4-Hydroxy-2-oxoglutaric acid (BioDeep_00000004583)
Secondary id: BioDeep_00001869273
human metabolite Endogenous natural product
代谢物信息卡片
(+/-)-2-hydroxy-4-oxopentanedioic acid
化学式: C5H6O6 (162.01643760000002)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 17.13%
分子结构信息
SMILES: C(C(C(=O)O)O)C(=O)C(=O)O
InChI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)
描述信息
4-Hydroxy-2-ketoglutaric acid is a substrate for Fructose-bisphosphate aldolase A. [HMDB]
4-Hydroxy-2-ketoglutaric acid is a substrate for Fructose-bisphosphate aldolase A.
同义名列表
14 个代谢物同义名
(+/-)-2-hydroxy-4-oxopentanedioic acid; 2-Keto-4-hydroxyglutarate, (+-)-isomer; (+/-)-2-hydroxy-4-oxopentanedioate; 2-hydroxy-4-oxo-pentanedioic acid; 2-Hydroxy-4-oxopentanedioic acid; 4-hydroxy-2-oxo-glutaric acid; 4-Hydroxy-2-oxoglutaric acid; 2-Hydroxy-4-oxopentanedioate; 2-hydroxy-4-oxoGlutaric acid; D-4-Hydroxy-2-ketoglutarate; 2-Keto-4-hydroxyglutarate; 4-Hydroxy-2-ketoglutarate; 2-oxo-4-Hydroxyglutarate; 4-Hydroxy-2-oxoglutarate
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:30923
- KEGG: C01127
- PubChem: 599
- HMDB: HMDB0002070
- Metlin: METLIN323
- foodb: FDB022830
- chemspider: 579
- CAS: 1187-99-1
- PMhub: MS000017111
- ChEBI: CHEBI:17742
- PubChem: 4358
- 3DMET: B00245
- NIKKAJI: J536.231H
- RefMet: 4-Hydroxy-2-oxoglutaric acid
- LOTUS: LTS0235573
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
40 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(2)
- 2-Oxo-glutaric acid + L-erythro-4-Hydroxy-glutamic acid = L-Glutamic acid + D-4-Hydroxy-2-oxo-glutaric acid ( Arginine and Proline metabolism ):
2-Oxo-glutaric acid + L-erythro-4-Hydroxy-glutamic acid ⟶ 4-Hydroxy-2-oxo-glutaric acid + L-Glutamic acid - Arginine and Proline metabolism ( Arginine and Proline metabolism ):
ATP + Creatine ⟶ ADP + N-Phospho-creatine
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(38)
- Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type I:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Ornithine Aminotransferase Deficiency (OAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia with Gyrate Atrophy (HOGA):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - L-Arginine:Glycine Amidinotransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine and Proline Metabolism:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine and Proline Metabolism:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type I:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Ornithine Aminotransferase Deficiency (OAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine and Proline Metabolism:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia with Gyrate Atrophy (HOGA):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - L-Arginine:Glycine Amidinotransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine and Proline Metabolism:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine and Proline Metabolism:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type I:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperprolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Ornithine Aminotransferase Deficiency (OAT Deficiency):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolinemia Type II:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolidase Deficiency (PD):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia with Gyrate Atrophy (HOGA):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - L-Arginine:Glycine Amidinotransferase Deficiency:
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolidase Deficiency (PD):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine - Prolidase Deficiency (PD):
Guanidoacetic acid + S-Adenosylmethionine ⟶ Creatine + S-Adenosylhomocysteine
PharmGKB(0)
11 个相关的物种来源信息
- 7458 - Apidae: LTS0235573
- 7459 - Apis: LTS0235573
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 7461 - Apis cerana: LTS0235573
- 6656 - Arthropoda: LTS0235573
- 2759 - Eukaryota: LTS0235573
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 50557 - Insecta: LTS0235573
- 33208 - Metazoa: LTS0235573
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Roel C Rabara, Prateek Tripathi, Paul J Rushton. Comparative Metabolome Profile between Tobacco and Soybean Grown under Water-Stressed Conditions.
BioMed research international.
2017; 2017(?):3065251. doi:
10.1155/2017/3065251. [PMID: 28127554] - Travis J Riedel, John Knight, Michael S Murray, Dawn S Milliner, Ross P Holmes, W Todd Lowther. 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition.
Biochimica et biophysica acta.
2012 Oct; 1822(10):1544-52. doi:
10.1016/j.bbadis.2012.06.014. [PMID: 22771891] - Michael Kube, Jelena Mitrovic, Bojan Duduk, Ralf Rabus, Erich Seemüller. Current view on phytoplasma genomes and encoded metabolism.
TheScientificWorldJournal.
2012; 2012(?):185942. doi:
10.1100/2012/185942. [PMID: 22550465] - Carla G Monico, Sandro Rossetti, Ruth Belostotsky, Andrea G Cogal, Regina M Herges, Barbara M Seide, Julie B Olson, Eric J Bergstrahl, Hugh J Williams, William E Haley, Yaacov Frishberg, Dawn S Milliner. Primary hyperoxaluria type III gene HOGA1 (formerly DHDPSL) as a possible risk factor for idiopathic calcium oxalate urolithiasis.
Clinical journal of the American Society of Nephrology : CJASN.
2011 Sep; 6(9):2289-95. doi:
10.2215/cjn.02760311. [PMID: 21896830] - Travis J Riedel, Lynnette C Johnson, John Knight, Roy R Hantgan, Ross P Holmes, W Todd Lowther. Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.
PloS one.
2011; 6(10):e26021. doi:
10.1371/journal.pone.0026021. [PMID: 21998747] - Ruth Belostotsky, Eric Seboun, Gregory H Idelson, Dawn S Milliner, Rachel Becker-Cohen, Choni Rinat, Carla G Monico, Sofia Feinstein, Efrat Ben-Shalom, Daniella Magen, Irith Weissman, Celine Charon, Yaacov Frishberg. Mutations in DHDPSL are responsible for primary hyperoxaluria type III.
American journal of human genetics.
2010 Sep; 87(3):392-9. doi:
10.1016/j.ajhg.2010.07.023. [PMID: 20797690] - T Shcheglova, S P Makker, A Tramontano. Covalent binding antibodies suppress advanced glycation: on the innate tier of adaptive immunity.
Acta naturae.
2009 Jul; 1(2):66-72. doi:
10.32607/20758251-2009-1-2-66-72. [PMID: 22649604] - Seongwon Seo, Harris A Lewin. Reconstruction of metabolic pathways for the cattle genome.
BMC systems biology.
2009 Mar; 3(?):33. doi:
10.1186/1752-0509-3-33. [PMID: 19284618]
