Angiotensin I (BioDeep_00000004502)

 

Secondary id: BioDeep_00001868632

human metabolite blood metabolite


代谢物信息卡片


(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-carboxypropanamido]-5-[(diaminomethylidene)amino]pentanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-3-(1H-imidazol-5-yl)propanamido]-4-methylpentanoic acid

化学式: C62H89N17O14 (1295.6775)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
InChI: InChI=1S/C62H89N17O14/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68)/t35-,41-,42-,43-,44-,45-,46-,47-,48-,50-,51-/m0/s1

描述信息

Angiotensin I appears to have no biological activity and exists solely as a precursor to angiotensin 2. Angiotensin I is formed by the action of renin on angiotensinogen. Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide (des-Asp) angiotensin I. Renin is produced in the kidneys in response to renal sympathetic activity, decreased intrarenal blood pressure at the juxtaglomerular cells, or decreased delivery of Na+ and Cl- to the macula densa.[3] If less Na+ is sensed by the macula densa, renin release by juxtaglomerular cells is increased. (Wikipedia)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
COVID info from WikiPathways, COVID-19 Disease Map
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Coronavirus
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COVID-19
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SARS
Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).

同义名列表

8 个代谢物同义名

(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-carboxypropanamido]-5-[(diaminomethylidene)amino]pentanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-3-(1H-imidazol-5-yl)propanamido]-4-methylpentanoic acid; (2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-carboxypropanamido]-5-[(diaminomethylidene)amino]pentanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-3-(3H-imidazol-4-yl)propanamido]-4-methylpentanoic acid; Angiotensins; Angiotonin; 5-Ile-angiotensin I; I, angiotensin; Angiotensin I; Angiotensin I (human, mouse, rat); Angiotensin I



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

42 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(13)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(2)

PathBank(26)

PharmGKB(1)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACE, ALB, ANPEP, CTSG, EDN1, MME, PREP
Peripheral membrane protein 1 CTSG
Endosome membrane 1 ATP6AP2
Endoplasmic reticulum membrane 1 ATP6AP2
Nucleus 3 ALB, CTSG, PREP
cytosol 4 ALB, AVP, CTSG, PREP
dendrite 2 AVP, MME
trans-Golgi network 1 MME
centrosome 1 ALB
Cell membrane 6 ACE, AGTR1, AGTR2, ANPEP, CTSG, MME
Cell projection, axon 1 ATP6AP2
Cytoplasmic granule 1 CTSG
Multi-pass membrane protein 3 AGTR1, AGTR2, CACNA1I
Synapse 2 MME, TAC1
cell surface 1 MME
Golgi apparatus 1 ALB
Golgi membrane 2 ATP6AP2, INS
lysosomal membrane 2 ANPEP, ATP6AP2
neuronal cell body 2 MME, TAC1
synaptic vesicle 1 MME
Cytoplasm, cytosol 1 CTSG
Cytoplasmic vesicle, secretory vesicle 1 NTS
Lysosome 3 ACE, ATP6AP2, CTSG
Presynapse 1 MME
endosome 1 ACE
plasma membrane 11 ACE, AGTR1, AGTR2, ANPEP, ATP6AP2, CACNA1I, CTSG, KNG1, MME, PRSS27, REN
synaptic vesicle membrane 1 ATP6AP2
Membrane 8 ACE, AGTR1, ATP6AP2, CACNA1I, CTSG, MME, PREP, REN
axon 3 ATP6AP2, MME, TAC1
brush border 1 MME
extracellular exosome 9 ACE, AGT, ALB, ANPEP, ATP6AP2, CPVL, CTSG, KNG1, MME
Lysosome membrane 1 ATP6AP2
endoplasmic reticulum 1 ALB
extracellular space 11 ACE, AGT, ALB, ANPEP, AVP, CTSG, EDN1, INS, KNG1, REN, TAC1
mitochondrion 1 PREP
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 2 CTSG, NTS
Single-pass type I membrane protein 2 ACE, ATP6AP2
Secreted 9 ACE, AGT, ALB, AVP, CTSG, EDN1, INS, NTS, REN
extracellular region 12 ACE, AGT, ALB, AVP, CTSG, EDN1, INS, KNG1, NTS, PRSS27, REN, TAC1
basal part of cell 1 EDN1
Mitochondrion matrix 1 PREP
mitochondrial matrix 1 PREP
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP6AP2
external side of plasma membrane 3 ACE, ANPEP, ATP6AP2
cytoplasmic vesicle 1 MME
Cytoplasmic vesicle, clathrin-coated vesicle membrane 1 ATP6AP2
clathrin-coated vesicle membrane 1 ATP6AP2
Early endosome 1 MME
apical part of cell 1 REN
Single-pass type II membrane protein 2 ANPEP, MME
postsynaptic membrane 1 ATP6AP2
Membrane raft 1 MME
focal adhesion 1 MME
collagen-containing extracellular matrix 3 AGT, CTSG, KNG1
secretory granule 2 AVP, CTSG
ciliary basal body 1 ALB
Cytoplasmic vesicle, autophagosome membrane 1 ATP6AP2
autophagosome membrane 1 ATP6AP2
centriole 1 ALB
Secreted, extracellular space 1 KNG1
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 3 AGT, ALB, KNG1
sperm midpiece 1 ACE
endosome lumen 1 INS
tertiary granule membrane 1 ATP6AP2
cytoplasmic stress granule 1 CTSG
basal plasma membrane 1 ACE
secretory granule lumen 1 INS
secretory granule membrane 2 ANPEP, MME
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, INS, KNG1
platelet alpha granule lumen 2 ALB, KNG1
axon terminus 1 NTS
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 3 EDN1, INS, NTS
azurophil granule lumen 1 CTSG
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 AVP
clathrin-coated endocytic vesicle membrane 1 AVP
endoplasmic reticulum-Golgi intermediate compartment 1 ANPEP
ficolin-1-rich granule membrane 1 ATP6AP2
Cell projection, dendritic spine membrane 1 ATP6AP2
dendritic spine membrane 1 ATP6AP2
proton-transporting V-type ATPase complex 1 ATP6AP2
vacuolar proton-transporting V-type ATPase complex 1 ATP6AP2
vacuolar proton-transporting V-type ATPase, V0 domain 1 ATP6AP2
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
neuron projection terminus 1 MME
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
ciliary transition fiber 1 ALB


