Oxidized dithiothreitol (BioDeep_00000004578)

 

Secondary id: BioDeep_00001868857

human metabolite


代谢物信息卡片


trans-4,5-Dihydroxy-1,2-dithiane

化学式: C4H8O2S2 (151.9966)
中文名称: 反式-4,5-二羟基-1,2-二硫烷
谱图信息: 最多检出来源 Homo sapiens(blood) 58.2%

分子结构信息

SMILES: C1C(C(CSS1)O)O
InChI: InChI=1S/C4H8O2S2/c5-3-1-7-8-2-4(3)6/h3-6H,1-2H2

描述信息

Oxidized dithiothreitol is part of the Ubiquinone and other terpenoid-quinone biosynthesis pathway. It is a substrate for: Vitamin K epoxide reductase complex subunit 1.

同义名列表

6 个代谢物同义名

trans-4,5-Dihydroxy-1,2-dithiane; (4R,5R)-1,2-dithiane-4,5-diol; (4S,5S)-1,2-Dithiane-4,5-diol; Oxidized dithiothreitol; DITHIANE diol; Oxidized dithiothreitol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(4)

  • Vitamin K Metabolism: Carbon dioxide + Oxygen + Peptidyl-4-carboxyglutamate + Phylloquinol ⟶ Peptidyl-glutamate + Vitamin K1 2,3-epoxide + Water
  • Vitamin K Metabolism: Carbon dioxide + Oxygen + Reduced Vitamin K (phylloquinone) + Unknown ⟶ Unknown + Vitamin K1 2,3-epoxide + Water
  • Vitamin K Metabolism: Oxidized dithiothreitol + Vitamin K1 ⟶ 1,4-Dithiothreitol + Vitamin K1 2,3-epoxide
  • Vitamin K Metabolism: Oxidized dithiothreitol + Vitamin K1 ⟶ 1,4-Dithiothreitol + Vitamin K1 2,3-epoxide

