27. doi: NULL. [PMID: 14205308]
  • A I SIDOROVA. [QUANTITATIVE METHOD FOR THE DETERMINATION OF FLORIMYCIN (VIOMYCIN) IN CULTURE MEDIUM FLUIDS]. Antibiotiki. 1963 Oct; 8(?):915-7. doi: NULL. [PMID: 14136420]
  • R A VEIS, Ia STOROZHEV, E K BEREZINA. [PHARMACOLOGY OF FLORIMYCIN (VIOMYCIN)]. Antibiotiki. 1963 Oct; 8(?):910-4. doi: NULL. [PMID: 14136419]
  • J O FROST. The problem of ototoxicity in the treatment of tuberculosis. Tuberculology and thoracic diseases. 1963 Apr; 21(?):4-9. doi: NULL. [PMID: 13945835]
  • P TANI, H POPPIUS. SIDE EFFECTS OF AN ANTITUBERCULOUS FIVE-DRUG REGIMEN: ETHIONAMIDE, CYCLOSERINE, PYRAZINAMIDE, VIOMYCIN AND ISONIAZID. Acta tuberculosea et pneumologica Scandinavica. 1963; 43(?):256-64. doi: NULL. [PMID: 14072347]
  • J PERNOD, P ROBERT, J KERMAREC. [Clinical study of the tolerance of viomycin by the cochlear apparatus and the kidney]. Therapie. 1962 Nov; 17(?):1169-83. doi: NULL. [PMID: 13942507]
  • TRUC, SCHILLIRO, DION. [Use of viomycin pentothenate in urinary tuberculosis]. Journal d'urologie et de nephrologie. 1962 Apr; 68(?):372-5. doi: NULL. [PMID: 14039824]
  • F MARANI, A BIANCO, V TORCELLO. [The use of a new drug (viomycin pantotenate) in the treatment of renal tuberculosis]. Minerva medica. 1961 Jan; 52(?):128-39. doi: . [PMID: 13766407]
  • TRUC, R SCHILLIRO, A BADOSA. Viomycin in renal tuberculosis. Journal d'urologie medicale et chirurgicale. 1959 Jan; 65(1-2):64-8. doi: . [PMID: 13665785]
  • TRUC, SCHILLIRO, BADOSA. [Viomycin in renal tuberculosis]. Journal d'urologie medicale et chirurgicale. 1958 Jul; 64(7-8):489-94. doi: . [PMID: 13611832]
  • M STAEMMLER, B KARHOFF. The acute nephrosis. II. Kidney damage from antibiotics. Virchows Archiv fur pathologische Anatomie und Physiologie und fur klinische Medizin. 1956; 328(5):481-502. doi: 10.1007/bf00955066. [PMID: 13352755]
  • G BELLIENI, R BIAGINI. [Diffusion of viomycin in parenchymatous organs]. Rivista di clinica pediatrica. 1953 Dec; 52(6):464-9. doi: NULL. [PMID: 13156379]
  • J H MOYER, P O JONES, R V FORD, D E JENKINS, L C MILLS. The effects of an intermittent dosage schedule of viomycin on renal function and on plasma electrolytes. American review of tuberculosis. 1953 Oct; 68(4):541-7. doi: 10.1164/art.1953.68.4.541. [PMID: 13104866]
  • J H MOYER, C A HANDLEY. Renal function during viomycin administration to dogs. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1953 Apr; 82(4):761-3. doi: 10.3181/00379727-82-20238. [PMID: 13055992]
  • W E DYE, W F BULL. Plasma levels of viomycin in man after single intramuscular injection. American journal of clinical pathology. 1953 Jan; 23(1):56-9. doi: 10.1093/ajcp/23.1.56. [PMID: 13016508]
  • A MASI, P MOGGI. [Levels of viomycin in blood, cerebrospinal fluid and urine]. Rivista di clinica pediatrica. 1951 Dec; 49(12):865-70. doi: NULL. [PMID: 14921668]