文献列表

  • Longyue Zhou, Shankang Chen, Yuanyi Wei, Yihui Sun, Yifan Yang, Bingqi Lin, Yuhao Li, Chunxia Wang. Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis. European journal of pharmacology. 2024 Feb; ?(?):176365. doi: 10.1016/j.ejphar.2024.176365. [PMID: 38316247]
  • Na Li, Qiongyu Zhang, Shiyu Dai, Wenzhuo Rao, Haitao Shi, Li Ding, Meiling Hong. Angiotensin-(1-7) plays an important role in regulating spermatogenesis in Trachemys scripta elegans under salinity stress. The Journal of experimental biology. 2024 Jan; 227(2):. doi: 10.1242/jeb.246742. [PMID: 38149682]
  • Dan Ye, Jiamin Liu, Long Lin, Pengwei Hou, Tianshun Feng, Shousen Wang. The Ang-(1-7)/MasR axis ameliorates neuroinflammation in hypothermic traumatic brain injury in mice by modulating phenotypic transformation of microglia. PloS one. 2024; 19(5):e0303150. doi: 10.1371/journal.pone.0303150. [PMID: 38728304]
  • Jose A Godoy-Lugo, Dora A Mendez, Ruben Rodriguez, Akira Nishiyama, Daisuke Nakano, Jose G Soñanez-Organis, Rudy M Ortiz. Improved lipogenesis gene expression in liver is associated with elevated plasma angiotensin 1-7 after AT1 receptor blockade in insulin-resistant OLETF rats. Molecular and cellular endocrinology. 2022 09; 555(?):111729. doi: 10.1016/j.mce.2022.111729. [PMID: 35921918]
  • Danielle Carvalho Oliveira Coutinho, Julliane V Joviano-Santos, Artur Santos-Miranda, Paulo Antônio Martins-Júnior, Analina Da Silva, Robson Augusto Souza Santos, Anderson José Ferreira. Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice. Biochemical and biophysical research communications. 2022 09; 619(?):90-96. doi: 10.1016/j.bbrc.2022.06.014. [PMID: 35749941]
  • Xin-Yue Liu, Jing-Chao Su, Xin-Fang Zhang, Shui-Ying Xiang, Chun-Mei Yi, Yu-Wen Wang, Cai-Yun Wang, Zi-Bing Liu. [Electroacupuncture preconditioning improves pulmonary function via inhibiting inflammatory response and up-regulating expression of ACE2 and Ang (1-7) in lipopolysaccharide-induced acute lung injury rats]. Zhen ci yan jiu = Acupuncture research. 2022 Aug; 47(8):684-9. doi: 10.13702/j.1000-0607.20210979. [PMID: 36036101]
  • Elshymaa A Abdel-Hakeem, Sara Mohamed Naguib Abdel Hafez, Bothina A Kamel, Heba A Abdel-Hamid. Angiotensin 1-7 mitigates rhabdomyolysis induced renal injury in rats via modulation of TLR-4/NF-kB/iNOS and Nrf-2/heme‑oxygenase-1 signaling pathways. Life sciences. 2022 Aug; 303(?):120678. doi: 10.1016/j.lfs.2022.120678. [PMID: 35654118]
  • Isabel Cristina Mallostro Emerich de Abreu, Raquel Cristina Melo Ferreira de Albuquerque, Ana Beatriz Pereira Brandão, Leticia Barssotti, Lívia Bruni de Souza, Fabiana Gomes Ferreira, Lilian Caroline Gonçalves de Oliveira, Rodrigo Yokota, Luiz Gustavo Sparvoli, Danielle da Silva Dias, Miguel Angel Castillo Salgado, Carla Taddei, Kátia De Angelis, Dulce Elena Casarini, Tatiana Sousa Cunha. Saccharomyces boulardii exerts renoprotection by modulating oxidative stress, renin angiotensin system and uropathogenic microbiota in a murine model of diabetes. Life sciences. 2022 Jul; 301(?):120616. doi: 10.1016/j.lfs.2022.120616. [PMID: 35533758]