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 CALR, CASP3, CYP2A6, DDIT3, ELANE, GRP, GSTM1, HPGDS, MAPK8, NFE2L2, XBP1, ZMYND8
Peripheral membrane protein 1 XBP1
Endoplasmic reticulum membrane 3 CALR, CYP2A6, XBP1
Nucleus 7 CALR, CASP3, DDIT3, MAPK8, NFE2L2, XBP1, ZMYND8
cytosol 10 CALR, CASP3, DDIT3, ELANE, GPT, GSTM1, HPGDS, MAPK8, NFE2L2, XBP1
phagocytic vesicle 1 ELANE
centrosome 1 NFE2L2
nucleoplasm 6 CASP3, HPGDS, MAPK8, NFE2L2, XBP1, ZMYND8
RNA polymerase II transcription regulator complex 3 DDIT3, NFE2L2, XBP1
Synapse 1 MAPK8
cell surface 2 CALR, ELANE
dendritic shaft 1 ZMYND8
glutamatergic synapse 2 CALR, CASP3
Golgi apparatus 1 NFE2L2
neuronal cell body 1 CASP3
postsynapse 1 CALR
smooth endoplasmic reticulum 1 CALR
Cytoplasm, cytosol 2 CALR, NFE2L2
acrosomal vesicle 1 CALR
plasma membrane 1 NFE2L2
Membrane 3 CALR, CYP2A6, XBP1
axon 1 MAPK8
extracellular exosome 3 CALR, ELANE, GPT
endoplasmic reticulum 2 CALR, XBP1
extracellular space 3 CALR, ELANE, GRP
perinuclear region of cytoplasm 1 CALR
intracellular membrane-bounded organelle 2 CYP2A6, HPGDS
postsynaptic density 1 CASP3
Secreted 1 GRP
extracellular region 3 CALR, ELANE, GRP
transcription regulator complex 1 DDIT3
external side of plasma membrane 1 CALR
Secreted, extracellular space, extracellular matrix 2 CALR, GRP
dendritic spine 1 ZMYND8
nucleolus 1 ZMYND8
Single-pass type II membrane protein 1 XBP1
focal adhesion 1 CALR
extracellular matrix 1 GRP
collagen-containing extracellular matrix 2 CALR, ELANE
secretory granule 1 ELANE
Late endosome 1 DDIT3
Cell projection, neuron projection 1 GRP
neuron projection 1 GRP
chromatin 3 DDIT3, NFE2L2, ZMYND8
mediator complex 1 NFE2L2
phagocytic vesicle membrane 1 CALR
Chromosome 1 ZMYND8
intercellular bridge 1 GSTM1
nuclear envelope 1 CALR
secretory granule lumen 1 GRP
endoplasmic reticulum quality control compartment 1 CALR
endoplasmic reticulum lumen 1 CALR
transcription repressor complex 1 ELANE
specific granule lumen 1 ELANE
azurophil granule lumen 1 ELANE
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 CALR
neuronal dense core vesicle 1 GRP
Sarcoplasmic reticulum lumen 1 CALR
[Isoform 2]: Nucleus 1 XBP1
[Isoform 1]: Nucleus 1 XBP1
cytoplasmic microtubule 1 CYP2A6
protein-DNA complex 2 DDIT3, NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
lumenal side of endoplasmic reticulum membrane 1 CALR
MHC class I peptide loading complex 1 CALR
Cytoplasmic vesicle, phagosome 1 ELANE
site of DNA damage 1 ZMYND8
endocytic vesicle lumen 1 CALR
ribosome 1 CALR
Cytoplasmic vesicle, secretory vesicle lumen 1 GRP
Cytoplasmic vesicle, secretory vesicle, Cortical granule 1 CALR
cortical granule 1 CALR
Cytolytic granule 1 CALR
CHOP-C/EBP complex 1 DDIT3
[X-box-binding protein 1, cytoplasmic form]: Cytoplasm 1 XBP1
CHOP-ATF3 complex 1 DDIT3
CHOP-ATF4 complex 1 DDIT3


文献列表

  • Woo-Suk Jung, Jeehyun Lee, Myung-Il Kim, Jun Ma, Tomohisa Nagamatsu, Eunhye Goo, Hongsup Kim, Ingyu Hwang, Jaehong Han, Sangkee Rhee. Structural and functional analysis of phytotoxin toxoflavin-degrading enzyme. PloS one. 2011; 6(7):e22443. doi: 10.1371/journal.pone.0022443. [PMID: 21799856]
  • Senait Asmellash, James L Stevens, Takaharu Ichimura. Modulating the endoplasmic reticulum stress response with trans-4,5-dihydroxy-1,2-dithiane prevents chemically induced renal injury in vivo. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Dec; 88(2):576-84. doi: 10.1093/toxsci/kfi303. [PMID: 16150886]
  • W James Gilmore, Gordon M Kirby. Endoplasmic reticulum stress due to altered cellular redox status positively regulates murine hepatic CYP2A5 expression. The Journal of pharmacology and experimental therapeutics. 2004 Feb; 308(2):600-8. doi: 10.1124/jpet.103.060111. [PMID: 14610226]
  • Cheng-Chieh Hung, Takaharu Ichimura, James L Stevens, Joseph V Bonventre. Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation. The Journal of biological chemistry. 2003 Aug; 278(31):29317-26. doi: 10.1074/jbc.m302368200. [PMID: 12738790]
  • M M Halleck, H Liu, J North, J L Stevens. Reduction of trans-4,5-dihydroxy-1,2-dithiane by cellular oxidoreductases activates gadd153/chop and grp78 transcription and induces cellular tolerance in kidney epithelial cells. The Journal of biological chemistry. 1997 Aug; 272(35):21760-6. doi: 10.1074/jbc.272.35.21760. [PMID: 9268305]