  • Andrzej K Ciechanowicz, Wen Xin Lay, Jefte Prado Paulino, Erika Suchocki, Susanne Leszczak, Christian Leszczak, Magdalena Kucia. Angiotensin 1-7 Stimulates Proliferation of Lung Bronchoalveolar Progenitors-Implications for SARS-CoV-2 Infection. Cells. 2022 Jul; 11(13):. doi: 10.3390/cells11132102. [PMID: 35805187]
  • Asif Zaman, Anees A Banday. Angiotensin (1-7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats. American journal of physiology. Renal physiology. 2022 07; 323(1):F33-F47. doi: 10.1152/ajprenal.00283.2021. [PMID: 35532070]
  • Xiu-Yun Chen, Cheng Lin, Guo-Ying Liu, Chun Pei, Gui-Qing Xu, Lie Gao, Shi-Zhong Wang, Yan-Xia Pan. ACE2 gene combined with exercise training attenuates central AngII/AT1 axis function and oxidative stress in a prehypertensive rat model. Journal of applied physiology (Bethesda, Md. : 1985). 2022 06; 132(6):1460-1467. doi: 10.1152/japplphysiol.00459.2021. [PMID: 35546127]
  • Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukla. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease. ACS chemical neuroscience. 2022 05; 13(10):1491-1504. doi: 10.1021/acschemneuro.1c00797. [PMID: 35533351]
  • Yi Xu, Fang Zhang, Chunhui Li, Huiyao Hao, Yongmei Hao. Angiotensin-(1-7) improves diabetes mellitus-induced erectile dysfunction in rats by regulating nitric oxide synthase levels. Peptides. 2022 05; 151(?):170765. doi: 10.1016/j.peptides.2022.170765. [PMID: 35181349]
  • George El-Arif, Shaymaa Khazaal, Antonella Farhat, Julien Harb, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Hervé Kovacic, Ziad Abi Khattar, Ziad Fajloun, Jean-Marc Sabatier. Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072048. [PMID: 35408447]
  • Mauro G Silva, Nora L Falcoff, Gerardo R Corradi, José Alfie, Rolando F Seguel, Gabriela C Tabaj, Laura I Iglesias, Myriam Nuñez, Gabriela R Guman, Mariela M Gironacci. Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes. Life sciences. 2022 Mar; 293(?):120324. doi: 10.1016/j.lfs.2022.120324. [PMID: 35032553]
  • Che Mohd Nasril Che Mohd Nassir, Mohd K I Zolkefley, Muhammad Danial Ramli, Haziq Hazman Norman, Hafizah Abdul Hamid, Muzaimi Mustapha. Neuroinflammation and COVID-19 Ischemic Stroke Recovery-Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis and NLRP3 Inflammasome. International journal of molecular sciences. 2022 Mar; 23(6):. doi: 10.3390/ijms23063085. [PMID: 35328506]
  • Marta Kuczeriszka, Leszek Dobrowolski, Agnieszka Walkowska, Iwona Baranowska, Joanna D Sitek, Elżbieta Kompanowska-Jezierska. Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats. Clinical and experimental pharmacology & physiology. 2022 03; 49(3):432-441. doi: 10.1111/1440-1681.13618. [PMID: 34870864]
  • Kaiming Wang, Mahmoud Gheblawi, Anish Nikhanj, Matt Munan, Erika MacIntyre, Conar O'Neil, Marko Poglitsch, Daniele Colombo, Franca Del Nonno, Zamaneh Kassiri, Wendy Sligl, Gavin Y Oudit. Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries. Hypertension (Dallas, Tex. : 1979). 2022 02; 79(2):365-378. doi: 10.1161/hypertensionaha.121.18295. [PMID: 34844421]
  • Santoshi Sahu, C R Patil, Sachin Kumar, Subbu Apparsundaram, Ramesh K Goyal. Role of ACE2-Ang (1-7)-Mas axis in post-COVID-19 complications and its dietary modulation. Molecular and cellular biochemistry. 2022 Jan; 477(1):225-240. doi: 10.1007/s11010-021-04275-2. [PMID: 34655418]
  • Hala Attia, Norah Albekairi, Layal Albdeirat, Arwa Soliman, Reem Rajab, Hend Alotaibi, Rehab Ali, Amira Badr. Chrysin Attenuates Fructose-Induced Nonalcoholic Fatty Liver in Rats via Antioxidant and Anti-Inflammatory Effects: The Role of Angiotensin-Converting Enzyme 2/Angiotensin (1-7)/Mas Receptor Axis. Oxidative medicine and cellular longevity. 2022; 2022(?):9479456. doi: 10.1155/2022/9479456. [PMID: 35720181]
  • Flavia L Martins, Caio A M Tavares, Pamella A Malagrino, Thiago Rentz, Acaris Benetti, Thiago M S Rios, Gabriel M D Pereira, Bruno Caramelli, Samantha K Teixeira, José E Krieger, Adriana C C Girardi. Sex differences in the lung ACE/ACE2 balance in hypertensive rats. Bioscience reports. 2021 12; 41(12):. doi: 10.1042/bsr20211201. [PMID: 34751382]
  • Ralmony de Alcantara Santos, Vinicius Guzzoni, Kleiton Augusto Santos Silva, Danielle Sanches Aragão, Rodolfo de Paula Vieira, Nádia Bertoncello, Nestor Schor, Flávio Aimbire, Dulce Elena Casarini, Tatiana Sousa Cunha. Resistance exercise shifts the balance of renin-angiotensin system toward ACE2/Ang 1-7 axis and reduces inflammation in the kidney of diabetic rats. Life sciences. 2021 Dec; 287(?):120058. doi: 10.1016/j.lfs.2021.120058. [PMID: 34673118]
  • Elaine F Barry, Julie O'Neill, Mohammed H Abdulla, Edward J Johns. The renal excretory responses to acute renal interstitial angiotensin (1-7) infusion in anaesthetised spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. 2021 12; 48(12):1674-1684. doi: 10.1111/1440-1681.13570. [PMID: 34375480]
  • Wei Hu, Wenchuang Gao, Jiayi Miao, Ziheng Xu, Lei Sun. Alamandine, a derivative of angiotensin-(1-7), alleviates sepsis-associated renal inflammation and apoptosis by inhibiting the PI3K/Ak and MAPK pathways. Peptides. 2021 12; 146(?):170627. doi: 10.1016/j.peptides.2021.170627. [PMID: 34400214]
  • Omar Echeverría-Rodríguez, Beatriz Godínez-Chaparro, María V Gómez-García, Alfonso Mata-Bermúdez, Leonardo Del Valle-Mondragón, Itzell A Gallardo-Ortíz, Rafael Villalobos-Molina. Participation of angiotensin-(1-7) in exercise-induced analgesia in rats with neuropathic pain. Peptides. 2021 12; 146(?):170670. doi: 10.1016/j.peptides.2021.170670. [PMID: 34634392]
  • Taylor Morganstein, Zahraa Haidar, Joshua Trivlidis, Ilan Azuelos, Megan Jiaxin Huang, David H Eidelman, Carolyn J Baglole. Involvement of the ACE2/Ang-(1-7)/MasR Axis in Pulmonary Fibrosis: Implications for COVID-19. International journal of molecular sciences. 2021 Nov; 22(23):. doi: 10.3390/ijms222312955. [PMID: 34884756]
  • Tomas Rajtik, Peter Galis, Linda Bartosova, Ludovit Paulis, Eva Goncalvesova, Jan Klimas. Alternative RAS in Various Hypoxic Conditions: From Myocardial Infarction to COVID-19. International journal of molecular sciences. 2021 Nov; 22(23):. doi: 10.3390/ijms222312800. [PMID: 34884604]
  • Masayoshi Kukida, Lei Cai, Dien Ye, Hisashi Sawada, Yuriko Katsumata, Michael K Franklin, Peter I Hecker, Kenneth S Campbell, A H Jan Danser, Adam E Mullick, Alan Daugherty, Ryan E Temel, Hong S Lu. Renal Angiotensinogen Is Predominantly Liver Derived in Nonhuman Primates. Arteriosclerosis, thrombosis, and vascular biology. 2021 11; 41(11):2851-2853. doi: 10.1161/atvbaha.121.316590. [PMID: 34496634]
  • Oliver von Bohlen Und Halbach. The angiotensin converting enzyme 2 (ACE2) system in the brain: possible involvement in Neuro-Covid. Histology and histopathology. 2021 Nov; 36(11):1125-1131. doi: 10.14670/hh-18-356. [PMID: 34142714]
  • Christina Hoyer-Kimura, John P Konhilas, Heidi M Mansour, Robin Polt, Kristian P Doyle, Dean Billheimer, Meredith Hay. Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia. Journal of neuroinflammation. 2021 Oct; 18(1):236. doi: 10.1186/s12974-021-02281-1. [PMID: 34654436]
  • Juliana Fabiana Gregório, Giselle Santos Magalhães, Maria Glória Rodrigues-Machado, Kézia Emanoeli Ramos Gonzaga, Daisy Motta-Santos, Puebla Cassini-Vieira, Lucíola Silva Barcelos, Maria Aparecida Ribeiro Vieira, Robson Augusto Souza Santos, Maria Jose Campagnole-Santos. Angiotensin-(1-7)/Mas receptor modulates anti-inflammatory effects of exercise training in a model of chronic allergic lung inflammation. Life sciences. 2021 Oct; 282(?):119792. doi: 10.1016/j.lfs.2021.119792. [PMID: 34229006]
  • Daniele T Alves, Luiz Felipe Mendes, Walkyria O Sampaio, Leda M C Coimbra-Campos, Maria Aparecida R Vieira, Anderson J Ferreira, Almir S Martins, Elena Popova, Mihail Todiras, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Robson A S Santos, Maria Jose Campagnole-Santos. Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein. Clinical science (London, England : 1979). 2021 09; 135(18):2197-2216. doi: 10.1042/cs20210599. [PMID: 34494083]
  • Xuming Sun, Hao Wang, Hunter Hodge, Kendra N Wright, Sarfaraz Ahmad, Carlos M Ferrario, Leanne Groban. Amplifying effect of chronic lisinopril therapy on diastolic function and the angiotensin-(1-7) Axis by the G1 agonist in ovariectomized spontaneously hypertensive rats. Translational research : the journal of laboratory and clinical medicine. 2021 09; 235(?):62-76. doi: 10.1016/j.trsl.2021.04.004. [PMID: 33915312]
  • Mohammad Mahmudur Rahman, Maruf Hasan, Asif Ahmed. Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients. Reviews in medical virology. 2021 09; 31(5):1-12. doi: 10.1002/rmv.2213. [PMID: 33426683]
  • Fernanda Ribeiro Marins, Aline Cristina Oliveira, Fatimunnisa Qadri, Daisy Motta-Santos, Natalia Alenina, Michael Bader, Marco Antonio Peliky Fontes, Robson Augusto Souza Santos. Alamandine but not angiotensin-(1-7) produces cardiovascular effects at the rostral insular cortex. American journal of physiology. Regulatory, integrative and comparative physiology. 2021 09; 321(3):R513-R521. doi: 10.1152/ajpregu.00308.2020. [PMID: 34346721]
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